|
Name |
Accession |
Description |
Interval |
E-value |
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2297-2406 |
4.47e-39 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 142.36 E-value: 4.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2297 VTQTFHITLHPVDDSLPVVQ-NLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQhfHLTSTF 2375
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 2376 TMKDIYQNRVSYSHDGSNSLKDRFTFTVSDG 2406
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2183-2293 |
2.74e-34 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 128.87 E-value: 2.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2183 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSF 2261
Cdd:pfam16184 1 RSVPFTFNITIIPvNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|..
gi 256000767 2262 TQADLTSRNVQYVHSSeAEKHSDAFSFTLSDG 2293
Cdd:pfam16184 81 TQADIDSGLVVYVHDG-SESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2425-2537 |
7.86e-27 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 107.30 E-value: 7.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2425 PQPFRVDILPVDDGTPRIVTNLGLQWLEymdGkATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAAT 2504
Cdd:pfam16184 4 PFTFNITIIPVNDEAPVLTTNTGLRLWE---G-SSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN 79
|
90 100 110
....*....|....*....|....*....|...
gi 256000767 2505 FTQEDVNLGLIRYVlHKEKiREMMDSFQFLVKD 2537
Cdd:pfam16184 80 FTQADIDSGLVVYV-HDGS-ESTSDGFTFQVTD 110
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1203-1310 |
1.69e-25 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 103.45 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1203 SEPQL--INIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNP-QDVVIEIIDPPLHGQLLQTLqSPATPIYQF 1279
Cdd:pfam16184 2 SVPFTfnITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 1280 QLDELSRGLLHYAHDGSDSTSDVAVLQANDG 1310
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2073-2179 |
6.08e-22 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 93.44 E-value: 6.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2073 LPASD-TPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLeqisikgPIRSFTQAD 2151
Cdd:pfam16184 12 IPVNDeAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL-------PVTNFTQAD 84
|
90 100
....*....|....*....|....*...
gi 256000767 2152 ISQGHVEYSHgTGEPGGSFAFKFDVVDG 2179
Cdd:pfam16184 85 IDSGLVVYVH-DGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1941-2059 |
1.84e-20 |
|
Cadherin-like;
:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 89.20 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1941 RSEIHSINITIERKNDEPPRMTL-QPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENg 2019
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 256000767 2020 rvlvqgstFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDG 2059
Cdd:pfam16184 80 --------FTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1314-1438 |
6.56e-18 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 81.88 E-value: 6.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1314 HNILFQVKTVPQNDRGLQLVANS--MVWvpEGGMLQITNRILQAEAPGASAEEIIYKITQDyPQFGEVVLLvnmpadspa 1391
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTTNTglRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK--------- 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 256000767 1392 degqhlpdGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVS 1438
Cdd:pfam16184 71 --------GAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVT 109
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1446-1574 |
7.60e-17 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 78.80 E-value: 7.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1446 RLESHMFNIAILPQTPEAPKVSLEASLHMTarEDGLTVIQPHSLSFINSEKPSGKIVYNITLPlhPNQGIIEHRDHPHSP 1525
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLP 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 256000767 1526 IRYFTQEDINQGKVMYRpppaapHLqelmafsfAGLPESVKFHFTVSDG 1574
Cdd:pfam16184 77 VTNFTQADIDSGLVVYV------HD--------GSESTSDGFTFQVTDG 111
|
|
| VSP super family |
cl31427 |
Giardia variant-specific surface protein; |
396-673 |
2.56e-16 |
|
Giardia variant-specific surface protein;
The actual alignment was detected with superfamily member pfam03302:
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 84.64 E-value: 2.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 396 CPPCPVGTlALEVKGQCCPdcTSVHCH-PDCLTCSQSPDH-CDLCQDPTKLLQNGWCVHSCG-LGFYQAGSlCLACQPQC 472
Cdd:pfam03302 1 CDECKPGY-ELSADKTKCT--SSAPCKtENCKACSNDKREvCEECNSNNYLTPTSQCIDDCAkIGNYYYTT-NANNKKIC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 473 STCTSGlECSSCQppllmRHGQCvPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLAC---------RDPLHVLRDGGC 543
Cdd:pfam03302 77 KECTVA-NCKTCE-----DQGQC-QACNDGFYKSGDACSPCHESCKTCSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 544 ESSCGKGFYNRQGT-------CSACDQSCDS-----CGPSSPRCL-TCTEKTVlHDGKCmSECPGGYYAdATGRC----- 605
Cdd:pfam03302 150 TTGTGAGACKTCGLtidgtsyCSECATETEYpqngvCTSTAARATaTCKASSV-ANGMC-SSCANGYFR-MNGGCyettk 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 606 ----KVCH--NSCASCSGPTPSH------CTACSPP-KALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGpAPSHCTG 672
Cdd:pfam03302 227 fpgkSVCEeaNSGGTCQKEAPGYklnngdLVTCSPGcKTCTSNTVCTTCMDGYVKTSDSCTKCDSSCETCTG-ATTTCKT 305
|
.
gi 256000767 673 C 673
Cdd:pfam03302 306 C 306
|
|
| VSP super family |
cl31427 |
Giardia variant-specific surface protein; |
691-1060 |
6.82e-16 |
|
Giardia variant-specific surface protein;
The actual alignment was detected with superfamily member pfam03302:
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 83.10 E-value: 6.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 691 PSGECLAQCRAHFYLESTgicEACHQSCFRCA-------GKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTEC 761
Cdd:pfam03302 34 DKREVCEECNSNNYLTPT---SQCIDDCAKIGnyyyttnANNKKICKECTVANCKTceDQGQCQACNDGFYKSGDACSPC 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 762 HPTCRQCHGPLESDCISCYPHISL------TNGNCRTSCREEQflnlvGYCAdchhlCQHCAADLHNTgSICLRCQNAHY 835
Cdd:pfam03302 111 HESCKTCSGGTASDCTECLTGKALrygndgTKGTCGEGCTTGT-----GAGA-----CKTCGLTIDGT-SYCSECATETE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 836 LLLGDHCVPDcpsgyyAERgACKKCHSScRTCQGRgpfsCSSCDTNLVLSHTGTCSTTCFPGHYLddnhvcqpcnthcgs 915
Cdd:pfam03302 180 YPQNGVCTST------AAR-ATATCKAS-SVANGM----CSSCANGYFRMNGGCYETTKFPGKSV--------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 916 CDSQASCTSCRDPnkvllfgecqyescAPQYYLDfsTNTCKECDWSCSACSGplKTDCLQCMDGYVlqdgacveqclssf 995
Cdd:pfam03302 233 CEEANSGGTCQKE--------------APGYKLN--NGDLVTCSPGCKTCTS--NTVCTTCMDGYV-------------- 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256000767 996 yQDSGLCKNCDSYCLQCQGphectrckgpflllEAQCVQECGKGYFADHAKH-KCTACP--------QGCLQCS 1060
Cdd:pfam03302 281 -KTSDSCTKCDSSCETCTG--------------ATTTCKTCATGYYKSGTGCvSCTSSEsdngitgvKGCLNCA 339
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2555-2650 |
8.30e-16 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
:
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 75.37 E-value: 8.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2555 ISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASsssrvssqpGQQDYVEYAGQVQFDEREDTKSCTIVIN 2634
Cdd:smart00237 4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT---------AGSDYEPVPGELTFPPGETEKEIRIKII 74
|
90
....*....|....*.
gi 256000767 2635 DDDVFENVESFTVELS 2650
Cdd:smart00237 75 DDDIYEKDETFYVRLS 90
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1577-1691 |
9.41e-16 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 75.72 E-value: 9.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1577 TSPEMVLTIHLLPSDQQLPVfqVTAPR-LAVSPGGS---TSVGLQVVvrDAETAPKELFFELRRPPQHGVLLKHTAefrr 1652
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPV--LTTNTgLRLWEGSSrpiTPDLLQAE--DPDTPPEDLTYTVVQGPSHGHLALKGA---- 72
|
90 100 110
....*....|....*....|....*....|....*....
gi 256000767 1653 PMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDG 1691
Cdd:pfam16184 73 PGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Calx-beta super family |
cl02522 |
Calx-beta domain; |
2798-2894 |
2.15e-14 |
|
Calx-beta domain;
The actual alignment was detected with superfamily member smart00237:
Pssm-ID: 413355 [Multi-domain] Cd Length: 90 Bit Score: 71.13 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2798 ASTVSLGNTAFTVSEDAGTVKIPVIRHGtDLSTFASVwcaTRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD 2877
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVV---PYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76
|
90
....*....|....*..
gi 256000767 2878 TQYpviEGLETFVVFLS 2894
Cdd:smart00237 77 DIY---EKDETFYVRLS 90
|
|
| caca super family |
cl36745 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2907-3134 |
2.25e-14 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
The actual alignment was detected with superfamily member TIGR00845:
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 80.22 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2907 AVIAINDTFQDVPS-MQFAKDLLLVKEKEGVLHVPITRSG-DLSYESSVRCYTQSHSAQVMEDFEERQNAdssrITFLKG 2984
Cdd:TIGR00845 387 HEVATDDEENDPVSkIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFTEGT----LVFKPG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2985 DKVKNCTVYIHDDSMFEPEEQFRVYL---------GLPLGNHWSG-ARIGKNNMATITISNDEDAPTIEFEEAAYQVREP 3054
Cdd:TIGR00845 463 ETQKEFRIGIIDDDIFEEDEHFYVRLsnlrvgsedGILEANHVSAvAQLASPNTATVTILDDDHAGIFTFEEDVFHVSES 542
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3055 AGpdaiaILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG 3133
Cdd:TIGR00845 543 IG-----IMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELG 617
|
.
gi 256000767 3134 P 3134
Cdd:TIGR00845 618 E 618
|
|
| caca super family |
cl36745 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2553-2803 |
8.05e-12 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
The actual alignment was detected with superfamily member TIGR00845:
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 71.75 E-value: 8.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2553 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSrvssqpgqqDYVEYAGQVQFDEREDTKSCTI 2631
Cdd:TIGR00845 400 SKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGS---------DYEFTEGTLVFKPGETQKEFRI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2632 VINDDDVFENVESFTVELSMP---------------AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPI 2696
Cdd:TIGR00845 471 GIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKV 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2697 ERKGDASSIVSAICYTVPKSAMGsslyaleSGSDFKsrgmSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADA 2776
Cdd:TIGR00845 551 LRTSGARGTVIVPYRTVEGTARG-------GGKDFE----DTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
|
250 260
....*....|....*....|....*..
gi 256000767 2777 SDNARIGRVATAKVLISGPNDASTVSL 2803
Cdd:TIGR00845 620 RWAKRGIKAALLLNETITDDDQKLTSK 646
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
95-152 |
4.80e-11 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
:
Pssm-ID: 278520 Cd Length: 57 Bit Score: 60.52 E-value: 4.80e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 95 CHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAfIPEGSCCPVC 152
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLE-IPPGECCPVC 57
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1699-1811 |
8.24e-11 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.85 E-value: 8.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1699 VRVEVSLSEDRGPRLAAGSSLSITVASksTAIITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVeelsEVSNF 1778
Cdd:pfam16184 7 FNITIIPVNDEAPVLTTNTGLRLWEGS--SRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL----PVTNF 80
|
90 100 110
....*....|....*....|....*....|....
gi 256000767 1779 TMEDINNKKIRYSAvfetDGHLVT-DSFYFSVSD 1811
Cdd:pfam16184 81 TQADIDSGLVVYVH----DGSESTsDGFTFQVTD 110
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1816-1938 |
1.12e-10 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.46 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1816 HLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDD---DNLQRDAIiklsALPKYGCIENTGTGDRf 1892
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDtppEDLTYTVV----QGPSHGHLALKGAPGL- 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 256000767 1893 gPETasdleaSFPIQDVLENYIYYfqsVHESIEPTHDIFSFYVSDG 1938
Cdd:pfam16184 76 -PVT------NFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
221-278 |
4.07e-09 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
:
Pssm-ID: 278520 Cd Length: 57 Bit Score: 55.12 E-value: 4.07e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 221 CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCgKGQSRARRHGQCCEEC 278
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
159-216 |
7.16e-08 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
:
Pssm-ID: 278520 Cd Length: 57 Bit Score: 51.66 E-value: 7.16e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 159 CSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCnQDETVVRVPGKCCPQC 216
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| Cadherin_3 super family |
cl28802 |
Cadherin-like; |
1102-1198 |
8.02e-08 |
|
Cadherin-like;
The actual alignment was detected with superfamily member pfam16184:
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 53.38 E-value: 8.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1102 TPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLsRNGKEVQLDkagRFSWKDVNEKKVRFV 1181
Cdd:pfam16184 18 APVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL-KGAPGLPVT---NFTQADIDSGLVVYV 93
|
90
....*....|....*..
gi 256000767 1182 HSKEKLRKGYLFLKISD 1198
Cdd:pfam16184 94 HDGSESTSDGFTFQVTD 110
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
367-416 |
2.11e-06 |
|
von Willebrand factor (vWF) type C domain;
:
Pssm-ID: 214564 Cd Length: 59 Bit Score: 47.51 E-value: 2.11e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 256000767 367 RIPEGEKWEDGPCKVCEC-RGAQVTCYEPSCPP---CPVGTLAlEVKGQCCPDC 416
Cdd:smart00214 7 VYNDGETWKPDPCQICTClDGTTVLCDPVECPPppdCPNPERV-KPPGECCPRC 59
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
28-87 |
1.32e-05 |
|
von Willebrand factor (vWF) type C domain;
:
Pssm-ID: 214564 Cd Length: 59 Bit Score: 45.20 E-value: 1.32e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256000767 28 CVYQDSLLADATIWKPDSCQSCRCH-GDIVICKPAVC-RNPQCAFekgEVLQIAANQCCPEC 87
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLdGTTVLCDPVECpPPPDCPN---PERVKPPGECCPRC 59
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
285-342 |
2.95e-05 |
|
von Willebrand factor (vWF) type C domain;
:
Pssm-ID: 214564 Cd Length: 59 Bit Score: 44.43 E-value: 2.95e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 285 CSYDGVVRYQDEMWKGSACEFCMCDHGQ-VTCQTGECAKV-ECARDEELIHlDGKCCPEC 342
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKP-PGECCPRC 59
|
|
| FU |
smart00261 |
Furin-like repeats; |
1046-1087 |
2.39e-03 |
|
Furin-like repeats;
:
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 38.64 E-value: 2.39e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 256000767 1046 KHKCTACPQGCLQCSHRDR--CHLCDHGFFLKSGLCVYNCVPGF 1087
Cdd:smart00261 1 DGECKPCHPECATCTGPGPddCTSCKHGFFLDGGKCVSECPPGT 44
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2297-2406 |
4.47e-39 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 142.36 E-value: 4.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2297 VTQTFHITLHPVDDSLPVVQ-NLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQhfHLTSTF 2375
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 2376 TMKDIYQNRVSYSHDGSNSLKDRFTFTVSDG 2406
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2183-2293 |
2.74e-34 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 128.87 E-value: 2.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2183 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSF 2261
Cdd:pfam16184 1 RSVPFTFNITIIPvNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|..
gi 256000767 2262 TQADLTSRNVQYVHSSeAEKHSDAFSFTLSDG 2293
Cdd:pfam16184 81 TQADIDSGLVVYVHDG-SESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2425-2537 |
7.86e-27 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 107.30 E-value: 7.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2425 PQPFRVDILPVDDGTPRIVTNLGLQWLEymdGkATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAAT 2504
Cdd:pfam16184 4 PFTFNITIIPVNDEAPVLTTNTGLRLWE---G-SSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN 79
|
90 100 110
....*....|....*....|....*....|...
gi 256000767 2505 FTQEDVNLGLIRYVlHKEKiREMMDSFQFLVKD 2537
Cdd:pfam16184 80 FTQADIDSGLVVYV-HDGS-ESTSDGFTFQVTD 110
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1203-1310 |
1.69e-25 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 103.45 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1203 SEPQL--INIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNP-QDVVIEIIDPPLHGQLLQTLqSPATPIYQF 1279
Cdd:pfam16184 2 SVPFTfnITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 1280 QLDELSRGLLHYAHDGSDSTSDVAVLQANDG 1310
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2073-2179 |
6.08e-22 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 93.44 E-value: 6.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2073 LPASD-TPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLeqisikgPIRSFTQAD 2151
Cdd:pfam16184 12 IPVNDeAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL-------PVTNFTQAD 84
|
90 100
....*....|....*....|....*...
gi 256000767 2152 ISQGHVEYSHgTGEPGGSFAFKFDVVDG 2179
Cdd:pfam16184 85 IDSGLVVYVH-DGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1941-2059 |
1.84e-20 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 89.20 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1941 RSEIHSINITIERKNDEPPRMTL-QPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENg 2019
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 256000767 2020 rvlvqgstFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDG 2059
Cdd:pfam16184 80 --------FTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1314-1438 |
6.56e-18 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 81.88 E-value: 6.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1314 HNILFQVKTVPQNDRGLQLVANS--MVWvpEGGMLQITNRILQAEAPGASAEEIIYKITQDyPQFGEVVLLvnmpadspa 1391
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTTNTglRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK--------- 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 256000767 1392 degqhlpdGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVS 1438
Cdd:pfam16184 71 --------GAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVT 109
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1446-1574 |
7.60e-17 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 78.80 E-value: 7.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1446 RLESHMFNIAILPQTPEAPKVSLEASLHMTarEDGLTVIQPHSLSFINSEKPSGKIVYNITLPlhPNQGIIEHRDHPHSP 1525
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLP 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 256000767 1526 IRYFTQEDINQGKVMYRpppaapHLqelmafsfAGLPESVKFHFTVSDG 1574
Cdd:pfam16184 77 VTNFTQADIDSGLVVYV------HD--------GSESTSDGFTFQVTDG 111
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
396-673 |
2.56e-16 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 84.64 E-value: 2.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 396 CPPCPVGTlALEVKGQCCPdcTSVHCH-PDCLTCSQSPDH-CDLCQDPTKLLQNGWCVHSCG-LGFYQAGSlCLACQPQC 472
Cdd:pfam03302 1 CDECKPGY-ELSADKTKCT--SSAPCKtENCKACSNDKREvCEECNSNNYLTPTSQCIDDCAkIGNYYYTT-NANNKKIC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 473 STCTSGlECSSCQppllmRHGQCvPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLAC---------RDPLHVLRDGGC 543
Cdd:pfam03302 77 KECTVA-NCKTCE-----DQGQC-QACNDGFYKSGDACSPCHESCKTCSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 544 ESSCGKGFYNRQGT-------CSACDQSCDS-----CGPSSPRCL-TCTEKTVlHDGKCmSECPGGYYAdATGRC----- 605
Cdd:pfam03302 150 TTGTGAGACKTCGLtidgtsyCSECATETEYpqngvCTSTAARATaTCKASSV-ANGMC-SSCANGYFR-MNGGCyettk 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 606 ----KVCH--NSCASCSGPTPSH------CTACSPP-KALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGpAPSHCTG 672
Cdd:pfam03302 227 fpgkSVCEeaNSGGTCQKEAPGYklnngdLVTCSPGcKTCTSNTVCTTCMDGYVKTSDSCTKCDSSCETCTG-ATTTCKT 305
|
.
gi 256000767 673 C 673
Cdd:pfam03302 306 C 306
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
691-1060 |
6.82e-16 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 83.10 E-value: 6.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 691 PSGECLAQCRAHFYLESTgicEACHQSCFRCA-------GKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTEC 761
Cdd:pfam03302 34 DKREVCEECNSNNYLTPT---SQCIDDCAKIGnyyyttnANNKKICKECTVANCKTceDQGQCQACNDGFYKSGDACSPC 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 762 HPTCRQCHGPLESDCISCYPHISL------TNGNCRTSCREEQflnlvGYCAdchhlCQHCAADLHNTgSICLRCQNAHY 835
Cdd:pfam03302 111 HESCKTCSGGTASDCTECLTGKALrygndgTKGTCGEGCTTGT-----GAGA-----CKTCGLTIDGT-SYCSECATETE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 836 LLLGDHCVPDcpsgyyAERgACKKCHSScRTCQGRgpfsCSSCDTNLVLSHTGTCSTTCFPGHYLddnhvcqpcnthcgs 915
Cdd:pfam03302 180 YPQNGVCTST------AAR-ATATCKAS-SVANGM----CSSCANGYFRMNGGCYETTKFPGKSV--------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 916 CDSQASCTSCRDPnkvllfgecqyescAPQYYLDfsTNTCKECDWSCSACSGplKTDCLQCMDGYVlqdgacveqclssf 995
Cdd:pfam03302 233 CEEANSGGTCQKE--------------APGYKLN--NGDLVTCSPGCKTCTS--NTVCTTCMDGYV-------------- 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256000767 996 yQDSGLCKNCDSYCLQCQGphectrckgpflllEAQCVQECGKGYFADHAKH-KCTACP--------QGCLQCS 1060
Cdd:pfam03302 281 -KTSDSCTKCDSSCETCTG--------------ATTTCKTCATGYYKSGTGCvSCTSSEsdngitgvKGCLNCA 339
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2555-2650 |
8.30e-16 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 75.37 E-value: 8.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2555 ISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASsssrvssqpGQQDYVEYAGQVQFDEREDTKSCTIVIN 2634
Cdd:smart00237 4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT---------AGSDYEPVPGELTFPPGETEKEIRIKII 74
|
90
....*....|....*.
gi 256000767 2635 DDDVFENVESFTVELS 2650
Cdd:smart00237 75 DDDIYEKDETFYVRLS 90
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1577-1691 |
9.41e-16 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 75.72 E-value: 9.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1577 TSPEMVLTIHLLPSDQQLPVfqVTAPR-LAVSPGGS---TSVGLQVVvrDAETAPKELFFELRRPPQHGVLLKHTAefrr 1652
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPV--LTTNTgLRLWEGSSrpiTPDLLQAE--DPDTPPEDLTYTVVQGPSHGHLALKGA---- 72
|
90 100 110
....*....|....*....|....*....|....*....
gi 256000767 1653 PMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDG 1691
Cdd:pfam16184 73 PGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
2553-2650 |
1.32e-15 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 74.59 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2553 SLISFKYTSYNVSEKAGSVSVTVQRT-GNLNQYAIVLCRTEQGTASsssrvssqpGQQDYVEYAGQVQFDEREDTKSCTI 2631
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTAT---------AGDDYEPVEGELVFGPGETEKCINV 72
|
90
....*....|....*....
gi 256000767 2632 VINDDDVFENVESFTVELS 2650
Cdd:pfam03160 73 TIIDDDVYEGDENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2798-2894 |
2.15e-14 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 71.13 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2798 ASTVSLGNTAFTVSEDAGTVKIPVIRHGtDLSTFASVwcaTRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD 2877
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVV---PYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76
|
90
....*....|....*..
gi 256000767 2878 TQYpviEGLETFVVFLS 2894
Cdd:smart00237 77 DIY---EKDETFYVRLS 90
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2907-3134 |
2.25e-14 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 80.22 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2907 AVIAINDTFQDVPS-MQFAKDLLLVKEKEGVLHVPITRSG-DLSYESSVRCYTQSHSAQVMEDFEERQNAdssrITFLKG 2984
Cdd:TIGR00845 387 HEVATDDEENDPVSkIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFTEGT----LVFKPG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2985 DKVKNCTVYIHDDSMFEPEEQFRVYL---------GLPLGNHWSG-ARIGKNNMATITISNDEDAPTIEFEEAAYQVREP 3054
Cdd:TIGR00845 463 ETQKEFRIGIIDDDIFEEDEHFYVRLsnlrvgsedGILEANHVSAvAQLASPNTATVTILDDDHAGIFTFEEDVFHVSES 542
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3055 AGpdaiaILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG 3133
Cdd:TIGR00845 543 IG-----IMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELG 617
|
.
gi 256000767 3134 P 3134
Cdd:TIGR00845 618 E 618
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
3039-3133 |
3.72e-14 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 70.74 E-value: 3.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3039 APTIEFEEAAYQVREPAGpdaiaILNIKVIRR-GDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEIL 3117
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDG-----VAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTII 75
|
90
....*....|....*.
gi 256000767 3118 SNEDREWHESFSLVLG 3133
Cdd:pfam03160 76 DDDVYEGDENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
3041-3133 |
3.69e-13 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 67.66 E-value: 3.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3041 TIEFEEAAYQVREPAGPdaiaiLNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNE 3120
Cdd:smart00237 3 SVGFEQPVYTVSESDGE-----VEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDD 77
|
90
....*....|...
gi 256000767 3121 DREWHESFSLVLG 3133
Cdd:smart00237 78 IYEKDETFYVRLS 90
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
2798-2894 |
9.81e-13 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 66.50 E-value: 9.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2798 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATrpSDpASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD 2877
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRT--ED-GTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77
|
90
....*....|....*..
gi 256000767 2878 TQYpviEGLETFVVFLS 2894
Cdd:pfam03160 78 DVY---EGDENFFVLLS 91
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2553-2803 |
8.05e-12 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 71.75 E-value: 8.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2553 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSrvssqpgqqDYVEYAGQVQFDEREDTKSCTI 2631
Cdd:TIGR00845 400 SKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGS---------DYEFTEGTLVFKPGETQKEFRI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2632 VINDDDVFENVESFTVELSMP---------------AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPI 2696
Cdd:TIGR00845 471 GIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKV 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2697 ERKGDASSIVSAICYTVPKSAMGsslyaleSGSDFKsrgmSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADA 2776
Cdd:TIGR00845 551 LRTSGARGTVIVPYRTVEGTARG-------GGKDFE----DTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
|
250 260
....*....|....*....|....*..
gi 256000767 2777 SDNARIGRVATAKVLISGPNDASTVSL 2803
Cdd:TIGR00845 620 RWAKRGIKAALLLNETITDDDQKLTSK 646
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
543-747 |
2.97e-11 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 69.95 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 543 CESSCGKGFYNRQGTCSACDQSCDSCGPSSPR-CLTCTEKTVLH-------DGKCMSECP-------GGYYADATGRCKV 607
Cdd:PTZ00214 417 CRCVCKPTFYNSSGTCTPCTDSCAVCKDGTPTgCQQCSPGKILEfsivsseSADCVDQCSvgsecaeCGITIDGSRYCTR 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 608 CHNSC---------------ASCSGPTPSHCTACSPPKALRQGHCLPR--------CG-----------EGFY-SDHGVC 652
Cdd:PTZ00214 497 CKDAStypfngvcipntqrdAYCTSTANGACTTCSGAAFLMNGGCYTTehypgstiCDkqsngkctttkKGYGiSPDGKL 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 653 KACHSSCLACMGPAPSHCTGCkkPEEGLqVEQLSdvGIPSGECL--AQCRAHFYLE-------STGICEACHQSCFrcag 723
Cdd:PTZ00214 577 LECDPTCLACTAPGPGRCTRC--PSDKL-LKRAS--GAATGSCVdpGACVDGYYADgdaclpcATPGCKTCGHASF---- 647
|
250 260
....*....|....*....|....*.
gi 256000767 724 ksphnCTDC-GPSHVLLDGQ-CLSQC 747
Cdd:PTZ00214 648 -----CTECaGELFVSLDGQsCLEEC 668
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
95-152 |
4.80e-11 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 60.52 E-value: 4.80e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 95 CHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAfIPEGSCCPVC 152
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLE-IPPGECCPVC 57
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1699-1811 |
8.24e-11 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.85 E-value: 8.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1699 VRVEVSLSEDRGPRLAAGSSLSITVASksTAIITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVeelsEVSNF 1778
Cdd:pfam16184 7 FNITIIPVNDEAPVLTTNTGLRLWEGS--SRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL----PVTNF 80
|
90 100 110
....*....|....*....|....*....|....
gi 256000767 1779 TMEDINNKKIRYSAvfetDGHLVT-DSFYFSVSD 1811
Cdd:pfam16184 81 TQADIDSGLVVYVH----DGSESTsDGFTFQVTD 110
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1816-1938 |
1.12e-10 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.46 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1816 HLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDD---DNLQRDAIiklsALPKYGCIENTGTGDRf 1892
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDtppEDLTYTVV----QGPSHGHLALKGAPGL- 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 256000767 1893 gPETasdleaSFPIQDVLENYIYYfqsVHESIEPTHDIFSFYVSDG 1938
Cdd:pfam16184 76 -PVT------NFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
608-653 |
5.99e-10 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 57.14 E-value: 5.99e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 256000767 608 CHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD--HGVCK 653
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADteGGVCL 49
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
545-925 |
6.45e-10 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 65.71 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 545 SSCGKGFYNRQGtcSACDQSCDscGPSSPRCLTCTEKTVLHDGKCMSECPGGYYaDATGRCKVCHNSCASCSGPTPSHCT 624
Cdd:PTZ00214 377 TRCSAGYLGVDG--KSCSESCS--GDTRGVCTKVAEGSESTEVSCRCVCKPTFY-NSSGTCTPCTDSCAVCKDGTPTGCQ 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 625 ACSPPKALR-------QGHCLPRCGEGfysdhgvckachSSCLAC--MGPAPSHCTGCKKPeeglQVEQLSDVGIPSGEC 695
Cdd:PTZ00214 452 QCSPGKILEfsivsseSADCVDQCSVG------------SECAECgiTIDGSRYCTRCKDA----STYPFNGVCIPNTQR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 696 LAQCRAhfylESTGICEACHQSCFRCAGKSphNCTDCGPSHVLLDGQCLSQC---PDGY-FHQEGSCTECHPTCRQCHGP 771
Cdd:PTZ00214 516 DAYCTS----TANGACTTCSGAAFLMNGGC--YTTEHYPGSTICDKQSNGKCtttKKGYgISPDGKLLECDPTCLACTAP 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 772 LESDCiscyphisltngncrTSCREEQFLNLVGYCAdchhlcqhcaadlhnTGSiclrcqnahylllgdhCVPD--CPSG 849
Cdd:PTZ00214 590 GPGRC---------------TRCPSDKLLKRASGAA---------------TGS----------------CVDPgaCVDG 623
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 850 YYAERGACKKCHS-SCRTCqGRGPFsCSSCDTNLVLSHTG-TCSTTC--------FPGHY------------LDDNHV-- 905
Cdd:PTZ00214 624 YYADGDACLPCATpGCKTC-GHASF-CTECAGELFVSLDGqSCLEECtgdkvvgeVSGGVrrcwcergflpaLDRSGCvl 701
|
410 420
....*....|....*....|...
gi 256000767 906 ---CQPCNTHCGSCDSQASCTSC 925
Cdd:PTZ00214 702 pteCPPDMPSCAACDESGRCLLC 724
|
|
| FU |
smart00261 |
Furin-like repeats; |
602-646 |
1.09e-09 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 56.36 E-value: 1.09e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 602 TGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFY 646
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
95-152 |
2.64e-09 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 55.60 E-value: 2.64e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 95 CHHEKKIHEHGTEWASSPCSVCSCNHGE-VRCTPQPCPP-LSCGHQELaFIPEGSCCPVC 152
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPER-VKPPGECCPRC 59
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
221-278 |
4.07e-09 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 55.12 E-value: 4.07e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 221 CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCgKGQSRARRHGQCCEEC 278
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| FU |
smart00261 |
Furin-like repeats; |
952-996 |
1.98e-08 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 52.90 E-value: 1.98e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 952 TNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFY 996
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
859-907 |
6.51e-08 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.37 E-value: 6.51e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 256000767 859 KCHSSCRTCQGRGPFSCSSCDTNLVLsHTGTCSTTCFPGHYLDD-NHVCQ 907
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYL-DGGTCVSECPEGTYADTeGGVCL 49
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
159-216 |
7.16e-08 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 51.66 E-value: 7.16e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 159 CSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCnQDETVVRVPGKCCPQC 216
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1102-1198 |
8.02e-08 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 53.38 E-value: 8.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1102 TPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLsRNGKEVQLDkagRFSWKDVNEKKVRFV 1181
Cdd:pfam16184 18 APVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL-KGAPGLPVT---NFTQADIDSGLVVYV 93
|
90
....*....|....*..
gi 256000767 1182 HSKEKLRKGYLFLKISD 1198
Cdd:pfam16184 94 HDGSESTSDGFTFQVTD 110
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
221-278 |
9.61e-07 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 48.67 E-value: 9.61e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 221 CSAAGQVYEHGEQWSENACTTCICDRGE-VRCHKQAC-LPLRCGKGQsRARRHGQCCEEC 278
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECpPPPDCPNPE-RVKPPGECCPRC 59
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
367-416 |
2.11e-06 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 47.51 E-value: 2.11e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 256000767 367 RIPEGEKWEDGPCKVCEC-RGAQVTCYEPSCPP---CPVGTLAlEVKGQCCPDC 416
Cdd:smart00214 7 VYNDGETWKPDPCQICTClDGTTVLCDPVECPPppdCPNPERV-KPPGECCPRC 59
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
159-216 |
3.09e-06 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 47.13 E-value: 3.09e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 159 CSYEGHVFQDGEDWRLSRCAKCLCRNG-VAQCFTAQCQPLF-CNQDETVVrVPGKCCPQC 216
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdCPNPERVK-PPGECCPRC 59
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
28-87 |
1.32e-05 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 45.20 E-value: 1.32e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256000767 28 CVYQDSLLADATIWKPDSCQSCRCH-GDIVICKPAVC-RNPQCAFekgEVLQIAANQCCPEC 87
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLdGTTVLCDPVECpPPPDCPN---PERVKPPGECCPRC 59
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
366-416 |
1.41e-05 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 45.11 E-value: 1.41e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 256000767 366 KRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPP--CPVGTLAlEVKGQCCPDC 416
Cdd:pfam00093 6 VVYENGETWKPDLCTICTCDDGKVLCDKIICPPldCPNPRLE-IPPGECCPVC 57
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2675-2764 |
2.33e-05 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 45.71 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2675 TLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSdfksrgmsaasrVIFGPGVTMSTCD 2754
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGE------------LTFPPGETEKEIR 70
|
90
....*....|
gi 256000767 2755 VMLIDDSEYE 2764
Cdd:smart00237 71 IKIIDDDIYE 80
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
285-342 |
2.95e-05 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 44.43 E-value: 2.95e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 285 CSYDGVVRYQDEMWKGSACEFCMCDHGQ-VTCQTGECAKV-ECARDEELIHlDGKCCPEC 342
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKP-PGECCPRC 59
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
2146-2405 |
3.13e-05 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 50.43 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2146 SFTQADISQGHVeyshgtgepggsFAFKFDVVDGEGNRLIDkSFSISILEDKSPPVITTNKGLVLDENSVkkiTTLQLSA 2225
Cdd:NF038112 1242 SFTAPEVTADTV------------LTFQLVVSDGTKTSAPD-TVTVLVRNVNRAPVAVAGAPATVDERST---VTLDGSG 1305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2226 TDQDSGPTELIYRITRQPQLGhLEHAASPgiqISSFTQADLTSrNVQYVhsseaekhsdaFSFTLSDGVSEVTQTFHITL 2305
Cdd:NF038112 1306 TDADGDALTYAWTQTSGPAVT-LTGATTA---TATFTAPEVTA-DTQLT-----------FTLTVSDGTASATDTVTVTV 1369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2306 HPVDDSlPVVqNLGMRVQEGMRKTITefeLKAVDADTEAESVTFTIVQPPrhGTIERTSNGQhfHLTSTFTMKDIYQN-- 2383
Cdd:NF038112 1370 RNVNRA-PVA-NAGADQTVDERSTVT---LSGSATDPDGDALTYAWTQTA--GPTVTLTGAD--TATASFTAPEVAADte 1440
|
250 260
....*....|....*....|....*
gi 256000767 2384 ---RVSYSHDGSNSLKDRFTFTVSD 2405
Cdd:NF038112 1441 ltfQLTVSADGQASADVTVTVTVRN 1465
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
285-342 |
6.48e-05 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 43.18 E-value: 6.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 285 CSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECArDEELIHLDGKCCPEC 342
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCP-NPRLEIPPGECCPVC 57
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
28-87 |
1.60e-04 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 42.03 E-value: 1.60e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEvlqIAANQCCPEC 87
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLE---IPPGECCPVC 57
|
|
| FU |
smart00261 |
Furin-like repeats; |
650-704 |
3.31e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.96 E-value: 3.31e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 256000767 650 GVCKACHSSCLACMGPAPSHCTGCKKPEEGLQveqlsdvgipsGECLAQCRAHFY 704
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDG-----------GKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
654-709 |
1.24e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.42 E-value: 1.24e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 256000767 654 ACHSSCLACMGPAPSHCTGCKKPEEGLQveqlsdvgipsGECLAQCRAHFYLESTG 709
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDG-----------GTCVSECPEGTYADTEG 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
1046-1087 |
2.39e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 38.64 E-value: 2.39e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 256000767 1046 KHKCTACPQGCLQCSHRDR--CHLCDHGFFLKSGLCVYNCVPGF 1087
Cdd:smart00261 1 DGECKPCHPECATCTGPGPddCTSCKHGFFLDGGKCVSECPPGT 44
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
493-605 |
6.08e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 493 GQCVPTCGDGfyqdrhscAVCHESCAGCWGPTEKHCLAC----RDPLHVlrdGGCESSCGKGFYNRQGTC-SACDQSCDS 567
Cdd:NF041328 43 GACGVACGAG--------QTCVAGACGCGPGTVACGGACvdtaSDPAHC---GACGAACAPGQVCEGGACrEACSEGLTR 111
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 256000767 568 CGPSsprcltCTEKTV--LHDGKCMSECPGGYYADAtGRC 605
Cdd:NF041328 112 CGGA------CVDLATdpLHCGACGVACDPGESCRG-GAC 144
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2297-2406 |
4.47e-39 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 142.36 E-value: 4.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2297 VTQTFHITLHPVDDSLPVVQ-NLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQhfHLTSTF 2375
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTtNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPG--LPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 2376 TMKDIYQNRVSYSHDGSNSLKDRFTFTVSDG 2406
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2183-2293 |
2.74e-34 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 128.87 E-value: 2.74e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2183 RLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISSF 2261
Cdd:pfam16184 1 RSVPFTFNITIIPvNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|..
gi 256000767 2262 TQADLTSRNVQYVHSSeAEKHSDAFSFTLSDG 2293
Cdd:pfam16184 81 TQADIDSGLVVYVHDG-SESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2425-2537 |
7.86e-27 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 107.30 E-value: 7.86e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2425 PQPFRVDILPVDDGTPRIVTNLGLQWLEymdGkATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQPGRAAAT 2504
Cdd:pfam16184 4 PFTFNITIIPVNDEAPVLTTNTGLRLWE---G-SSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN 79
|
90 100 110
....*....|....*....|....*....|...
gi 256000767 2505 FTQEDVNLGLIRYVlHKEKiREMMDSFQFLVKD 2537
Cdd:pfam16184 80 FTQADIDSGLVVYV-HDGS-ESTSDGFTFQVTD 110
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1203-1310 |
1.69e-25 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 103.45 E-value: 1.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1203 SEPQL--INIQAFSTQAPYVLRNEVLHISRGERATITTQMLDIRDDDNP-QDVVIEIIDPPLHGQLLQTLqSPATPIYQF 1279
Cdd:pfam16184 2 SVPFTfnITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPpEDLTYTVVQGPSHGHLALKG-APGLPVTNF 80
|
90 100 110
....*....|....*....|....*....|.
gi 256000767 1280 QLDELSRGLLHYAHDGSDSTSDVAVLQANDG 1310
Cdd:pfam16184 81 TQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
2073-2179 |
6.08e-22 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 93.44 E-value: 6.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2073 LPASD-TPHLAINQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLeqisikgPIRSFTQAD 2151
Cdd:pfam16184 12 IPVNDeAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL-------PVTNFTQAD 84
|
90 100
....*....|....*....|....*...
gi 256000767 2152 ISQGHVEYSHgTGEPGGSFAFKFDVVDG 2179
Cdd:pfam16184 85 IDSGLVVYVH-DGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1941-2059 |
1.84e-20 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 89.20 E-value: 1.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1941 RSEIHSINITIERKNDEPPRMTL-QPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWRQTASEPLENg 2019
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTnTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGLPVTN- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 256000767 2020 rvlvqgstFTYQDILAGLVGYVPSVPGMVVDEFQFSLTDG 2059
Cdd:pfam16184 80 --------FTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1314-1438 |
6.56e-18 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 81.88 E-value: 6.56e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1314 HNILFQVKTVPQNDRGLQLVANS--MVWvpEGGMLQITNRILQAEAPGASAEEIIYKITQDyPQFGEVVLLvnmpadspa 1391
Cdd:pfam16184 3 VPFTFNITIIPVNDEAPVLTTNTglRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG-PSHGHLALK--------- 70
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 256000767 1392 degqhlpdGRTATPTSTFTQQDINEGIVWYRHSGAPAQSDSFRFEVS 1438
Cdd:pfam16184 71 --------GAPGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVT 109
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1446-1574 |
7.60e-17 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 78.80 E-value: 7.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1446 RLESHMFNIAILPQTPEAPKVSLEASLHMTarEDGLTVIQPHSLSFINSEKPSGKIVYNITLPlhPNQGIIEHRDHPHSP 1525
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLW--EGSSRPITPDLLQAEDPDTPPEDLTYTVVQG--PSHGHLALKGAPGLP 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 256000767 1526 IRYFTQEDINQGKVMYRpppaapHLqelmafsfAGLPESVKFHFTVSDG 1574
Cdd:pfam16184 77 VTNFTQADIDSGLVVYV------HD--------GSESTSDGFTFQVTDG 111
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
396-673 |
2.56e-16 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 84.64 E-value: 2.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 396 CPPCPVGTlALEVKGQCCPdcTSVHCH-PDCLTCSQSPDH-CDLCQDPTKLLQNGWCVHSCG-LGFYQAGSlCLACQPQC 472
Cdd:pfam03302 1 CDECKPGY-ELSADKTKCT--SSAPCKtENCKACSNDKREvCEECNSNNYLTPTSQCIDDCAkIGNYYYTT-NANNKKIC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 473 STCTSGlECSSCQppllmRHGQCvPTCGDGFYQDRHSCAVCHESCAGCWGPTEKHCLAC---------RDPLHVLRDGGC 543
Cdd:pfam03302 77 KECTVA-NCKTCE-----DQGQC-QACNDGFYKSGDACSPCHESCKTCSGGTASDCTECltgkalrygNDGTKGTCGEGC 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 544 ESSCGKGFYNRQGT-------CSACDQSCDS-----CGPSSPRCL-TCTEKTVlHDGKCmSECPGGYYAdATGRC----- 605
Cdd:pfam03302 150 TTGTGAGACKTCGLtidgtsyCSECATETEYpqngvCTSTAARATaTCKASSV-ANGMC-SSCANGYFR-MNGGCyettk 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 606 ----KVCH--NSCASCSGPTPSH------CTACSPP-KALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMGpAPSHCTG 672
Cdd:pfam03302 227 fpgkSVCEeaNSGGTCQKEAPGYklnngdLVTCSPGcKTCTSNTVCTTCMDGYVKTSDSCTKCDSSCETCTG-ATTTCKT 305
|
.
gi 256000767 673 C 673
Cdd:pfam03302 306 C 306
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
691-1060 |
6.82e-16 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 83.10 E-value: 6.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 691 PSGECLAQCRAHFYLESTgicEACHQSCFRCA-------GKSPHNCTDCGPSHVLL--DGQCLSQCPDGYFHQEGSCTEC 761
Cdd:pfam03302 34 DKREVCEECNSNNYLTPT---SQCIDDCAKIGnyyyttnANNKKICKECTVANCKTceDQGQCQACNDGFYKSGDACSPC 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 762 HPTCRQCHGPLESDCISCYPHISL------TNGNCRTSCREEQflnlvGYCAdchhlCQHCAADLHNTgSICLRCQNAHY 835
Cdd:pfam03302 111 HESCKTCSGGTASDCTECLTGKALrygndgTKGTCGEGCTTGT-----GAGA-----CKTCGLTIDGT-SYCSECATETE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 836 LLLGDHCVPDcpsgyyAERgACKKCHSScRTCQGRgpfsCSSCDTNLVLSHTGTCSTTCFPGHYLddnhvcqpcnthcgs 915
Cdd:pfam03302 180 YPQNGVCTST------AAR-ATATCKAS-SVANGM----CSSCANGYFRMNGGCYETTKFPGKSV--------------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 916 CDSQASCTSCRDPnkvllfgecqyescAPQYYLDfsTNTCKECDWSCSACSGplKTDCLQCMDGYVlqdgacveqclssf 995
Cdd:pfam03302 233 CEEANSGGTCQKE--------------APGYKLN--NGDLVTCSPGCKTCTS--NTVCTTCMDGYV-------------- 280
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256000767 996 yQDSGLCKNCDSYCLQCQGphectrckgpflllEAQCVQECGKGYFADHAKH-KCTACP--------QGCLQCS 1060
Cdd:pfam03302 281 -KTSDSCTKCDSSCETCTG--------------ATTTCKTCATGYYKSGTGCvSCTSSEsdngitgvKGCLNCA 339
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2555-2650 |
8.30e-16 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 75.37 E-value: 8.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2555 ISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASsssrvssqpGQQDYVEYAGQVQFDEREDTKSCTIVIN 2634
Cdd:smart00237 4 VGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT---------AGSDYEPVPGELTFPPGETEKEIRIKII 74
|
90
....*....|....*.
gi 256000767 2635 DDDVFENVESFTVELS 2650
Cdd:smart00237 75 DDDIYEKDETFYVRLS 90
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1577-1691 |
9.41e-16 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 75.72 E-value: 9.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1577 TSPEMVLTIHLLPSDQQLPVfqVTAPR-LAVSPGGS---TSVGLQVVvrDAETAPKELFFELRRPPQHGVLLKHTAefrr 1652
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPV--LTTNTgLRLWEGSSrpiTPDLLQAE--DPDTPPEDLTYTVVQGPSHGHLALKGA---- 72
|
90 100 110
....*....|....*....|....*....|....*....
gi 256000767 1653 PMATGDTFTYEDVEKNALQYIHDGSSTREDSMEISVTDG 1691
Cdd:pfam16184 73 PGLPVTNFTQADIDSGLVVYVHDGSESTSDGFTFQVTDG 111
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
2553-2650 |
1.32e-15 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 74.59 E-value: 1.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2553 SLISFKYTSYNVSEKAGSVSVTVQRT-GNLNQYAIVLCRTEQGTASsssrvssqpGQQDYVEYAGQVQFDEREDTKSCTI 2631
Cdd:pfam03160 2 GVIGFEPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTAT---------AGDDYEPVEGELVFGPGETEKCINV 72
|
90
....*....|....*....
gi 256000767 2632 VINDDDVFENVESFTVELS 2650
Cdd:pfam03160 73 TIIDDDVYEGDENFFVLLS 91
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2798-2894 |
2.15e-14 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 71.13 E-value: 2.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2798 ASTVSLGNTAFTVSEDAGTVKIPVIRHGtDLSTFASVwcaTRPSDPASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD 2877
Cdd:smart00237 1 AGSVGFEQPVYTVSESDGEVEVCVVRTG-GARGPVVV---PYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76
|
90
....*....|....*..
gi 256000767 2878 TQYpviEGLETFVVFLS 2894
Cdd:smart00237 77 DIY---EKDETFYVRLS 90
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2907-3134 |
2.25e-14 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 80.22 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2907 AVIAINDTFQDVPS-MQFAKDLLLVKEKEGVLHVPITRSG-DLSYESSVRCYTQSHSAQVMEDFEERQNAdssrITFLKG 2984
Cdd:TIGR00845 387 HEVATDDEENDPVSkIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFTEGT----LVFKPG 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2985 DKVKNCTVYIHDDSMFEPEEQFRVYL---------GLPLGNHWSG-ARIGKNNMATITISNDEDAPTIEFEEAAYQVREP 3054
Cdd:TIGR00845 463 ETQKEFRIGIIDDDIFEEDEHFYVRLsnlrvgsedGILEANHVSAvAQLASPNTATVTILDDDHAGIFTFEEDVFHVSES 542
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3055 AGpdaiaILNIKVIRRGDQNRTSKVRCSTRDGSAQ-SGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLG 3133
Cdd:TIGR00845 543 IG-----IMEVKVLRTSGARGTVIVPYRTVEGTARgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELG 617
|
.
gi 256000767 3134 P 3134
Cdd:TIGR00845 618 E 618
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
3039-3133 |
3.72e-14 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 70.74 E-value: 3.72e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3039 APTIEFEEAAYQVREPAGpdaiaILNIKVIRR-GDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEIL 3117
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDG-----VAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTII 75
|
90
....*....|....*.
gi 256000767 3118 SNEDREWHESFSLVLG 3133
Cdd:pfam03160 76 DDDVYEGDENFFVLLS 91
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2780-3047 |
4.55e-14 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 79.07 E-value: 4.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2780 ARIGRVATAKVLISGP----NDASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATrpsDPASATPGVDYVPS 2855
Cdd:TIGR00845 377 ADAARKAVSMHEVATDdeenDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRT---EDGTANAGSDYEFT 453
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2856 SRKVEFGPGVIEQYCTLTILDDTqypVIEGLETFVVFLS-----SAQG----------AELTKPFQAVIAINDtfQDVPS 2920
Cdd:TIGR00845 454 EGTLVFKPGETQKEFRIGIIDDD---IFEEDEHFYVRLSnlrvgSEDGileanhvsavAQLASPNTATVTILD--DDHAG 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2921 M-QFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQV-MEDFEERQnadsSRITFLKGDKVKNCTVYIHDDS 2998
Cdd:TIGR00845 529 IfTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGgGKDFEDTC----GELEFENDETEKTIRVKIVDDE 604
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 256000767 2999 MFEPEEQFRVYLGLPlgnHWSGARIGKNNMATITISNDEDAPTIEFEEA 3047
Cdd:TIGR00845 605 EYEKNDTFFIELGEP---RWAKRGIKAALLLNETITDDDQKLTSKEEEE 650
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
462-620 |
2.26e-13 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 70.16 E-value: 2.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 462 GSLCLACQPQCSTCTSGLEC---SSCQ---PPllmrhgQCVPTCgdgfyQDRHSCavCHESCAG-CWGPTEKHCLACRdp 534
Cdd:pfam00757 5 GDVCPGTMEKCHSCCNNGYCwgpGHCQkvcPE------QCKKRC-----TKPGEC--CHEQCLGgCTGPNDSDCLACR-- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 535 lHVLRDGGCESSCGKGFYNRQGTCsacdQSCDSCgpSSPRCLTCTEKtVLHDGKCMSECPGGYYADATGRckvchNSCAS 614
Cdd:pfam00757 70 -HFNDEGTCVDQCPPGTYQFGWRC----VTFKEC--PKSHLPGYNPL-VIHNGECVRECPSGYTEVENNS-----RKCEP 136
|
....*.
gi 256000767 615 CSGPTP 620
Cdd:pfam00757 137 CEGLCP 142
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
3041-3133 |
3.69e-13 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 67.66 E-value: 3.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3041 TIEFEEAAYQVREPAGPdaiaiLNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNE 3120
Cdd:smart00237 3 SVGFEQPVYTVSESDGE-----VEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDD 77
|
90
....*....|...
gi 256000767 3121 DREWHESFSLVLG 3133
Cdd:smart00237 78 IYEKDETFYVRLS 90
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
2798-2894 |
9.81e-13 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 66.50 E-value: 9.81e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2798 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATrpSDpASATPGVDYVPSSRKVEFGPGVIEQYCTLTILDD 2877
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRT--ED-GTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77
|
90
....*....|....*..
gi 256000767 2878 TQYpviEGLETFVVFLS 2894
Cdd:pfam03160 78 DVY---EGDENFFVLLS 91
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
2553-2803 |
8.05e-12 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 71.75 E-value: 8.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2553 SLISFKYTSYNVSEKAGSVSVTVQRTG-NLNQYAIVLCRTEQGTASSSSrvssqpgqqDYVEYAGQVQFDEREDTKSCTI 2631
Cdd:TIGR00845 400 SKIFFEPGHYTCLENCGTVALTVVRRGgDLTNTVYVDYRTEDGTANAGS---------DYEFTEGTLVFKPGETQKEFRI 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2632 VINDDDVFENVESFTVELSMP---------------AYALLGEFTQAKVIINDTEDEPTLEFDKKIYWVNESAGFLFAPI 2696
Cdd:TIGR00845 471 GIIDDDIFEEDEHFYVRLSNLrvgsedgileanhvsAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKV 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2697 ERKGDASSIVSAICYTVPKSAMGsslyaleSGSDFKsrgmSAASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADA 2776
Cdd:TIGR00845 551 LRTSGARGTVIVPYRTVEGTARG-------GGKDFE----DTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEP 619
|
250 260
....*....|....*....|....*..
gi 256000767 2777 SDNARIGRVATAKVLISGPNDASTVSL 2803
Cdd:TIGR00845 620 RWAKRGIKAALLLNETITDDDQKLTSK 646
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
543-747 |
2.97e-11 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 69.95 E-value: 2.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 543 CESSCGKGFYNRQGTCSACDQSCDSCGPSSPR-CLTCTEKTVLH-------DGKCMSECP-------GGYYADATGRCKV 607
Cdd:PTZ00214 417 CRCVCKPTFYNSSGTCTPCTDSCAVCKDGTPTgCQQCSPGKILEfsivsseSADCVDQCSvgsecaeCGITIDGSRYCTR 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 608 CHNSC---------------ASCSGPTPSHCTACSPPKALRQGHCLPR--------CG-----------EGFY-SDHGVC 652
Cdd:PTZ00214 497 CKDAStypfngvcipntqrdAYCTSTANGACTTCSGAAFLMNGGCYTTehypgstiCDkqsngkctttkKGYGiSPDGKL 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 653 KACHSSCLACMGPAPSHCTGCkkPEEGLqVEQLSdvGIPSGECL--AQCRAHFYLE-------STGICEACHQSCFrcag 723
Cdd:PTZ00214 577 LECDPTCLACTAPGPGRCTRC--PSDKL-LKRAS--GAATGSCVdpGACVDGYYADgdaclpcATPGCKTCGHASF---- 647
|
250 260
....*....|....*....|....*.
gi 256000767 724 ksphnCTDC-GPSHVLLDGQ-CLSQC 747
Cdd:PTZ00214 648 -----CTECaGELFVSLDGQsCLEEC 668
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
512-665 |
4.41e-11 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 63.16 E-value: 4.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 512 VCHESC--AGCWGPTEKHCLACRDplhvlrdggcesscgkgfYNRQGTCSAcdqSCDSCGPSsprcltctektvlhdgkc 589
Cdd:pfam14843 1 VCDPLCssEGCWGPGPDQCLSCRN------------------FSRGGTCVE---SCNILQGE------------------ 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 590 msecPGGYYADatGRCKVCHNSC------ASCSGPTPSHCTACSppkALRQG-HCLPRCGEG---------FYSDH-GVC 652
Cdd:pfam14843 42 ----PREYVVN--STCVPCHPEClpqngtATCSGPGADNCTKCA---HFRDGpHCVSSCPSGvlgendliwKYADAnGVC 112
|
170
....*....|....
gi 256000767 653 KACHSSC-LACMGP 665
Cdd:pfam14843 113 QPCHPNCtQGCTGP 126
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
95-152 |
4.80e-11 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 60.52 E-value: 4.80e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 95 CHHEKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAfIPEGSCCPVC 152
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLE-IPPGECCPVC 57
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1699-1811 |
8.24e-11 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.85 E-value: 8.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1699 VRVEVSLSEDRGPRLAAGSSLSITVASksTAIITRSHLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVeelsEVSNF 1778
Cdd:pfam16184 7 FNITIIPVNDEAPVLTTNTGLRLWEGS--SRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLALKGAPGL----PVTNF 80
|
90 100 110
....*....|....*....|....*....|....
gi 256000767 1779 TMEDINNKKIRYSAvfetDGHLVT-DSFYFSVSD 1811
Cdd:pfam16184 81 TQADIDSGLVVYVH----DGSESTsDGFTFQVTD 110
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1816-1938 |
1.12e-10 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 61.46 E-value: 1.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1816 HLDNQIFTIMITPAENPPPVIAFADLITVDEGGRAPLSFHHFFATDDD---DNLQRDAIiklsALPKYGCIENTGTGDRf 1892
Cdd:pfam16184 1 RSVPFTFNITIIPVNDEAPVLTTNTGLRLWEGSSRPITPDLLQAEDPDtppEDLTYTVV----QGPSHGHLALKGAPGL- 75
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 256000767 1893 gPETasdleaSFPIQDVLENYIYYfqsVHESIEPTHDIFSFYVSDG 1938
Cdd:pfam16184 76 -PVT------NFTQADIDSGLVVY---VHDGSESTSDGFTFQVTDG 111
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
3028-3159 |
1.24e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 67.89 E-value: 1.24e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 3028 MATITISNDEDAPTIE--FEEAAYQVREPAGPdaiaiLNIKVIRRG-DQNRTSKVRCSTRDGSAQSGVDYYPKSRVLKFS 3104
Cdd:TIGR00845 386 MHEVATDDEENDPVSKifFEPGHYTCLENCGT-----VALTVVRRGgDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFK 460
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 3105 PGVDHIFFKVEILSNEDREWHESFSLVLG-----------PDDPVEAV--LGDVTTATVTILDQEAAG 3159
Cdd:TIGR00845 461 PGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgilEANHVSAVaqLASPNTATVTILDDDHAG 528
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
655-777 |
1.66e-10 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 61.62 E-value: 1.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 655 CHSSCLA--CMGPAPSHCTGCKKPEEGlqveqlsdvgipsGECLAQCRAHFYL----ESTGICEACHQSCFR------CA 722
Cdd:pfam14843 2 CDPLCSSegCWGPGPDQCLSCRNFSRG-------------GTCVESCNILQGEpreyVVNSTCVPCHPECLPqngtatCS 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 256000767 723 GKSPHNCTDCgpSHVLLDGQCLSQCPDG----------YFHQEGSCTECHPTCRQ-CHGPLESDCI 777
Cdd:pfam14843 69 GPGADNCTKC--AHFRDGPHCVSSCPSGvlgendliwkYADANGVCQPCHPNCTQgCTGPGLTGCP 132
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
607-729 |
5.35e-10 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 60.08 E-value: 5.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 607 VCHNSCAS--CSGPTPSHCTACSppKALRQGHCLPRC----GE-GFYSDHGVCKACHSSCLA------CMGPAPSHCTGC 673
Cdd:pfam14843 1 VCDPLCSSegCWGPGPDQCLSCR--NFSRGGTCVESCnilqGEpREYVVNSTCVPCHPECLPqngtatCSGPGADNCTKC 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 674 KKPEEGLQ-VEQlsdvgIPSGECLAQCRAHFYLESTGICEACHQSCFR-CAGKSPHNC 729
Cdd:pfam14843 79 AHFRDGPHcVSS-----CPSGVLGENDLIWKYADANGVCQPCHPNCTQgCTGPGLTGC 131
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
379-673 |
5.54e-10 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 65.71 E-value: 5.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 379 CKVCECRGAQVTCYEpscppCPVGTLAleVKGQCCPDCTSVHCHPDCLTCSQSPDHCDLCqdptkllqngwCVHSCGLGF 458
Cdd:PTZ00214 364 CATCGYNSGAVTCTR-----CSAGYLG--VDGKSCSESCSGDTRGVCTKVAEGSESTEVS-----------CRCVCKPTF 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 459 YQAGSLCLACQPQCSTCTSGLE--CSSCQPPLLMR-------HGQCVPTCGDGfyqdrHSCAVCHESCAGcwgptEKHCL 529
Cdd:PTZ00214 426 YNSSGTCTPCTDSCAVCKDGTPtgCQQCSPGKILEfsivsseSADCVDQCSVG-----SECAECGITIDG-----SRYCT 495
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 530 ACRDPLHVLRDGGCESSCGKGFY---NRQGTCSACDQSC----DSCGPSS--PRCLTCTEKTvlhDGKCmSECPGGYYAD 600
Cdd:PTZ00214 496 RCKDASTYPFNGVCIPNTQRDAYctsTANGACTTCSGAAflmnGGCYTTEhyPGSTICDKQS---NGKC-TTTKKGYGIS 571
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 601 ATGRCKVCHNSCASCSGPTPSHCTACSPPKALRQ------GHCLP--RCGEGFYSDHGVCKACHS-SCLACmGPApSHCT 671
Cdd:PTZ00214 572 PDGKLLECDPTCLACTAPGPGRCTRCPSDKLLKRasgaatGSCVDpgACVDGYYADGDACLPCATpGCKTC-GHA-SFCT 649
|
..
gi 256000767 672 GC 673
Cdd:PTZ00214 650 EC 651
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
608-653 |
5.99e-10 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 57.14 E-value: 5.99e-10
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 256000767 608 CHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSD--HGVCK 653
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADteGGVCL 49
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
545-925 |
6.45e-10 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 65.71 E-value: 6.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 545 SSCGKGFYNRQGtcSACDQSCDscGPSSPRCLTCTEKTVLHDGKCMSECPGGYYaDATGRCKVCHNSCASCSGPTPSHCT 624
Cdd:PTZ00214 377 TRCSAGYLGVDG--KSCSESCS--GDTRGVCTKVAEGSESTEVSCRCVCKPTFY-NSSGTCTPCTDSCAVCKDGTPTGCQ 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 625 ACSPPKALR-------QGHCLPRCGEGfysdhgvckachSSCLAC--MGPAPSHCTGCKKPeeglQVEQLSDVGIPSGEC 695
Cdd:PTZ00214 452 QCSPGKILEfsivsseSADCVDQCSVG------------SECAECgiTIDGSRYCTRCKDA----STYPFNGVCIPNTQR 515
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 696 LAQCRAhfylESTGICEACHQSCFRCAGKSphNCTDCGPSHVLLDGQCLSQC---PDGY-FHQEGSCTECHPTCRQCHGP 771
Cdd:PTZ00214 516 DAYCTS----TANGACTTCSGAAFLMNGGC--YTTEHYPGSTICDKQSNGKCtttKKGYgISPDGKLLECDPTCLACTAP 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 772 LESDCiscyphisltngncrTSCREEQFLNLVGYCAdchhlcqhcaadlhnTGSiclrcqnahylllgdhCVPD--CPSG 849
Cdd:PTZ00214 590 GPGRC---------------TRCPSDKLLKRASGAA---------------TGS----------------CVDPgaCVDG 623
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 850 YYAERGACKKCHS-SCRTCqGRGPFsCSSCDTNLVLSHTG-TCSTTC--------FPGHY------------LDDNHV-- 905
Cdd:PTZ00214 624 YYADGDACLPCATpGCKTC-GHASF-CTECAGELFVSLDGqSCLEECtgdkvvgeVSGGVrrcwcergflpaLDRSGCvl 701
|
410 420
....*....|....*....|...
gi 256000767 906 ---CQPCNTHCGSCDSQASCTSC 925
Cdd:PTZ00214 702 pteCPPDMPSCAACDESGRCLLC 724
|
|
| FU |
smart00261 |
Furin-like repeats; |
602-646 |
1.09e-09 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 56.36 E-value: 1.09e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 602 TGRCKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFY 646
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
95-152 |
2.64e-09 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 55.60 E-value: 2.64e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 95 CHHEKKIHEHGTEWASSPCSVCSCNHGE-VRCTPQPCPP-LSCGHQELaFIPEGSCCPVC 152
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPpPDCPNPER-VKPPGECCPRC 59
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
221-278 |
4.07e-09 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 55.12 E-value: 4.07e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 221 CSAAGQVYEHGEQWSENACTTCICDRGEVRCHKQACLPLRCgKGQSRARRHGQCCEEC 278
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
1007-1096 |
4.54e-09 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 56.67 E-value: 4.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1007 SYCLQCQGPHECTRCKGP-FLLLE-------AQCVQECGKGYFADHAK--HKCTAC-PQGCLQCSHRDRCHLCDHGFFLK 1075
Cdd:pfam15913 2 SGCVLCSEENGCLTCQPRlFLLLErngirqyGVCLHSCPPGYFGIRGQevNRCTKCkAENCESCFSKDFCTKCKEGFYLH 81
|
90 100
....*....|....*....|.
gi 256000767 1076 SGLCVYNCVPGFSVHTSNETC 1096
Cdd:pfam15913 82 KGKCLDTCPEGTAAQNSTMEC 102
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
827-913 |
1.14e-08 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 56.23 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 827 CLRCQNAHYlllGDHCVPDCPSGY-----YAERGACKKCHSSC------RTCQGRGPFSCSSC----DTNLVLSH--TGT 889
Cdd:pfam14843 19 CLSCRNFSR---GGTCVESCNILQgepreYVVNSTCVPCHPEClpqngtATCSGPGADNCTKCahfrDGPHCVSScpSGV 95
|
90 100
....*....|....*....|....
gi 256000767 890 CSTTCFPGHYLDDNHVCQPCNTHC 913
Cdd:pfam14843 96 LGENDLIWKYADANGVCQPCHPNC 119
|
|
| Big_9 |
pfam17963 |
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains. |
2298-2407 |
1.41e-08 |
|
Bacterial Ig domain; This entry represents a wide variety of bacterial Ig domains.
Pssm-ID: 465590 [Multi-domain] Cd Length: 90 Bit Score: 54.65 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2298 TQTFHITLHPVDDSlPVVQNLGMRVQEGMRKTItefelkAVDADTEA---ESVTFTIVQPPRHGTIERTSNGQhfhltst 2374
Cdd:pfam17963 1 TATVTVTVTPVNDA-PVAVDDSVTVTEDTVLAN------DSDPDGDPltiTSLTVTIVTAPANGTVTVNADGT------- 66
|
90 100 110
....*....|....*....|....*....|...
gi 256000767 2375 ftmkdiyqnrVSYSHDGSNSLKDRFTFTVSDGT 2407
Cdd:pfam17963 67 ----------LTYTPNAGFSGTDSFTYTVSDGS 89
|
|
| FU |
smart00261 |
Furin-like repeats; |
952-996 |
1.98e-08 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 52.90 E-value: 1.98e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 952 TNTCKECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFY 996
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
708-752 |
2.34e-08 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 52.51 E-value: 2.34e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 708 TGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYF 752
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
721-1068 |
3.39e-08 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 59.93 E-value: 3.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 721 CAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTECHPTCRQCHGPLESDCISCYPH-------ISLTNGNCRTS 793
Cdd:PTZ00214 395 CSGDTRGVCTKVAEGSESTEVSCRCVCKPTFYNSSGTCTPCTDSCAVCKDGTPTGCQQCSPGkilefsiVSSESADCVDQ 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 794 CreeqflNLVGYCADChhlcqhcaaDLHNTGS-ICLRCQNAHYLLLGDHCVPDCPSGYYaergackkchsscrtCQGRGP 872
Cdd:PTZ00214 475 C------SVGSECAEC---------GITIDGSrYCTRCKDASTYPFNGVCIPNTQRDAY---------------CTSTAN 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 873 FSCSSCDTNLVLSHTGTCSTTCFPGHYLddnhvcqpcnthcgsCDSQAS--CTSCRD-----PNKVLLfgecqyescapq 945
Cdd:PTZ00214 525 GACTTCSGAAFLMNGGCYTTEHYPGSTI---------------CDKQSNgkCTTTKKgygisPDGKLL------------ 577
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 946 yyldfstntckECDWSCSACSGPLKTDCLQCMDGYVLQ------DGACVE--QCLSSFYQDSGLCKNCDSY-CLQCQGPH 1016
Cdd:PTZ00214 578 -----------ECDPTCLACTAPGPGRCTRCPSDKLLKrasgaaTGSCVDpgACVDGYYADGDACLPCATPgCKTCGHAS 646
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 1017 ECTRCKGP-FLLLEAQ-CVQECG------------------KGYFADHAKHKC---TACPQG---CLQCSHRDRCHLC 1068
Cdd:PTZ00214 647 FCTECAGElFVSLDGQsCLEECTgdkvvgevsggvrrcwceRGFLPALDRSGCvlpTECPPDmpsCAACDESGRCLLC 724
|
|
| FU |
smart00261 |
Furin-like repeats; |
507-552 |
4.51e-08 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 51.74 E-value: 4.51e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 256000767 507 RHSCAVCHESCAGCWGPTEKHCLACRDPLHvLRDGGCESSCGKGFY 552
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFF-LDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
859-907 |
6.51e-08 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.37 E-value: 6.51e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 256000767 859 KCHSSCRTCQGRGPFSCSSCDTNLVLsHTGTCSTTCFPGHYLDD-NHVCQ 907
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYL-DGGTCVSECPEGTYADTeGGVCL 49
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
159-216 |
7.16e-08 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 51.66 E-value: 7.16e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 159 CSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCnQDETVVRVPGKCCPQC 216
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
|
|
| Cadherin_3 |
pfam16184 |
Cadherin-like; |
1102-1198 |
8.02e-08 |
|
Cadherin-like;
Pssm-ID: 465048 [Multi-domain] Cd Length: 111 Bit Score: 53.38 E-value: 8.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 1102 TPSLHVNGSLILPIGSIKPLDFSLLNVQDQEGRVEDLLFHVVSTPTNGQLVLsRNGKEVQLDkagRFSWKDVNEKKVRFV 1181
Cdd:pfam16184 18 APVLTTNTGLRLWEGSSRPITPDLLQAEDPDTPPEDLTYTVVQGPSHGHLAL-KGAPGLPVT---NFTQADIDSGLVVYV 93
|
90
....*....|....*..
gi 256000767 1182 HSKEKLRKGYLFLKISD 1198
Cdd:pfam16184 94 HDGSESTSDGFTFQVTD 110
|
|
| FU |
smart00261 |
Furin-like repeats; |
854-899 |
1.05e-07 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 50.59 E-value: 1.05e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 256000767 854 RGACKKCHSSCRTCQGRGPFSCSSCDTNLVLsHTGTCSTTCFPGHY 899
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFL-DGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
513-552 |
1.70e-07 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 50.21 E-value: 1.70e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 256000767 513 CHESCAGCWGPTEKHCLACRDPLHvLRDGGCESSCGKGFY 552
Cdd:cd00064 2 CHPSCATCTGPGPDQCTSCRHGFY-LDGGTCVSECPEGTY 40
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2920-3011 |
3.89e-07 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 50.72 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2920 SMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQVMEDFEerqnADSSRITFLKGDKVKNCTVYIHDDSM 2999
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYE----PVPGELTFPPGETEKEIRIKIIDDDI 78
|
90
....*....|..
gi 256000767 3000 FEPEEQFRVYLG 3011
Cdd:smart00237 79 YEKDETFYVRLS 90
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
713-762 |
7.84e-07 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 48.28 E-value: 7.84e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 256000767 713 ACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLSQCPDGYFHQEGScTECH 762
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEG-GVCL 49
|
|
| FU |
smart00261 |
Furin-like repeats; |
755-799 |
9.23e-07 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 48.27 E-value: 9.23e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 755 EGSCTECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQF 799
Cdd:smart00261 1 DGECKPCHPECATCTGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
221-278 |
9.61e-07 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 48.67 E-value: 9.61e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 221 CSAAGQVYEHGEQWSENACTTCICDRGE-VRCHKQAC-LPLRCGKGQsRARRHGQCCEEC 278
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECpPPPDCPNPE-RVKPPGECCPRC 59
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
761-871 |
1.56e-06 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 50.07 E-value: 1.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 761 CHPTC--RQCHGPLESDCISCypHISLTNGNCRTSCREEQFLN----LVGYCADCHHLCQHCAADLHNTGS---ICLRCq 831
Cdd:pfam14843 2 CDPLCssEGCWGPGPDQCLSC--RNFSRGGTCVESCNILQGEPreyvVNSTCVPCHPECLPQNGTATCSGPgadNCTKC- 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 256000767 832 nAHYLLlGDHCVPDCPSGYYAER----------GACKKCHSSC-RTCQGRG 871
Cdd:pfam14843 79 -AHFRD-GPHCVSSCPSGVLGENdliwkyadanGVCQPCHPNCtQGCTGPG 127
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
367-416 |
2.11e-06 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 47.51 E-value: 2.11e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 256000767 367 RIPEGEKWEDGPCKVCEC-RGAQVTCYEPSCPP---CPVGTLAlEVKGQCCPDC 416
Cdd:smart00214 7 VYNDGETWKPDPCQICTClDGTTVLCDPVECPPppdCPNPERV-KPPGECCPRC 59
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
709-864 |
2.44e-06 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 49.74 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 709 GICEACHQSCFRCAGKSPHNC-TDCGPshvlldgQCLSQCPDgyfhqEGSCteCHPTCR-QCHGPLESDCISC--YPHis 784
Cdd:pfam00757 10 GTMEKCHSCCNNGYCWGPGHCqKVCPE-------QCKKRCTK-----PGEC--CHEQCLgGCTGPNDSDCLACrhFND-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 785 ltNGNCRTSCREEQFLnlvgYCADC--HHLCQHCAADLHNtgsiclrcqnaHYLLLGDHCVPDCPSGYYA---ERGACKK 859
Cdd:pfam00757 74 --EGTCVDQCPPGTYQ----FGWRCvtFKECPKSHLPGYN-----------PLVIHNGECVRECPSGYTEvenNSRKCEP 136
|
....*
gi 256000767 860 CHSSC 864
Cdd:pfam00757 137 CEGLC 141
|
|
| FU |
smart00261 |
Furin-like repeats; |
556-598 |
2.61e-06 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 46.73 E-value: 2.61e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 256000767 556 GTCSACDQSCDSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYY 598
Cdd:smart00261 2 GECKPCHPECATCtGPGPDDCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
957-1000 |
2.67e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 46.74 E-value: 2.67e-06
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 256000767 957 ECDWSCSACSGPLKTDCLQCMDGYVLQDGACVEQCLSSFYQDSG 1000
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTE 44
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
159-216 |
3.09e-06 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 47.13 E-value: 3.09e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 159 CSYEGHVFQDGEDWRLSRCAKCLCRNG-VAQCFTAQCQPLF-CNQDETVVrVPGKCCPQC 216
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGtTVLCDPVECPPPPdCPNPERVK-PPGECCPRC 59
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
827-897 |
3.37e-06 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 48.20 E-value: 3.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 827 CLRCQNAHYLLLGDH-------CVPDCPSGYYAERGA----CKKCHSS-CRTCqgrgpFS---CSSCDTNLVLsHTGTCS 891
Cdd:pfam15913 13 CLTCQPRLFLLLERNgirqygvCLHSCPPGYFGIRGQevnrCTKCKAEnCESC-----FSkdfCTKCKEGFYL-HKGKCL 86
|
....*.
gi 256000767 892 TTCFPG 897
Cdd:pfam15913 87 DTCPEG 92
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
560-606 |
3.73e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 46.36 E-value: 3.73e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 256000767 560 ACDQSCDSC-GPSSPRCLTCTEKTVLHDGKCMSECPGGYYADAT-GRCK 606
Cdd:cd00064 1 PCHPSCATCtGPGPDQCTSCRHGFYLDGGTCVSECPEGTYADTEgGVCL 49
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
509-600 |
7.35e-06 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 47.43 E-value: 7.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 509 SCAVCHEscagcwgptEKHCLACRDPLHVL--RD-----GGCESSCGKGFYNRQGT----CSACD-QSCDSCGpSSPRCL 576
Cdd:pfam15913 3 GCVLCSE---------ENGCLTCQPRLFLLleRNgirqyGVCLHSCPPGYFGIRGQevnrCTKCKaENCESCF-SKDFCT 72
|
90 100
....*....|....*....|....
gi 256000767 577 TCTEKTVLHDGKCMSECPGGYYAD 600
Cdd:pfam15913 73 KCKEGFYLHKGKCLDTCPEGTAAQ 96
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
760-801 |
7.79e-06 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 45.59 E-value: 7.79e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 256000767 760 ECHPTCRQCHGPLESDCISCYPHISLTNGNCRTSCREEQFLN 801
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDGGTCVSECPEGTYAD 42
|
|
| PTZ00214 |
PTZ00214 |
high cysteine membrane protein Group 4; Provisional |
543-1039 |
9.20e-06 |
|
high cysteine membrane protein Group 4; Provisional
Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 51.84 E-value: 9.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 543 CESSCGKgFYNRQGTcsACDQSCDSCgpSSPRCLtctektVLHDGKCMSECPGGYyADATGRCKVCHNSCASCSGP---- 618
Cdd:PTZ00214 14 CGASTDT-YYNKFGV--ECGGKQENC--AQNRCI------LLGSDELCTQCVSGY-VPINGKCQLYPGDASSVCIPddas 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 619 TPSHCTACSPPkalrqghclprcgEGFYSDHGVCKACHSSCLA---CMGPAPSHCTGCKKPEEGLQVEQLSDVGipsgec 695
Cdd:PTZ00214 82 SPTRCIECKSE-------------QNVFLFYGGCYTIDQSTVGsfiCSQASNGRCTECNVSTTEKYVFTNPDTS------ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 696 laqcrahfyleSTGICEACHQSCFRCAGKSPHNCTDCGPSHVLLDGQCLsqcpdgyfhqegsCTECHPTCRQCH-GPLES 774
Cdd:PTZ00214 143 -----------AAEKCILCSDTVGFNGYKGASGCLDCLPPITDKIGIAL-------------CTKCHYTEQNRHfYPIDY 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 775 DCISCYPHiSLTNGNCrTSCREEQFLNLVGyCADCHH-----LCQHCAADLHNTGSICLRCQNAHYLLLGDHCVP----- 844
Cdd:PTZ00214 199 QCQAKGLH-NCVNGYC-TSCYKTHLFYEYG-CYSRHSstgfaICAEANQYELDNVTICKECVNTSYAPKNGGCTLvgesa 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 845 -------------------DCPSG--YYAERGAC--KKCHSSCRTCQGRGPFSCSSCDTNL--VLSHTGTCSTtcfpGHY 899
Cdd:PTZ00214 276 sieslfsdctkdaskglctACSSSakSFLFYGGCydRDSHIGSRLCSRIGSGVCTQWNSAFdfIFSKNDDNNG----DGY 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 900 L---DDNHVCQPCNThCGSCDSQASCTSCRdpnkvllfgecqyescapQYYLDFSTNTCKEcdwscsACSGPLKTDCLQC 976
Cdd:PTZ00214 352 LcgdATNGGVSGCAT-CGYNSGAVTCTRCS------------------AGYLGVDGKSCSE------SCSGDTRGVCTKV 406
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 256000767 977 MDGYVLQDGACVEQCLSSFYQDSGLCKNCDSYCLQCQG--PHECTRCKgPFLLLE--------AQCVQECGKG 1039
Cdd:PTZ00214 407 AEGSESTEVSCRCVCKPTFYNSSGTCTPCTDSCAVCKDgtPTGCQQCS-PGKILEfsivssesADCVDQCSVG 478
|
|
| Calx-beta |
pfam03160 |
Calx-beta domain; |
2918-3011 |
1.06e-05 |
|
Calx-beta domain;
Pssm-ID: 397326 [Multi-domain] Cd Length: 91 Bit Score: 46.47 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2918 VPSMQFAKDLLLVKEKEGVLHVPITR-SGDLSYESSVRCYTQSHSAQVMEDFEerqnADSSRITFLKGDKVKNCTVYIHD 2996
Cdd:pfam03160 1 AGVIGFEPPTYQVSENDGVAEVCVVRmSGTLRRTVVVPYRTEDGTATAGDDYE----PVEGELVFGPGETEKCINVTIID 76
|
90
....*....|....*
gi 256000767 2997 DSMFEPEEQFRVYLG 3011
Cdd:pfam03160 77 DDVYEGDENFFVLLS 91
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
472-557 |
1.07e-05 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 47.04 E-value: 1.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 472 CSTCTSGLECSSCQPPLLM--------RHGQCVPTCGDGFY----QDRHSCAVCH-ESCAGCWgpTEKHCLACRDPLHvL 538
Cdd:pfam15913 4 CVLCSEENGCLTCQPRLFLllerngirQYGVCLHSCPPGYFgirgQEVNRCTKCKaENCESCF--SKDFCTKCKEGFY-L 80
|
90
....*....|....*....
gi 256000767 539 RDGGCESSCGKGFYNRQGT 557
Cdd:pfam15913 81 HKGKCLDTCPEGTAAQNST 99
|
|
| FU |
smart00261 |
Furin-like repeats; |
462-504 |
1.10e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 45.19 E-value: 1.10e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 462 GSLCLACQPQCSTCTSGLE--CSSCQPPLLMRHGQCVPTCGDGFY 504
Cdd:smart00261 1 DGECKPCHPECATCTGPGPddCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
28-87 |
1.32e-05 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 45.20 E-value: 1.32e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 256000767 28 CVYQDSLLADATIWKPDSCQSCRCH-GDIVICKPAVC-RNPQCAFekgEVLQIAANQCCPEC 87
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLdGTTVLCDPVECpPPPDCPN---PERVKPPGECCPRC 59
|
|
| FU |
smart00261 |
Furin-like repeats; |
999-1041 |
1.33e-05 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 44.81 E-value: 1.33e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 999 SGLCKNCDSYCLQCQGPHE--CTRCKGPFLLLEAQCVQECGKGYF 1041
Cdd:smart00261 1 DGECKPCHPECATCTGPGPddCTSCKHGFFLDGGKCVSECPPGTY 45
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
366-416 |
1.41e-05 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 45.11 E-value: 1.41e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 256000767 366 KRIPEGEKWEDGPCKVCECRGAQVTCYEPSCPP--CPVGTLAlEVKGQCCPDC 416
Cdd:pfam00093 6 VVYENGETWKPDLCTICTCDDGKVLCDKIICPPldCPNPRLE-IPPGECCPVC 57
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
588-718 |
1.48e-05 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 47.82 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 588 KCMSECPGGYYADatGRCkvCHNSCA-SCSGPTPSHCTACSppKALRQGHCLPRCGEGFYSDHGVCkACHSSCLACMGPA 666
Cdd:pfam00757 33 VCPEQCKKRCTKP--GEC--CHEQCLgGCTGPNDSDCLACR--HFNDEGTCVDQCPPGTYQFGWRC-VTFKECPKSHLPG 105
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 256000767 667 PSHctgckkpeeglqveqlsdVGIPSGECLAQCRAHFYL--ESTGICEACHQSC 718
Cdd:pfam00757 106 YNP------------------LVIHNGECVRECPSGYTEveNNSRKCEPCEGLC 141
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
563-650 |
1.82e-05 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 46.27 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 563 QSCDSCGpSSPRCLTCTEKTVL--------HDGKCMSECPGGYYA---DATGRCKVCH-NSCASCSgpTPSHCTACSPPK 630
Cdd:pfam15913 2 SGCVLCS-EENGCLTCQPRLFLllerngirQYGVCLHSCPPGYFGirgQEVNRCTKCKaENCESCF--SKDFCTKCKEGF 78
|
90 100
....*....|....*....|
gi 256000767 631 ALRQGHCLPRCGEGFYSDHG 650
Cdd:pfam15913 79 YLHKGKCLDTCPEGTAAQNS 98
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
906-1056 |
1.92e-05 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 47.43 E-value: 1.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 906 CQP-CNTHCGSCDSQASCTSCRDPNKvllfgeCQYEsCAPQyyldfSTNTCKE----CDWSCSA-CSGPLKTDCLQCMdg 979
Cdd:pfam00757 4 CGDvCPGTMEKCHSCCNNGYCWGPGH------CQKV-CPEQ-----CKKRCTKpgecCHEQCLGgCTGPNDSDCLACR-- 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 980 YVLQDGACVEQCLSSFYQDSGLCKNCDsyclQCQGPHECTrcKGPFLLLEAQCVQECGKGYFADHA-KHKCTACPQGC 1056
Cdd:pfam00757 70 HFNDEGTCVDQCPPGTYQFGWRCVTFK----ECPKSHLPG--YNPLVIHNGECVRECPSGYTEVENnSRKCEPCEGLC 141
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
1005-1049 |
2.08e-05 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.43 E-value: 2.08e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 256000767 1005 CDSYCLQCQGPHE--CTRCKGPFLLLEAQCVQECGKGYFADHAKHKC 1049
Cdd:cd00064 2 CHPSCATCTGPGPdqCTSCRHGFYLDGGTCVSECPEGTYADTEGGVC 48
|
|
| Calx_beta |
smart00237 |
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ... |
2675-2764 |
2.33e-05 |
|
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)
Pssm-ID: 197594 [Multi-domain] Cd Length: 90 Bit Score: 45.71 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2675 TLEFDKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSdfksrgmsaasrVIFGPGVTMSTCD 2754
Cdd:smart00237 3 SVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGE------------LTFPPGETEKEIR 70
|
90
....*....|
gi 256000767 2755 VMLIDDSEYE 2764
Cdd:smart00237 71 IKIIDDDIYE 80
|
|
| VSP |
pfam03302 |
Giardia variant-specific surface protein; |
376-572 |
2.34e-05 |
|
Giardia variant-specific surface protein;
Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 49.97 E-value: 2.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 376 DGPCKVCECRGAQvtcyepSCPPCPVGTLAL----EVKGQCCPDCTSVHCHPDCLTCSQSPD---HCDLCQDPTKLLQNG 448
Cdd:pfam03302 111 HESCKTCSGGTAS------DCTECLTGKALRygndGTKGTCGEGCTTGTGAGACKTCGLTIDgtsYCSECATETEYPQNG 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 449 WC-------VHSCGLGFYQAGsLCLACQ----------------PQCSTCTSGLECSSCQPPLLMRHGQ------CVP-- 497
Cdd:pfam03302 185 VCtstaaraTATCKASSVANG-MCSSCAngyfrmnggcyettkfPGKSVCEEANSGGTCQKEAPGYKLNngdlvtCSPgc 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 498 ----------TCGDGFYQDRHSCAVCHESCAGCWGPTEkhclACRdplhvlrdggcesSCGKGFYNRQGTCSACDQS--- 564
Cdd:pfam03302 264 ktctsntvctTCMDGYVKTSDSCTKCDSSCETCTGATT----TCK-------------TCATGYYKSGTGCVSCTSSesd 326
|
250
....*....|....*.
gi 256000767 565 --------CDSCGPSS 572
Cdd:pfam03302 327 ngitgvkgCLNCAPPS 342
|
|
| Furin-like_2 |
pfam15913 |
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
425-509 |
2.50e-05 |
|
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.
Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 45.88 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 425 CLTCSQSpDHCDLCQDPTKLL-------QNGWCVHSCGLGFY----QAGSLCLACQ-PQCSTCTSGLECSSCQPPLLMRH 492
Cdd:pfam15913 4 CVLCSEE-NGCLTCQPRLFLLlerngirQYGVCLHSCPPGYFgirgQEVNRCTKCKaENCESCFSKDFCTKCKEGFYLHK 82
|
90
....*....|....*..
gi 256000767 493 GQCVPTCGDGFYQDRHS 509
Cdd:pfam15913 83 GKCLDTCPEGTAAQNST 99
|
|
| VWC |
smart00214 |
von Willebrand factor (vWF) type C domain; |
285-342 |
2.95e-05 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214564 Cd Length: 59 Bit Score: 44.43 E-value: 2.95e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 285 CSYDGVVRYQDEMWKGSACEFCMCDHGQ-VTCQTGECAKV-ECARDEELIHlDGKCCPEC 342
Cdd:smart00214 1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpDCPNPERVKP-PGECCPRC 59
|
|
| myxo_dep_M36 |
NF038112 |
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ... |
2146-2405 |
3.13e-05 |
|
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.
Pssm-ID: 468355 [Multi-domain] Cd Length: 1597 Bit Score: 50.43 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2146 SFTQADISQGHVeyshgtgepggsFAFKFDVVDGEGNRLIDkSFSISILEDKSPPVITTNKGLVLDENSVkkiTTLQLSA 2225
Cdd:NF038112 1242 SFTAPEVTADTV------------LTFQLVVSDGTKTSAPD-TVTVLVRNVNRAPVAVAGAPATVDERST---VTLDGSG 1305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2226 TDQDSGPTELIYRITRQPQLGhLEHAASPgiqISSFTQADLTSrNVQYVhsseaekhsdaFSFTLSDGVSEVTQTFHITL 2305
Cdd:NF038112 1306 TDADGDALTYAWTQTSGPAVT-LTGATTA---TATFTAPEVTA-DTQLT-----------FTLTVSDGTASATDTVTVTV 1369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 2306 HPVDDSlPVVqNLGMRVQEGMRKTITefeLKAVDADTEAESVTFTIVQPPrhGTIERTSNGQhfHLTSTFTMKDIYQN-- 2383
Cdd:NF038112 1370 RNVNRA-PVA-NAGADQTVDERSTVT---LSGSATDPDGDALTYAWTQTA--GPTVTLTGAD--TATASFTAPEVAADte 1440
|
250 260
....*....|....*....|....*
gi 256000767 2384 ---RVSYSHDGSNSLKDRFTFTVSD 2405
Cdd:NF038112 1441 ltfQLTVSADGQASADVTVTVTVRN 1465
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
411-519 |
3.76e-05 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 46.66 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 411 QCCPDCTSVH--CHPDCL-TCSQS-PDHCDLCQdptKLLQNGWCVHSCGLGFYQAGSLCLAcQPQCSTCTSGLEcsscqP 486
Cdd:pfam00757 37 QCKKRCTKPGecCHEQCLgGCTGPnDSDCLACR---HFNDEGTCVDQCPPGTYQFGWRCVT-FKECPKSHLPGY-----N 107
|
90 100 110
....*....|....*....|....*....|...
gi 256000767 487 PLLMRHGQCVPTCGDGFYQDRHSCAVCHEsCAG 519
Cdd:pfam00757 108 PLVIHNGECVRECPSGYTEVENNSRKCEP-CEG 139
|
|
| Furin-like |
pfam00757 |
Furin-like cysteine rich region; |
760-917 |
5.15e-05 |
|
Furin-like cysteine rich region;
Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 46.28 E-value: 5.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 760 ECHPTCrqcHGPLESDCISCYPHISLTNGNCRTSCREEqflnLVGYCADCHHLC-QHCAA--DLHNTgSICLRCQNAHYl 836
Cdd:pfam00757 3 ECGDVC---PGTMEKCHSCCNNGYCWGPGHCQKVCPEQ----CKKRCTKPGECChEQCLGgcTGPND-SDCLACRHFND- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 837 llGDHCVPDCPSGYYaergackKCHSSC---RTCQgrgpfSCSSCDTNLVLSHTGTCSTTCFPGHYLDDNHV--CQPCNt 911
Cdd:pfam00757 74 --EGTCVDQCPPGTY-------QFGWRCvtfKECP-----KSHLPGYNPLVIHNGECVRECPSGYTEVENNSrkCEPCE- 138
|
....*.
gi 256000767 912 hcGSCD 917
Cdd:pfam00757 139 --GLCP 142
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
285-342 |
6.48e-05 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 43.18 E-value: 6.48e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 256000767 285 CSYDGVVRYQDEMWKGSACEFCMCDHGQVTCQTGECAKVECArDEELIHLDGKCCPEC 342
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCP-NPRLEIPPGECCPVC 57
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
958-1058 |
8.20e-05 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 45.06 E-value: 8.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 958 CDWSCSA--CSGPLKTDCLQCMdgYVLQDGACVEQC-----LSSFYQDSGLCKNCDSYCLQ------CQGPHE--CTRCK 1022
Cdd:pfam14843 2 CDPLCSSegCWGPGPDQCLSCR--NFSRGGTCVESCnilqgEPREYVVNSTCVPCHPECLPqngtatCSGPGAdnCTKCA 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 256000767 1023 ----GPFllleaqCVQECGKGY---------FADhAKHKCTACPQGCLQ 1058
Cdd:pfam14843 80 hfrdGPH------CVSSCPSGVlgendliwkYAD-ANGVCQPCHPNCTQ 121
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
467-506 |
1.36e-04 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 42.12 E-value: 1.36e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 256000767 467 ACQPQCSTCTSGLE--CSSCQPPLLMRHGQCVPTCGDGFYQD 506
Cdd:cd00064 1 PCHPSCATCTGPGPdqCTSCRHGFYLDGGTCVSECPEGTYAD 42
|
|
| GF_recep_IV |
pfam14843 |
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
412-529 |
1.50e-04 |
|
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).
Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 44.29 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 412 CCPDCTSVHC---HPD-CLTCSQSpdhcdlcqdptklLQNGWCVHSCGLGF-----YQAGSLCLACQPQCSTCTSGLECS 482
Cdd:pfam14843 2 CDPLCSSEGCwgpGPDqCLSCRNF-------------SRGGTCVESCNILQgepreYVVNSTCVPCHPECLPQNGTATCS 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 256000767 483 -----SCQPPLLMRHGQ-CVPTCGDG---------FYQDR-HSCAVCHESCA-GCWGPTEKHCL 529
Cdd:pfam14843 69 gpgadNCTKCAHFRDGPhCVSSCPSGvlgendliwKYADAnGVCQPCHPNCTqGCTGPGLTGCP 132
|
|
| VWC |
pfam00093 |
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ... |
28-87 |
1.60e-04 |
|
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.
Pssm-ID: 278520 Cd Length: 57 Bit Score: 42.03 E-value: 1.60e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 28 CVYQDSLLADATIWKPDSCQSCRCHGDIVICKPAVCRNPQCAFEKGEvlqIAANQCCPEC 87
Cdd:pfam00093 1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLDCPNPRLE---IPPGECCPVC 57
|
|
| FU |
smart00261 |
Furin-like repeats; |
804-851 |
2.69e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.96 E-value: 2.69e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 256000767 804 GYCADCHHLCQHCAADLHNTgsiCLRCQNaHYLLLGDHCVPDCPSGYY 851
Cdd:smart00261 2 GECKPCHPECATCTGPGPDD---CTSCKH-GFFLDGGKCVSECPPGTY 45
|
|
| FU |
smart00261 |
Furin-like repeats; |
650-704 |
3.31e-04 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 40.96 E-value: 3.31e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 256000767 650 GVCKACHSSCLACMGPAPSHCTGCKKPEEGLQveqlsdvgipsGECLAQCRAHFY 704
Cdd:smart00261 2 GECKPCHPECATCTGPGPDDCTSCKHGFFLDG-----------GKCVSECPPGTY 45
|
|
| VWC_out |
smart00215 |
von Willebrand factor (vWF) type C domain; |
221-274 |
3.95e-04 |
|
von Willebrand factor (vWF) type C domain;
Pssm-ID: 214565 Cd Length: 67 Bit Score: 41.39 E-value: 3.95e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 256000767 221 CSAAGQVYEHGEQWSENaCTTCICDRGEVRCHKQACLPLRCGKGQSrarrHGQC 274
Cdd:smart00215 1 CWNNGSYYPPGAKWDDD-CNRCTCLNGRVSCTKVWCGPKPCLLHNL----SGEC 49
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
654-709 |
1.24e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.42 E-value: 1.24e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 256000767 654 ACHSSCLACMGPAPSHCTGCKKPEEGLQveqlsdvgipsGECLAQCRAHFYLESTG 709
Cdd:cd00064 1 PCHPSCATCTGPGPDQCTSCRHGFYLDG-----------GTCVSECPEGTYADTEG 45
|
|
| SerH |
pfam06873 |
Cell surface immobilization antigen SerH; This family consists of several cell surface ... |
384-728 |
1.96e-03 |
|
Cell surface immobilization antigen SerH; This family consists of several cell surface immobilization antigen SerH proteins which seem to be specific to Tetrahymena thermophila. The SerH locus of Tetrahymena thermophila is one of several paralogous loci with genes encoding variants of the major cell surface protein known as the immobilization antigen (i-ag).
Pssm-ID: 284327 [Multi-domain] Cd Length: 418 Bit Score: 43.76 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 384 CRGAQVTCYEPSCPPCPV---GTLALEVKGQCCPDCTSVHChpDCLTCSqspdhcdlcqdPTKLLQNGWCvHSCGLGFYQ 460
Cdd:pfam06873 30 CAGLPSCSCSTSCPVPTItgtGTACSWGAGTDATNCAITDC--TCLNTT-----------PATGLTDLFC-KSCKGSNQN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 461 -----AGSLCLACQPQCSTCTSGL----ECSSCQPPllmrhgqcvptcGDGFYQDRHSCAVCHESCAGCWGPTEKHCLAC 531
Cdd:pfam06873 96 syansAGTACVSSSASCSNRRRGAwtdgDCTLCNPS------------TPAAVSDKSTCVSCTACSSITSGWTDANCNAC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 532 rdplhvlrDGGCESSCGKGFYNRQGtcSACDQSCDSCGPSSprcltcTEKTVLHDGKCMSECPGGYYADATGRCKV---C 608
Cdd:pfam06873 164 --------ATTASPKGNNVFANSAG--SACVAASASCGSTS------RGSTAWTDADCLACTPATPYASADKSSCVassC 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 609 HNSCASCSGPTPSHCTACSPPKAlrqghclPRCGEGFYSDHG-VCKACHSSCL-ACMGPAP---SHCTGCKKPEEGLQVE 683
Cdd:pfam06873 228 AACSTVTSGWTDSDCNACATTAS-------PATKNLFANAAGsSCVASSASCTtASRGTTAwtdSDCTLCTPSTPAASLD 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 256000767 684 QLSDVGIpsgECLAQCRAhfyleSTGICEACHQSCFRCAGKSPHN 728
Cdd:pfam06873 301 ASPCVVS---SCVACNSI-----TSGWTDANCNSCAMTASPSTKN 337
|
|
| FU |
smart00261 |
Furin-like repeats; |
1046-1087 |
2.39e-03 |
|
Furin-like repeats;
Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 38.64 E-value: 2.39e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 256000767 1046 KHKCTACPQGCLQCSHRDR--CHLCDHGFFLKSGLCVYNCVPGF 1087
Cdd:smart00261 1 DGECKPCHPECATCTGPGPddCTSCKHGFFLDGGKCVSECPPGT 44
|
|
| FU |
cd00064 |
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
809-853 |
4.60e-03 |
|
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 37.88 E-value: 4.60e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 256000767 809 CHHLCQHCAADLHNTgsiCLRCQNaHYLLLGDHCVPDCPSGYYAE 853
Cdd:cd00064 2 CHPSCATCTGPGPDQ---CTSCRH-GFYLDGGTCVSECPEGTYAD 42
|
|
| C_rich_MXAN6577 |
NF041328 |
MXAN_6577-like cysteine-rich domain; |
493-605 |
6.08e-03 |
|
MXAN_6577-like cysteine-rich domain;
Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 40.13 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 493 GQCVPTCGDGfyqdrhscAVCHESCAGCWGPTEKHCLAC----RDPLHVlrdGGCESSCGKGFYNRQGTC-SACDQSCDS 567
Cdd:NF041328 43 GACGVACGAG--------QTCVAGACGCGPGTVACGGACvdtaSDPAHC---GACGAACAPGQVCEGGACrEACSEGLTR 111
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 256000767 568 CGPSsprcltCTEKTV--LHDGKCMSECPGGYYADAtGRC 605
Cdd:NF041328 112 CGGA------CVDLATdpLHCGACGVACDPGESCRG-GAC 144
|
|
| TNFRSF6_teleost |
cd13423 |
Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas ... |
498-615 |
8.24e-03 |
|
Tumor necrosis factor receptor superfamily member 6 (TNFRSF6) in teleosts; also known as fas cell surface death receptor (FasR); This subfamily of TNFRSF6 (also known as fas cell surface death receptor (FasR) or Fas; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A) is found in teleosts. It contains a death domain and plays a central role in the physiological regulation of programmed cell death. In humans, it has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The receptor interactions with the Fas ligand (FasL), allowing the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10; autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, leading to apoptosis. This receptor has also been shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. In channel catfish and the Japanese rice fish, medaka, homologs of Fas receptor (FasR), as well as FADD and caspase 8, have been identified and characterized, and likely constitute the teleost equivalent of the death-inducing signaling complex (DISC). FasL/FasR are involved in the initiation of apoptosis and suggest that mechanisms of cell-mediated cytotoxicity in teleosts are similar to those used by mammals; presumably, the mechanism of apoptosis induction via death receptors was evolutionarily established during the appearance of vertebrates.
Pssm-ID: 276928 [Multi-domain] Cd Length: 103 Bit Score: 38.56 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 256000767 498 TCGDGFYQdrhscavcHESCAGCWGPT----EKHCLACRDplhvlrDGGCESsCGKGFYNRQGTCSACDQSCDSCGPSS- 572
Cdd:cd13423 1 SCEDGTYQ--------HEGLTCCLCPAgqhvEKHCTNNGT------DGECEA-CEDGTYNSHPNSLDSCEPCTSCDPNAn 65
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 256000767 573 ----PRCltctekTVLHDGKCmsECPGGYYADATGRCKVCHnSCASC 615
Cdd:cd13423 66 leveERC------TPSSDTVC--RCKEGHYCDKGEECKVCY-PCDTC 103
|
|
| |
