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histone deacetylase complex subunit SAP130 isoform b [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
661-1031
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 661 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 740
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 741 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 817
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 818 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 897
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 898 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 977
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 19923597 978 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1031
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
373-877
9.99e-06
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 524 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 603
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 604 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 666
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 667 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 742
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 743 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 819
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 820 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 877
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
45-365
1.82e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 19923597 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
661-1031
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 661 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 740
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 741 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 817
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 818 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 897
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 898 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 977
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 19923597 978 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1031
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
373-877
9.99e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 524 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 603
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 604 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 666
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 667 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 742
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 743 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 819
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 820 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 877
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
45-365
1.82e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 19923597 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
436-812
5.30e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.99
E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 436 QQI TH T S P riq P DYP A ERSSLI P I S GHRASPNPV A METRSDNR PSVP V Q FQ yf LP T YP P SAYPLA ah T YT P I T SSVS T IR 515
Cdd:pfam03154 164 QQI LQ T Q P --- P VLQ A QSGAAS P P S PPPPGTTQA A TAGPTPSA PSVP P Q GS -- PA T SQ P PNQTQS -- T AA P H T LIQQ T PT 236
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 516 QY P VSAQA P NSAITAQ T GVGVA S T V HLN P MQL ------------- MTVDA SH AR H IQGI QP A P IST Q GI Q PA pi GT PG IQ 582
Cdd:pfam03154 237 LH P QRLPS P HPPLQPM T QPPPP S Q V SPQ P LPQ pslhgqmppmphs LQTGP SH MQ H PVPP QP F P LTP Q SS Q SQ -- VP PG PS 314
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 583 PA PL G TQGIHSA TP INTQG LQ PAPMGTQ QP Q P EGKT S AVVLADGA T IVANPIS NP F S AAPAATTVVQTHS Q SA S TNA P AQ 662
Cdd:pfam03154 315 PA AP G QSQQRIH TP PSQSQ LQ SQQPPRE QP L P PAPL S MPHIKPPP T TPIPQLP NP Q S HKHPPHLSGPSPF Q MN S NLP P PP 394
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 663 GSS P RP S ILRKK P ATDGAK P KSEIHV S MAT P VTVSMET V SN Q NNDQ P TI A VPPTAQQPPPTI P TMIAAASP P SQ P AVALS 742
Cdd:pfam03154 395 ALK P LS S LSTHH P PSAHPP P LQLMPQ S QQL P PPPAQPP V LT Q SQSL P PP A ASHPPTSGLHQV P SQSPFPQH P FV P GGPPP 474
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923597 743 TI P GAV P I T PPITTIAAAP PP --- SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 812
Cdd:pfam03154 475 IT P PSG P P T STSSAMPGIQ PP ssa SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
605-840
3.87e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 41.37
E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 605 AP M G TQQPQPE G KT -- SAVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 682
Cdd:PRK07003 367 AP G G GVPARVA G AV pa PGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 683 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 761
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19923597 762 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 840
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
661-1031
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 661 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 740
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 741 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 817
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 818 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 897
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 898 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 977
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 19923597 978 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1031
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
373-877
9.99e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 524 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 603
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 604 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 666
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 667 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 742
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 743 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 819
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 820 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 877
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
45-365
1.82e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 19923597 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
124-518
8.72e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.86
E-value: 8.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 124 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTLSL P PKVP G QVTVTMES S - I P QASAI P VATISG 193
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 194 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 260
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 261 A QP A VQHIIHQ P IQSRPPVTT S N A I P P A VVATVSATRAQS P V - ITTT A AHA T DSALSR P TLSIQHPPSAAISIQ RPA QSR 339
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S P A L P A A PAPPAVPAGPAT P G g PARP A RPP T TAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 340 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTI P SATTA G SVSHTQAP tsti V TMTV 413
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 414 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPA E RSS L I P ISGH R ASPNPVAMETRSDNR P SV P V Q F Q YFL P TY P 493
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 19923597 494 PSAY PLA AH T YTPITSSV S TIRQY P 518
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
436-812
5.30e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.99
E-value: 5.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 436 QQI TH T S P riq P DYP A ERSSLI P I S GHRASPNPV A METRSDNR PSVP V Q FQ yf LP T YP P SAYPLA ah T YT P I T SSVS T IR 515
Cdd:pfam03154 164 QQI LQ T Q P --- P VLQ A QSGAAS P P S PPPPGTTQA A TAGPTPSA PSVP P Q GS -- PA T SQ P PNQTQS -- T AA P H T LIQQ T PT 236
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 516 QY P VSAQA P NSAITAQ T GVGVA S T V HLN P MQL ------------- MTVDA SH AR H IQGI QP A P IST Q GI Q PA pi GT PG IQ 582
Cdd:pfam03154 237 LH P QRLPS P HPPLQPM T QPPPP S Q V SPQ P LPQ pslhgqmppmphs LQTGP SH MQ H PVPP QP F P LTP Q SS Q SQ -- VP PG PS 314
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 583 PA PL G TQGIHSA TP INTQG LQ PAPMGTQ QP Q P EGKT S AVVLADGA T IVANPIS NP F S AAPAATTVVQTHS Q SA S TNA P AQ 662
Cdd:pfam03154 315 PA AP G QSQQRIH TP PSQSQ LQ SQQPPRE QP L P PAPL S MPHIKPPP T TPIPQLP NP Q S HKHPPHLSGPSPF Q MN S NLP P PP 394
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 663 GSS P RP S ILRKK P ATDGAK P KSEIHV S MAT P VTVSMET V SN Q NNDQ P TI A VPPTAQQPPPTI P TMIAAASP P SQ P AVALS 742
Cdd:pfam03154 395 ALK P LS S LSTHH P PSAHPP P LQLMPQ S QQL P PPPAQPP V LT Q SQSL P PP A ASHPPTSGLHQV P SQSPFPQH P FV P GGPPP 474
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19923597 743 TI P GAV P I T PPITTIAAAP PP --- SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 812
Cdd:pfam03154 475 IT P PSG P P T STSSAMPGIQ PP ssa SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
605-840
3.87e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 41.37
E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 605 AP M G TQQPQPE G KT -- SAVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 682
Cdd:PRK07003 367 AP G G GVPARVA G AV pa PGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 683 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 761
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19923597 762 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 840
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
276-669
4.56e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 41.12
E-value: 4.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 276 R PPVTTSN A IP PA VV A TVS A TR A QSPV i TTT AA H A TDS A LSRPTLSIQH P PS A AISIQR P AQSRDVTTRITL PS H P ALGT 355
Cdd:PRK07764 383 R RLGVAGG A GA PA AA A PSA A AA A PAAA - PAP AA A A PAA A AAPAPAAAPQ P AP A PAPAPA P PSPAGNAPAGGA PS P P PAAA 461
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 356 P KQ Q LHTMAQKTIFS T GT P VA A ATV AP il A TNTI P S A TT A GSVSHTQAPTS T I ------ VTMT VP SH S SHAT A VTTSNIP 429
Cdd:PRK07764 462 P SA Q PAPAPAAAPEP T AA P AP A PPA AP -- A PAAA P A A PA A PAAPAGADDAA T L rerwpe ILAA VP KR S RKTW A ILLPEAT 539
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 430 V AK V VPQQ -- ITHTSP ---- R I - Q P DYPAE - RSS L IPIS G HRASPNP V AMETRSDNRPSV P VQFQYFL P TYP --- P S A YP 498
Cdd:PRK07764 540 V LG V RGDT lv LGFSTG glar R F a S P GNAEV l VTA L AEEL G GDWQVEA V VGPAPGAAGGEG P PAPASSG P PEE aar P A A PA 619
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 499 LA A HTYT P ITSSVSTIRQYPVS A Q AP NS A ITAQTGVG VA ST vhl NPMQLMTVDASH A RHIQGIQ P A P ISTQGIQP AP I G T 578
Cdd:PRK07764 620 AP A APAA P APAGAAAAPAEASA A P AP GV A APEHHPKH VA VP --- DASDGGDGWPAK A GGAAPAA P P P APAPAAPA AP A G A 696
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923597 579 PGI QPAP LGTQGIHSATPINTQGLQ P APMGTQQPQPEGKTSA V V L ADGAT iv AN P ISNPFS A A P AATTVVQTHSQS A STN 658
Cdd:PRK07764 697 APA QPAP APAATPPAGQADDPAAQP P QAAQGASAPSPAADDP V P L PPEPD -- DP P DPAGAP A Q P PPPPAPAPAAAP A AAP 774
410
....*....|.
gi 19923597 659 A P AQG S SPRPS 669
Cdd:PRK07764 775 P P SPP S EEEEM 785
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
