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Conserved domains on  [gi|47059143|ref|NP_081240|]
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coiled-coil domain-containing protein 124 [Mus musculus]

Protein Classification

coiled-coil domain-containing protein 124( domain architecture ID 10533331)

coiled-coil domain-containing protein 124 (CCDC124) is a component of the centrosome during interphase and G2/M transition which is involved in cytokinesis

Gene Ontology:  GO:0006366|GO:0051301|GO:0003713|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ccdc124 pfam06244
Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription ...
 126-208 6.02e-42

Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore, human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologs from human (cJun) and arabidopsis (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein 124), were identified as a novel component of the centrosome during interphase and G2/M transition and is involved in cytokinesis.


:

Pssm-ID: 461858 [Multi-domain]  Cd Length: 84  Bit Score: 137.00  E-value: 6.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059143   126 NLNRRLQEEGSVEARTVEDAIAVLSVAEE-ADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDN 204
Cdd:pfam06244   1 NINRLRADEGAVEARTVDDAIAVLSVGEEpADRHPEKRMKAAYKAFEEENLPRLKEENPGLRLSQLKQMLKKEWQKSPEN 80


                  ....
gi 47059143   205 PMNQ 208
Cdd:pfam06244  81 PLNQ 84
 
Name Accession Description Interval E-value
Ccdc124 pfam06244
Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription ...
 126-208 6.02e-42

Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore, human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologs from human (cJun) and arabidopsis (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein 124), were identified as a novel component of the centrosome during interphase and G2/M transition and is involved in cytokinesis.


Pssm-ID: 461858 [Multi-domain]  Cd Length: 84  Bit Score: 137.00  E-value: 6.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059143   126 NLNRRLQEEGSVEARTVEDAIAVLSVAEE-ADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDN 204
Cdd:pfam06244   1 NINRLRADEGAVEARTVDDAIAVLSVGEEpADRHPEKRMKAAYKAFEEENLPRLKEENPGLRLSQLKQMLKKEWQKSPEN 80


                  ....
gi 47059143   205 PMNQ 208
Cdd:pfam06244  81 PLNQ 84
 
Name Accession Description Interval E-value
Ccdc124 pfam06244
Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription ...
 126-208 6.02e-42

Coiled-coil domain-containing protein 124 /Oxs1; Oxs1 (oxidative stress transcription corepressor Oxs1) and Pap1 form a complex to regulate transcription when cells are exposed to diamide or Cd that causes disulfide stress. In fission yeast such as S. pombe, heterologous Oxs1-like proteins can enhance diamide stress tolerance. Furthermore, human and arabidopsis Oxs1 can interchangeably bind Pap1 or Pap1 homologs from human (cJun) and arabidopsis (bZIP10), suggesting that Oxs1 may be a component of an evolutionarily-conserved stress response pathway. Family members found in human such as Ccdc124 (Coiled-Coil Domain Containing Protein 124), were identified as a novel component of the centrosome during interphase and G2/M transition and is involved in cytokinesis.


Pssm-ID: 461858 [Multi-domain]  Cd Length: 84  Bit Score: 137.00  E-value: 6.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 47059143   126 NLNRRLQEEGSVEARTVEDAIAVLSVAEE-ADRHPERRMRAAFTAFEEVQLPRLKQENPNMRLSQLKQLLKKEWLRSPDN 204
Cdd:pfam06244   1 NINRLRADEGAVEARTVDDAIAVLSVGEEpADRHPEKRMKAAYKAFEEENLPRLKEENPGLRLSQLKQMLKKEWQKSPEN 80


                  ....
gi 47059143   205 PMNQ 208
Cdd:pfam06244  81 PLNQ 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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