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Conserved domains on  [gi|13385104|ref|NP_079915|]
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centromere protein M isoform 1 [Mus musculus]

Protein Classification

CENP-M domain-containing protein( domain architecture ID 10567496)

CENP-M domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-M pfam11111
Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the ...
 1-171 4.75e-103

Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.


:

Pssm-ID: 463224  Cd Length: 173  Bit Score: 293.45  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104     1 MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASELRVHLANSLPLPSNVN--RPRIDLIVFVINLHSKYSL 78
Cdd:pfam11111   1 MSVLRPFDKLPELNTATVLLVGTEEALLQQLAEAMLKEDTEFELQVRLATSLPLPSENDelRPRIDLIVFIIDLHSKLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104    79 QKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVP 158
Cdd:pfam11111  81 QTVESSLKHLDVSFFLGKVCFLVTGAGRESHCSVDLNTVRKLADTYHSPLLFCELETEDGRAALAQRLLRMLQICAGHVP 160

                         170
                  ....*....|...
gi 13385104   159 GVSALNLMSLLRS 171
Cdd:pfam11111 161 GVSALLLSSLMRS 173
 
Name Accession Description Interval E-value
CENP-M pfam11111
Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the ...
 1-171 4.75e-103

Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.


Pssm-ID: 463224  Cd Length: 173  Bit Score: 293.45  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104     1 MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASELRVHLANSLPLPSNVN--RPRIDLIVFVINLHSKYSL 78
Cdd:pfam11111   1 MSVLRPFDKLPELNTATVLLVGTEEALLQQLAEAMLKEDTEFELQVRLATSLPLPSENDelRPRIDLIVFIIDLHSKLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104    79 QKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVP 158
Cdd:pfam11111  81 QTVESSLKHLDVSFFLGKVCFLVTGAGRESHCSVDLNTVRKLADTYHSPLLFCELETEDGRAALAQRLLRMLQICAGHVP 160

                         170
                  ....*....|...
gi 13385104   159 GVSALNLMSLLRS 171
Cdd:pfam11111 161 GVSALLLSSLMRS 173
 
Name Accession Description Interval E-value
CENP-M pfam11111
Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the ...
 1-171 4.75e-103

Centromere protein M (CENP-M); The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.


Pssm-ID: 463224  Cd Length: 173  Bit Score: 293.45  E-value: 4.75e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104     1 MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKDDCASELRVHLANSLPLPSNVN--RPRIDLIVFVINLHSKYSL 78
Cdd:pfam11111   1 MSVLRPFDKLPELNTATVLLVGTEEALLQQLAEAMLKEDTEFELQVRLATSLPLPSENDelRPRIDLIVFIIDLHSKLSL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13385104    79 QKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAHTYRSPLLLCDLQVESFRAAMARRLVRILQICAGHVP 158
Cdd:pfam11111  81 QTVESSLKHLDVSFFLGKVCFLVTGAGRESHCSVDLNTVRKLADTYHSPLLFCELETEDGRAALAQRLLRMLQICAGHVP 160

                         170
                  ....*....|...
gi 13385104   159 GVSALNLMSLLRS 171
Cdd:pfam11111 161 GVSALLLSSLMRS 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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