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Conserved domains on  [gi|13385762|ref|NP_080529|]
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leucine-rich repeat-containing protein 18 isoform 1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-200 7.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 7.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  30 KRLDLSKMGITTFPKCILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLT 109
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 110 TngLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPaSIAKLPKLKKLNIKRNPFPNADESEmfv 189
Cdd:COG4886 196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--- 269

                       170
                ....*....|.
gi 13385762 190 dSIKRLENLYL 200
Cdd:COG4886 270 -NLTNLKTLDL 279
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-200 7.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 7.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  30 KRLDLSKMGITTFPKCILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLT 109
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 110 TngLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPaSIAKLPKLKKLNIKRNPFPNADESEmfv 189
Cdd:COG4886 196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--- 269

                       170
                ....*....|.
gi 13385762 190 dSIKRLENLYL 200
Cdd:COG4886 270 -NLTNLKTLDL 279
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-200 7.03e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.75  E-value: 7.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   49 LSDIDELDLSRNMIR-KIPDSIAKFQNLRWLDLHSNYI-DKLPESIGQMTSLLFLNVSNNRLTtNGLPVELNQLKNIRTV 126
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLV-GQIPRELGQMKSLKWI 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  127 NLG-----------------LNHLD--------SVPTTLGALKELHEVGLHDNLLT-TIPASIAKLPKLKKLNIKRNPFp 180
Cdd:PLN00113 218 YLGynnlsgeipyeiggltsLNHLDlvynnltgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL- 296

                        170       180
                 ....*....|....*....|
gi 13385762  181 nADESEMFVDSIKRLENLYL 200
Cdd:PLN00113 297 -SGEIPELVIQLQNLEILHL 315
LRR_8 pfam13855
Leucine rich repeat;
54-108 4.67e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 4.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13385762    54 ELDLSRNMIRKIPDSIAK-FQNLRWLDLHSNYIDKL-PESIGQMTSLLFLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-179 4.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  55 LDLSRNMIRKIpDSIAKFQNLRWLDLHSNYIDKLpESIGQMTSLLFLNVSNNRLTtNGLPVELNQ------LKNIRTVNL 128
Cdd:cd21340  51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalSNSLRVLNI 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13385762 129 GLNHLDSVpTTLGALKELHEVGLHDNLLTTIPA---SIAKLPKLKKLNIKRNPF 179
Cdd:cd21340 128 SGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-200 7.89e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.10  E-value: 7.89e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  30 KRLDLSKMGITTFPKCILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLT 109
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 110 TngLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPaSIAKLPKLKKLNIKRNPFPNADESEmfv 189
Cdd:COG4886 196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA--- 269

                       170
                ....*....|.
gi 13385762 190 dSIKRLENLYL 200
Cdd:COG4886 270 -NLTNLKTLDL 279
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-201 1.43e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 1.43e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  30 KRLDLSKMGITTFPKCILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLT 109
Cdd:COG4886 139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 110 TngLPVELNQLKNIRTVNLGLNHLDSVPtTLGALKELHEVGLHDNLLTTIPASiAKLPKLKKLNIKRNPFPNADESEMFV 189
Cdd:COG4886 219 D--LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDLKLKELEL 294

                       170
                ....*....|..
gi 13385762 190 DSIKRLENLYLV 201
Cdd:COG4886 295 LLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-200 2.07e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.25  E-value: 2.07e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  46 ILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLTTngLPVELNQLKNIRT 125
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLTNLKE 186

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13385762 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPASIAKLPKLKKLNIKRNPFPNADEsemfVDSIKRLENLYL 200
Cdd:COG4886 187 LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE----LGNLTNLEELDL 257
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-200 9.07e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.16  E-value: 9.07e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  46 ILRLSDIDELDLSRNmirkipDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRLTTngLPVELNQLKNIRT 125
Cdd:COG4886  92 LGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKS 163

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13385762 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPASIAKLPKLKKLNIKRNPFPNADESemfVDSIKRLENLYL 200
Cdd:COG4886 164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDL 235
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-200 7.03e-20

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 88.75  E-value: 7.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   49 LSDIDELDLSRNMIR-KIPDSIAKFQNLRWLDLHSNYI-DKLPESIGQMTSLLFLNVSNNRLTtNGLPVELNQLKNIRTV 126
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLV-GQIPRELGQMKSLKWI 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  127 NLG-----------------LNHLD--------SVPTTLGALKELHEVGLHDNLLT-TIPASIAKLPKLKKLNIKRNPFp 180
Cdd:PLN00113 218 YLGynnlsgeipyeiggltsLNHLDlvynnltgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL- 296

                        170       180
                 ....*....|....*....|
gi 13385762  181 nADESEMFVDSIKRLENLYL 200
Cdd:PLN00113 297 -SGEIPELVIQLQNLEILHL 315
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-230 3.78e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 3.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   30 KRLDLSKMGITTFPKCilrLSD-IDELDLSRNMIRKIPDSIAkfQNLRWLDLHSNYIDKLPESIGQmtSLLFLNVSNNRL 108
Cdd:PRK15370 223 KTLYANSNQLTSIPAT---LPDtIQEMELSINRITELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSI 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  109 TTngLPVELNQlkNIRTVNLGLNHLDSVPTTLGALKELHEVGlhDNLLTTIPASIAklPKLKKLNIKRNPFPNADES--- 185
Cdd:PRK15370 296 RT--LPAHLPS--GITHLNVQSNSLTALPETLPPGLKTLEAG--ENALTSLPASLP--PELQVLDVSKNQITVLPETlpp 367

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 13385762  186 ---EMFVDsikrlENLyLVEEKDMCSSCLQRCQQARDKLNKIKSMAPS 230
Cdd:PRK15370 368 titTLDVS-----RNA-LTNLPENLPAALQIMQASRNNLVRLPESLPH 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-200 3.07e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  32 LDLSKMGITTFPKCILRLSDIDELDLSRNMIRKIPDSIAKFQNLRWLDLHSNYIDKLPESIGQMTSLLFLNVSNNRlttn 111
Cdd:COG4886  32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 112 glpvELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPASIAKLPKLKKLNIKRNPFPNADESemfVDS 191
Cdd:COG4886 108 ----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE---LGN 180


                ....*....
gi 13385762 192 IKRLENLYL 200
Cdd:COG4886 181 LTNLKELDL 189
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-139 5.47e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 5.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   30 KRLDLSKMGIT-TFPKCILRLSDIDELDLSRNMIR-KIPDSIAKFQNLRWLDL-HSNYIDKLPESIGQMTSLLFLNVSNN 106
Cdd:PLN00113 478 ENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQN 557

                         90       100       110
                 ....*....|....*....|....*....|....
gi 13385762  107 RLTTNgLPVELNQLKNIRTVNLGLNHLD-SVPTT 139
Cdd:PLN00113 558 QLSGE-IPKNLGNVESLVQVNISHNHLHgSLPST 590
PLN03150 PLN03150
hypothetical protein; Provisional
 52-167 1.39e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.21  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   52 IDELDLSRNMIR-KIPDSIAKFQNLRWLDLHSNYID-KLPESIGQMTSLLFLNVSNNRLttNGlpvelnqlknirtvnlg 129
Cdd:PLN03150 420 IDGLGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSF--NG----------------- 480

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 13385762  130 lnhldSVPTTLGALKELHEVGLHDNLLT-TIPASIAKLP 167
Cdd:PLN03150 481 -----SIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-200 6.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.31  E-value: 6.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   50 SDIDELDLS-RNMIRKIPDSIAKFQNLRWLDLHSNYID-KLPESIGQMT-SLLFLNVSNNRLTTnglPVELNQLKNIRTV 126
Cdd:PLN00113  69 SRVVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG---SIPRGSIPNLETL 145

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13385762  127 NLGLNHLD-SVPTTLGALKELHEVGLHDNLLT-TIPASIAKLPKLKKLNIKRNPFPNADESEMfvDSIKRLENLYL 200
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGQIPREL--GQMKSLKWIYL 219
PLN03150 PLN03150
hypothetical protein; Provisional
 32-109 3.13e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.97  E-value: 3.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   32 LDLSKMGITTF-PKCILRLSDIDELDLSRNMIR-KIPDSIAKFQNLRWLDLHSNYID-KLPESIGQMTSLLFLNVSNNRL 108
Cdd:PLN03150 423 LGLDNQGLRGFiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 13385762  109 T 109
Cdd:PLN03150 503 S 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-179 1.09e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 1.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   55 LDLSRN-MIRKIPDSIAKfQNLRWLDLHSNYIDK-LPESIGQMTSLLFLNVSNNRLTTNgLPVELNQLKNIRTVNLGLNH 132
Cdd:PLN00113 457 LSLARNkFFGGLPDSFGS-KRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGE-IPDELSSCKKLVSLDLSHNQ 534

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 13385762  133 LD-SVPTTLGALKELHEVGLHDNLLT-TIPASIAKLPKLKKLNIKRNPF 179
Cdd:PLN00113 535 LSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
54-108 4.67e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 4.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 13385762    54 ELDLSRNMIRKIPDSIAK-FQNLRWLDLHSNYIDKL-PESIGQMTSLLFLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-179 4.79e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 4.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  55 LDLSRNMIRKIpDSIAKFQNLRWLDLHSNYIDKLpESIGQMTSLLFLNVSNNRLTtNGLPVELNQ------LKNIRTVNL 128
Cdd:cd21340  51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQRLP-PGEKLTFDPrslaalSNSLRVLNI 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13385762 129 GLNHLDSVpTTLGALKELHEVGLHDNLLTTIPA---SIAKLPKLKKLNIKRNPF 179
Cdd:cd21340 128 SGNNIDSL-EPLAPLRNLEQLDASNNQISDLEElldLLSSWPSLRELDLTGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-205 8.43e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 8.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  30 KRLDLSKMGITTFPKcILRLSDIDELDLSRNMIRKIPDSiAKFQNLRWLDLHSNYI-----DKLPESIGQMTSLLFLNVS 104
Cdd:COG4886 231 ETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLL 308

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 105 NNRLTTNGLPVELNQLKNIRTVNLGLNHLDSVPTTLGALKELHEVGLHDNLLTTIPASIAKLPKLKKLNIKRNPFPNADE 184
Cdd:COG4886 309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                       170       180
                ....*....|....*....|.
gi 13385762 185 SEMFVDSIKRLENLYLVEEKD 205
Cdd:COG4886 389 LLLLLLTTTAGVLLLTLALLD 409
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
50-179 5.15e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 5.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   50 SDIDELDLSRNMIRKIPDSIAKFQNLrWLdlHSNYIDKLPESIGQMTSLLflnVSNNRLTTngLPVELNQLKNIRTVNLG 129
Cdd:PRK15387 342 SGLQELSVSDNQLASLPTLPSELYKL-WA--YNNRLTSLPALPSGLKELI---VSGNRLTS--LPVLPSELKELMVSGNR 413

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 13385762  130 LNHLDSVPTTLGALKelhevgLHDNLLTTIPASIAKLPKLKKLNIKRNPF 179
Cdd:PRK15387 414 LTSLPMLPSGLLSLS------VYRNQLTRLPESLIHLSSETTVNLEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-200 1.86e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  55 LDLSRNMIRKIPDsIAKFQNLRWLDLHSNYIDKLpESIGQMTSLLFLNVSNNRLTT----NGLP--------------VE 116
Cdd:cd21340   7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKienlENLVnlkklylggnrisvVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762 117 -LNQLKNIRTVNLGLNHLDS------VPTTLGALKE-LHEVGLHDNLLTTIpASIAKLPKLKKLNIKRNPFPNADESEMF 188
Cdd:cd21340  85 gLENLTNLEELHIENQRLPPgekltfDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLDL 163

                       170
                ....*....|..
gi 13385762 189 VDSIKRLENLYL 200
Cdd:cd21340 164 LSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
73-133 2.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13385762    73 QNLRWLDLHSNYIDKL-PESIGQMTSLLFLNVSNNRLTTNGlPVELNQLKNIRTVNLGLNHL 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-204 2.66e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.06  E-value: 2.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   58 SRNMIRKIPDSIAKFQNLRWLDLHSNYID-KLPESIGQMTSLLFLNVSNNRLTTNgLPVELNQLKNIRTVNLGLNHLD-S 135
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGE-IPKSLGACRSLRRVRLQDNSFSgE 419

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13385762  136 VPTTLGALKELHEVGLHDN-LLTTIPASIAKLPKLKKLNIKRNPF----PNADESemfvdsiKRLENLYLVEEK 204
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNnLQGRINSRKWDMPSLQMLSLARNKFfgglPDSFGS-------KRLENLDLSRNQ 486
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
27-180 4.44e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 38.22  E-value: 4.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762   27 DGRKRLDLSKMGITTFPKCILrlSDIDELDLSRNMIRKIPdsiAKFQNLRWLDLHSNYIDKLPEsigQMTSLLFLNVSNN 106
Cdd:PRK15387 201 NGNAVLNVGESGLTTLPDCLP--AHITTLVIPDNNLTSLP---ALPPELRTLEVSGNQLTSLPV---LPPGLLELSIFSN 272

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13385762  107 RLT-TNGLPVELNQLKnirtvnLGLNHLDSVPTTLGALKELhevGLHDNLLTTIPASIAKLPKLKKLNIKRNPFP 180
Cdd:PRK15387 273 PLThLPALPSGLCKLW------IFGNQLTSLPVLPPGLQEL---SVSDNQLASLPALPSELCKLWAYNNQLTSLP 338
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 54-178 5.39e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 5.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  54 ELDLSRNMIRK-----IPDSIAKFQNLRWLDLHSNYIDK-----LPESIGQMTSLLFLNVSNNRLTTNG---LPVELNQL 120
Cdd:COG5238 212 TLWLKRNPIGDegaeiLAEALKGNKSLTTLDLSNNQIGDegviaLAEALKNNTTVETLYLSGNQIGAEGaiaLAKALQGN 291

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13385762 121 KNIRTVNLGLNHLD-----SVPTTLGALKELHEVGLHDNLLTT-----IPASIAKLPKLKKLNIKRNP 178
Cdd:COG5238 292 TTLTSLDLSVNRIGdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQ 359
LRR_8 pfam13855
Leucine rich repeat;
30-85 6.55e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 6.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 13385762    30 KRLDLSKMGITTF-PKCILRLSDIDELDLSRNMIRKI-PDSIAKFQNLRWLDLHSNYI 85
Cdd:pfam13855   4 RSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
122-179 7.22e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.04  E-value: 7.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13385762   122 NIRTVNLGLNHLDSVP----TTLGALKELHevgLHDNLLTTI-PASIAKLPKLKKLNIKRNPF 179
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSNLKVLD---LSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-179 9.69e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.95  E-value: 9.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385762  49 LSDIDELDLSRN-----MIRKIPDSIAKFQNLRWLDLHSNYID-----KLPESIGQMTSLLFLNVSNNRLTTNGLPVELN 118
Cdd:cd00116 164 NRDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAGAAALAS 243

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13385762 119 QLKN----IRTVNLGLNHL--DSVPTTLGALKE---LHEVGLHDNLLTT------IPASIAKLPKLKKLNIKRNPF 179
Cdd:cd00116 244 ALLSpnisLLTLSLSCNDItdDGAKDLAEVLAEkesLLELDLRGNKFGEegaqllAESLLEPGNELESLWVKDDSF 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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