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Conserved domains on  [gi|39995086|ref|NP_079235|]
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mitochondrial sodium/calcium exchanger protein isoform 1 precursor [Homo sapiens]

Protein Classification

cation/calcium exchanger( domain architecture ID 1004073)

cation/calcium exchanger belonging to the Ca(2+):cation antiporter (CaCA) family, such as mitochondrial sodium/calcium exchanger protein, an antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion

Gene Ontology:  GO:0015368|GO:0016020|GO:0070588
PubMed:  23685453
SCOP:  3002205
TCDB:  2.A.19

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN03151 super family cl33648
cation/calcium exchanger; Provisional
63-584 4.19e-60

cation/calcium exchanger; Provisional


The actual alignment was detected with superfamily member PLN03151:

Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 211.16  E-value: 4.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   63 DRCDFIRTNPDChSDGGYLDYLEGIFCHFPpSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGV 142
Cdd:PLN03151 105 DQCEFLKAHPIC-SSGGFFDYLKFFYCSCE-DFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGV 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  143 TFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITIL---HPFMAASRPFFRDIVFYMVAVFLTFLM 219
Cdd:PLN03151 183 TLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLVI 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  220 LFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRR-------------GSLFCP-----MPV-TPEILSDSEED---- 276
Cdd:PLN03151 263 LMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRlkldvvtpllpvqGSIFSPsveedESMySPLLESDTESDvprl 342
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  277 -----------RVSSNTNSYDYG---DEYRPLFFYQETTAQIlvralnpldymkwrrKSAYWKALKVFKL---PVEFLLL 339
Cdd:PLN03151 343 qtslpqwmwasNVAIYSNHFAKGsvhDEERPPWGWTDEGAEV---------------ESSLFSCSKLFSLlemPLTIPRR 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  340 LTVPVVDPDKddqnWKRPLNCLHLVISPLVVVLTLQS-------GTYGVYEIGGlvpvwvvvvIAGTALASVTFFATSDS 412
Cdd:PLN03151 408 LTIPIVEEDR----WSKTYAVASASLAPVLLAFLWSSqddvslqARIAAYFIGV---------AIGSTLGFLAYKYTEPD 474
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  413 QPPR---LHWLFAflGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYP--RMA 487
Cdd:PLN03151 475 RPPRrflIPWVLG--GFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIA 552
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  488 FSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEP-DGLLVWVLaGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLN 566
Cdd:PLN03151 553 MSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPeDSSLFYTM-GFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLI 631
                        570
                 ....*....|....*...
gi 39995086  567 FLVVALLTEFGVIHLKSM 584
Cdd:PLN03151 632 FLTFRVSTAMGFIPWAGL 649
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
63-584 4.19e-60

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 211.16  E-value: 4.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   63 DRCDFIRTNPDChSDGGYLDYLEGIFCHFPpSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGV 142
Cdd:PLN03151 105 DQCEFLKAHPIC-SSGGFFDYLKFFYCSCE-DFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGV 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  143 TFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITIL---HPFMAASRPFFRDIVFYMVAVFLTFLM 219
Cdd:PLN03151 183 TLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLVI 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  220 LFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRR-------------GSLFCP-----MPV-TPEILSDSEED---- 276
Cdd:PLN03151 263 LMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRlkldvvtpllpvqGSIFSPsveedESMySPLLESDTESDvprl 342
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  277 -----------RVSSNTNSYDYG---DEYRPLFFYQETTAQIlvralnpldymkwrrKSAYWKALKVFKL---PVEFLLL 339
Cdd:PLN03151 343 qtslpqwmwasNVAIYSNHFAKGsvhDEERPPWGWTDEGAEV---------------ESSLFSCSKLFSLlemPLTIPRR 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  340 LTVPVVDPDKddqnWKRPLNCLHLVISPLVVVLTLQS-------GTYGVYEIGGlvpvwvvvvIAGTALASVTFFATSDS 412
Cdd:PLN03151 408 LTIPIVEEDR----WSKTYAVASASLAPVLLAFLWSSqddvslqARIAAYFIGV---------AIGSTLGFLAYKYTEPD 474
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  413 QPPR---LHWLFAflGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYP--RMA 487
Cdd:PLN03151 475 RPPRrflIPWVLG--GFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIA 552
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  488 FSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEP-DGLLVWVLaGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLN 566
Cdd:PLN03151 553 MSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPeDSSLFYTM-GFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLI 631
                        570
                 ....*....|....*...
gi 39995086  567 FLVVALLTEFGVIHLKSM 584
Cdd:PLN03151 632 FLTFRVSTAMGFIPWAGL 649
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
421-573 3.93e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 95.75  E-value: 3.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNIL 500
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39995086   501 VGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVplqcFQLSRVYGFCLLLFYLNFLVVALL 573
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF----GRLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
72-244 7.90e-16

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 81.20  E-value: 7.90e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086     72 PDCHSDGGYldylegifchfPPSLLPLA------VTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFL 145
Cdd:TIGR00927  434 PDLHPKAEY-----------PPDLFSVEerrqgwVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFM 502
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086    146 AFGNGAPDIFSALVAFSDPHTaGLALGALFGAGVLVTTVVAGGITILhpfmaaSR--------PFFRDIVFYMVAvfLTF 217
Cdd:TIGR00927  503 AAGGSAPELFTSLIGVFISHS-NVGIGTIVGSAVFNILFVIGTCALF------SReilnltwwPLFRDVSFYILD--LMM 573
                          170       180
                   ....*....|....*....|....*....
gi 39995086    218 LMLFRGRVTLAW--ALGYLGLYVFYVVTV 244
Cdd:TIGR00927  574 LILFFLDSLIAWweSLLLLLAYALYVFTM 602
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
126-256 3.04e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 73.63  E-value: 3.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086 126 LSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDpHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRD 205
Cdd:COG0530   8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALD-GSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVLRRD 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 39995086 206 IVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVtvilctWIYQRQRR 256
Cdd:COG0530  87 LPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------YLIRRARK 131
 
Name Accession Description Interval E-value
PLN03151 PLN03151
cation/calcium exchanger; Provisional
63-584 4.19e-60

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 211.16  E-value: 4.19e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   63 DRCDFIRTNPDChSDGGYLDYLEGIFCHFPpSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGV 142
Cdd:PLN03151 105 DQCEFLKAHPIC-SSGGFFDYLKFFYCSCE-DFRILGYAVLGVWLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGV 182
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  143 TFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITIL---HPFMAASRPFFRDIVFYMVAVFLTFLM 219
Cdd:PLN03151 183 TLLPLGNGAPDVFASIAAFVGKDAGEVGLNSVLGGAVFVTCVVVGIVSLCvadKEVQIDKRCFIRDLCFFLFTLVSLLVI 262
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  220 LFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRR-------------GSLFCP-----MPV-TPEILSDSEED---- 276
Cdd:PLN03151 263 LMVGKVTVGGAIAFVSIYVVYAFLVAANEILRKHARRlkldvvtpllpvqGSIFSPsveedESMySPLLESDTESDvprl 342
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  277 -----------RVSSNTNSYDYG---DEYRPLFFYQETTAQIlvralnpldymkwrrKSAYWKALKVFKL---PVEFLLL 339
Cdd:PLN03151 343 qtslpqwmwasNVAIYSNHFAKGsvhDEERPPWGWTDEGAEV---------------ESSLFSCSKLFSLlemPLTIPRR 407
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  340 LTVPVVDPDKddqnWKRPLNCLHLVISPLVVVLTLQS-------GTYGVYEIGGlvpvwvvvvIAGTALASVTFFATSDS 412
Cdd:PLN03151 408 LTIPIVEEDR----WSKTYAVASASLAPVLLAFLWSSqddvslqARIAAYFIGV---------AIGSTLGFLAYKYTEPD 474
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  413 QPPR---LHWLFAflGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYP--RMA 487
Cdd:PLN03151 475 RPPRrflIPWVLG--GFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNGGDgvQIA 552
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086  488 FSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEP-DGLLVWVLaGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLN 566
Cdd:PLN03151 553 MSGCYAGPMFNTLVGLGMSMLLGAWSKSPESYMLPeDSSLFYTM-GFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLI 631
                        570
                 ....*....|....*...
gi 39995086  567 FLVVALLTEFGVIHLKSM 584
Cdd:PLN03151 632 FLTFRVSTAMGFIPWAGL 649
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
421-573 3.93e-23

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 95.75  E-value: 3.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNIL 500
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 39995086   501 VGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVplqcFQLSRVYGFCLLLFYLNFLVVALL 573
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLF----GRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
106-246 3.13e-16

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 76.10  E-value: 3.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   106 WLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHtAGLALGALFGAGVLVTTVV 185
Cdd:pfam01699   4 LLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNILLV 82
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 39995086   186 AG------GITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVIL 246
Cdd:pfam01699  83 LGlsaligPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
72-244 7.90e-16

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 81.20  E-value: 7.90e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086     72 PDCHSDGGYldylegifchfPPSLLPLA------VTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFL 145
Cdd:TIGR00927  434 PDLHPKAEY-----------PPDLFSVEerrqgwVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFM 502
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086    146 AFGNGAPDIFSALVAFSDPHTaGLALGALFGAGVLVTTVVAGGITILhpfmaaSR--------PFFRDIVFYMVAvfLTF 217
Cdd:TIGR00927  503 AAGGSAPELFTSLIGVFISHS-NVGIGTIVGSAVFNILFVIGTCALF------SReilnltwwPLFRDVSFYILD--LMM 573
                          170       180
                   ....*....|....*....|....*....
gi 39995086    218 LMLFRGRVTLAW--ALGYLGLYVFYVVTV 244
Cdd:TIGR00927  574 LILFFLDSLIAWweSLLLLLAYALYVFTM 602
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
126-256 3.04e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 73.63  E-value: 3.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086 126 LSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDpHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRD 205
Cdd:COG0530   8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALD-GSPDIAVGNVVGSNIANILLILGLAALIRPLAVDRRVLRRD 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 39995086 206 IVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVtvilctWIYQRQRR 256
Cdd:COG0530  87 LPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------YLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
421-579 1.61e-13

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 73.88  E-value: 1.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086    421 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNIL 500
Cdd:TIGR00927  933 FFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 1012
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086    501 VGVGLGCLL-QISRSHTEVKLEPDGLLVWVLagALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVI 579
Cdd:TIGR00927 1013 VGLPVPWLLfSLINGLQPVPVSSNGLFCAIV--LLFLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLEDRII 1090
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
107-255 4.58e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 67.35  E-value: 4.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   107 LLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAfSDPHTAGLALGALFGAGVLVTTVVA 186
Cdd:TIGR00367   6 YLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIA-SLMGQPDIGVGNVIGSNIFNILLIL 84
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39995086   187 GGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVvtvilcTWIYQRQR 255
Cdd:TIGR00367  85 GLSAIFSPIIVDKDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYL------LFLVKNER 147
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
106-244 3.26e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 58.22  E-value: 3.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086 106 WLLYLFLILG----VTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHtAGLALGALFGAGVLV 181
Cdd:COG0530 151 WKALLLLVLGlallVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGE-DDLAVGNIIGSNIFN 229
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 39995086 182 TTVVAGGITILHPFMAASRPFFRDIVFY-MVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTV 244
Cdd:COG0530 230 ILLVLGIGALITPIPVDPAVLSFDLPVMlAATLLLLGLLRTGGRIGRWEGLLLLALYLAYLALL 293
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
446-572 3.27e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 48.98  E-value: 3.27e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086 446 SLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLlqISRSHTEVKlepdgL 525
Cdd:COG0530  10 ALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAAL--IRPLAVDRR-----V 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 39995086 526 LVWVLAGALGLSLVFSLVSVPlqcFQLSRVYGFCLLLFYLNFLVVAL 572
Cdd:COG0530  83 LRRDLPFLLLASLLLLALLLD---GTLSRIDGVILLLLYVLYLYYLI 126
lysS PRK02983
bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX;
415-543 2.14e-03

bifunctional lysylphosphatidylglycerol synthetase/lysine--tRNA ligase LysX;


Pssm-ID: 235095 [Multi-domain]  Cd Length: 1094  Bit Score: 41.10  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39995086   415 PRLHWLFaFLGFLTSAL-------WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLA-------- 479
Cdd:PRK02983   55 TSLAWAF-VLALLAAALrrrkraaWWVLLAYLVLAALLNVALLALGVNTAAETFGENSLSIIGFAVHVVAIVllvlarre 133
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 39995086   480 -----RQGYPRMAFSACFGGIIFNILVGVGlgcLLQISRSHtevkLEPDGLLVWVLAGALGLSLVFSLV 543
Cdd:PRK02983  134 fparvRRGALRKALAVLVGGLAVGILVGWG---LVELFPGS----LAPPERLGWALNRVVGFALADPDL 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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