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Conserved domains on  [gi|284807142|ref|NP_076987|]
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transmembrane gamma-carboxyglutamic acid protein 3 isoform 1 [Homo sapiens]

Protein Classification

Gla domain-containing protein( domain architecture ID 10457053)

Gla domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 24-63 6.09e-25

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


:

Pssm-ID: 459861  Cd Length: 41  Bit Score: 92.59  E-value: 6.09e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 284807142   24 LEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGY 63
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
 
Name Accession Description Interval E-value
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 24-63 6.09e-25

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 92.59  E-value: 6.09e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 284807142   24 LEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGY 63
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 2-63 7.58e-22

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 85.05  E-value: 7.58e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 284807142     2 AVFLEAKDAHSVLKRFPRANEF-LEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGY 63
Cdd:smart00069   2 SVFLSRQEANKVLRRQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
 
Name Accession Description Interval E-value
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 24-63 6.09e-25

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 92.59  E-value: 6.09e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 284807142   24 LEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGY 63
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 2-63 7.58e-22

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 85.05  E-value: 7.58e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 284807142     2 AVFLEAKDAHSVLKRFPRANEF-LEELRQGTIERECMEEICSYEEVKEVFENKEKTMEFWKGY 63
Cdd:smart00069   2 SVFLSRQEANKVLRRQRRANAFlLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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