protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform 1 [Mus musculus]
glycosyltransferase family 13 protein; glycosyltransferase family 8 protein( domain architecture ID 10195368)
glycosyltransferase family 13 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds| glycosyltransferase family 8 protein containing a class I SAM-dependent methyltransferase domain, catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds, and possibly the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor
List of domain hits
Name | Accession | Description | Interval | E-value | ||||||
GT13_GLCNAC-TI | cd02514 | GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type ... |
301-628 | 0e+00 | ||||||
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GLCNAC-T I , GNT-I) transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide, an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus. The catalytic domain is located at the C-terminus. These proteins are members of the glycosy transferase family 13. : Pssm-ID: 133007 Cd Length: 334 Bit Score: 522.66 E-value: 0e+00
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PANDER_GnT-1_2_like | cd13937 | PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ... |
99-246 | 1.09e-96 | ||||||
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined. : Pssm-ID: 260111 Cd Length: 148 Bit Score: 293.44 E-value: 1.09e-96
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Name | Accession | Description | Interval | E-value | ||||||
GT13_GLCNAC-TI | cd02514 | GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type ... |
301-628 | 0e+00 | ||||||
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GLCNAC-T I , GNT-I) transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide, an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus. The catalytic domain is located at the C-terminus. These proteins are members of the glycosy transferase family 13. Pssm-ID: 133007 Cd Length: 334 Bit Score: 522.66 E-value: 0e+00
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PANDER_GnT-1_2_like | cd13937 | PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ... |
99-246 | 1.09e-96 | ||||||
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined. Pssm-ID: 260111 Cd Length: 148 Bit Score: 293.44 E-value: 1.09e-96
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GNT-I | pfam03071 | GNT-I family; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, ... |
302-559 | 7.48e-46 | ||||||
GNT-I family; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) EC:2.4.1.101 transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus, and is probably distributed in all tissues. The catalytic domain is located at the C-terminus. Pssm-ID: 397273 Cd Length: 434 Bit Score: 168.55 E-value: 7.48e-46
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ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
129-217 | 1.89e-32 | ||||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 120.06 E-value: 1.89e-32
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Name | Accession | Description | Interval | E-value | ||||||
GT13_GLCNAC-TI | cd02514 | GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type ... |
301-628 | 0e+00 | ||||||
GT13_GLCNAC-TI is involved in an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GLCNAC-T I , GNT-I) transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide, an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus. The catalytic domain is located at the C-terminus. These proteins are members of the glycosy transferase family 13. Pssm-ID: 133007 Cd Length: 334 Bit Score: 522.66 E-value: 0e+00
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PANDER_GnT-1_2_like | cd13937 | PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1, ... |
99-246 | 1.09e-96 | ||||||
PANDER-like domain of N-acetylglucosaminyltransferases; O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 participates in O-mannosyl glycosylation and may be responsible for creating GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moieties on alpha dystroglycan and other O-mannosylated proteins. The domain characterized by this model lies N-terminal to the catalytic domain. Its function has not been determined. Pssm-ID: 260111 Cd Length: 148 Bit Score: 293.44 E-value: 1.09e-96
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PANDER_like | cd13936 | Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) ... |
99-246 | 3.76e-50 | ||||||
Domains similar to the Pancreatic-derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. This wider family contains FAM3B and FAM4C, N-terminal domains of N-acetylglucosaminyltransferases, and domains in poorly characterized proteins that have been associated with deafness and the progression of cancer. Pssm-ID: 260110 Cd Length: 149 Bit Score: 171.37 E-value: 3.76e-50
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GNT-I | pfam03071 | GNT-I family; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, ... |
302-559 | 7.48e-46 | ||||||
GNT-I family; Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (GNT-I, GLCNAC-T I) EC:2.4.1.101 transfers N-acetyl-D-glucosamine from UDP to high-mannose glycoprotein N-oligosaccharide. This is an essential step in the synthesis of complex or hybrid-type N-linked oligosaccharides. The enzyme is an integral membrane protein localized to the Golgi apparatus, and is probably distributed in all tissues. The catalytic domain is located at the C-terminus. Pssm-ID: 397273 Cd Length: 434 Bit Score: 168.55 E-value: 7.48e-46
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ILEI | pfam15711 | Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily ... |
129-217 | 1.89e-32 | ||||||
Interleukin-like EMT inducer; ILEI is a family of proteins found in vertebrates. It is heavily involved in the process of the transition from epithelial to mesenchymal tissue - EMT - during all of embryonic development, cancer progression, metastasis, and chronic inflammation/fibrosis. ILEI is upregulated exclusively at the level of translation, and abnormal ILEI expression, ie cytoplasmic over-expression instead of vesicular localization, is associated with EMT in human cancerous tissue. In order to induce and maintain the EMT of hepatocytes in a TGF-beta-independent fashion ILEI needs the cooperation of oncogenic Ras. Pssm-ID: 464817 Cd Length: 89 Bit Score: 120.06 E-value: 1.89e-32
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PANDER_like_TMEM2 | cd13938 | PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a ... |
122-219 | 2.23e-22 | ||||||
PANDER-like domain of the transmembrane protein TMEM2; TMEM2 has been characterized as a transmembrane protein that maps to the DFNB7-DFNB11 deafness locus on human chromosome 9. It contains a domain similar to the Pancreatic-derived factor PANDER, C-terminal to a glycine rich G8-domain. The function of the PANDER-like domain in TMEM2 has not been characterized. Pssm-ID: 260112 Cd Length: 168 Bit Score: 94.31 E-value: 2.23e-22
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ILEI_FAM3C | cd13940 | Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) ... |
112-228 | 3.37e-16 | ||||||
Interleukin-like EMT inducer; The secreted factor FAM3C or ILEI (InterLeukin-like Emt Inducer) has been identifed as a protein involved in the epithelial-mesenchymal transition (EMT) and in processes associated with metastasis formation and the progression of cancer. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3C designation. ILEI has been found to be widely expressed, and to be involved in retinal development. Pssm-ID: 260114 Cd Length: 171 Bit Score: 76.54 E-value: 3.37e-16
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PANDER_FAM3B | cd13939 | Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a ... |
112-217 | 2.75e-12 | ||||||
Pancreatic derived factor; FAM3B or PANDER (PANcreatic DERived factor) has been identifed as a regulator of glucose homeostasis and beta cell function. The protein is expressed in the endocrine pancreas and co-secreted with insulin in response to glucose, particularly under conditions of insulin resistance. The protein had initially been predicted to be a member of the four-helical cytokine family, hence the FAM3B designation. PANDER induces apoptosis of insulin-secreting beta-cells when over-expressed in vitro. It has been associated with the progression of type 2 diabetes by downregulating beta cell function as well as insulin sensitivity in the liver. Pssm-ID: 260113 Cd Length: 175 Bit Score: 65.71 E-value: 2.75e-12
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Blast search parameters | ||||
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