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Conserved domains on  [gi|13027422|ref|NP_076458|]
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neuropeptide Y receptor type 2 [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11607520)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
51-336 0e+00

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


:

Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 509.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15399  81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWPNG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:cd15399 161 T-LNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15399 240 SDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
 
Name Accession Description Interval E-value
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
51-336 0e+00

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 509.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15399  81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWPNG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:cd15399 161 T-LNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15399 240 SDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
67-325 6.26e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.04  E-value: 6.26e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422    67 GNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLAVQVSTITLTVIA 145
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   146 LDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFreySLIEIIPDFEIVACTEKWPgeEKSVYGTVYSLST 223
Cdd:pfam00001  81 IDRYLAIVHPLRYKrrRTPRRAKVLILVIWVLALLLSLPPLLF---GWTLTVPEGNVTVCFIDFP--EDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   224 LLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHyHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEY 303
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSER-TQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|..
gi 13027422   304 KLIFTVFHIIAMCSTFANPLLY 325
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
53-335 5.21e-18

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 84.06  E-value: 5.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   53 LILAYCSIILLGVVGNSLVIHVVIKFKSmRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  133 AVQVSTITLTVIALDRHRCIVYHLES-KI-SKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWPGE 210
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSnKInTVKYGYIVSLVIWIISIIETTPILFVYTTK-----KDHETLICCMFYNNK 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  211 EKsVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:PHA03087 196 TM-NWKLFINFEINIIGMLIPLTILLYCYSKILITLKGI--------NKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFV 266
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 13027422  291 VDIDS-HVLD----LKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:PHA03087 267 YSLHIlHFKSgckaVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKH 316
 
Name Accession Description Interval E-value
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
51-336 0e+00

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 509.75  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15399   1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15399  81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEISPDFKIQACSEKWPNG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:cd15399 161 T-LNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNHVSPGGGNDHYHQRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15399 240 SDIDSKVLDLKEYKLIYTIFHVIAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
51-336 2.99e-115

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 337.27  E-value: 2.99e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWPFGSILCKLVPSLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEI-IPDFEIVACTEKWPG 209
Cdd:cd15203  81 GVSIFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIeILPYCGYFCTESWPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAS--------DHYHQRRHKTTKMLVCVVVVFAVSW 281
Cdd:cd15203 161 SS---SRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKrtlssrrrRSELRRKRRTNRLLIAMVVVFAVCW 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 282 LPLHAFQLAVDIDSHVLDLKEY-KLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15203 238 LPLNLFNLLRDFEPLPQIDGRHfYLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
51-336 9.33e-81

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 249.08  E-value: 9.33e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15207   1 VLFIVSYSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15207  81 GVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFWPSD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAS------DHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15207 161 E---YRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPGGGSasreaqAAVSKKKVRVIKMLIVVVVLFALSWLPL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 285 HAFQLAVDI------DSHVLdlkeYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15207 238 HTVTMLDDFgnlspnQREVL----YVYIYPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
51-336 1.55e-76

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 238.27  E-value: 1.55e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLI--EIIPDFEIVACTEK 206
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRvsTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIisSEPGTITIYICTED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYgtvYSLSTLLILYVLPLGIISFSYTRIWSKL-------KNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAV 279
Cdd:cd14993 161 WPSPELRKA---YNVALFVVLYVLPLLIISVAYSLIGRRLwrrkppgDRGSANSTSSRRILRSKKKVARMLIVVVVLFAL 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 280 SWLPLHAFQLAVDIDSHVLDLKEY--KLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14993 238 SWLPYYVLSILLDFGPLSSEESDEnfLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
51-336 3.89e-69

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 219.15  E-value: 3.89e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15392   1 VIIILMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILqYWPFGEFMCPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFR---EYSLIEIIPDFeivaCTEK 206
Cdd:cd15392  81 QAVSVFVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSrlfEDSNASCGQYI----CTES 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRH----KTTKMLVCVVVVFAVSWL 282
Cdd:cd15392 157 WPSDT---NRYIYSLVLMILQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENNRDQRMAeskrKLVKMMITVVAIFALCWL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 283 PLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15392 234 PLNILNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
51-335 2.82e-67

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 214.12  E-value: 2.82e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15389   1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15389  81 YCSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERTRSRCLPSFPEP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSVYGTVySLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDH--YHQRR--HKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15389 161 SDLFWKYL-DLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIGDVTTEqyVAQRRkkKKTIKMLMLVVLLFAICWLPLNC 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 287 FQLAvdIDSHvlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15389 240 YHVL--LSSH--PIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
53-334 4.24e-65

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 208.83  E-value: 4.24e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTL-MGEWKMGPVLCHLVPYAQG 131
Cdd:cd15394   3 IIPLYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFePRGWVFGRFMCYFVFLMQP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYslIEIIP-DFEIvaCTEKWPGE 210
Cdd:cd15394  83 VTVYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYY--VEFKGlDFSI--CEEFWFGQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSvyGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAS----DHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15394 159 EKQ--RLAYACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTqsqaEWDRARRRKTFRLLVVVVVAFAICWLPLHI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 287 FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15394 237 FNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
51-336 8.24e-65

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 208.13  E-value: 8.24e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15202   1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPgE 210
Cdd:cd15202  81 YCSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDWP-E 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG-AASDHYH---QRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15202 160 RADLFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGdATTERYFalrRKKKKVIKMLMVVVVLFALCWLPFNI 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 287 FQLAVDIDshVLDLKEY-KLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15202 240 YVLLLSSK--PDYLIKTiNAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
53-329 3.45e-62

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 200.98  E-value: 3.45e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFREYslieiipdFEIVACTEKWPGE 210
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLryRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGV--------YDYGGYCCCCLCW 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG------AASDHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd00637 153 PDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIrssssnSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 285 HAFQLAVDIDSHVLDLkeYKLIFTVFHIIAMCSTFANPLLYGWMN 329
Cdd:cd00637 233 FILLLLDVFGPDPSPL--PRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
54-336 2.50e-60

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 196.36  E-value: 2.50e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15390   4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKS 213
Cdd:cd15390  84 VAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPQLLYSTTETYYYYTGSERTVCFIAWPDGPNS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR---RHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:cd15390 164 LQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRQLESvraKRKVVKMMIVVVVIFAICWLPYHLYFIL 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15390 244 TYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
51-334 4.75e-59

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 193.42  E-value: 4.75e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15397   1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFR-----EYSLIEIIPDF--EIVAC 203
Cdd:cd15397  81 CMSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAFHiltdePYKNLSHFFAPlaDKAVC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEEKSvygTVYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYHQRRHK-TTKMLVCVVVVFAVS 280
Cdd:cd15397 161 TESWPSEHHK---LAYTTWLLLFQYCLPLLFILVCYLRIYLRLrrRKDMLERRGEYNRRAGHSKrINVMLVSLVAAFALC 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 281 WLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15397 238 WLPLNVFNAIADWNHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFKK 291
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
51-336 6.81e-59

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 192.65  E-value: 6.81e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14992   1 IILGVALVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIF-REYSLIEIIPDFEIVACTEKW 207
Cdd:cd14992  81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRhrQSYTTTVIIIITIWVVSLLLAIPQLYYaTTEVLFSVKNQEKIFCCQIPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG---AASDHYHQR-RHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd14992 161 VDNK--TYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGfsiKEVERKRLKcKRRVIKMLVCVVVLFVICWLP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 284 LHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14992 239 FHLFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
51-336 6.75e-57

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 187.62  E-value: 6.75e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15393   1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIF-REYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd15393  81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALAlRVEELTDKTNNGVKPFCLPVGPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASD----HYHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15393 161 DD---WWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKAPGNAQDvrddEILKNKKKVIKMLIIVVALFALCWLPLQ 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 286 AFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15393 238 TYNLLNEIKPEINKYKYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
60-336 3.02e-56

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 185.95  E-value: 3.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15095  10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDFEIVACTEKWPGEEksvYGT 217
Cdd:cd15095  90 TLTALSVDRYYAIVHPIRSLRfrTPRVAVVVSACIWIVSFLLSIPVAIY--YRLEEGYWYGPQTYCREVWPSKA---FQK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 218 VYSLSTLLILYVLPLGIISFSYT----RIWS-KLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVD 292
Cdd:cd15095 165 AYMIYTVLLTYVIPLAIIAVCYGlilrRLWRrSVDGNNQSEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNLWQR 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 293 IDShvlDLKEYKLIFtVFHIIAMCSTFA----NPLLYGWMNSNYRKAF 336
Cdd:cd15095 245 FDP---NFPETYATY-ALKIAALCLSYAnsavNPFVYAFMGENFRKYF 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
67-325 6.26e-56

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 184.04  E-value: 6.26e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422    67 GNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLAVQVSTITLTVIA 145
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   146 LDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFreySLIEIIPDFEIVACTEKWPgeEKSVYGTVYSLST 223
Cdd:pfam00001  81 IDRYLAIVHPLRYKrrRTPRRAKVLILVIWVLALLLSLPPLLF---GWTLTVPEGNVTVCFIDFP--EDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   224 LLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHyHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEY 303
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSER-TQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|..
gi 13027422   304 KLIFTVFHIIAMCSTFANPLLY 325
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
51-336 3.88e-55

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 183.44  E-value: 3.88e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15205   1 TAFVITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREyslIEIIPDF----EIVACT 204
Cdd:cd15205  81 STAVVTSILTMTCIAVERHQGIVHPLKMKWqyTNRRAFTMLGLVWIVSVIVGSPMLFVQQ---LEVKYDFlyekRHVCCL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPGEeksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYHQRRHKTT--------KMLVCVV 274
Cdd:cd15205 158 ERWYSP---TQQKIYTTFILVILFLLPLTTMLFLYSRIGYELwiKKRVGDASVLQTIHGIEMSKIsrkkkravKMMVTVV 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 275 VVFAVSWLPLHAFQLAVDID--SHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15205 235 LLFAVCWAPFHVVHMMIEYSnlENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-336 1.02e-50

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 171.31  E-value: 1.02e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM--GEWKMGPVLCHLVPY 128
Cdd:cd15204   1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEMDYYVVrqRSWTHGDVLCAVVNY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDFEIVACTEKWP 208
Cdd:cd15204  81 LRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAV---YSKTTPYANQGKIFCGQIWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG---AASDHYHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15204 158 VDQQAYY-KAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVPGqqtEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYY 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 286 AFQLAVDIdSHVLDLKEyKLIFTVFHI---IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15204 237 GYAIVRDF-FPTLLSKE-KLNTTIFYIveaLAMSNSMINTVVYVAFNNNIRKYL 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
53-333 2.78e-50

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 170.39  E-value: 2.78e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15391   3 LINLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASpLAIFREYSLIEIIPDFEIVACTEKWPGEEK 212
Cdd:cd15391  83 SVTASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSS-VQLFAGRTQRYGQYSEGRVLCGESWPGPDT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SvyGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAA----SDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15391 162 S--RSAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTAPGNAdkgrDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFN 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 289 LAVDIDSHVLDLKEY--KLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15391 240 LVQDFSTVFRNMPQHttRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-336 1.38e-48

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 165.04  E-value: 1.38e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWpg 209
Cdd:cd14967  81 LCCTASILNLCAISLDRYLAITRplRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 eeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspgaasdhyhqrrHKTTKMLVCVVVVFAVSWLPlhaFQL 289
Cdd:cd14967 159 ---------YVLVSSVISFFIPLLIMIVLYARIFRVARRE--------------LKAAKTLAIIVGAFLLCWLP---FFI 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 290 AVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14967 213 IYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
51-336 3.91e-47

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 161.87  E-value: 3.91e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14971   1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDfEIVACTEKWP 208
Cdd:cd14971  81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHirTPRNALAASGCIWVVSLAVAAPVLAL--HRLRNYTPG-NRTVCSEAWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSvygTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd14971 158 SRAHR---RAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAIL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIfTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14971 235 LLVALGPFPLTYATYALR-IWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
51-334 6.88e-47

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 161.52  E-value: 6.88e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15395   1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFR-----EYSLIEIIPDFEI--VAC 203
Cdd:cd15395  81 CISITVSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQvltdePFKNVNVSLDAYKgkYVC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEEKSVygtVYSLSTLLILYVLPLGIISFSYTRIWSKLK--NHVSPGAASDHYHQRRHK-TTKMLVCVVVVFAVS 280
Cdd:cd15395 161 LDQFPSDTIRL---SYTTCLLVLQYFGPLCFIFICYLKIYIRLKrrNNMMDKMRDNKYRSSETKrINIMLISIVVAFAVC 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 281 WLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15395 238 WLPLNIFNAVFDWNHEAIATCNHNLLFLICHLTAMISTCVNPIFYGFLNKNFQR 291
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-336 8.27e-47

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 161.79  E-value: 8.27e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15208   2 VLIALYILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIPYLQT 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFRE-YSLIEIIPDFEIV-ACTEKWPG 209
Cdd:cd15208  82 VSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMEcSRVVPLANKTILLtVCDERWSD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EeksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL-----------------KNHVSPGAASDHYHQRRHKTTKMLVC 272
Cdd:cd15208 162 S---IYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnKPRKSAVAAEEKQLRSRRKTAKMLIV 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 273 VVVVFAVSWLPLHAFQ-LAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15208 239 VVIMFAICYLPVHLLNiLRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
54-336 9.72e-47

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 160.52  E-value: 9.72e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15001   3 IIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVYHLESKISKQISFL--IIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGee 211
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRArkVALLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPS-- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 kSVYGTVYSLSTLLILYVLPLGIISFSYTRIwsklknhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd15001 161 -TLYSRLYVVYLAIVIFFIPLIVMTFAYARD-------------------TRKQVIKMLISVVVLFAVCWGPLLIDNLLV 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 292 DIDSH-VLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15001 221 SFDVIsTLHTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
51-336 1.82e-45

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 157.17  E-value: 1.82e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQIS--FLIIGLAWGVSALLASPLAIFREYSLIEiipDFEIVACTEKWP 208
Cdd:cd15206  81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLShaYKVIAGIWLLSFLIMSPILVFSNLIPMS---RPGGHKCREVWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEeksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15206 158 NE---IAEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLL-------------EAKKRVIRMLFVIVVEFFICWTPLYVIN 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15206 222 TWKAFDPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
53-330 6.78e-45

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 155.70  E-value: 6.78e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15398   3 LIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDFEIVA------CTEK 206
Cdd:cd15398  83 SVMVSTLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVF--HKIVDLSETFNLESlknkylCIES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15398 161 WPSDS---YRIAFTISLLFVQYILPLVCLTVSHTSVCRSVK--------------RSRSVFYRLTIVILAFAVSWMPLHL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 287 FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNS 330
Cdd:cd15398 224 FHLVTDFNANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNN 267
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
52-334 9.73e-44

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 153.45  E-value: 9.73e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15396   2 LLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDHWIFGETMCKLTSFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFRE-----YSLIEIIPDF--EIVACT 204
Cdd:cd15396  82 VSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQltdepFRNLSSHSDFykDKVVCI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPGEEKSVygtVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTK---MLVCVVVVFAVSW 281
Cdd:cd15396 162 EAWPSETERL---IFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIDRMRENESRLSENKRintMLISIVVTFAACW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 282 LPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15396 239 LPLNIFNVVFDWNHEVLMSCHHNLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
52-336 1.16e-43

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 153.50  E-value: 1.16e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15980   2 VFIASYLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIF----REYSLIEIIPDFE----IVAC 203
Cdd:cd15980  82 ISVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMlhvqEEKNYRVVLGSQNktspVYWC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEE-KSVYGTVYSLStlliLYVLPLGIISFSYTRIWSKLKNHVSPgAASDHYHQRRH-------KTTKMLVCVVV 275
Cdd:cd15980 162 REDWPNQEmRKIYTTVLFAN----IYLAPLSLIVIMYARIGITLFKTAMP-HTGKHNQEQRHvvsrkkqKVIKMLLIVAL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 276 VFAVSWLPLHAFQLAVDIDShvLDLKEYKL----IFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15980 237 LFILSWLPLWTLMMLSDYAN--LSPNQLQIiniyIYPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
51-336 2.63e-43

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 152.06  E-value: 2.63e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES------KISKQISFLIiglaWGVSALLASPLAIFREysliEIIPDFEIVACT 204
Cdd:cd14970  80 AYNMFTSIFCLTVMSVDRYLAVVHPVKSlrfrtpRKAKLVSLCV----WALSLVLGLPVIIFAR----TLQEEGGTISCN 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPgEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSP-GAASDHYHQRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd14970 152 LQWP-DPPDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLsTSGAREKRRARRKVTRLVLVVVAVFVVCWLP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 284 LHAFQLAvdidSHVLDLKEYKLIFTVFH-IIAM--CSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14970 231 FHVFQIV----RLLIDPPETLTVVGVFLfCIALsyANSCLNPILYAFLDENFRKSF 282
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
51-336 4.87e-42

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 148.98  E-value: 4.87e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREpWLLGEFMCKLVPFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEkw 207
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKyvCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTPVAVCRT-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 pgEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR-----RHKTTKMLVCVVVVFAVSWL 282
Cdd:cd14997 159 --PADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAANRhtlrsRRQVVYMLITVVVLFFVCLL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 283 PLHAFQL----AVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14997 237 PFRVVTLwiifAPDEDLQALGLEGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRSAF 294
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
51-336 7.97e-42

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 148.43  E-value: 7.97e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15981   1 AMFILAYLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIE---IIPDFE----IVAC 203
Cdd:cd15981  81 GMSVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEhhfMVDDYNnsypLYSC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEE-KSVYGTVYslstLLILYVLPLGIISFSYTRIWSKL-------KNHVSPGAASDHYHQRRHKTTKMLVCVVV 275
Cdd:cd15981 161 WEAWPDTEmRKIYTTVL----FSHIYLAPLTLIVIMYARIAFKLfkssapiRGSQGEEEEGRRVSKRKIKVINMLIIVAL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 276 VFAVSWLPLHAFQLAVDIDShvldLKEYKL------IFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15981 237 FFTLSWLPLWTLMLLTDYGH----LSEDQLnlvtvyVFPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
60-336 1.42e-41

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 147.44  E-value: 1.42e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15096  10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAI-FREYSLIEIIPDFEivACTEKWpgeEKSVYG 216
Cdd:cd15096  90 TLVLMSLDRYLAVVHPITSMSirTERNTLIAIVGIWIVILVANIPVLFlHGVVSYGFSSEAYS--YCTFLT---EVGTAA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAA-SDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQL--AVDI 293
Cdd:cd15096 165 QTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRrSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLlkYYGV 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13027422 294 DSHVldlKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15096 245 LPET---VLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-336 1.55e-41

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 147.38  E-value: 1.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd16003   5 LAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDFEIvaCTEKWPGEEKSV 214
Cdd:cd16003  85 FASIYSMTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCL---YSKTKVMPGRTL--CFVAWPGGPDQH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YgtVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR---RHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd16003 160 F--TYHIIVIVLVYCLPLLVMGITYTIVGITLWGGEIPGDTSDKYHEQlraKRKVVKMMIIVVLTFAICWLPYHIYFIVT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 292 DIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd16003 238 GLYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
51-336 3.25e-41

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 146.64  E-value: 3.25e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILaYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15927   2 VVPIL-FALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLA--WGVSALLASPLAIFREYSLIEIIPDFEIVACTeKWP 208
Cdd:cd15927  81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAAsiWIVSILLAIPEAIFSHVVTFTLTDNQTIQICY-PYP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYT----RIWSKLKNHVS-PGAASDHYHQRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15927 160 QELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVlmarHLIRSTRNIGSgQNQAAQRQIEARKKVAKTVLAFVVLFAVCWLP 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 284 LHAFQLAVDIDSHvlDLKEYKLIFTVFHIIAMCSTFA----NPLLYGWMNSNYRKAF 336
Cdd:cd15927 240 RHVFMLWFHFAPN--GLVDYNAFWHVLKIVGFCLSFInscvNPVALYLLSGSFRRHF 294
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
51-336 1.45e-40

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 144.54  E-value: 1.45e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15094   1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPFLIVTMILKYWPFGAAMCKIYMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQ--ISFLIIGLAWGVSALLASPLAIFReysliEIIPDFEIVACTEKWP 208
Cdd:cd15094  80 SINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTpfIAKVVCATTWSISFLVMLPIILYA-----STVPDSGRYSCTIVWP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15094 155 DSSAVNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRT-VGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQ 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 289 LAVDIDSHVLDLKEYK-LIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15094 234 VHLIFLPPGTDMPKWEiLMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-336 2.52e-39

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 141.54  E-value: 2.52e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd16002   5 VAYSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDFeiVACTEKWPGEEKSV 214
Cdd:cd16002  85 FASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGY---YSDTEEMPGR--VVCYVEWPEHEERK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR---RHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd16002 160 YETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIPGDSSDRYHEQvsaKRKVVKMMIVVVCTFAICWLPYHIYFLLQ 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 292 DIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd16002 240 YFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
60-336 4.02e-38

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 138.32  E-value: 4.02e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSM--RTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15098  10 IFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDFEIVACTEKWPGEEKSvy 215
Cdd:cd15098  90 IFTLVAMSVDRYIAVVHSRTSSSlrTRRNALLGVLVIWVLSLAMASPVAVH--QDLVHHWTASNQTFCWENWPEKQQK-- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 gTVYSLSTLLILYVLPLGIISFSYTRI----WSKLKNHVSPGAASdhyhqrRHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd15098 166 -PVYVVCTFVFGYLLPLLLITFCYAKVlnhlHKKLKNMSKKSERS------KKKTAQTVLVVVVVFGISWLPHHIIHLWV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 292 DIDSHVLDLKEYkliftVFHIIAMCSTFA----NPLLYGWMNSNYRKAF 336
Cdd:cd15098 239 EFGDFPLTQASF-----VLRITAHCLAYAnscvNPIIYAFLSENFRKAY 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
55-336 1.91e-37

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 136.98  E-value: 1.91e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd15123   5 VTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVDATRYIADTWLFGRIGCKLLSFIQLTSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLESKISKQI--SFLIIGLAWGVSALLASPLAIFRE-YSLIEIIPDFEIVACTeKWPGEE 211
Cdd:cd15123  85 GVSVFTLTVLSADRYRAIVKPLELQTSDAVlkTCCKAGCVWIVSMLFAIPEAVFSDlYSFRDPEKNTTFEACA-PYPVSE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KsVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR-----RHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15123 164 K-ILQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNMPAEEHSHARkqiesRKRVAKTVLVLVALFAFCWLPNHI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 FQLAVDIDSHV-LDLKEYKLIFTVF-HIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15123 243 LYLYRSFTYHTsVDSSAFHLIATIFsRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-336 2.54e-37

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 136.05  E-value: 2.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELF-MLGLPFLAASNALRHWPFGSVLCRLVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES------KISKQISFLIiglaWGVSALLASPLAIFreySLIEIIPDfEIVACT 204
Cdd:cd15093  80 GINMFTSIFCLTVMSVDRYLAVVHPIKSarwrrpRVAKVVNLAV----WVASLLVILPVVVF---AGTRENQD-GSSACN 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPGEEkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15093 152 MQWPEPA-AAWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKS-AGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 285 HAFQLAvdidSHVLDLKEYKLIFTVFHIIAMCS---TFANPLLYGWMNSNYRKAF 336
Cdd:cd15093 230 YVLQLV----NVFVQLPETPALVGVYHFVVILSyanSCANPILYGFLSDNFKKSF 280
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
51-336 8.42e-36

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 131.94  E-value: 8.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHL-ESKISKQISFLIIGLAWGVSALLASPLaifreysLI---EIIPDFEIVACTEK 206
Cdd:cd14969  81 TFLGLVSISTLAALAFERYLVIVRPLkAFRLSKRRALILIAFIWLYGLFWALPP-------LFgwsSYVPEGGGTSCSVD 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WpgEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASD-----HYHQRRH-KTTKMLVCVVVVFAVS 280
Cdd:cd14969 154 W--YSKDPNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKnsaitKRTKKAEkKVAKMVLVMIVAFLIA 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 281 WLPLHAFQLAVDIDSHVldlKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14969 232 WTPYAVVSLYVSFGGES---TIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-336 1.17e-34

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 129.19  E-value: 1.17e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd16004   5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEIipDFEIVACTEKWPGEEKSV 214
Cdd:cd16004  85 FVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCF---YSTVTM--DQGRTKCIVAWPGDSGGK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG-AASDHYH---QRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:cd16004 160 HQLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGhQAHGAYHrqlQAKKKFVKTMVVVVVTFAICWLPYHLYFIL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd16004 240 GSFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
51-336 4.56e-34

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 127.49  E-value: 4.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLM-GEWKMGPVLCHLVPYA 129
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPLWATYTANqYDWPFGAFLCKVSSYV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKW 207
Cdd:cd14985  80 ISVNMFASIFLLTCMSVDRYLAIVHPVASRRlrRRRQARVTCALIWVVACLLSLPTFLLRS---LQAIENLNKTACIMLY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVygtVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaaSDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd14985 157 PHEAWHF---GLSLELNILGFVLPLLIILTCYFHIARSLRKRYER---TGKNGRKRRKSLKIIFALVVAFLVCWLPFHFF 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 288 QlAVDIDSHVLDLKEY------KLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14985 231 K-FLDFLAQLGAIRPCfwelflDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
52-336 4.57e-34

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 127.24  E-value: 4.57e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15979   2 VRILLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd15979  82 VSVSVSTFSLVAIAIERYSAICNPLQSRVwqTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWPS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEksVYGTVYSLsTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaasdhyhqrRHKTTKMLVCVVVVFAVSWLPLHAFQL 289
Cdd:cd15979 162 AQ--VRQAWYVL-LLLILFFIPGVVMIVAYGLISRELYRGLLA----------KKRVIRMLVVIVAMFFLCWLPIFSANT 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 290 --AVDIDSHVLDLKEYKLIFtvFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15979 229 wrAFDPLSAHRALSGAPISF--IHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
51-333 8.84e-33

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 124.41  E-value: 8.84e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14986   1 VSRVAVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGEWVAGDVLCRIVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASP-LAIFREYSLIEIIPDfeivaCTEKWPG 209
Cdd:cd14986  81 VVGLFASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPqLVIFVERELGDGVHQ-----CWSSFYT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEksvYGTVYSLSTLLILYVLPLGIISFSYTRI----WSKLKNHVSPGAASDHYHQR---------------RHKTTKML 270
Cdd:cd14986 156 PW---QRKVYITWLATYVFVIPLIILSYCYGRIlrtiWIRSRQKTDRPIAPTAMSCRsvscvssrvslisraKIKTIKMT 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 271 VCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEyklIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd14986 233 LVIILAFILCWTPYFIVQLLDVYAGMQQLEND---AYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
51-336 1.05e-32

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 123.43  E-value: 1.05e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELF-MLSVPFLAASAALQHWPFGSAMCRTVLSVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQ--ISFLIIGLAWGVSALLASPLAIFREYSlieiIPDFEIVACTEKWP 208
Cdd:cd15973  80 GINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRptVAKMINICVWILSLLVISPIIIFADTA----TRKGQAVACNLIWP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYslsTLLILYVLPLGIISFSYTRIWSKLKNhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15973 156 HPAWSAAFVIY---TFLLGFLLPVLAIGLCYILIIGKMRA-VALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQ 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 289 LavdidshvLDLKEYKLIFTVFH---IIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15973 232 L--------LNLFLPRLDATVNHaslILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
51-336 3.06e-32

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 122.60  E-value: 3.06e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELF-MLGLPFLATQNAISYWPFGSFLCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQ--ISFLIIGLAWGVSALLASPLAIFReysliEIIPDFEivACTEKWP 208
Cdd:cd15974  80 GVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRprVAKLINATVWTLSFLVVLPVIIFS-----DVQPDLN--TCNISWP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 gEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvSPGAASDHYHQRR--HKTTKMLVCVVVVFAVSWLPLHa 286
Cdd:cd15974 153 -EPVSVWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVK---SSGLRVGSTKRRKseRKVTRMVVIIVVVFVFCWLPFY- 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 287 fqlAVDIDSHVLDLKEYKLIFTVFH---IIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15974 228 ---MLNIVNLIVILPEEPAFVGVYFfvvVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
51-336 4.84e-32

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 121.87  E-value: 4.84e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15971   1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELF-MLGLPFLAIQVALVHWPFGKAICRVVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQ--ISFLIIGLAWGVSALLASPLAIFReysliEIIPDFEIVACTEKWP 208
Cdd:cd15971  80 GINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKprTAKMINMAVWGVSLLVILPIMIYA-----GVQTKHGRSSCTIIWP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvSPG--AASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15971 155 GESSAWY-TGFIIYTFILGFFVPLTIICLCYLFIIIKVK---SSGirVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYI 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 FQlAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15971 231 FN-VSSVSVSISPTPGLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
52-336 1.72e-31

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 120.36  E-value: 1.72e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15978   2 VRILLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd15978  82 ISVSVSTFNLVAISLERYSAICKPLKSRVwqTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EeksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQL 289
Cdd:cd15978 162 D---VTQQSWYIFLLLILFLIPGIVMMTAYGLISLELYRGIK-------FLMAKKRVIRMLIVIVILFFLCWTPIFSANA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 290 AVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15978 232 WRAFDTRSADRLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
51-336 7.32e-31

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 118.20  E-value: 7.32e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15064   1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKwp 208
Cdd:cd15064  81 VTCCTASILHLCVIALDRYWAITDAVEyaHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSE-----DPSECLIS-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 geeKSVYGTVYslSTLLILYVlPLGIISFSYTRIWSklknhvspgAAsdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15064 154 ---QDIGYTIF--STFGAFYI-PLLLMLILYWKIYR---------AA-----ARERKAAKTLGIILGAFIVCWLPFFLVA 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVldlKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15064 214 LIVPLCSHC---WIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-336 9.96e-31

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 118.90  E-value: 9.96e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15125   2 VIPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLA--WGVSALLASPLAIFREYSLIEIIPDFEIVACTeKWPg 209
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIaiWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACI-PYP- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYHQR---RHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15125 160 QTDEMHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLikSAHNIPGEYSEHSKRQmetRKRLAKIVLVFVGLFAFCWFPN 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 285 HAFQLAVDIDSHVLDLKEYKLIFT-VFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15125 240 HVLYMYRSFNYNEIDSSLGHMIVTlVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
51-334 2.32e-30

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 117.55  E-value: 2.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLM--GEWKMGPVLCHLVPY 128
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLF-MLGMPF-LIHQFAidGQWYFGEVMCKIITA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLES-KISKQ-ISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDfEIVACTEK 206
Cdd:cd15088  79 LDANNQFTSTYILTAMSVDRYLAVVHPIRStKYRTRfVAKLVNVGLWAASFLSILPVWV---YSSLIYFPD-GTTFCYVS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYGTVYSlstLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15088 155 LPSPDDLYWFTIYH---FILGFAVPLVVITVCYILILHRLARGVAPGNQS-HGSSRTKRVTKMVILIVVVFIVCWLPFHV 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 FQLAvdidshVLDLKEYKLIFTVFHIIAMCSTFA----NPLLYGWMNSNYRK 334
Cdd:cd15088 231 VQLV------NLAMNRPTLAFEVAYFLSICLGYAnsclNPFVYILVSENFRK 276
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
60-336 9.03e-30

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 115.99  E-value: 9.03e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSlIEIIPDFeivacTEKWPGEEKSVYGTVY 219
Cdd:cd15000  89 ALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYR-ERQWKNF-----LETYCAENTQVLPIYW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 220 SLsTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHK--TTKMLVCVVVVFAVSWLPLHAFQLAVDIDshV 297
Cdd:cd15000 163 HV-IITVLVWLPLGIMLICYSAIFWKLDKYERRVLRREHPSVVRYKkkAAKTLFIVLITFVVCRIPFTALIFYRYKL--V 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 298 LDLKEYKLIFTVFHIIAMCSTF-------ANPLLYGWMNSNYRKAF 336
Cdd:cd15000 240 PNDNTQNSVSGSFHILWFASKYlmflnaaVNPLIYGFTNENFRKAF 285
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
57-336 1.28e-29

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 115.39  E-value: 1.28e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15970   7 YSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELL-MLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQISFL-IIGLA-WGVSALLASPLAIFREYSlieiiPDFE-IVACTEKWPgEEKS 213
Cdd:cd15970  86 SIYCLTVLSIDRYIAVVHPIKAARYRRPTVAkMVNLGvWVFSILVILPIIIFSNTA-----PNSDgSVACNMQMP-EPSQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAvdi 293
Cdd:cd15970 160 RWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMR-VVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLV--- 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 13027422 294 dsHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15970 236 --SVFVGQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
51-336 3.42e-29

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 114.15  E-value: 3.42e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSM-RTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIpdfEIVACTEKW 207
Cdd:cd15097  81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRElrTPRNAVAAIALIWGLSLLFAGPYLSY--YDLIDYA---NSTVCMPGW 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTvyslSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15097 156 EEARRKAMDT----CTFAFGYLIPVLVVSLSYTRTIKYLWTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVV 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 288 QLAVDIDSHVLDLKEYKLIFtVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15097 232 ILCYLYGDFPFNQATYAFRL-LSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
52-336 6.05e-29

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 114.06  E-value: 6.05e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd14977  82 TSLGVTVFSLCALSIDRYRAAVnsMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCIMKPST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYhQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd14977 162 PFAETYPKARSWWLFGCYFCLPLAFTAVCYLLMARTLirAAKEYTRGTKKHM-KQRRQLAKTVLCLVLVFAFCWLPEHIS 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 288 QL--AVDIDSHVLDLKEYKLIftvFHIIAMCSTF----ANPLLYGWMNSNYRKAF 336
Cdd:cd14977 241 NIlrATLYNEVLIDTRSTLDI---LDLIGQFLSFfnscVNPIALYLLSEPFRRAF 292
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
57-334 2.11e-28

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 112.15  E-value: 2.11e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLlVNTLCLPFTLTYT-LMGEWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15193   7 YLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADL-VFVLTLPFWAASTaLGGQWLFGEGLCKLSSFIIAVNRC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSlieiipdfEIVACTEkwpgEEKS 213
Cdd:cd15193  86 SSILFLTGMSVDRYLAVVKLLDSRPlrTRRCALITCCIIWAVSLVLGIPSLVYRNLI--------NESVCVE----DSSS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGaasDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ---LA 290
Cdd:cd15193 154 RFFQGISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGA---KRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKavrLL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 291 VDIDSHVLDLKEYKLI---FTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15193 231 LELGGGVLPCHTTVAIrqgLTITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
51-336 2.26e-28

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 112.30  E-value: 2.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLII--GLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWP 208
Cdd:cd15124  81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLkaALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFVSCAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 gEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVS--PGAASDHYHQR---RHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15124 161 -HSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYnlPVEGNVHVRRQiesRKRLAKTVLVFVGLFAFCWLP 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 284 LHAFQLAVDIDSHVLDLKEYKLIFTVF-HIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15124 240 NHIIYLYRSYHYSEVDTSMLHFVSSICaRILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
51-336 2.49e-28

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 112.42  E-value: 2.49e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLtYTLMGE--WKMGPVLCHLVPY 128
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFEL-YTIWQQypWVFGEVFCKLRAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQIS--FLIIGLAWGVSALLASPLAI-----FREYSLI--EIIPDFE 199
Cdd:cd15134  80 LSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSraIRIIIAIWIIAFVCALPFAIqtrivYLEYPPTsgEALEESA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 200 IVACTEKWPGEEksvygTVYSLSTlLILYVLPLGIISFSYTRIWSKLKNH--VSPGAASDH----YHQRRHKTTKMLVCV 273
Cdd:cd15134 160 FCAMLNEIPPIT-----PVFQLST-FLFFIIPMIAIIVLYVLIGLQLRRStlLRRGQRSVSggrrSSQSRRTVLRMLVAV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 274 VVVFAVSWLPLHAFQL----AVDIDSHVLDLkeYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15134 234 VVAFFICWAPFHAQRLltvyAKNMTPPYLFI--NRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
51-336 5.30e-28

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 110.85  E-value: 5.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVViKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd14974   1 IVSLVLYALIFLLGLPGNGLVIWVA-GFKMKRTVNTVWFLNLALADFLF-CLFLPFLIVYIAMGHhWPFGSVLCKLNSFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQI--SFLIIGLAWGVSALLASPLAIFREySLIEIIPDFEIVACTEKW 207
Cdd:cd14974  79 ISLNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVrlASVVCVGIWILALVLSVPYFVFRD-TVTHHNGRSCNLTCVEDY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYgtVYSLSTLLILYVLPLGIISFSYTRIWSKLKnHVSPGAASdhyhqrrhKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd14974 158 DLRRSRHK--ALTVIRFLCGFLLPLLIIAICYSVIAVKLR-RKRLAKSS--------KPLRVLLAVVVAFFLCWLPYHVF 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 288 QLAVDIDSHVLDLKEYKLIFTVfHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14974 227 ALLELVAAAGLPEVVLLGLPLA-TGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
52-335 1.46e-27

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 109.84  E-value: 1.46e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDFEiVACTEKWPG 209
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKqlLTAARLRVTIVTVWLTSAVYNTPYFVF--SQTVEILVTQD-GQEEEICVL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIwsklkNHVSPGAASDhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQL 289
Cdd:cd15012 158 DREMFNSKLYDTINFIVWYLIPLLIMTVLYSKI-----SIVLWKSSSI---EARRKVVRLLVAVVVSFALCNLPYHARKM 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 290 AVDIDSHVLDLKEYKLIFTVF-HIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15012 230 WQYWSEPYRCDSNWNALLTPLtFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
51-336 5.10e-27

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 108.55  E-value: 5.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCH---LVP 127
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKawlVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAvqvSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIFreyslieiipdFEIVACTE 205
Cdd:cd15048  81 YTLCTA---SALTIVLISLDRYLSVTKavKYRAKQTKRRTVLLMALVWILAFLLYGPAIIG-----------WDLWTGYS 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSV---YGTVYSLSTLLILYVLPLGIISFSYTRI------WSKLKNHVSPGAAS------------DHYHQRRH 264
Cdd:cd15048 147 IVPTGDCEVeffDHFYFTFITSVLEFFIPFISVSFFNLLIylnirkRSRRRPLRSVPILPasqnpsrarsqrEQVKLRRD 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 265 -KTTKMLVCVVVVFAVSWLPLHAFQLAVDIdSHVLDLKEYKLIFTVFHIiaMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15048 227 rKAAKSLAILVLVFLICWAPYTILTIIRSF-CSGSCVDSYLYEFTFWLL--WTNSAINPFLYAACHPRFRKAF 296
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-336 5.19e-27

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 107.81  E-value: 5.19e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPlaifreyslieiiPDFEIVACTEKWP 208
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEynLKRTPRRAKAMIAAVWIISAVISLP-------------PLFGWKDEQPWHG 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTV--YSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15059 148 AEPQCELSDDpgYVLFSSIGSFYIPLLIMIIVYARIYRAAKR-------------KERRFTLVLGVVMGAFVLCWLPFFF 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 FQL--AVDIDSHVLDlkeykLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15059 215 TYPlvVVCKTCGVPE-----LLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
55-336 5.57e-27

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 107.82  E-value: 5.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15053   5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNgGKWYLGPILCDIYIAMDVMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVYHL---ESKISKQISfLIIGLAWGVSALLASPLAI------FREYSLIEI-IPDFeivac 203
Cdd:cd15053  85 STASIFNLCAISIDRYIAVTQPIkyaRQKNSKRVL-LTIAIVWVVSAAIACPLLFglnnvpYRDPEECRFyNPDF----- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 tekwpgeekSVYGTVYSlstllilYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15053 159 ---------IIYSSISS-------FYIPCIVMLLLYYRIFRALR--------------REKKATKTLAIVLGVFLFCWLP 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 284 LhaFQLAVdIDSHVLDLKEYK-----LIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15053 209 F--FTLNI-LNAICPKLQNQSchvgpALFSLTTWLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
51-334 5.98e-27

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 108.12  E-value: 5.98e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd14982   1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGgWWPFGDFLCRLTGLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISF--LIIGLAWGVSALLASPLAIFReyslIEIIPDFEIVACTEKW 207
Cdd:cd14982  80 FYINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYavGVCAGVWILVLVASVPLLLLR----STIAKENNSTTCFEFL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYgtVYSLSTLLILYVLPLGIISFSYTRIWSKLKnHVSPGAASdhyHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd14982 156 SEWLASAA--PIVLIALVVGFLIPLLIILVCYSLIIRALR-RRSKQSQK---SVRKRKALRMILIVLAVFLVCFLPYHVT 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 288 QLA--VDIDSHVLDLKEYKLIFTvFHIIAMCSTFAN----PLLYGWMNSNYRK 334
Cdd:cd14982 230 RILylLVRLSFIADCSARNSLYK-AYRITLCLASLNscldPLIYYFLSKTFRK 281
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
57-336 8.40e-27

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 107.90  E-value: 8.40e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15192   7 YSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCF-LITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKISKQISF--LIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWPgEEKS 213
Cdd:cd15192  86 ASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVarVTCIVIWLLAGVASLPAIIHRD---VFFIENTNITVCAFHYP-SQNS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasDHYHQRRHKTT-----KMLVCVVVVFAVSWLPLHAF- 287
Cdd:cd15192 162 TLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALK---------KAYEIQRNKPRndeifKMIMAVVLFFFFCWIPHQIFt 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 288 ------QLAVDIDSHVLDLKEYKLIFTVfhIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15192 233 fldvliQLKVIQDCHIADIVDTAMPFTI--CIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
51-336 1.39e-26

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 107.44  E-value: 1.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLT-YTLMGEWKMGPVLCHLVPYA 129
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYnFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIF--REY-SLIEIIPDFEIVACT 204
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIWLVSILCAIPILFLmgIQYlNGPLPGPVPDSAVCT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 ekwPGEEKSVYGTVYSLSTlLILYVLPLGIISFSYTRIWSKLK-----------NHVSPGAASDHyHQRRHKTTKMLVCV 273
Cdd:cd14979 161 ---LVVDRSTFKYVFQVST-FIFFVLPMFVISILYFRIGVKLRsmrnikkgtraQGTRNVELSLS-QQARRQVVKMLGAV 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 274 VVVFAVSWLPLHAFQL-AVDIDSHVLDLKE-YKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14979 236 VIAFFVCWLPFHAQRLmFSYASKEDTFLFDfYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
62-334 1.69e-26

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 106.84  E-value: 1.69e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITL 141
Cdd:cd15008  11 LVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 142 TVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDfeivACTEKWPGEekSVYGTVYSL 221
Cdd:cd15008  91 LSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAFVSPALFFYGSN-----WG----PHCNFFLPD--SWDGAAYAI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 222 STLLILYVLPLGIISFSYTR----IWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAvdiDSHV 297
Cdd:cd15008 160 IHLLVGFLVPSILIILFYQKvikyIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYVVQLW---HPRE 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 13027422 298 LDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15008 237 SDYRQSSLVFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
57-336 2.83e-26

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 106.37  E-value: 2.83e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15191   7 YSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLF-LATLPLWATYYSYGyNWLFGSVMCKICGSLLTLNLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLES--KISKQISFlIIGLAWGVSALLASPLAIFREYSLIEiipDFEIVACTEKWPGEEKS 213
Cdd:cd15191  86 ASIFFITCMSVDRYLAVVYPLRSqrRRSWQARL-VCLLVWVLACLSSLPTFYFRDTYYIE---ELGVNACIMAFPNEKYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAF------ 287
Cdd:cd15191 162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNK----QRRDKVLKMVAAVVLAFLICWFPFHVLtfldal 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 288 -QLAVDIDSHVLDLKEYKLIFTVfhiiamCSTFA----NPLLYGWMNSNYRKAF 336
Cdd:cd15191 238 aRMGVINNCWVITVIDKALPFAI------CLGFSnsciNPFLYCFVGNHFREKL 285
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
51-336 3.67e-26

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 105.96  E-value: 3.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILaYCSIILLGVVGNSLVIHVVI--KFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15002   1 LVPIL-LGVICLLGFAGNLMVIGILLnnARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPLAIFReySLIEIIPDFEIVACTEKW 207
Cdd:cd15002  80 FGHACMAAKSFTIAVLAKACYMYVVNPTKQvTIKQRRITAVVASIWVPACLLPLPQWLFR--TVKQSEGVYLCILCIPPL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSlstlLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15002 158 AHEFMSAFVKLYP----LFVFCLPLTFALFYFWRAYGQCQRRGTKTQNL-RNQIRSRKLTHMLLSVVLAFTILWLPEWVA 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 288 QLAVDIDSHVlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15002 233 WLWLIHIKSS-GSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
51-334 1.41e-25

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 104.22  E-value: 1.41e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYtLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLF-VLTLPFWAVY-AADGWVFGSFLCKLVSALY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISK--QISFLIIGLAWGVSALLASPLAIFReysliEIIPDFEIVACTEKWP 208
Cdd:cd14984  79 TINFYSGILFLACISIDRYLAIVHAVSALRARtlLHGKLTCLGVWALALLLSLPEFIFS-----QVSEENGSSICSYDYP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhVSPgaasdhyHQRRHKTTKMLVCVVVVFAVSWLP----- 283
Cdd:cd14984 154 EDTATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLL--RAR-------NHKKHRALRVIFAVVVVFFLCWLPynivl 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 284 -LHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd14984 225 lLDTLQLLGIISRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRK 276
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
57-334 9.11e-25

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 102.35  E-value: 9.11e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSII-LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15074   6 YLTVIgILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVY-HLESKISKQISFLIIGLAWGVSALLA-SPLAIFREYSlIEIIPdfeiVACTEKWPGEEKS 213
Cdd:cd15074  86 CSINTLTAISIYRYLKICHpPYGPKLSRRHVCIVIVAIWLYALFWAvAPLVGWGSYG-PEPFG----TSCSIDWTGASAS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNH----VSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLP------ 283
Cdd:cd15074 161 VGGMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSrkrvAGFDSRSKRQHKIERKVTKVAVLICAGFLIAWTPyavvsm 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 284 LHAFQLAVDIDShvldlkeykLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15074 241 WSAFGSPDSVPI---------LASILPALFAKSSCMYNPIIYLLFSSKFRQ 282
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
51-336 1.18e-24

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 101.24  E-value: 1.18e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYslIEIIPDFEIVACTEKWP 208
Cdd:cd15049  81 YVASNASVMNLLLISFDRYFSVTRPLTyrAKRTPKRAILMIALAWVISFVLWAPAILGWQY--FVGERTVPDGQCYIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVyslstlLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15049 159 DDPAITFGTA------IAAFYLPVLVMTILYWRIYRETA--------------RERKAARTLSAILLAFIITWTPYNILV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 289 L-----AVDIDSHVLDLKeYKLIFtvfhiiaMCSTFaNPLLYGWMNSNYRKAF 336
Cdd:cd15049 219 LvstfcAKCIPDTLWSFG-YWLCY-------INSTI-NPFCYALCNKTFRKTF 262
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
51-336 1.62e-24

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 101.57  E-value: 1.62e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTlCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTT-TMPFQSTVYLMNSWPFGDVLCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLA-WGVSALLASPLAIFREYSLIEiipDFEIVACTEKWP 208
Cdd:cd15091  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKAlDFRTPLKAKIINICiWLLSSSVGISAIVLGGTKVRE---DVDSTECSLQFP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15091 157 DDDYSWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKS-VRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 289 LA---VDIDSHVLDLKEYkliftvFHIIAMCSTFA--NPLLYGWMNSNYRKAF 336
Cdd:cd15091 236 LVealGSVSHSTAAVSSY------YFCIALGYTNSslNPILYAFLDENFKRCF 282
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
53-269 1.92e-24

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 101.50  E-value: 1.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15079   3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLE-SKISKQISFLIIGLAWGVSALLASP--LAIFREYslieiIPDFEIVAC-----T 204
Cdd:cd15079  82 SGIGSIWTNAAIAYDRYNVIVKPLNgNPLTRGKALLLILFIWLYALPWALLplLFGWGRY-----VPEGFLTSCsfdylT 156
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 205 EKWPGEeksvygtVYSLSTLLILYVLPLGIISFSYTRIWsklknhvspGAASDHYHQRRHKTTKM 269
Cdd:cd15079 157 RDWNTR-------SFVATIFVFAYVIPLIIIIYCYSFIV---------KAVFAHEKALREQAKKM 205
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
53-335 2.16e-24

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 100.97  E-value: 2.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIIL--LGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15073   1 NIVAAYLIVAgiISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYH-LESKISKQISFLIIGLAWGVSALLAS-PLAIFREYSlieiiPDFEIVACTEKWP 208
Cdd:cd15073  81 IFFGMASIGLLTVVAVDRYLTICRPdLGRKMTTNTYTVMILLAWTNAFFWAAmPLVGWASYA-----LDPTGATCTINWR 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLliLYVLPLGIISFSYTRIWSKLKNHVSPGAAS----DHYHQRrhKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15073 156 KNDSSFVSYTMSVIVV--NFIVPLAVMFYCYYNVSRFVKKVLASDCLEsvniDWTDQN--DVTKMSVIMIVMFLVAWSPY 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 285 HAFQLAVDIdshvldlKEYKLIFTVFHII----AMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15073 232 SIVCLWASF-------GEPKKIPPWMAIIpplfAKSSTFYNPCIYVIANKKFRRA 279
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
58-336 3.28e-24

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 100.03  E-value: 3.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15210   8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYH-LESKISKQISF-LIIGLAW--GVSALLASPLAIFREYSLieiipDFEIVACTekwpgEEKS 213
Cdd:cd15210  88 LLTLVLITLNRYILIAHPsLYPRIYTRRGLaLMIAGTWifSFGSFLPLWLGIWGRFGL-----DPKVCSCS-----ILRD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKlknhvspgaasdhyhqrrhKTTKMLVCVVVVFAVSWLPLHAFQLAVDI 293
Cdd:cd15210 158 KKGRSPKTFLFVFGFVLPCLVIIICYARREDR-------------------RLTRMMLVIFLCFLVCYLPITLVNVFDDE 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 294 DSHvldlkeyklifTVFHIIAMC----STFANPLLYGWMNSNYRKAF 336
Cdd:cd15210 219 VAP-----------PVLHIIAYVliwlSSCINPIIYVAMNRQYRQAY 254
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
51-336 3.93e-24

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 99.97  E-value: 3.93e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLA-SPLAIFREYSlieiiPDFEIVACTEKW 207
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRypSIMTERRGLLALLCVWVLSLVISiGPLFGWKEPA-----PEDETICQITEE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGeeksvygtvYSLSTLLILYVLPLGIISFSYTRIW-SKLKnhvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPlha 286
Cdd:cd15325 156 PG---------YALFSALGSFYLPLAIILVMYCRVYvVALK------------FSREKKAAKTLGIVVGCFVLCWLP--- 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15325 212 FFLVMPIGSIFPAYKPSDTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
51-336 5.01e-24

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 100.26  E-value: 5.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYH-LESKISKQISFLIIGLAWGVSALLaSPLAIFREYSLIEIIPDFEIVACtekwPG 209
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAICCQpLVYKMTPLRVAVMLGGCWVIPTFI-SFLPIMQGWNHIGIEDLIAFNCA----SG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVY--GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHV--------SPGAASDHYHQRRH------KTTKMLVCV 273
Cdd:cd15056 156 STSCVFmvNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAhqirslqrAGSSNHEADQHRNSrmrtetKAAKTLGII 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 274 VVVFAVSWLPlhaFQLAVDIDShVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15056 236 MGCFCVCWAP---FFVTNIVDP-FIGYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
51-336 5.45e-24

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 100.10  E-value: 5.45e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLasplaifreySLIEI-----IPDFEI--V 201
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITapLRYPSRVTPRRVAIALAAIWVVSLAV----------SFLPIhlgwnTPDGRVqnG 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 202 ACTEKWPGEEKSVYGTVYSLSTllilYVLPLGIISFSYTRIWS------KLKNHVSPGAASDHYHQ----RRHKTTKMLV 271
Cdd:cd15051 151 DTPNQCRFELNPPYVLLVAIGT----FYLPLLIMCGVYLRIFRiareqaKRINALTPASTANSSKSaataREHKATVTLA 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 272 CVVVVFAVSWLPLhafqlavdidshvldlkeykliFTVFHIIAMCS------------------TFANPLLYGWMNSNYR 333
Cdd:cd15051 227 AVLGAFIICWFPY----------------------FTYFTYRGLCGdninetalsvvlwlgyanSALNPILYAFLNRDFR 284

                ...
gi 13027422 334 KAF 336
Cdd:cd15051 285 RAF 287
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
52-336 1.43e-23

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 98.58  E-value: 1.43e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQ 130
Cdd:cd15067   1 LLGVVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGyWLFGRDWCDVWHSFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPlAIFREYSLIEIIPDFEIVACTEKwp 208
Cdd:cd15067  81 VLASTASILNLCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFP-AIAWWRAVDPGPSPPNQCLFTDD-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 geeksvygTVYSLSTLLILYVLPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15067 158 --------SGYLIFSSCVSFYIPLVVMLFTYYRIYR---------AAA-----KEQKAAKTLGIVMGVFILCWLPFFVTN 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLdLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15067 216 ILIGFCPSNC-VSNPDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
52-336 1.51e-23

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 98.20  E-value: 1.51e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPlaifreyslieiipdfEIVACTEKWPG 209
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKyrTKRSRRLAITMILAVWVISLLITSP----------------PLVGPSWHGRR 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTV---YSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15061 145 GLGSCYYTYdkgYRIYSSMGSFFLPLLLMLFVYLRIFRVIA--------------KERKTAKTLAIVVGCFIVCWLPFFI 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 FQLAVDIDSHVLdlkeYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15061 211 MYLIEPFCDCQF----SEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
52-335 1.65e-23

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 98.72  E-value: 1.65e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILL-GVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLtYTLMG--EWKMGPVLCHLVPY 128
Cdd:cd15928   1 AAVTAVCSVLMLvGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLI-FLVLPLDL-YRLWRyrPWRFGDLLCRLMYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTek 206
Cdd:cd15928  79 FSETCTYASILHITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECT-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 wPGEEKSVYGTVYSLSTlLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15928 157 -VVNVSSGLLSVMLWVS-TSFFFVPMVCLSLLYGLIGRALwdRRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPF 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 285 HA----FQLAVDIDSHVLDLKEY--KLIFTVFHIiamcSTFANPLLYGWMNSNYRKA 335
Cdd:cd15928 235 HVgrviFNHSRASTKHLHYVSQYfnLVSFVLFYL----SAAINPILYNLMSKRYRYA 287
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
51-336 1.84e-23

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 98.40  E-value: 1.84e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFQGTDIFLGFWPFGNALCKTVIAID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCI---VYHLESKISKQISFLIIGLaWGVSALLASPLAIFREYSLieiipDFEIVACTEKW 207
Cdd:cd15092  80 YYNMFTSTFTLTAMSVDRYVAIchpIKALDVRTPHKAKVVNVCI-WALASVVGVPVMVMGSAQV-----EDEEIECLVEI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKN-HVSPGAASDHYHQRRhkTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15092 154 PTPQ-DYWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGvRLLSGSKEKDRNLRR--ITRLVLVVVAVFVGCWTPIQI 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 287 FQLAVDIDSHVldLKEYKLIFTVFHI-IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15092 231 FVLAQGLGVQP--SSETAVAILRFCTaLGYVNSSLNPVLYAFLDENFKACF 279
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
61-336 2.20e-23

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 98.06  E-value: 2.20e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15327  11 ILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWgVSALLAS--PLAIFREysliEIIPDFEIVACTEKwPGeeksvyg 216
Cdd:cd15327  91 LCVISVDRYVGVKHSLKypTIMTERKAGVILVLLW-VSSMVISigPLLGWKE----PPPPDESICSITEE-PG------- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 tvYSLSTLLILYVLPLGIISFSYTRIW-SKLKnhvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPlhaFQLAVDIDS 295
Cdd:cd15327 158 --YALFSSLFSFYLPLMVILVMYFRVYvVALK------------FSREKKAAKTLAIVVGVFILCWFP---FFFVLPLGS 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15327 221 FFPALKPSEMVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
51-336 6.37e-23

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 97.18  E-value: 6.37e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELF-MLGLPFLAAQNALSYWPFGSFMCRLVMTVD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES------KISKQISFLIiglaWGVSALLASPLAIFREYSLieiipdfEIVACT 204
Cdd:cd15972  80 AINQFTSIFCLTVMSVDRYLAVVHPIRSskwrkpPVAKTVNATV----WALSFLVVLPVVIFSGVPG-------GMGTCH 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPgEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQR-RHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15972 149 IAWP-EPAQVWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGsERKVTRMVVIVVAAFVLCWLP 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 284 LHAFQLAVDIDSHVLDLKEYKLIFTVFhIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15972 228 FYALNIVNLVCPLPEEPSLFGLYFFVV-VLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
51-336 1.16e-22

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 96.47  E-value: 1.16e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15055   1 VLLYIVLSSISLLTVLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMPFSMIRSIETCWYFGDTFCKLHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAifreYSLIEIIPDFEIVACtekwP 208
Cdd:cd15055  81 YILTSASIFNLVLIAIDRYVAVCDplLYPTKITIRRVKICICLCWFVSALYSSVLL----YDNLNQPGLIRYNSC----Y 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHV----SPGAASDHYHQRR-------HKTTKMLVCVVVVF 277
Cdd:cd15055 153 GECVVVVNFIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQArairSHTAQVSLEGSSKkvskkseRKAAKTLGIVVGVF 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027422 278 AVSWLPLHAFQLA---VDIDSHVLDLkeykLIFTVFhiiamCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15055 233 LLCWLPYYIVSLVdpyISTPSSVFDV----LIWLGY-----FNSCLNPLIYALFYPWFRKAL 285
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
51-335 1.23e-22

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 96.33  E-value: 1.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCsiillGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15336   6 VILIIGIT-----GMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSalLASPLAIFREYSliEIIPDFEIVACTEKWP 208
Cdd:cd15336  81 ALFGITSMITLLAISLDRYLVITKPLASirWVSKKRAMIIILLVWLYS--LAWSLPPLFGWS--AYVPEGLLTSCTWDYM 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGtvYSLSTLLILYVLPLGIISFSYTRIWSKLK---------NHVSPGAASDHYHQRRH--KTTKMLVCVVVVF 277
Cdd:cd15336 157 TFTPSVRA--YTMLLFCFVFFIPLGIIIYCYLFIFLAIRstgrevqklGSQDRKEKAKQYQRMKNewKMAKIAFVVILLF 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 278 AVSWLPLHAFQL-AVDIDSHVLDlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15336 235 VLSWSPYACVALiAWAGYAHLLT----PYMKSVPAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
60-335 1.74e-22

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 95.86  E-value: 1.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15083  10 IGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSIN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLAS-PLAIFREYslieiIPDFEIVACTekWPGEEKSVYG 216
Cdd:cd15083  90 TLAAIAVDRYLVITRPMKAsvRISHRRALIVIAVVWLYSLLWVLpPLFGWSRY-----VLEGLLTSCS--FDYLSRDDAN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLSTLLILYVLPLGIISFSYTRIWSKLKNH------------VSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15083 163 RSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHekamkemakrfsKSELSSPKARRQAEVKTAKIALLLVLLFCLAWTPY 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 285 HAFQL-AVDIDSHVldLKEYKLIFTVFhiIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15083 243 AVVALiGQFGYLEV--LTPLATAIPAA--FAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
58-336 2.11e-22

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 95.90  E-value: 2.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIH-VVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15383   8 FVLFVLSACSNLAVLWsATRNRRRKLSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASP-LAIFReysLIEIIPDFEIVAC------TEKWpg 209
Cdd:cd15383  88 SAFVTVVISLDRHAAILNPLAIGSARRRNRIMLCAAWGLSALLALPqLFLFH---TVTATPPVNFTQCathgsfPAHW-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 eeksvYGTVYSLSTLLILYVLPLGIISFSYTRI-WS------KLKNHVSPGAA----SDHYHQRRHKTTKMLVCVVVVFA 278
Cdd:cd15383 163 -----QETLYNMFTFFCLFLLPLLIMIFCYTRIlLEisrrmkEKKDSAKNEVAlrssSDNIPKARMRTLKMTIVIVSSFI 237
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 279 VSWLPLHA------FQLAVDID------SHVLdlkeykLIFTVFHiiamcsTFANPLLYGWMNSNYRKAF 336
Cdd:cd15383 238 VCWTPYYLlglwywFSPEMLEQtvpeslSHIL------FLFGLLN------ACLDPLIYGLFTISFRRGL 295
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
51-336 2.14e-22

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 95.03  E-value: 2.14e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15329   1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLA-SPLAIFREYSLIE----IIPDFeivac 203
Cdd:cd15329  81 VLLCTASILNLCAISVDRYLVITRPLTyaVKRTPKRMALMIAIVWLLSALISiPPLFGWKNKVNDPgvcqVSQDF----- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 tekwpgeeksVYgTVYslSTLLILYvLPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15329 156 ----------GY-QIY--ATFGAFY-IPLIVMLVLYYKIYR---------AAK-----SERKAIKTLGIIMGAFTLCWLP 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 284 LHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15329 208 FFILALLRPFLKPIKCSCIPLWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-330 2.34e-22

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 95.95  E-value: 2.34e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15197   8 WVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASP-LAIFREYSLIEiipdfEIVACTEKWPgeeKSVYG 216
Cdd:cd15197  88 TYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIPmLIIFEKTGLSN-----GEVQCWILWP---EPWYW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLSTLLILYVLPLGIISFSY----TRIWSKLKNHVSPGAASDHYHQRRH------------KTTKMLVCVVVVFAVS 280
Cdd:cd15197 160 KVYMTIVAFLVFFIPATIISICYiiivRTIWKKSKIQVTINKAGLHDGSSRRsssrgiiprakiKTIKMTFVIVTVFIIC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 281 WLPLHAFQLAVDIDshVLDLKEYKLIFTVF-HIIAMCSTFANPLLYGWMNS 330
Cdd:cd15197 240 WSPYFVFDLLDVFG--LLPRSKTKIAAATFiQSLAPLNSAINPLIYCLFST 288
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
54-336 2.41e-22

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 95.14  E-value: 2.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15066   3 GFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDVYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLaSPLAIFREYSLIEiipdfEIVACTEKWPGEE 211
Cdd:cd15066  83 STASILHLCCISVDRYYAIVQPLEypSKMTKRRVAIMLANVWISPALI-SFLPIFLGWYTTE-----EHLQYRKTHPDQC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPlhaFQLAV 291
Cdd:cd15066 157 EFVVNKIYALISSSVSFWIPCIVMIFTYYRIYLEAK--------------REHKAAKTLGIIMGAFILCWLP---FFLWY 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 292 DIDSHVLDLKEY-KLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15066 220 VTTTLCGDACPYpPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
52-336 2.55e-22

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 95.98  E-value: 2.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAycSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15058   4 LLLLA--LIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLaSPLAIFREYSLIEiipDFEIVACTEKwPG 209
Cdd:cd15058  82 LCVTASIETLCVIAVDRYIAITRPLRyqVLLTKRRARVIVCVVWIVSALV-SFVPIMNQWWRAN---DPEANDCYQD-PT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIW------------SKLKNHVSPGAASDHYHQRR-------------- 263
Cdd:cd15058 157 CCDFRTNMAYAIASSVVSFYIPLLIMIFVYARVFliatrqlqlidkRRLRFQSECPAPQTTSPEGKrssgrrpsrltvvk 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 264 -HKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDlkeyKLIFTVFHIIAMCSTFANPLLYgWMNSNYRKAF 336
Cdd:cd15058 237 eHKALKTLGIIMGTFTLCWLPFFIANIINVFNRNLPP----GEVFLLLNWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
55-336 3.41e-22

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 95.31  E-value: 3.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLtYTLMGEWK--MGPVLCHLVPYAQGL 132
Cdd:cd15357   5 LVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEV-YEMWSNYPflFGPVGCYFKTALFET 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASP--------LAIFREYSLieiIPDFEIva 202
Cdd:cd15357  84 VCFASILSVTTVSVERYVAILHPFRAKLnsTRERALKIIVVLWVLSVLFSIPntsihgikLQYFPNGTL---IPDSAT-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPgeeKSVYGTVYSLSTLLiLYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYH-QR--RHKTTKMLVCVVVVFAV 279
Cdd:cd15357 159 CTVVKP---LWIYNLIIQITSLL-FYVLPMGVISVLYYLMGLKLRGDKSLEADEMNVNiQRpsRKSVTKMLFVLVLVFAI 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027422 280 SWLPLHAFQLAVdidSHVLDLKE-----YKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15357 235 CWAPFHVDRLFF---SFVVEWTEplanvFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
49-248 4.83e-22

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 94.83  E-value: 4.83e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAycsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVP 127
Cdd:cd15212   2 AQALVLLA---IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPgWLFGDRLCLANG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASP---LAIFREYSLIEIIPDFEIVACT 204
Cdd:cd15212  79 FFNACFGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPwylLASAPEYYEKLGFYHCLYVLHS 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 13027422 205 EKWPGeeksvyGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKN 248
Cdd:cd15212 159 GPSRL------GAAYSSVLIVLCYLLPFALMCFCHYNICKTVRL 196
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-336 8.27e-22

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 93.71  E-value: 8.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLA-SPLAIFREysliEIIPDFEIVACTEKw 207
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNypTIVTARRATVALLIVWVLSLVISiGPLLGWKE----PAPADEQACGVNEE- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGeeksvygtvYSLSTLLILYVLPLGIISFSYTRIW-SKLKnhvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPlha 286
Cdd:cd15062 156 PG---------YVLFSSLGSFYLPLAIILVMYCRVYvVAFK------------FSREKKAAKTLGIVVGAFVLCWFP--- 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15062 212 FFVVLPLGSLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
61-336 9.85e-22

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 93.69  E-value: 9.85e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15209  11 IVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWgvsalLASPLAIFREYSLIEIIPDFEIVACTEKWpgeeksVYGTV 218
Cdd:cd15209  91 ITAIAINRYCYICHSLqyDRLYSLRNTCCYLCLTW-----LLTVLAVLPNFFIGSLQYDPRIYSCTFAQ------TVSTV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIWSKL---KNHVSPGAASDHYHQRRHKTTKMLvCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15209 160 YTITVVVIHFLLPLLIVSFCYLRIWVLVlqvRQRVKPDQRPKLKPADVRNFLTMF-VVFVLFAVCWAPLNFIGLAVAINP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15209 239 KEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
60-336 2.25e-21

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 93.04  E-value: 2.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15958  10 IVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIE 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLaSPLAIFREYSLIEiipDFEIVACTEKwPGEEKSVYGT 217
Cdd:cd15958  90 TLCVIAIDRYLAITspFRYQSLLTRARAKGIVCTVWAISALV-SFLPIMMHWWRDE---DDQALKCYED-PGCCDFVTNR 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 218 VYSLSTLLILYVLPLGIISFSYTRIWSKLK---------------NHVSPGAASDHYHQ-----RRHKTTKMLVCVVVVF 277
Cdd:cd15958 165 AYAIASSIISFYIPLLIMIFVYLRVYREAKkqikkidkcegrfhnTLTGLGRKCKRRPSrilalREQKALKTLGIIMGVF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 278 AVSWLPlhaFQLAVDIDSHVLDLKEYKLiFTVFHIIAMCSTFANPLLYgWMNSNYRKAF 336
Cdd:cd15958 245 TLCWLP---FFLVNVVNVFNRELVPDWL-FVFFNWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
51-336 2.37e-21

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 92.88  E-value: 2.37e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15087   1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLF-TLVLPINIAEHLLQQWPFGELLCKLILSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESK--------ISKQISFLIiglaWGVSALLASPLAIFREYSlieiIPDFEIVA 202
Cdd:cd15087  80 HYNIFSSIYFLTVMSVDRYLVVLATVRSRrmpyrtyrAAKIVSLCV----WLLVTIIVLPFTVFAGVY----SNELGRKS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPGEEkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNH--VSPGAASDhyhQRRHKTTKMLVCVVVVFAVS 280
Cdd:cd15087 152 CVLSFPSPE-SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMrlNSNAKALD---KAKKKVTLMVLVVLAVCLFC 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 281 WLPLHafqLAVdIDSHVLDLKEYKLIFTVFHIIAMCS---TFANPLLYGWMNSNYRKAF 336
Cdd:cd15087 228 WTPFH---LST-VVALTTDLPQTPLVIGISYFITSLSyanSCLNPFLYAFLDDSFRKSF 282
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
52-242 2.62e-21

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 92.30  E-value: 2.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLV---NTL-CLPFTLTYTLMGewkmGPVLCHLVP 127
Cdd:cd15196   2 VEIAVLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLValfNVLpQLIWDITYRFYG----GDLLCRLVK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASP-LAIFreySLIEIIPD-FEIVAC- 203
Cdd:cd15196  78 YLQVVGMYASSYVLVATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPqLFIF---SYQEVGSGvYDCWATf 154
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 13027422 204 TEKWpgeEKSVYGTVYSLStlliLYVLPLGIISFSYTRI 242
Cdd:cd15196 155 EPPW---GLRAYITWFTVA----VFVVPLIILAFCYGRI 186
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
51-182 3.10e-21

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 91.72  E-value: 3.10e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 131 GLAVQVSTITLTVIALDR----HRCIVYHLESKISKQIsfLIIGLAWGVSALLASP 182
Cdd:cd15060  81 ILCCTASILNLCAIALDRywaiHDPINYAQKRTLKRVL--LMIVVVWALSALISVP 134
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
51-336 3.27e-21

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 92.32  E-value: 3.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSAKYLMETWPFGELLCKAVLSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRH-------RCIVYHLESKiSKQISFLIiglaWGVSALLASPLAIFReyslIEIIPDFEIVAC 203
Cdd:cd15089  80 YYNMFTSIFTLTMMSVDRYiavchpvKALDFRTPAK-AKLINICI----WVLSSGVGVPIMVMA----VTKTPRDGAVVC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEEkSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvSPGAASDHYHQRRH--KTTKMLVCVVVVFAVSW 281
Cdd:cd15089 151 MLQFPSPS-WYWDTVTKICVFIFAFVVPILVITVCYGLMILRLR---SVRLLSGSKEKDRNlrRITRMVLVVVAAFIICW 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 282 LPLHAFQLA---VDIDshvldlKEYKLIFTVFHI-IAMCSTFA--NPLLYGWMNSNYRKAF 336
Cdd:cd15089 227 TPIHIFVIVwtlVDID------RRNPLVVAALHLcIALGYANSslNPVLYAFLDENFKRCF 281
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
51-336 4.11e-21

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 92.49  E-value: 4.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMR-TVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPvLCHLVPYA 129
Cdd:cd15057   1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGS-FCDVWVSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSAL---LASPLAIFREYSLIE-IIPDFEIVAC 203
Cdd:cd15057  80 DIMCSTASILNLCVISVDRYWAISspFRYERRMTRRRAFIMIAVAWTLSALisfIPVQLGWHRADDTSEaLALYADPCQC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 tekwpgeeKSVYGTVYSLSTLLILYVLPLGIISFSYTRIW----------SKLKNHVSPGAASDHYHQ----RRHKTTKM 269
Cdd:cd15057 160 --------DSSLNRTYAISSSLISFYIPVAIMIVTYTRIYriarrqirriAALERAAQESTNPDSSLRsslrRETKALKT 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 270 LVCVVVVFAVSWLPLhaFQLAVDIDSHVLDLKEYKLI----FTVFHIIAMCSTFANPLLYGWmNSNYRKAF 336
Cdd:cd15057 232 LSIIMGVFVCCWLPF--FILNCVLPFCDLRTAQFPCVpdttFIVFVWLGWANSSLNPIIYAF-NADFRKAF 299
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
60-325 6.78e-21

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 91.85  E-value: 6.78e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15957  10 IVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIE 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSAlLASPLAIFREYSLI---EIIPDFEIVACTEKWPGEeksv 214
Cdd:cd15957  90 TLCVIAVDRYFAITspFKYQSLLTKNKARVIILMVWIVSG-LTSFLPIQMHWYRAthqEAINCYAEETCCDFFTNQ---- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 ygtVYSLSTLLILYVLPLGIISFSYTRIWSKLK----------------NHVSPGAASDHYHQRR-------HKTTKMLV 271
Cdd:cd15957 165 ---AYAIASSIVSFYVPLVIMVFVYSRVFQEAKrqlqkidksegrfhnqNIDQNGSGGGGGNRRRskfclkeHKALKTLG 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 272 CVVVVFAVSWLPLhafqLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLY 325
Cdd:cd15957 242 IIMGTFTLCWLPF----FIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIY 291
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
60-336 7.79e-21

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 90.84  E-value: 7.79e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15052  10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGGvWPLPLVLCLLWVTLDVLFCTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFreySLIEIIPDFEIVACTekWPGEEKSVYG 216
Cdd:cd15052  90 MHLCTISLDRYMAIRYPLRtrRNKSRTTVFLKIAIVWLISIGISSPIPVL---GIIDTTNVLNNGTCV--LFNPNFVIYG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSlstllilYVLPLGIISFSYTRIWSKLKNhvspgaasdhyhqrRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSH 296
Cdd:cd15052 165 SIVA-------FFIPLLIMVVTYALTIRLLSN--------------EQKASKVLGIVFAVFVICWCPFFITNILTGLCEE 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 13027422 297 VLDLKEYKLiFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15052 224 CNCRISPWL-LSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
51-336 1.51e-20

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 90.64  E-value: 1.51e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVvikFKSMRTVT-----NFFIANLAVADLLVnTLCLPF-TLTYTLMGEWKMGPVLCH 124
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYL---LKSNKKLRqqsesNKFVFNLALTDLIF-VLTLPFwAVEYALDFVWPFGTAMCK 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 125 LVPYAQGLAVQVSTITLTVIALDRHrCIV-------YHLESKISKQISFLIiglaWGVSALLASPLAIFREYSLiEIIPD 197
Cdd:cd14976  77 VVRYVTKLNMYSSIFFLTALSVTRY-IAVaralkhgWIRKAFGAFATTIAI----WAAAALAAIPEAIFSTDTW-SSVNH 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 198 feiVACTEKWPGEEKSVYGT----VYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAasdhyhQRRHKTTKMLVCV 273
Cdd:cd14976 151 ---TLCLLRFPKNSSVTRWYnwlgMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSK------RRKSRVTKSVFIV 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 274 VVVFAVSWLPLHAFQL---AVDIDShVLDLKEYKLIFTVFHIIAMCSTFA----NPLLYGWMNSNYRKAF 336
Cdd:cd14976 222 VLSFFICWLPNQALSLwsaLIKFDD-VPFSDAFFAFQTYAFPVAICLAHSnsclNPVLYCLVRREFRDAL 290
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
61-336 3.13e-20

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 89.58  E-value: 3.13e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15401  11 IVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSAllaspLAIFREYSLIEIIPDFEIVACTekwpgeEKSVYGTV 218
Cdd:cd15401  91 ITAIAINRYCYICHSLryDKLYNMKKTCCYVCLTWVLTL-----AAIVPNFFVGSLQYDPRIYSCT------FAQTVSSS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIWSkLKNHVSPGAASDHYHQRRHKTTK---MLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15401 160 YTITVVVVHFIVPLSIVTFCYLRIWV-LVIQVKHRVRQDSKQKLKANDIRnflTMFVVFVLFAVCWGPLNFIGLAVAINP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15401 239 LKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
61-336 4.84e-20

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 88.81  E-value: 4.84e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15402  11 IVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSAllaspLAIFREYSLIEIIPDFEIVACTekwpgEEKSVyGTV 218
Cdd:cd15402  91 ITGIAINRYCYICHSLkyDKLYSDKNSLCYVLLIWVLTV-----AAIVPNLFVGSLQYDPRIYSCT-----FAQSV-SSA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIW-------SKLKNHVSPGAASdhyHQRRHKTTkmLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd15402 160 YTIAVVFFHFILPIIIVTFCYLRIWilviqvrRRVKPDNKPKLKP---HDFRNFVT--MFVVFVLFAVCWAPLNFIGLAV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 292 DIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15402 235 AVDPETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
60-336 5.31e-20

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 89.68  E-value: 5.31e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRT-VTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGpVLCHLVPYAQGLAVQVST 138
Cdd:cd15320  11 LILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFG-SFCNIWVAFDIMCSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLaSPLAIFREYSLIEIIPDFEIVACTEKWPGEE-KSVY 215
Cdd:cd15320  90 LNLCVISVDRYWAISspFRYERKMTPKVAFIMISVAWTLSVLI-SFIPVQLNWHKAKPTSFLDLNASLRDLTMDNcDSSL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHV-----------------------------SPGAASDHYHQRRHKT 266
Cdd:cd15320 169 NRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIrrisaleraavhakncqnstgnrgsgdcqQPESSFKMSFKRETKV 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 267 TKMLVCVVVVFAVSWLPLHAFQLAVD-----------IDSHVLDlkeykliftVFHIIAMCSTFANPLLYGWmNSNYRKA 335
Cdd:cd15320 249 LKTLSVIMGVFVCCWLPFFILNCMVPfckptstepfcISSTTFD---------VFVWFGWANSSLNPIIYAF-NADFRKA 318

                .
gi 13027422 336 F 336
Cdd:cd15320 319 F 319
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-335 6.92e-20

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 89.05  E-value: 6.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMR-TVTNFFIANLAVADL-LVNTLclPFTLTYTLMG-EWKMGPVLCHLVP 127
Cdd:cd15190  11 ALIPVIYMLVFVLGLSGNGLVLWTVFRSKRKRrRSADTFIANLALADLtFVVTL--PLWAVYTALGyHWPFGSFLCKLSS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLIE------IIPDFE 199
Cdd:cd15190  89 YLVFVNMYASVFCLTGLSFDRYLAIVRSLASAKlrSRTSGIVALGVIWLLAALLALPALILRTTSDLEgtnkviCDMDYS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 200 IVACTEkwpgeEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRhkTTKMLVCVVVVFAV 279
Cdd:cd15190 169 GVVSNE-----SEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKLRRKEDKKKRR--LLKIIITLVVTFAL 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 280 SWLPLHAFQLAVDIDShvLDLKEYKLIFTVF----HIIAMCSTFA----NPLLYGWMNSNYRKA 335
Cdd:cd15190 242 CWLPFHLVKTLYALMY--LGILPFSCGFDLFlmnaHPYATCLAYVnsclNPFLYAFFDPRFRQQ 303
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
47-336 7.55e-20

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 88.06  E-value: 7.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  47 VEVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLV 126
Cdd:cd15321   3 VQATAAIAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 127 PYAQGLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACT 204
Cdd:cd15321  83 LALDVLFCTSSIVHLCAISLDRYWSVSRAIEynSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWpgeeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLP- 283
Cdd:cd15321 163 EAW-----------YILSSSIGSFFAPCLIMILVYLRIYLIAKN-------------REKRFTFVLAVVIGVFVLCWFPf 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 284 LHAFQLAVDIDSHVldlKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15321 219 FFSYSLGAICPELC---KVPHSLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
60-336 9.22e-20

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 88.56  E-value: 9.22e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15065   9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCI--VYHLESKISKQISFLIIGLAWGVSALLaSPLAIFREYSlieiIPDFEIVACTEKWPGEEKSVY-- 215
Cdd:cd15065  89 NLCAISLDRYIHIkkPLKYERWMTTRRALVVIASVWILSALI-SFLPIHLGWH----RLSQDEIKGLNHASNPKPSCAld 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 -GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHV-------------------SPGAASDHYHQRRHKTTKMLVCVVV 275
Cdd:cd15065 164 lNPTYAVVSSLISFYIPCLVMLLIYSRLYLYARKHVvniksqklpsesgskfqvpSLSSKHNNQGVSDHKAAVTLGIIMG 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 276 VFAVSWLPLHAFQLAVDIDSHVLDLKEYKlIFTVFHIIAMCstfANPLLYGWMNSNYRKAF 336
Cdd:cd15065 244 VFLICWLPFFIINIIAAFCKTCIPPKCFK-ILTWLGYFNSC---LNPIIYSIFNSEFRRAF 300
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
51-336 9.29e-20

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 87.64  E-value: 9.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15326   1 ILLGLVLGAFILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLA-SPLAIFREYSlieiIPDFEIVACTEKw 207
Cdd:cd15326  81 VLCCTASILSLCAISIDRYIGVRHSLQypTIVTRKRAILALLGVWVLSTVISiGPLLGWKEPA----PPDDKVCEITEE- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 pgeeksvygTVYSLSTLLILYVLPLGIISFSYTRIW-SKLKnhvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPlha 286
Cdd:cd15326 156 ---------PFYALFSSLGSFYIPLIVILVMYCRVYiVALK------------FSREKKAAKTLGIVVGMFILCWLP--- 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15326 212 FFIALPLGSLFSHLKPPETLFKIIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
60-334 9.68e-20

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 88.27  E-value: 9.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd14999   9 MCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLY-LLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIF 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVYGTV 218
Cdd:cd14999  88 TLTVMSTERYLAVVKPLDTvKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWSEESYKVYLTL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 yslsTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLavdIDSHVL 298
Cdd:cd14999 168 ----LFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQL---LYLYSP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 13027422 299 DLKEYKLIFTVFHIIAMCSTF----ANPLLYGWMNSNYRK 334
Cdd:cd14999 241 SLSLSPRTTTYVNYLLTCLTYsnscINPFLYTLLTKNYKE 280
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
51-336 9.68e-20

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 88.10  E-value: 9.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGeWKMGPVLCHLVPYAQ 130
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLF-ALTLPFWAVSVVKG-WIFGTFMCKLVSLLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQ-ISFLIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWPG 209
Cdd:cd15178  79 EANFYSGILLLACISVDRYLAIVHATRALTQKRhLVKFVCAGVWLLSLLLSLPALLNRD---AFKPPNSGRTVCYENLGN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTR-IWSKLKNHvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPLHafq 288
Cdd:cd15178 156 ESADKWRVVLRILRHTLGFLLPLVVMLFCYGFtIKTLLQTR----------SFQKHRAMRVIFAVVLAFLLCWLPYN--- 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 289 LAVDIDShvldLKEYKLI-FT------------VFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15178 223 VTVLIDT----LMRTKLItETcelrnhvdvalyVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
60-331 1.57e-19

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 87.94  E-value: 1.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15198  10 ILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELLGDrWMAGDVACRLLKLLQASARGASA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLESKISkqiSFLIIGLAWGVSALLASPLA-IFREYSLIEIIPDFEIVACTEKWPGEEKSVYGT 217
Cdd:cd15198  90 NLVVLLALDRHQAIRAPLGQPLR---AWKLAALGWLLALLLALPQAyVFRVDFPDDPASAWPGHTLCRGIFAPLPRWHLQ 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 218 VYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRH-----------------KTTKMLVCVVVVFAVS 280
Cdd:cd15198 167 VYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAKKPWKKPSkshlratapsalprakvKTLKMTLVIALLFVGC 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 281 WLPLHAFQLAVDIDSHVldlKEYKLIFTVFHIIAMCSTFANPLLYGWMNSN 331
Cdd:cd15198 247 SLPYFIAELAAAFGSGD---WEPEKVAAALGVMAVANSATNPFVFLFFNAG 294
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
53-336 1.61e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 87.76  E-value: 1.61e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSII-LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADL---LVNtlCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15337   2 LIGIYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFgfsAVN--GFPLKTISSFNKKWIWGKVACELYGF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLA-SPLAIFREYslieiIPDFEIVACTE 205
Cdd:cd15337  80 AGGIFGFMSITTLAAISIDRYLVIAKPLEAmkKMTFKRAFIMIIIIWLWSLLWSiPPFFGWGRY-----VPEGFQTSCTF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPgeEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNH------------VSPGAASDHYHQRRHKTTKMLVCV 273
Cdd:cd15337 155 DYL--SRDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIRAVRNHekemtqtaksgmGKDTEKNDARKKAEIRIAKVAIIL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 274 VVVFAVSWLPLHAFQLavdidshvLDLKEYKLIFTVF-----HIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15337 233 ISLFLLSWTPYAVVAL--------LGQFGPAYWITPYvselpVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
52-336 1.70e-19

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 86.95  E-value: 1.70e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSII-LLGVVGNSLVIhvvIKFK---SMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVP 127
Cdd:cd17790   1 VLIVITTGILsLVTVTGNLLVL---ISFKvnsELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiiPDFEIVACTE 205
Cdd:cd17790  78 ALDYVASNASVMNLLIISFDRYFSITRPLtyRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGE--RTVLAGQCYI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVyslstlLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd17790 156 QFLSQPIITFGTA------IAAFYLPVTIMIILYWRIYRETI--------------KEKKAARTLSAILLAFILTWTPYN 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 286 AFQLAVDIDSHVLDLKEYKLIFTVFHIiamcSTFANPLLYGWMNSNYRKAF 336
Cdd:cd17790 216 IMVLVSTFCKDCVPKTLWELGYWLCYV----NSTVNPMCYALCNKSFRDTF 262
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
51-336 1.88e-19

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 86.92  E-value: 1.88e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFL--IIGLAWGVSALLASPLAIFREYSlieiIPDFEIVACT---E 205
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkcIIFIVWVISAVISFPPLITIEKK----SGQPEGPICKindE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWpgeeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLP-L 284
Cdd:cd15322 157 KW-----------YIISSCIGSFFAPCLIMVLVYIRIYQIAKN-------------REKRFTFVLAVVIGVFVICWFPfF 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 285 HAFQLAVDIDSHVLdlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15322 213 FTYTLTAVCDCSVP-----ETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
51-336 2.21e-19

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 87.17  E-value: 2.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMR---TVTNFFIANLAVADLLVnTLCLPFtLTYTLMGE--WKMGPVLCHL 125
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLF-LLGMPF-LIHQLLGNgvWHFGETMCTL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 126 VPYAQGLAVQVSTITLTVIALDRHRCIVYHLES-KISK-QISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDfEIVAC 203
Cdd:cd15338  79 ITALDTNSQITSTYILTVMTLDRYLATVHPIRStKIRTpRVAVAVICLVWILSLLSITPVWM---YAGLMPLPD-GSVGC 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPGEEKSVYGtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgAASDHYHQRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15338 155 ALLLPNPETDTYW--FTLYQFFLAFALPLVVICVVYFKILQNMASTVAP-LPQRSLRVRTKKVTRMAVAICLAFFICWAP 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 284 LHAFQLAvdidSHVLDLKEYKLIFTVFHIIAM--CSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15338 232 FYILQLA----HLSIDRPSLAFLYAYNVAISMgyANSCINPFLYIMLSETFKRQF 282
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
51-336 2.22e-19

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 87.13  E-value: 2.22e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIhVVIKFKSMRTVTNFFIANLAVADLLVNTLcLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15116   1 ILSMVIYSVVFVLGVLGNGLVI-FITGFKMKKTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDfHWPFGRFMCKLNSFL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLieiIPDFEIVACTEKW 207
Cdd:cd15116  79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQnhRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAP---SQNNNKIICFNNF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 ----PGEEKSVYG------TVYSLSTLLILYVLPLGIISFSYTRIWSKLK-NHVSpgaasdhyhqRRHKTTKMLVCVVVV 276
Cdd:cd15116 156 slsgDNSSPEVNQlrnmrhQVMTITRFLLGFLIPFTIIICCYAAIVLKLKrNRLA----------KSSKPFKIIAAVIVT 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 277 FAVSWLPLHAFqlavdidsHVLDLKEYKLIFTVFHI-------IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15116 226 FFLCWAPYHIL--------NLLEMEATRSPASVFKIglpitssLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-335 2.34e-19

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 87.16  E-value: 2.34e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  47 VEVQVVLILaycsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLtYTLMGE--WKMGPVLCH 124
Cdd:cd15132   1 IPVTIVCLI----LFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDL-YRLWKSrpWIFGEFLCR 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 125 LVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLaifreYSLIEIIPDFEIVA 202
Cdd:cd15132  75 LYHYISEGCTYATILHITALSIERYLAICFPLRAKvlVTRRRVKCVIAALWAFALLSAGPF-----LFLVGVEQDNNIHP 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 ------CTEKWPGEEKSVYGTVYSLSTllILYVLPLGIISFSYTRIWSKL---KNHV-SPGAASdhyHQRRHK-TTKMLV 271
Cdd:cd15132 150 ddfsreCKHTPYAVSSGLLGIMIWVTT--TYFFLPMLCLSFLYGFIGRKLwksKNDLrGPNAAA---RERSHRqTVRILA 224
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 272 CVVVVFAVSWLPLHAFQL--AVDIDSHVLDLKEYkliftvFHIIAM----CSTFANPLLYGWMNSNYRKA 335
Cdd:cd15132 225 VVVLAFIICWLPFHIGRIlfANTEDYRTMMFSQY------FNIVAMqlfyLSASINPILYNLISRKYRAA 288
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
51-335 2.49e-19

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 86.65  E-value: 2.49e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLEsKISKQISFLIIGLAWGVSALLASPLAIfrEYSLIEIIPDfeivaCTEKWPGE 210
Cdd:cd15213  81 WFFVLEGVAILLIISVDRYLIIVQRQD-KLNPHRAKILIAVSWVLSFCVSFPPLV--GWGKYEFPPR-----APQCVLGY 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdHYHQRRHKTTKMLvcvVVVFAVSWLPlHAFQLA 290
Cdd:cd15213 153 TESPADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVR----------SFKTRAFTTILIL---FIGFSVCWLP-YTVYSL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 291 VDIDSHVLDlkEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15213 219 LSVFSRYSS--SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFREA 261
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
51-336 2.70e-19

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 86.67  E-value: 2.70e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMG--EWKMGPVLCHLVPY 128
Cdd:cd14995   1 VVATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGpdSWIYGYAGCLLITY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQIS--FLIIGLAWGVSALLASPLAIFREYSlIEIIPDFEIVACTEK 206
Cdd:cd14995  81 LQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSraKKIICFVWIFTSLYCSPWLFLLDLS-IKHYGDDIVVRCGYK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WpgeEKSVYGTVYsLSTLLILYVLPLGIISFSYTRIWSKLknhvspgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPlha 286
Cdd:cd14995 160 V---SRHYYLPIY-LADFVLFYVIPLLLAIVLYGLIGRIL-------------FSSRKQVTKMLAVVVVLFALLWMP--- 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 FQLAVDIDSHVLD--LKEYKLIFTVFHIIAMCSTfaNPLLYGWMNSNYRKAF 336
Cdd:cd14995 220 YRTLVVYNSFASPpyLDLWFLLFCRTCIYLNSAI--NPILYNLMSQKFRAAF 269
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
51-336 2.81e-19

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 86.40  E-value: 2.81e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLvpyaq 130
Cdd:cd15063   1 LISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQI----- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQV-----STITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVAC 203
Cdd:cd15063  76 WLAVDVwmctaSILNLCAISLDRYLAITRPIRypSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 tekwPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15063 156 ----PCTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYR---------AAR-----METKAAKTVAIIVGCFIFCWLP 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 284 LHAFQLAVDIDSHVLDlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15063 218 FFTVYLVRAFCEDCIP----PLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-285 3.18e-19

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 86.83  E-value: 3.18e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15976   8 CLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGIT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESK---ISKQISFLIIgLAWGVSALLASPLAIfrEYSLIEIIPDFEIVACTEKWPGEEKS- 213
Cdd:cd15976  88 VLSLCALSIDRYRAVASWSRIKgigVPKWTAVEIV-LIWVVSIILAVPEAI--GFDMITMDYKGELLRICLLHPIQKTAf 164
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 214 --VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAASDHYHQRRhKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15976 165 mqFYKTAKDWWLFSFYFCLPLACTAVFYTLMTCEMlrKKNGMQIALNDHLKQRR-EVAKTVFCLVLVFALCWLPLH 239
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
57-283 5.15e-19

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 85.88  E-value: 5.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLmGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15182   7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLF-TFTLPFWASYHS-SGWIFGEILCKAVTSIFYIGFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLES-KISKQISFLIIGLA-WGVSALLASPLAIFreYSLIEiiPDFEIVACTEKWPGEEKSV 214
Cdd:cd15182  85 SILFLTLMTIDRYLAVVHPLSAlRSRKLRYASLVSVAvWVISILASLPELIL--STVMK--SDEDGSLCEYSSIKWKLGY 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 215 YgtvyslSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15182 161 Y------YQQNLFFLIPLGIIVYCYVRILQTLMRTRT---------MRKHRTVKLIFVIVLVFFLSWAP 214
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
51-336 8.82e-19

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 85.17  E-value: 8.82e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWP 208
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKylKYRTKTRASLMISGAWLLSFLWVIPILGWHHFA-----RGGERVVLEDKCE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVygTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLhaFQ 288
Cdd:cd15050 156 TDFHDV--TWFKVLTAILNFYIPSLLMLWFYAKIFKAVN--------------RERKAAKQLGFIMAAFILCWIPY--FI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFhiIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15050 218 LFMVIAFCKNCCNENLHMFTIW--LGYINSTLNPFIYPLCNENFKKTF 263
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
59-336 1.09e-18

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 84.65  E-value: 1.09e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  59 SIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15330   9 TLILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDfeivACT-EKWPGeeksvy 215
Cdd:cd15330  89 LHLCAIALDRYWAITDPIDyvNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPD----ACTiSKDPG------ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 gtvYSLSTLLILYVLPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15330 159 ---YTIYSTFGAFYIPLILMLVLYGRIFK---------AAA-----RERKTVKTLGIIMGTFILCWLPFFIVALVLPFCE 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEykLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15330 222 STCHMPE--LLGAIINWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
60-336 1.10e-18

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 84.60  E-value: 1.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15323  10 LIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLE---SKISKQISFLIIGLaWGVSALLA-SPLAIFREYSLIEIIPDFEIvaCTEKWpgeeksvy 215
Cdd:cd15323  90 HLCAISLDRYWSVTQAVEynlKRTPRRVKAIIVTV-WLISAVISfPPLISMYRDPEGDVYPQCKL--NDETW-------- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 gtvYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15323 159 ---YILSSCIGSFFAPCLIMILVYIRIYRVAK-------------AREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICR 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEykLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15323 223 EACEVPE--PLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
60-335 1.16e-18

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 85.32  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLtYTLMG--EWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15131  10 LFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDL-YRLWQyrPWNFGDLLCKLFQFVSESCTYST 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVY 215
Cdd:cd15131  88 ILNITALSVERYFAICFPLRAKvvVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRSGLL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTllILYVLPLGIISFSYT----RIWSKLKNHVSPGAAsdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd15131 168 TIMVWVSS--VFFFLPVFCLTVLYSligrKLWRRRRENIGPNAS--HRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRYLF 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 292 DIDSHVLDLkEYKLI--------FTVFHIiamcSTFANPLLYGWMNSNYRKA 335
Cdd:cd15131 244 SKSFEAGSL-EIALIsqycnlvsFVLFYL----SAAINPILYNIMSKKYRVA 290
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
55-336 1.48e-18

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 85.21  E-value: 1.48e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLtYTLmgeWKMGPVL-----CHLVPYA 129
Cdd:cd15358   5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YEM---WSNYPFLlgaggCYFKTLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLIEI-----IPDFEIva 202
Cdd:cd15358  81 FETVCFASILNVTALSVERYIAVVHPLKAKyvVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQLTVpcrgpVPDSAT-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPgeeKSVYGTVYSLSTLLiLYVLPLGIISFSYTRIWSKLKNH-------VSPGAASDHYHQ--------RRHKTT 267
Cdd:cd15358 159 CMLVKP---RWMYNLIIQITTLL-FFFLPMGTISVLYLLIGLQLKREkmllvleAKGSKAGDSYQHrriqqekrRRRQVT 234
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 268 KMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDlkEYKLIFTVFHIIA----MCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15358 235 KMLFVLVVVFGICWAPFHTDRLMWSFISQWTG--ELHLAFQYVHIISgvffYLSSAANPVLYNLMSTRFREMF 305
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
51-336 1.61e-18

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 84.15  E-value: 1.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15324   1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRH----RCIVYHLEsKISKQISfLIIGLAWGVSALLASPLAIFREYSlieiipDFEIVACTEK 206
Cdd:cd15324  81 VLFCTSSIVHLCAISLDRYwsvtKAVSYNLK-RTPKRIK-RMIAVVWVISAVISFPPLLMTKHD------EWECLLNDET 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WpgeeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPL-- 284
Cdd:cd15324 153 W-----------YILSSCTVSFFAPGLIMILVYCKIYRVAK-------------MREKRFTFVLAVVMGVFVLCWFPFff 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 285 -HAFQLAVDIDSHVLDlkeykLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15324 209 tYSLHAVCRKRCGIPD-----ALFNLFFWIGYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
65-336 1.67e-18

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 84.52  E-value: 1.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  65 VVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVI 144
Cdd:cd15400  15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 145 ALDRHrCIVYH---LESKISKQISFLIIGLAWGVSAllaspLAIFREYSLIEIIPDFEIVACTekwpgeEKSVYGTVYSL 221
Cdd:cd15400  95 AINRY-CYICHsfaYDKLYSRWNTLLYVCLIWALTV-----VAIVPNFFVGSLEYDPRIYSCT------FVQTASSSYTI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 222 STLLILYVLPLGIISFSYTRIW-------SKLKNHVSPgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDID 294
Cdd:cd15400 163 AVVVIHFIVPITVVSFCYLRIWvlviqvrRKVKSESKP-----RLKPSDFRNFLTMFVVFVIFAICWAPLNLIGLAVAIN 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 13027422 295 SHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15400 238 PQEMAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
50-343 2.33e-18

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 84.23  E-value: 2.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  50 QVVLILAYCSII-LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15299   2 QVVLIAFLTGILaLVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFREYSL-IEIIPDFEivaCTE 205
Cdd:cd15299  82 IDYVASNASVMNLLVISFDRYFSITRPLtyRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVgKRTVPPDE---CFI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVyslstlLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPlh 285
Cdd:cd15299 159 QFLSEPIITFGTA------IAAFYLPVTIMTILYWRIYKETI--------------KEKKAAQTLSAILLAFIITWTP-- 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 286 aFQLAVDIDSHVLDLKEyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCE 343
Cdd:cd15299 217 -YNIMVLVNTFCDSCIP-KTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
51-336 2.35e-18

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 84.22  E-value: 2.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLvpyAQ 130
Cdd:cd15314   1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKI---HS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVST---ITLTVIALDRHR--CIVYHLESKISKQISFLIIGLAWGVSALLASPLaIFREYSLIEIipDFEIVACTE 205
Cdd:cd15314  78 SFDITLCTasiLNLCFISIDRYYavCQPLLYRSKITVRVVLVMILISWSVSALVGFGI-IFLELNIKGI--YYNHVACEG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVYSlstlLILYVLPLGIISFSYTRIWSKLKNHV--------SPGAASDhyhQRRHKTTKMLVCVVVVF 277
Cdd:cd15314 155 GCLVFFSKVSSVVGS----VFSFYIPAVIMLCIYLKIFLVAQRQArsiqsartKSGASSS---KMERKATKTLAIVMGVF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 278 AVSWLPlhaFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFaNPLLYGWMNSNYRKAF 336
Cdd:cd15314 228 LLCWTP---FFLCNIIDPFINYSIPPVLIEVLNWLGYSNSTL-NPFIYAFFYSWFRKAF 282
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-336 2.84e-18

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 84.12  E-value: 2.84e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLtYTLMGEWK--MGPVLCHLVPYAQGL 132
Cdd:cd15133   5 LTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLEL-YELWQNYPflLGSGGCYFKTFLFET 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLA----SPLAIFREYSLIEiipdfEIVACTEK 206
Cdd:cd15133  84 VCLASILNVTALSVERYIAVVHPLAARTcsTRPRVTRVLGCVWGVSMLCAlpntSLHGIKFLGSGVP-----ASAQCTVR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPgeeKSVYGTVYSLSTLLiLYVLPLGIISFSYTRIWSKLKNHVS------PGAASDHYHQ------RRHKTTKMLVCVV 274
Cdd:cd15133 159 KP---QAIYNMIPQHTGHL-FFVLPMAVISVLYLLMALRLARERGldatgaGSKIGTRTGQllqhprTRAQVTKMLFILV 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 275 VVFAVSWLPLHAFQLAVDIDSHVLDLkeYKLIFTVFHIIA----MCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15133 235 VVFAICWAPFHIDRLMWSFISDWTDN--LHEVFQYVHIISgvffYLSSAVNPILYNLMSTRFREMF 298
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
51-334 2.90e-18

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 83.67  E-value: 2.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVV-IKFKsmRTVTNFFIANLAVADLLVnTLCLPFTLTYTLM-GEWKMGPVLCHLVPY 128
Cdd:cd15115   1 ILSLVVLSLTFLLGVPGNGLVIWVAgLKMK--RTVNTIWFLNLAVADLLC-CLSLPFSIAHLLLnGHWPYGRFLCKLLPS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISF--LIIGLAWGVSALLASPLAIFREyslieIIPDFEIVACTEK 206
Cdd:cd15115  78 IIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLacLLCGCIWILALLLCLPVFIYRT-----TVTDGNHTRCGYD 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 wpgeeksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaaSDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15115 153 --------FLVAITITRAVFGFLLPLLIIAACYSFIAFRMQ--------RGRFAKSQSKTFRVIIAVVVAFFVCWAPYHI 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 287 FQLAVDIDSHvlDLKEYKLIFTVFHI-IAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15115 217 IGILSLYGDP--PLSKVLMSWDHLSIaLAYANSCLNPVLYVFMGKDFKK 263
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
51-335 3.69e-18

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 83.75  E-value: 3.69e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADlLVNTLCLPFTLTYTL-MGEWKMGPVLCHLVPYA 129
Cdd:cd15194   1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASD-FIFLVTLPLWVDKEVvLGPWRSGSFLCKGSSYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKw 207
Cdd:cd15194  80 ISVNMYCSVFLLTCMSLDRYLAIVLPLVSRKfrTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYE-----EKEYCNED- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 pgeEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15194 154 ---AGTPSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHHYQ---KSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 288 QLAVDIDShvLDLKEYKLIFTVFHI-------IAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15194 228 KALAIASG--LQVEVTCLPYTLAQLgmevsapLAFANSCANPFIYYFFDRYIRRA 280
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
53-335 5.21e-18

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 84.06  E-value: 5.21e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   53 LILAYCSIILLGVVGNSLVIHVVIKFKSmRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:PHA03087  43 LIVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLF-VMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  133 AVQVSTITLTVIALDRHRCIVYHLES-KI-SKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWPGE 210
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSnKInTVKYGYIVSLVIWIISIIETTPILFVYTTK-----KDHETLICCMFYNNK 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  211 EKsVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA 290
Cdd:PHA03087 196 TM-NWKLFINFEINIIGMLIPLTILLYCYSKILITLKGI--------NKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFV 266
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 13027422  291 VDIDS-HVLD----LKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:PHA03087 267 YSLHIlHFKSgckaVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKH 316
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
57-334 5.31e-18

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 83.34  E-value: 5.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVP--YAQGLAV 134
Cdd:cd15185   7 YSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLF-LFTLPFWIHYVRWNNWVFGHGMCKLLSgfYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIalDRHRCIVYHLESKISKQISFLIIG--LAWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWPGEEK 212
Cdd:cd15185  86 EIFFIILLTI--DRYLAIVHAVFALRARTVTFGIITsiITWGLAVLAALPEFIFYETQ-----ELFEEFLCSPLYPEDTE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVD 292
Cdd:cd15185 159 DSWKRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPS---------KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSA 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 293 IDSHVLDL-----KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15185 230 FQSIFFETdcersKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
51-336 5.50e-18

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 83.12  E-value: 5.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA-TSTLPFQSVNYLMGTWPFGNILCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCI---VYHLESKISKQISFLIIgLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKW 207
Cdd:cd15090  80 YYNMFTSIFTLCTMSVDRYIAVchpVKALDFRTPRNAKIVNV-CNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 pgeeksVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvSPGAASDHYHQRRH--KTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15090 159 ------YWENLLKICVFIFAFIMPVLIITVCYGLMILRLK---SVRMLSGSKEKDRNlrRITRMVLVVVAVFIVCWTPIH 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 286 AFQlavdIDSHVLDLKEYKLIFTVFHI-IAMCSTFA--NPLLYGWMNSNYRKAF 336
Cdd:cd15090 230 IYV----IIKALVTIPETTFQTVSWHFcIALGYTNSclNPVLYAFLDENFKRCF 279
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
58-242 1.65e-17

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 81.39  E-value: 1.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15054   8 CLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLieiipDFEIVACTEKWPGEEKSVY 215
Cdd:cd15054  88 ILNLCVISLDRYLLIISPLRYKlrMTPPRALALILAAWTLAALASFLPIELGWHEL-----GHERTLPNLTSGTVEGQCR 162
                       170       180       190
                ....*....|....*....|....*....|
gi 13027422 216 GTV---YSLSTLLILYVLPLGIISFSYTRI 242
Cdd:cd15054 163 LLVslpYALVASCLTFFLPSGAICFTYCRI 192
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
51-336 1.65e-17

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 82.06  E-value: 1.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15195   1 LVRVLVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASP-LAIFREYSLIEIIPDFeiVACTEKWPG 209
Cdd:cd15195  81 QFGMYLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPqSFIFSVLRKMPEQPGF--HQCVDFGSA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKN-----HVSPGAA----SDHYHQR-RHKTTKMLVCVVVVFAV 279
Cdd:cd15195 159 PTKKQE-RLYYFFTMILSFVIPLIITVTCYLLILFEISKmakraRDTPISNrrrsRTNSLERaRMRTLRMTALIVLTFIV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 280 SWLPLHAFQL--AVDIDSHVLDLKEYKLIFTVFhiiaMCS-TFANPLLYGWMNSNYRKAF 336
Cdd:cd15195 238 CWGPYYVLGLwyWFDKESIKNLPPALSHIMFLL----GYLnPCLHPIIYGVFMKEIRNWI 293
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
52-336 2.69e-17

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 80.77  E-value: 2.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGV-VGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd15328   1 VLVLTLLAMLVVATfLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRrWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLA-SPLAI--FREYSlieiiPDFEIVACT 204
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYtlRTRRRISNVMIALTWALSAVISlAPLLFgwGETYS-----EDSEECQVS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPGEEKSVYGTVYslstllilyvLPLGIISFSYTRIWSklknhvspgAAsdhyhQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15328 156 QEPSYTVFSTFGAFY----------LPLCVVLFVYWKIYK---------AA-----QKEKRAALMVGILIGVFVLCWIPF 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 285 HAFQLAVDIDSHVLDlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15328 212 FLTELISPLCSCDIP----PIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
58-336 2.98e-17

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 81.49  E-value: 2.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15977   8 CVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGIT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCI-----VYHLESKISKQISFLIIglaWGVSALLASPLAIfrEYSLIEI-IPDFEIVACTekWPGEE 211
Cdd:cd15977  88 VLSLCALSIDRYRAVaswsrIRGIGIPVWKAVEVTLI---WAVAIIVAVPEAI--AFDMVEIdYRGQTLLVCM--LPMEQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KSVYGTVYSLSTLLIL----YVLPLGIISFSYTRIWSKL---KNHVSPgAASDHYHQRRhKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15977 161 TSSFMRFYQDVKDWWLfgfyFCLPLACTGVFYTLMSCEMlsiKNGMRI-ALNDHMKQRR-EVAKTVFCLVVIFALCWLPL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 285 HAFQLAVDI-----DSHVLDLKEYKLIFTVFHI-IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15977 239 HLSRILKKTiydvkDPQRCELLSFLLVMDYTGInMASLNSCINPVALYFVSRKFKNCF 296
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
51-246 3.42e-17

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 80.86  E-value: 3.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILF-TLALPGRIAYYALGfDWPFGDWLCRLTALL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVY-HLESKISK-QISFLIIGLAWGVSALLASPLAIFreySLIEIIPDFeiVACTEkW 207
Cdd:cd15159  80 FYINTYAGVNFMTCLSVDRYIAVVHpLRRHRLRKvKVVRYICVFVWVLVFLQTLPLLFM---PMTKEMGGR--ITCME-Y 153
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL 246
Cdd:cd15159 154 PNFEKIKRLPLILLGACVIGFGVPVGIILFCYSQITLKL 192
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
51-242 4.16e-17

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 80.56  E-value: 4.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGeWKMGPVLCHLVPYAQ 130
Cdd:cd15181   1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLL-LLTFPFSVVESIAG-WVFGTFLCKLVGAIH 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES-KISKQISF-LIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWP 208
Cdd:cd15181  79 KLNFYCSSLLLACISVDRYLAIVHAIHSyRHRRLRSVhLTCGSIWLVCFLLSLPNLVFLE---VETSTNANRTSCSFHQY 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRI 242
Cdd:cd15181 156 GIHESNWWLTSRFLYHVVGFFLPLLIMGYCYATI 189
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
51-336 4.66e-17

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 80.01  E-value: 4.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSL-IEIIPDFEivaCTEKW 207
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTypVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVgGRTVPEGE---CYIQF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVyslstlLILYVLPLGIISFSYtriWsklknHVSPGAAsdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15297 158 FSNAAVTFGTA------IAAFYLPVIIMTVLY---W-----QISRASS------REKKVTRTILAILLAFIITWTPYNVM 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 288 QLAVDIDSHVLDlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15297 218 VLINTFCASCIP----NTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
60-334 4.85e-17

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 80.58  E-value: 4.85e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15381  10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLL-VCCLPFWAINISNGfNWPFGEFLCKSVNAVIYMNLYSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLE------SKISKQISFLIiglaWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWPGEEK 212
Cdd:cd15381  89 YFLMMVSIDRYLALVKTMSsgrmrrPACAKLNCLII----WMFGLLMSTPMIVFRT---VMYFPEYNITACVLDYPSEGW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYgtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLavd 292
Cdd:cd15381 162 HVA---LNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKEI---QTERKATVLVLAVLLMFFICWLPFHIFTF--- 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 293 IDS-HVLDLKEYKLIFTVFHIIAMCSTFA-------NPLLYGWMNSNYRK 334
Cdd:cd15381 233 LDTlHKLGLISGCRWEDILDIGTQIATFLaysnsclNPLLYVIVGKHFRK 282
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-285 4.90e-17

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 80.64  E-value: 4.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEW-----KMGPVLCHLVPYAQGL 132
Cdd:cd15128   8 CLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVYKLLAMDWpfgdqPFGQFLCKLVPFIQKA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIfrEYSLIEI-IPDFEIVACTEKWPG 209
Cdd:cd15128  88 SVGITVLNLCALSVDRYRAVAswSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAI--GFDMVRFnYKGVTLRTCLLRPET 165
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 210 EEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG---AASDHYHQRRhKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15128 166 SFMKFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMlriALNEHLKQRR-EVAKTVFCLVVIFALCWLPLH 243
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
51-335 5.80e-17

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 80.43  E-value: 5.80e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIK-FKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRnRRRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVESHPCVTWFSQCVTFNFFPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEksvYGTVYSLSTLLILYVLPLGIISFSYTRIW------SKLKNHVSPGAAS---------DHYHQRRHKTTKMLVCVV 274
Cdd:cd15382 161 HD---HELAYNIFNMITMYALPLIIIVFCYSLILceisrkSKEKKEDVSEKSSsvrlrrssvGLLERARSRTLKMTIVIV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 275 VVFAVSWLPLHAFQLAVDIDSHV---LDLKEYKLIFtvfhIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15382 238 LVFIICWTPYFIMSLWYWFDRESaskVDPRIQKGLF----LFAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
51-336 6.04e-17

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 79.58  E-value: 6.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYcsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15335   3 IVLTLAL--ITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDTWTLGYFICEIWLSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIvactekwp 208
Cdd:cd15335  81 MTCCTCSILHLCVIALDRYWAITDAIEyaRKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCII-------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 gEEKSVYGTVYslSTLLILYVlPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15335 153 -QHDHVIYTIY--STFGAFYI-PLTLILILYYRIYH---------AAS-----RERKAARILGLILGAFILSWLPFFIKE 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHIiamcSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15335 215 LIVGLSVMTVSPEVADFLTWLGYV----NSLVNPLLYTSFNEDFKLAF 258
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
49-336 6.15e-17

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 79.87  E-value: 6.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAYCSiiLLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15301   1 VLIVIVAAVLS--LVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRH----RCIVYHLESKISKQIsfLIIGLAWGVSALLASPLAIFREYslIEIIPDFEIVACT 204
Cdd:cd15301  79 IDYLASNASVLNLLIISFDRYfsvtRPLTYRARRTTKKAA--VMIASAWIISLLLWPPWIYSWPY--IEGKRTVPAGTCY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPgeEKSVYGTvysLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdhyHQRRH--KTTKMLVCVVVVFAVSWL 282
Cdd:cd15301 155 IQFL--ETNPYVT---FGTALAAFYVPVTIMCILYWRIWRETKK-----------RQKKQesKAAKTLSAILLAFIVTWT 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 283 PLHAFQLAVDIDSHVLDLKEYklIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15301 219 PYNVLVLIKAFFPCSDTIPTE--LWDFSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
59-334 9.64e-17

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 79.82  E-value: 9.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  59 SIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADlLVNTLCLPF-TLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15189   9 SLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAAD-LVFVSGLPFwAMNILNQFNWPFGELLCRVVNGVIKVNLYTS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESKISKQISF--LIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWPGEeksvy 215
Cdd:cd15189  88 IYLLVMISQDRYLALVKTMAARRLRRRRYakLICVLIWVVGLLLSIPTFLLRK---IKAIPDLNITACVLLYPHE----- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 gtVYSLSTLLIL----YVLPLGIISFSYTRIWSKLKNHVSPGAASDhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQ-LA 290
Cdd:cd15189 160 --AWHFAHIVLLnivgFLLPLLVITFCNYNILQALRTREESTRCED---RNDSKATALVLAVTLLFLVCWGPYHFFTfLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 291 VDIDSHVLDLKEYKLIFTVFHIIAMCSTFA----NPLLYGWMNSNYRK 334
Cdd:cd15189 235 FLFDVGVLDECFWEHFIDIGLQLAVFLAFSnsclNPVLYVFVGRYFRR 282
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
53-336 1.10e-16

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 79.28  E-value: 1.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQG 131
Cdd:cd15168   3 LPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLY-LLSLPFLIYYYANGDhWIFGDFMCKLVRFLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKWPG 209
Cdd:cd15168  82 FNLYGSILFLTCISVHRYLGICHPLRSlgKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKN-----NRTTCYDTTSP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQl 289
Cdd:cd15168 157 EELNDY-VIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVTS----ALRRKSIRLVIIVLALFAVCFLPFHVTR- 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 290 AVDIDSHVLDLKEYK---LIFTVFHII----AMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15168 231 TINLAARLLSGTASCatlNGIYVAYKVtrplASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
55-336 1.53e-16

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 78.47  E-value: 1.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15310   5 LSYCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTgGVWNFSRICCDVFVTLDVMM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVY-----HLESKISKQISFLIIGLAWGVSALLASPLaifreysLIEIIPDFEIVACtekwp 208
Cdd:cd15310  85 CTASILNLCAISIDRYTAVVMpvhyqHGTGQSSCRRVSLMITAVWVLAFAVSCPL-------LFGFNTTGDPTVC----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 geekSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLknhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPlhaFQ 288
Cdd:cd15310 153 ----SISNPDFVIYSSVVSFYLPFGVTLLVYVRIYVVL--------------LREKKATQMLAIVLGAFIVCWLP---FF 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15310 212 LTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
51-325 1.64e-16

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 78.71  E-value: 1.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYcsiiLLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15121   5 AILSLAF----ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAV-LLTAPFFLHFLSGGGWEFGSVVCKLCHYVC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFReysliEIIPDF-EIVACTEKW 207
Cdd:cd15121  80 GVSMYASIFLITLMSMDRCLAVAKPFLSQKmrTKRSVRALLLAIWIVAFLLSLPMPFYR-----TVLKKNiNMKLCIPYH 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSlstLLILYVLPLGIISFSYTRIWSKLKnhvspgaasDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15121 155 PSVGHEAFQYLFE---TITGFLLPFTAIVTCYSTIGRRLR---------SARFRRKRRTNRLVVLIIATFALFWLPYHVV 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 288 QLA------VDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLY 325
Cdd:cd15121 223 NLIqvagalQNQAGNASVLKAAKLARPNVTALAFLSSSVNPVLY 266
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
51-336 1.75e-16

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 78.93  E-value: 1.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15312   1 VAMYLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLaIFREYSLIEiIPDFEI-VACTEKW 207
Cdd:cd15312  81 MMLSTTSIFHLCFIAVDRYYAVCDplHYRTKITTPVIKVFLVISWSVPCLFAFGV-VFSEVNLEG-IEDYVAlVSCTGSC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVLPLGIIS--FSYTRIWSKLKNHVSPGAASDHYHQ----RRHKTTKMLVCVVVVFAVSW 281
Cdd:cd15312 159 VLIFNKLWGVIASLIAFFIPGTVMIGIYIkiFFVARKHAKVINNRPSVTKGDSKNKlskkKERKAAKTLSIVMGVFLLCW 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 282 LPlhaFQLAVDIDSHvLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15312 239 LP---FFVATLIDPF-LNFSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
51-336 1.90e-16

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 78.84  E-value: 1.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTlmgewkMGP---------V 121
Cdd:cd14968   1 AVYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILIS------LGLptnfhgclfM 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 122 LCHLVpyaqgLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLA----------SPLAIFREY 189
Cdd:cd14968  75 ACLVL-----VLTQSSIFSLLAIAIDRYLAIKIPLRYKSlvTGRRAWGAIAVCWVLSFLVGltpmfgwnngAPLESGCGE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 190 SLI-----EIIPD-----FEIVACTekwpgeeksvygtvysLSTLLILYVLPLGIisfsYTRIWSKLKNHVSPGAASD-- 257
Cdd:cd14968 150 GGIqclfeEVIPMdymvyFNFFACV----------------LVPLLIMLVIYLRI----FRVIRKQLRQIESLLRSRRsr 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 258 HYHQRRHKTTKMLVCVVVVFAVSWLPLHAfqlavdIDSHVLDLKEYKLIFTVFHIIAMCSTF---ANPLLYGWMNSNYRK 334
Cdd:cd14968 210 STLQKEVKAAKSLAIILFLFALCWLPLHI------INCITLFCPECKVPKILTYIAILLSHAnsaVNPIVYAYRIRKFRQ 283

                ..
gi 13027422 335 AF 336
Cdd:cd14968 284 TF 285
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
58-342 1.98e-16

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 78.75  E-value: 1.98e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15084  18 GMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVG 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHL-ESKISKQISFLIIGLAWGVSALLAS-PLAIFREYslieiIPDFEIVACTEKWpgEEKSVY 215
Cdd:cd15084  98 LWSLAILAFERYLVICKPMgDFRFQQRHAVSGCAFTWGWSLLWTSpPLFGWSSY-----VPEGLRTSCGPNW--YTGGTN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15084 171 NNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETTQRAEKEVTRMVIAMVMAFLICWLPYATFAMVVATNK 250
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 296 HVLDLKEYKLIFTVFHIIAmcsTFANPLLYGWMNSNYRKAFLSAFRC 342
Cdd:cd15084 251 DVVIQPTLASLPSYFSKTA---TVYNPIIYVFMNKQFRSCLLELLCC 294
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
51-336 2.25e-16

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 78.64  E-value: 2.25e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHR--CIVYHLESKISKQISFLIIGLAWGVSALLASPLaIFREYSLIEIIPDFEIVACTekwp 208
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYavCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGL-IYTGANDEGLEEYSSEISCV---- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVlPLGIISFSYTRIWS-------KLKNHVSPGAASDHYH-----QRRHKTTKMLVCVVVV 276
Cdd:cd15317 156 GGCQLLFNKIWVLLDFLTFFI-PCLIMIGLYAKIFLvarrqarKIQNMEDKFRSSEENSskasaSRERKAAKTLAIVMGI 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 277 FAVSWLPLHafqlavdIDSHVLDLKEYKLIFTVFHIIAMCSTF---ANPLLYGWMNSNYRKAF 336
Cdd:cd15317 235 FLFCWLPYF-------IDTIVDEYSNFITPAIVFDAVIWLGYFnsaFNPFIYAFFYPWFRKAF 290
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
60-336 2.80e-16

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 78.85  E-value: 2.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRT-VTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGpVLCHLVPYAQGLAVQVST 138
Cdd:cd15319  10 LILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFG-AFCDVWVAFDIMCSTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLA-SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSVY 215
Cdd:cd15319  89 LNLCVISVDRYWAISspFRYERKMTQRVALVMISVAWTLSVLISfIPVQLNWHKDSGDDWVGLHNSSISRQVEENCDSSL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWS----KLKNHVSPGAASDH-----------YHQ--------RRHKTTKMLVC 272
Cdd:cd15319 169 NRTYAISSSLISFYIPVAIMIVTYTRIYRiaqiQIRRISSLERAAEHaqscrsnridcHHHtslrtsikKETKVLKTLSV 248
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 273 VVVVFAVSWLPLHAFQLAVDI-DSHVLDLKE-----YKLIFTVFHIIAMCSTFANPLLYGWmNSNYRKAF 336
Cdd:cd15319 249 IMGVFVCCWLPFFILNCMVPFcDRPPADPDAglpcvSETTFDVFVWFGWANSSLNPIIYAF-NADFRKVF 317
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
61-284 3.00e-16

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 78.41  E-value: 3.00e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15959  11 ILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIET 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLaSPLAIFREYslIEIIPDFEIVACTEKwPGEEKSVYGTV 218
Cdd:cd15959  91 LCAIAVDRYLAITNPLryEALVTKRRARTAVCLVWAISAAI-SFLPIMNQW--WRDGADEEAQRCYDN-PRCCDFVTNMP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIWSKLKNHV--------------SPGAASDHYHQRR---------HKTTKMLVCVVV 275
Cdd:cd15959 167 YAIVSSTVSFYVPLLVMIFVYVRVFVVATRQVrlirkdkvrfppeeSPPAESRPACGRRpsrllaikeHKALKTLGIIMG 246

                ....*....
gi 13027422 276 VFAVSWLPL 284
Cdd:cd15959 247 TFTLCWLPF 255
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
49-336 3.09e-16

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 77.91  E-value: 3.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15333   3 LKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGTWTLGQVVCDIWLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPdfEIVACTEK 206
Cdd:cd15333  83 SDITCCTASILHLCVIALDRYWAITDAVEysKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVS--ECVVNTDH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYGTVYSLSTLLILYvlplgiisfsYTRIWSKLKnhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15333 161 ILYTVYSTVGAFYIPTLLLIAL----------YGRIYVEAR-------------ARERKATKTLGIILGAFIVCWLPFFI 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 FQLAVDI--DSHVLDLkeykLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15333 218 ISLVLPIckDACWFHL----AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
54-326 4.95e-16

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 77.86  E-value: 4.95e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLA 133
Cdd:cd15384   4 IVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEivAC------TEKW 207
Cdd:cd15384  84 LYLSTYITVLISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPFVEDFH--QCvtygfyTAEW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEeksvygtVYSLSTLLILYVLPLGIISFSYTRIWSKLKN-----HVSPGAASDHYHQRRH-------KTTKMLVCVVV 275
Cdd:cd15384 162 QEQ-------LYNMLSLVFMFPIPLVIMVTCYVLIFITLSKssrdfQGLEIYTRNRGPNRQRlfhkakvKSLRMSAVIVT 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 276 VFAVSWLP------LHAFQLAVDIDShvldlkeykLIFTVFHIIAMCSTFANPLLYG 326
Cdd:cd15384 235 AFILCWTPyyvimiWFLFFNPYPLND---------ILFDVIFFFGMSNSCVNPLIYG 282
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
57-335 4.97e-16

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 77.48  E-value: 4.97e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVntLC-LPFTLTYTLMGeWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15174   7 YWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF--LCtLPFWATAASSG-WVFGTFLCKVVNSMYKINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKISKQ----ISFLIIGLAWGVSALLASPLAIFReysliEIIPDFEIVACTEKWPGEE 211
Cdd:cd15174  84 SCMLLLTCISVDRYIAIVQATKAHNSKNkrllYSKLVCFFVWLLSTILSLPEILFS-----QSKEEESVTTCTMVYPSNE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd15174 159 SNRFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKR---------FQKHKALKVIIAVVTVFVLSQLPYNSILLIK 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 292 DIDSHVLD------LKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15174 230 TINAYNITitdcatSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKD 279
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
51-334 5.26e-16

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 77.50  E-value: 5.26e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMgEWKMGPVLCHLVPYAQ 130
Cdd:cd15179   1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLF-VLTLPFWAVDAAA-NWYFGNFLCKAVHVIY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQI--SFLIIGLAWGVSALLASPLAIFreySLIEIIPDFEIvaCTEKWP 208
Cdd:cd15179  79 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLlaEKVVYVGVWLPALLLTVPDLVF---AKVSELDDRYI--CDRIYP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLknhvspgaASDHYHQRRhKTTKMLVCVVVVFAVSWLPlhaFQ 288
Cdd:cd15179 154 EDTFELWVVAFRFQHILVGLVLPGLVILTCYCIIISKL--------SHSKGHQKR-KALKTTVILILAFFACWLP---YY 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 289 LAVDIDSHV-LDLKEYKLIFTVFHIIAMCSTFA--------NPLLYGWMNSNYRK 334
Cdd:cd15179 222 IGISIDTFMlLEIIKQSCEMEQTVHKWISITEAlaffhcclNPILYAFLGAKFKT 276
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
49-334 7.70e-16

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 77.10  E-value: 7.70e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAYcsiiLLGVVGNSLVIHV-VIKFKSMRTVTNFFIaNLAVADLLVNTlCLPFTLTYTLMGE-WKMGPVLCHLV 126
Cdd:cd14991   3 LPPLLILEF----VLGLPGNVVALWIfCFHSRTWKANTVYLF-NLVLADFLLLI-CLPFRIDYYLRGEhWIFGEAWCRVN 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 127 PYAQGLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACT 204
Cdd:cd14991  77 LFMLSVNRSASIAFLTAVALDRYFKVVHphHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNS-----NKSSCH 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 EKWPGEEKSVYGTVYSlSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAasdhyHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd14991 152 SFSSYTKPSLSIRWHN-ALFLLEFFLPLGLIVFCSVRIACNLRIRQSLGK-----QARVQRAIRLVFLVVIVFVLCFLPS 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 285 HAFQLAVDIDSHVLDLKEYKLIFTVFHiIAMCSTFAN----PLLYGWMNSNYRK 334
Cdd:cd14991 226 IIAGLLALVFKNLGSCRCLNSVAQLFH-ISLAFTYLNsaldPVIYCFSSPWFRN 278
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
57-336 9.06e-16

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 76.70  E-value: 9.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIkFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15117   7 YSSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAF-CLFLPFSVVYTALGFhWPFGWFLCKLYSTLVVFNLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFRE--------YSLIEIIPDFEIVACTE 205
Cdd:cd15117  85 ASVFLLTLISLDRCVSVLWPVwaRNHRTPARAALVAVGAWLLALALSGPHLVFRDtrkengctHCYLNFDPWNETAEDPV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspGAAsdhyHQRRHKttKMLVCVVVVFAVSWLPLH 285
Cdd:cd15117 165 LWLETVVQRL-SAQVITRFVLGFLVPLVIIGGCYGLIAARLWRE---GWV----HSSRPF--RVLTAVVAAFFLCWFPFH 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 286 AFQLAvdidsHVLDLKEYKLIFTVFHIIAMCSTFA--------NPLLYGWMNSNYRKAF 336
Cdd:cd15117 235 LVSLL-----ELVVILNQKEDLNPLLILLLPLSSSlacvnsclNPLLYVFVGRDFRERL 288
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
51-202 9.87e-16

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 76.37  E-value: 9.87e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVGGFCIPLYIPYVLTGRWKFGRGLCKLWLVVD 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 131 GLAVQVSTITLTVIALDRH----RCIVYHLESKISKQiSFLIIGLAWGVSALLASPLAIFREY-SLIEIIPDFEIVA 202
Cdd:cd15296  81 YLLCTASVFNIVLISYDRFlsvtRAVSYRAQKGMTRQ-AVLKMVLVWVLAFLLYGPAIISWEYiAGGSIIPEGECYA 156
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
51-335 1.21e-15

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 76.44  E-value: 1.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15318   1 LVIYLACAIGMLIIVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFR--EYSLIEIIPDFEIVactek 206
Cdd:cd15318  81 TLFCLTSIFHLCFISIDRHCAICDPLlyPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKavEEGLAELLTSVPCV----- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 wpGEEKSVYGTVYSLSTLLILYVLPLGIISFsYTRIWSKLKNHVSPGAASDHYH----QRRHKTTKMLVCVVVVFAVSWL 282
Cdd:cd15318 156 --GSCQLLYNKLWGWLNFPVFFIPCLIMIGL-YVKIFIVAKRQARAIASLLSDTngasKRERKAAKTLGIAVGVYLLCWL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 283 PlhaFQLAVDIDShVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15318 233 P---FTIDTMVDS-LLNFITPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
56-336 2.02e-15

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 75.62  E-value: 2.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  56 AYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd15921   6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLL-VCTLPLRLTYYVLnSHWPFGDIACRIILYVLYVNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEkwPGEEK 212
Cdd:cd15921  85 YSSIYFLTALSVFRYLALVwpYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQ-----HDEGSTRCLE--LAHDA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYGTVYSLSTLLILYVLPLGIISFSYTRIwskLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVD 292
Cdd:cd15921 158 VDKLLLINYVTLPVGFVVPFMTVIFCYIFI---IKNLLKPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 293 IDSHVLDLK-EYKLIFTVFHIIAMCSTFAN----PLLYGWMNSNYRKAF 336
Cdd:cd15921 235 ITERQIKEScGYILRVRKAAVITLCLAASNscfdPLLYFFVGENFRSRL 283
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
53-333 2.02e-15

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 75.58  E-value: 2.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIilLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15075   5 IIMAVFSI--ASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEGFAVAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASP-LAIFREYSLIEIIpdfeiVACTEKWPGE 210
Cdd:cd15075  83 FGIAALCTVAVIAVDRLFVVCKPLGTlTFQTRHALAGIASSWLWSLIWNTPpLFGWGSYQLEGVM-----TSCAPDWYSR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKsvYGTVYSLSTLLILYVLPLGIISFSYTRI----WSKLKNHVSPGAASDHYhqrRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15075 158 DP--VNVSYILCYFSFCFAIPFAIILVSYGYLlwtlRQVAKLGVAEGGSTAKA---EVQVARMVVVMVMAFLLCWLPYAA 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 287 FQLAVDIDShvlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15075 233 FALTVVSKP---DVYINPLIATVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
51-188 2.61e-15

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 75.55  E-value: 2.61e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVViKFKSMRTVTNFFIANLAVADLlVNTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15119   1 IVSIVIYIVAFVLGVPGNAIVIWVT-GFKWKKTVNTLWFLNLAIADF-VFVLFLPLHITYVALDfHWPFGVWLCKINSFV 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVY-HLESKI-SKQISFLIIGLAWGVSALLASPLAIFRE 188
Cdd:cd15119  79 AVLNMFASVLFLTVISLDRYISLAHpVWSHRYrTLKSALILCGIVWLSAAAISGPALYFRD 139
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
62-336 3.62e-15

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 74.68  E-value: 3.62e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIhvvIKFK---SMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15300  12 LITIVGNVLVM---ISFKvnsQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIE-IIPDFEivaCTEKWPGEEKSVY 215
Cdd:cd15300  89 MNLLVISFDRYFSITRPLtyRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKrTVPERE---CQIQFLSEPTITF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVyslstlLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15300 166 GTA------IAAFYIPVSVMTILYCRIYKETI--------------KERKAAQTLSAILLAFIITWTPYNIMVLVSTFCS 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEYKLIFTVFHIiamcSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15300 226 DCIPLTLWHLGYWLCYV----NSTVNPMCYALCNKTFRKTF 262
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
60-336 3.85e-15

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 75.36  E-value: 3.85e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKfKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMgewkMGPVLCHLVPYAQ--------G 131
Cdd:cd14978  10 ICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIA----DYSSSFLSYFYAYflpyiyplA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTV-IALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKWP 208
Cdd:cd14978  85 NTFQTASVWLTVaLTVERYIAVCHplKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISF-------SYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSW 281
Cdd:cd14978 165 RQNETYLLKYYFWLYAIFVVLLPFILLLIlnillirALRKSKKRRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICN 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 282 LPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14978 245 LPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
57-334 4.40e-15

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 74.91  E-value: 4.40e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVP--YAQGLAV 134
Cdd:cd15183   7 YSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVF-LFTLPFWIDYKLKDDWIFGDAMCKFLSgfYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIalDRHRCIVYHLESKISKQISFLIIG--LAWGVSALLASPLAIFREYSLieiipDFEIVACTEKWPGEEK 212
Cdd:cd15183  86 EIFFIILLTI--DRYLAIVHAVFALRARTVTFGIITsiITWALAILASMPCLYFFKSQW-----EFTHHTCSAHFPRKSL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLknHVSPgaasdhyHQRRHKTTKMLVCVVVVFAVSWLP------LHA 286
Cdd:cd15183 159 IRWKRFQALKLNLLGLILPLLVMIICYTGIINIL--LRRP-------NEKKAKAVRLIFVITLLFFLLWTPynlaafVSA 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 287 FQlAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15183 230 FQ-DVLFTPSCEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
60-334 5.82e-15

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 74.17  E-value: 5.82e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNT-LCLPFTLTYTLMGE-------WKMGPvLCHLVPYAQG 131
Cdd:cd15136  10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIyLGLLAIVDAKTLGEyynyaidWQTGA-GCKTAGFLAV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLAS-PLAIFREYSLIEIIPDFEIvactekwp 208
Cdd:cd15136  89 FSSELSVFTLTVITLERWYAITHamHLNKRLSLRQAAIIMLGGWIFALIMALlPLVGVSSYSKTSICLPFET-------- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 geeKSVYGTVYsLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDhyhqrrHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15136 161 ---ETPVSKAY-VIFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSND------TRIAKRMALLVFTDFLCWAPIAFFG 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 289 LAVDIDSHVLDLKEYKlIFTVFhiIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15136 231 LTAAFGLPLISVSNAK-ILLVF--FYPLNSCANPFLYAIFTKQFRR 273
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
51-336 7.26e-15

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 74.16  E-value: 7.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVT-NFFIANLAVADLLVnTLCLPF-TLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKKSSiNLFVTSLAVTDFQF-VLTLPFwAVENALDFTWLFGKAMCKIVSY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESK------ISKQISFLIiglaWGVSALLASPLAIFREYSLIeiipdFEIVA 202
Cdd:cd15926  80 VTAMNMYASVFFLTAMSVARYHSVASALKSKrrrgccSAKWLCVLI----WVLAILASLPNAIFSTTATV-----SNEEL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPGE--EKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdhyhQRRHKTTKMLVCVVVVFAVS 280
Cdd:cd15926 151 CLVKFPDNrgNAQFWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFITDKNITGSST----KRRSKVTKSVTIVVLSFFLC 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027422 281 WLPLHAFQL-AVDIDSHVLDLK-EYKL----IFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15926 227 WLPNQALTTwGILIKLNVVHFSyEYFTtqvyIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
53-334 9.93e-15

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 73.68  E-value: 9.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15187   3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLF-VFSLPF-QAYYLLDQWVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLAS-PLAIFREYSLIEiipdfEIVACTEKWPGE 210
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYAlKVRTASHGTILSLALWLVAILASvPLLVFYQVASED-----GRLQCIPFYPGQ 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSvyGTVYSLSTLLIL-YVLPLGIISFSYTRIWSKLKNhvspgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQL 289
Cdd:cd15187 156 GNS--WKVFTNFEVNILgLLIPFSILIFCYHNILRNLRR---------CHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLF 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 290 AVDIDS-HVLD----LKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15187 225 LDSLHSlHIIDgcqnSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
51-325 1.13e-14

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 73.68  E-value: 1.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVViKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd15118   1 VATICLHGIVSTLGIVENLLILWVV-GFRLRRTVISIWILNLALSDLLA-TLSLPFFTYYLASGHtWELGTTFCRIHSSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFL--IIGLAWGVSALLASPLAIFRE--------------YSLIE 193
Cdd:cd15118  79 FFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAkkICGVIWAMALINTIPYFVFRDvierkdgrklcyynFALFS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 194 IIPDFEIVACTEKWPGeeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdHYHQRRH-KTTKMLVC 272
Cdd:cd15118 159 PSPDNNHPICKQRQEG---------LAISKLLLAFLIPLVIIAVSYAVVSLIIR----------HRCRRRPgRFVRLVVS 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 273 VVVVFAVSWLPLHAF---QLAVDIDSHVLDLKEYKLIFTVfhIIAMCSTFANPLLY 325
Cdd:cd15118 220 VVVSFALCWAPYHIFsiiEVMAHNQHSLRPLVIQGLPFAT--TLAFLNSVLNPVLY 273
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
51-336 1.31e-14

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 73.27  E-value: 1.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVntLC-LPFtLTYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLF--LCtLPF-WAYSAAHEWIFGTVMCKITNGL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISF--LIIGLAWGVSALLASPLAIFREYSlieiipDFEIVACTE 205
Cdd:cd15173  78 YTINLYSSMLILTCITVDRFIVIVQATKAHNchAKKMRWgkVVCTLVWVISLLLSLPQFIYSEVR------NLSSKICSM 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVygtVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15173 152 VYPPDAIEV---VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKG---------FQKHKSLKIIFVVVAVFILTQLPYN 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 286 AFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15173 220 IMKLIRTLHIENTDSTNFKYAILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
59-182 1.33e-14

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 73.16  E-value: 1.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  59 SIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15331   9 LLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVAVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASI 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 139 ITLTVIALDRH---RCIVYhLESKISKQIsFLIIGLAWGVSALLASP 182
Cdd:cd15331  89 LHLVAIALDRYwavTNIDY-IRRRTAKRI-LIMIAVVWFVSLIISIA 133
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
51-336 1.79e-14

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 72.67  E-value: 1.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15334   1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSLIE----IIPDFEIVAct 204
Cdd:cd15334  81 ITCCTCSILHLSAIALDRYRAITDAVEyaRKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRedecIIKHDHIVF-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 ekwpgeeksvygTVYslSTLLILYVlPLGIISFSYTRIWSklknhvspgAASdhyhqRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15334 159 ------------TIY--STFGAFYI-PLALILILYYKIYR---------AAT-----RERKAATTLGLILGAFVICWLPF 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 285 HAFQLAVDIDSHVLDLKEYKLIFTVFHIIamcSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15334 210 FVKEVIVNTCDSCYISEEMSNFLTWLGYI---NSLINPLIYTIFNEDFKKAF 258
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
60-333 2.26e-14

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 72.55  E-value: 2.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEW-KMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15077  10 LVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIV-VCFGSTTAFYSFSQMYfVLGPLACKIEGFTATLGGMVSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLeSKISKQISFLIIG--LAWgVSALLAS--PLAIFREYslieiIPDFEIVACTEKWPGEEKSV 214
Cdd:cd15077  89 WSLAVVAFERFLVICKPL-GNFTFRGTHAIIGciATW-VFGLAASlpPLFGWSRY-----IPEGLQCSCGPDWYTTNNKW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQL-AVDI 293
Cdd:cd15077 162 NNESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALwVVTN 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 13027422 294 DSHVLDLKeyklIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15077 242 RGEPFDLR----LASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
58-334 2.86e-14

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 72.54  E-value: 2.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIillGVVGNSLVIHVVIKFKSmRTVTNFFIANLAVADLlVNTLCLPFTL-TYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15339  11 CST---GLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADL-VHIIVMPFLIhQWARGGEWVFGSPLCTIITSLDTCNQFA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEIIPDfEIVACTEKWPGEEKSV 214
Cdd:cd15339  86 CSAIMTAMSLDRYIALVhpFRLTSLRTRSKTIRINLLVWAASFILVLPVWV---YAKVIKFRD-GLESCAFNLTSPDDVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLlilYVLPLGIISFSYTRI----WSKLKNHVSPGAASDHY-HQRRHKTTKMLVCVVVVFAVSWLPLHAFQL 289
Cdd:cd15339 162 WYTLYQTITT---FFFPLPLILICYILIlcytWEMYRKNKKAGRYNTSIpRQRVMRLTKMVLVLVGVFLVSAAPYHVIQL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 290 aVDIDSHvldlkEYKLIFTVFHIIAMCSTFA----NPLLYGWMNSNYRK 334
Cdd:cd15339 239 -VNLSVS-----QPTLAFYVSYYLSICLSYAsssiNPFLYILLSGNFRK 281
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
59-325 3.10e-14

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 72.52  E-value: 3.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  59 SIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADlLVNTLCLPF-TLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd15380   9 AICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASD-LVFVLGLPFwAENIRNQFNWPFGNFLCRVISGVIKANLFIS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVACTEKWPGEeksVY 215
Cdd:cd15380  88 IFLVVAISQDRYRTLVHTMTSRRqrSRRQAQVICLLIWVFGGLLSIPTFLFRS---VKHVPDLNISACILLFPHE---AW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHyHQRRHKTTKMLVCVVVVFAVSWLPLHA-------FQ 288
Cdd:cd15380 162 HFARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCG-GLKDTKATRLILTLVLMFLVCWTPYHFfafldflFQ 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFhiIAMCSTFANPLLY 325
Cdd:cd15380 241 VEVIQGCFWEEFIDLGLQLANF--FAFANSCLNPVIY 275
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
51-336 3.67e-14

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 72.05  E-value: 3.67e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVViKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLM-GEWKMGPVLCHLVPYA 129
Cdd:cd15114   1 VVALVLYAVVFLVGVPGNALVAWVT-GFEAKRSVNAVWFLNLAVADLLC-CLSLPILAVPIAQdGHWPFGAAACKLLPSL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRH-------RCivyhlESKISKQISFLIIGLAWGVSALLASPLAIFREYsLIEIIPdfEIVA 202
Cdd:cd15114  79 ILLNMYASVLLLTAISADRCllvlrpvWC-----QNHRRARLAWIACGAAWLLALLLTVPSFIYRRI-HQEHFP--EKTV 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPGEEksvyGTVYSLST--LLILYVLPLGIISFSYTriwsKLKNHVSPGAAsdhyhQRRHKTTKMLVCVVVVFAVS 280
Cdd:cd15114 151 CVVDYGGST----GVEWAVAIirFLLGFLGPLVVIASCHG----VLLVRTWSRRR-----QKSRRTLKVVTAVVVGFFLC 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 281 WLPLHAFQLAVDI-DSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15114 218 WTPYHVVGLIIAAsAPNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
57-333 4.08e-14

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 71.70  E-value: 4.08e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGeWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15176   7 YTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFWAADAVNG-WVLGTAMCKITSALYTMNFSC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKWPGE-EKSVY 215
Cdd:cd15176  85 GMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENS-----DRYRCLPVFPPSlVTSAK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLIlYVLPLGIISFSYTRIWSKLKNhvSPGAasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15176 160 ATIQILEVLLG-FVLPFLVMVFCYSRVARALSR--TPNV-------KKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDV 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 296 HVLDL------KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15176 230 IYLLItdcsmsKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
51-325 4.66e-14

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 71.74  E-value: 4.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYcsiiLLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd14975   5 TLLSLAF----AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAV-LLTLPVWIYFLATGTWDFGLAACKGCVYVC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREyslIEIIPDFEIvaCTEKWP 208
Cdd:cd14975  80 AVSMYASVFLITLMSLERFLAVSRPFVSQGwrAKALAHKVLAIIWLLAVLLATPVIAFRH---VEETVENGM--CKYRHY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVygtVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspgaasdhYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd14975 155 SDGQLV---FHLLLETVVGFAVPFTAVVLCYSCLLRRLRRR---------RFRRRRRTGRLIASVVVAFAACWLPYHVGN 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 289 L-----AVDIDSHVLDL--KEYKLIFTVFHIIAMCSTFANPLLY 325
Cdd:cd14975 223 LlevvsELIGGSKMAGTlgKVAEAGRPIAGALAFLSSSINPLLY 266
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
60-336 4.90e-14

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 71.69  E-value: 4.90e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15086  10 ILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESKISK-QISFLIIGLAWGVSALLAS-PLAIFREYSlieiiPDFEIVACTEKWpgEEKSVYGT 217
Cdd:cd15086  90 SLAVLSYERYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLpPLLGWSSYG-----PEGPGTTCSVQW--TSRSANSI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 218 VYSLSTLLILYVLPLGIISFSYTRIWSKLKnHVSpGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHV 297
Cdd:cd15086 163 SYIICLFIFCLLLPFLVMVYCYGRLLYAIK-QVG-KINKSTARKREQHVLLMVVTMVICYLLCWLPYGVMALLATFGKPG 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13027422 298 LDLKEYKLIFTvfhIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15086 241 LVTPVASIVPS---ILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
51-336 5.81e-14

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 71.35  E-value: 5.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVvIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15120   1 VLIAVALFVTFLVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIF-TLILPFMAVHVLMDnHWAFGTVLCKVLNST 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISF--LIIGLAWGVSALLASPLAIFREYSLIE----IIPDFEIVAc 203
Cdd:cd15120  79 LSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWasAIVLGVWISAILLSIPYLAFRETRLDEkgktICQNNYALS- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 tEKWPGEEKSVYGT----VYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasDHYHQRRHKTTKMLVCVVVVFAV 279
Cdd:cd15120 158 -TNWESAEVQASRQwihvAMFVFRFLLGFLLPFLIITFCYVRMALKMK---------ERGLARSSKPFKVMFTAVVSFFV 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 280 SWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFhIIAMCSTFAnPLLYGWMNSNYRKAF 336
Cdd:cd15120 228 CWLPYHLHSGLVLTRGRPPSLTDITLLLTVG-TTCFNTCFT-PVLYLFVGENFKKVL 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
51-334 5.82e-14

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 71.40  E-value: 5.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15186   1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLF-VATLPF-WTHYLINEWGLHNAMCKLTTAFF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQI--SFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFeivactekwP 208
Cdd:cd15186  79 FIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVqhGVTISLGVWAAAILVAVPQFMFTKMKENECLGDY---------P 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL---KNHvspgaasdhyhqRRHKTTKMLVCVVVVFAVSWLP-- 283
Cdd:cd15186 150 EVLQEIWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLfscKNH------------KKARAIKLILLVVIVFFLFWTPyn 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 284 -------LHAFQLAVDIDShvldLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15186 218 vmifletLKLYDFFPSCDM----KKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
57-333 5.85e-14

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 71.33  E-value: 5.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTL-MGEWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd14987   7 YIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCV-VATLPVWVVSLVqHNQWPMGEFTCKITHLIFSINLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWgvsaLLASPLAIFREYSL-IEIIPDFEIVACTEKWPGEEK 212
Cdd:cd14987  86 GSIFFLTCMSVDRYLSVTLFGNtsSRRKKIVRRIICVLVW----LLAFVASLPDTYFLkTVTSPSNNETYCRSFYPEESF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgAASDhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLaVD 292
Cdd:cd14987 162 KEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAIS------ASSD---QERKSSRKIIFSYVVVFLVCWLPYHTVVL-LD 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 293 IDS--HVL----DLKEYklIFTVFHIIAMCSTF---ANPLLYGWMNSNYR 333
Cdd:cd14987 232 ILSflHLIpfscQLENF--LYAALHVTQCFSLVhccVNPILYSFINRNYR 279
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
51-336 5.99e-14

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 71.37  E-value: 5.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAycsiILLGVVGNSLVIHVVI--KFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15122   5 IFLLLA----ALLGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAV-LLLTPFFITFLTRKTWPFGQAVCKAVYY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDfEIVACTEK 206
Cdd:cd15122  80 LCCLSMYASIFIIGLMSLDRCLAVTrpYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMND-RICEPCHA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEekSVYGtvYSLSTLLIlYVLPLGIISFSYTRIWSKLKNHvspgaasdhYHQRRHKTTKMLVCVVVVFAVSWLPLHa 286
Cdd:cd15122 159 SRGH--AIFH--YTFETLVA-FVLPFGVILFSYSVILVRLKGA---------RFRRRARVEKLIAAIVVAFALLWVPYH- 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 287 fqlAVDIDSHVLDLKEYKLIFTVFHI----------IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15122 224 ---VVNLLQVVANLAPGEVLEKLGGAakaaragataLAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
60-336 7.74e-14

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 71.12  E-value: 7.74e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15304  10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLFSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCI---VYHLESKiSKQISFLIIGLAWGVSALLASPlaifreyslieiIPDFEIVACTEKWPGEEKSVY 215
Cdd:cd15304  90 MHLCAISLDRYIAIrnpIHHSRFN-SRTKAFLKIIAVWTISVGISMP------------IPVFGLQDDSKVFKEGSCLLA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15304 157 DENFVLIGSFVAFFIPLTIMVITYFLTIKSLQQSIS----------NEQKASKVLGIVFFLFVVMWCPFFITNVMAVICK 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15304 227 ESCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
60-342 7.82e-14

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 71.09  E-value: 7.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15305  10 IIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIfreyslIEIIPDFEIVACTEKWPGEEKSVyg 216
Cdd:cd15305  90 MHLCAISLDRYVAIRNPIEHSRfnSRTKAMMKIAAVWTISIGISMPIPV------IGLQDDEKVFVNGTCVLNDENFV-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 tvysLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSH 296
Cdd:cd15305 162 ----LIGSFVAFFIPLIIMVITYCLTIQVLQRQQAI--------NNERRASKVLGIVFFLFLIMWCPFFITNILSVLCKE 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 297 VLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRC 342
Cdd:cd15305 230 ACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
58-336 8.00e-14

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 70.78  E-value: 8.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLpFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVS 137
Cdd:cd14972   6 IVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFV-FTFLSVLLVSLTPSPATWLLRKGSLVLSLLAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 138 TITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASpLAIFREYSLIEIIPdfeivACTEKWPGEEKSVy 215
Cdd:cd14972  85 AYSLLAIAVDRYISIVHGLtyVNNVTNKRVKVLIALVWVWSVLLAL-LPVLGWNCVLCDQE-----SCSPLGPGLPKSY- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 gtvysLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDH---YHQRR--HKTTKMLVCVVVVFAVSWLPLHAFQLa 290
Cdd:cd14972 158 -----LVLILVFFFIALVIIVFLYVRIFWCLWRHANAIAARQEaavPAQPStsRKLAKTVVIVLGVFLVCWLPLLILLV- 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 291 vdIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14972 232 --LDVLCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
58-336 8.10e-14

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 71.43  E-value: 8.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEW-----KMGPVLCHLVPYAQGL 132
Cdd:cd15975   8 CIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWpfddsSFGVFLCKLVPFLQKA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIfreysLIEIIP----DFEIVACTEK 206
Cdd:cd15975  88 SVGITVLNLCALSVDRYRAVAswSRVQGIGIPLITAIEIFSIWVLSFILAIPEAI-----GFVMVPfeynGEQYRTCMLN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPG---AASDHYHQRRhKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15975 163 ATTKFMNFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNRRKGSlriALSEHLKQRR-EVAKTVFCLVVIFALCWFP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 284 LHAFQLA-----VDIDSHVLDLKEYKLIFTVFHI-IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15975 242 LHLSRILkktvyNENDPRRCELLSFLLVMDYISInLATMNSCINPIALYFVSKKFKNCF 300
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
51-335 8.13e-14

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 70.64  E-value: 8.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVyHLESKISKQISFLIIGLAWGVSALLASPLAIFReyslieiiPDFEIVactekwPGE 210
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLIIV-QKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGS--------PDLQIP------SRA 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSVYG-------TVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdhYHQRRHKTTKMLvcvVVVFAVSWLP 283
Cdd:cd15404 146 PQCVFGyttnpgyQAYVILIMLIFFFIPFMVMLYSFMGILNTVRS----------FKTRAFTTILIL---FIVFTVCWAP 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 284 LHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15404 213 FTTYSLVATFNSHFYHKHNFFEISTWLLWLCYLKSALNPLIYYWRIKKFRDA 264
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
59-336 9.01e-14

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 70.82  E-value: 9.01e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  59 SIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15298   9 SLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFREYSL-IEIIPDFEivaCTEKWPGEEKSVY 215
Cdd:cd15298  89 MNLLIISFDRYFCVTKPLTypARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVgKRTVPDNQ---CFIQFLSNPAVTF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVyslstlLILYVLPLGIISFSYTriwsklknHVSPGAAsdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15298 166 GTA------IAAFYLPVVIMTVLYI--------HISLASA------RERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQ 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 13027422 296 HVLDlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15298 226 SCIP----DTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
54-333 1.03e-13

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 70.65  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSII--LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLvpyaQG 131
Cdd:cd15085   2 ILSFLMFLnaTFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIF----QG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQ----VSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLA-SPLAIFREYSlieiiPDFEIVACTE 205
Cdd:cd15085  78 FAVNyfgiVSLWSLTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFCLFWAvAPLFGWSSYG-----PEGVQTSCSI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWpgEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLK--NHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLP 283
Cdd:cd15085 153 GW--EERSWSNYSYLILYFLMCFVIPVAIIGFSYGNVLRSLHklNKKIEQQGGKNCPEEEERAVIMVLAMVIAFLICWLP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 284 LHAFQLAVDIDShvlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15085 231 YTVFALIVVVNP---ELSISPLAATMPTYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
51-336 1.66e-13

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 70.09  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGvvGNSLVIHVVIKFKSMR-TVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLChLVPYA 129
Cdd:cd15104   2 AGVILAVLSPLIIT--GNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLC-LLRMC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAV-QVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLA-SPLaifreyslieIIPDFeivactE 205
Cdd:cd15104  79 FVITScAASVLSLAAIAFDRYLALKQPLRYKqiMTGKSAGALIAGLWLYSGLIGfLPL----------ISPQF------Q 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVYSLSTLLILYV---LP-LGIISFSYTRIWSKLKNHVSPGAASDH-----YHQRRH----KTTKMLVC 272
Cdd:cd15104 143 QTSYKGKCSFFAAFHPRVLLVLSCmvfFPaLLLFVFCYCDILKIARVHSRAIYKVEHalarqIHPRRTlsdfKAARTVAV 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 273 VVVVFAVSWLPlhaFQLA--VDIDSHVLDLKEYKLIFTVFhiIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15104 223 LIGCFLLSWLP---FQITglVQALCDECKLYDVLEDYLWL--LGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
49-179 1.91e-13

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 69.77  E-value: 1.91e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAYCSIILlgVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVP 127
Cdd:cd15302   1 ILLALITAILSIIT--VIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGDyWPLGWVLCDLWL 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 128 YAQGLAVQVSTITLTVIALDRH--RCIVYHLESKISKQISFLIIGLAWGVSALL 179
Cdd:cd15302  79 SVDYTVCLVSIYTVLLITIDRYcsVKIPAKYRNWRTPRKVLLIIAITWIIPALL 132
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
52-251 2.70e-13

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 69.34  E-value: 2.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLvNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQ 130
Cdd:cd15160   2 FLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLL-YILTLPLWIDYTANHHnWTFGPLSCKVVGFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKISKQISF-LIIGLAWGVSALLASPLAIFREYsLIEIIPDFEIvaCTEKWPG 209
Cdd:cd15160  81 YTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFaLKVSASIWVLELGTHSVFLGHDE-LFRDEPNHTL--CYEKYPM 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 13027422 210 EEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVS 251
Cdd:cd15160 158 EG---WQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPS 196
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
56-334 3.45e-13

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 69.03  E-value: 3.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  56 AYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGeWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15177   6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLL-LLTLPFAAAETLQG-WIFGNAMCKLIQGLYAINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIV----YHLESKISKQISFLIIGLAWGVSALLASPLAIfreYSLIEiiPDFEIVACTEKWPGEE 211
Cdd:cd15177  84 SGFLFLTCISVDRYVVIVratsAHRLRPKTLFYSVLTSLIVWLLSILFALPQLI---YSRVE--NRSELSSCRMIFPEVV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaasdhyhqRRHKTTKMLVCVVVVFAVSWLPlHAFQLAV 291
Cdd:cd15177 159 SRTVKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGW---------ERHRALRVIAALVVAFVLFQLP-YSVVLLL 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 292 DI-------DSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15177 229 DTadllatlELSCSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRR 278
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
57-329 3.73e-13

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 68.99  E-value: 3.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLvNTLCLPFTLTYTLMGEWKMGP-VLCHLVPYAQGLAVQ 135
Cdd:cd14964   5 LSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL-ASLVVLVLFFLLGLTEASSRPqALCYLIYLLWYGANL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVY---HLESKISKQISFlIIGLAWGVSALLASPLAIFREYslieiipDFEIVACTEKWPGEEK 212
Cdd:cd14964  84 ASIWTTLVLTYHRYFALCGplkYTRLSSPGKTRV-IILGCWGVSLLLSIPPLVGKGA-------IPRYNTLTGSCYLICT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 SVYGTVYSlstLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRH-KTTKMLVCVVVVFAVSWLPLHAFQLAV 291
Cdd:cd14964 156 TIYLTWGF---LLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNlKATKSLLILVITFLLCWLPFSIVFILH 232
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 13027422 292 DIDSHVLdLKEYKLIFTVFhiIAMCSTFANPLLYGWMN 329
Cdd:cd14964 233 ALVAAGQ-GLNLLSILANL--LAVLASTLNPFIYCLGN 267
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
51-335 4.61e-13

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 68.75  E-value: 4.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVV-IKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPY 128
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGF-ALTLPFWAVESALDfHWPFGGAMCKMVLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHrCIV-------YHLESKISKQISFLIiglaWGVSALLASPLAIFREyslieiipDFEIV 201
Cdd:cd15925  80 ATVLNVYASVFLLTAMSVTRY-WVVasaagpgTHLSTFWAKIITLAL----WAAALLATVPTAIFAT--------EGEVC 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 202 A---CTEKWPGEEksvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvspgAASDHYHQRRHKTTKMLVCVVVVFA 278
Cdd:cd15925 147 GvelCLLKFPSNY---WLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQH----KVNQNNRQRQSVIARSVRLVVASFF 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 279 VSWLPLHAFQL--------AVDIDSHVLDLKEYklIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15925 220 LCWFPNHVVTFwgvlvkfrAVPWNSTFYFIHTY--VFPVTTCLAHSNSCLNPVLYCLMRREFRQA 282
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
57-242 7.24e-13

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 68.24  E-value: 7.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIkFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15372   7 YTLVFLVGLPANGLALWVLA-TQVKRLPSTIFLINLAVADLLL-ILVLPFKISYHFLGNnWPFGEGLCRVVTAFFYGNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipDFEIVACTEKWPGEEKS 213
Cdd:cd15372  85 CSVLLLMCISLDRYLAVVHPFFARTlrSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLE---RLNITLCHDVLPLDEQD 161
                       170       180
                ....*....|....*....|....*....
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRI 242
Cdd:cd15372 162 TYLFYYFACLAVLGFLLPLVVILFCYGSV 190
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
60-190 8.17e-13

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 68.34  E-value: 8.17e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15127  10 IFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTF 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 140 TLTVIALDRHRC-----IVYHLESKISKQISFLIIglAWGVSALLASPLAIFREYS 190
Cdd:cd15127  90 TLCALCIDRFRAatnvqMYYEMIENCTSTTAKLAV--IWVGALLLALPEVVLRQLS 143
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
51-336 9.57e-13

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 67.88  E-value: 9.57e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPF-TLTYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd14988   1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGV-VLTLPVwMLEVMLDYTWLWGSFLCKFTHYF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPlaifrEYSLIEIIPDFEIVaCTEKW 207
Cdd:cd14988  80 YFANMYSSIFFLTCLSVDRYLTLTssSPFWQQHQHRIRRALCAGIWVLSAIIPLP-----EVVHMQLLDGVEPM-CLFLA 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaasdhyHQRRHktTKMLVCVVVVFAVSWLPLH-- 285
Cdd:cd14988 154 PFETYDEWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRP-------ESRRH--CLLIYAYILVFVVCWLPYHvt 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 286 AFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTF---ANPLLYGWMNSNYRKAF 336
Cdd:cd14988 225 LLLLTLHGSHISLHCNLVHFLYFFYDVIDCFSLLhcvANPILYNFLSKSFRGKL 278
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
53-242 1.33e-12

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 67.55  E-value: 1.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15078   3 LALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLESKIS---KQISFL-IIGLAWGVSALLASPLAIFREYSLieiipdfeivACTEKWp 208
Cdd:cd15078  83 FGIVSIMTLTVLAYERYIRVVHAKVVNFSwswRAITYIwLYSLAWTGAPLLGWNRYTLEVHGL----------GCSFDW- 151
                       170       180       190
                ....*....|....*....|....*....|....
gi 13027422 209 gEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRI 242
Cdd:cd15078 152 -KSKDPNDTSFVLLFFLGCLVVPLGIMAYCYGHI 184
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
51-336 3.62e-12

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 66.25  E-value: 3.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGeWKMGPVLCHLVPYAQ 130
Cdd:cd15180   1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILL-LVTLPFWAVQAVHG-WIFGTGLCKLAGAVF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVyHLESKISKQISFLIIG---LAWGVSALLASPLAIF------REYSLIEIIPDFEIV 201
Cdd:cd15180  79 KINFYCGIFLLACISFDRYLSIV-HAVQMYSRKKPMLVHLsclIVWLFCLLLSIPDFIFleatkdPRQNKTECVHNFPQS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 202 ACTEKwpgeeksvygTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaASDHyHQRRHKTTKMLVCVVVVFAVSW 281
Cdd:cd15180 158 DTYWW----------LALRLLYHIVGFLLPLAVMVYCYTSILLRLL-------RSSQ-GFQKQRAIRVIVAVVVVFFLCW 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 282 LPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFA------NPLLYGWMNSNYRKAF 336
Cdd:cd15180 220 TPYNIALLVDTLIDLSVLDRNCGTESRLDIALSVTSSLGyfhcclNPLLYAFVGVKFRRKL 280
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
52-336 4.82e-12

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 65.94  E-value: 4.82e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15154   2 LHLVGYSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLF-TLSLPLRIYYYANHYWPFGNFLCQFSGSIFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISK--QISFLIIGLAWGVSALLASPLAIFREYSLIEiIPDFEIVACTEKWPG 209
Cdd:cd15154  81 MNMYGSCLFLMCINVDRYLAIVHPLRFRHLRrpKVARLLCLAVWALILGGSVPAAIVHSSSDCL-LHGEKVYRCFESFSD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSvygtvySLSTLLIL-----YVLPLGIISFSYTRIWSKLKNHVSPGAasdhyhQRRHKTTKMLVCVVVVFAVSWLP- 283
Cdd:cd15154 160 NDWK------GLLPLVVLaeilgFLLPLAAVLYCSCRIFVELCRTQEPQQ------GRRRKTVRLLLVNLVIFLICFVPy 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 284 -----LHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15154 228 nttlaVYGLLRANLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
51-248 5.33e-12

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 65.50  E-value: 5.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15161   1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSY-VLILPMRLVYHLSGnHWPFGEVPCRLAGFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLES-KISKQI-SFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKW 207
Cdd:cd15161  80 FYLNMYASLYFLACISVDRFLAIVHPVKSmKIRKPLyAHVVCGFLWVIVTVAMAPLLVSPQTVEVN-----NTTVCLQLY 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13027422 208 pgEEKSVYGtvySLSTLLILYVLPLGIISFSYTRIWSKLKN 248
Cdd:cd15161 155 --REKASRG---ALVSLAVAFTIPFVTTVTCYLLIIRSLRT 190
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
60-333 5.64e-12

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 65.61  E-value: 5.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15076  10 VFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGW 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPlaIFREYSliEIIPDFEIVACTEKWPGEEKSVYGTV 218
Cdd:cd15076  90 SLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLP--PFFGWS--RYIPEGLQCSCGPDWYTVGTKYRSEY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQL-AVDIDSHV 297
Cdd:cd15076 166 YTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESASTQKAEREVSRMVVVMVGSFCLCYVPYAALAMyMVNNRDHG 245
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 13027422 298 LDLKeyklIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15076 246 LDLR----LVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
60-343 6.99e-12

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 65.36  E-value: 6.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15307  10 LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLE---SKISKQISFLIIgLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWPgeeksvyG 216
Cdd:cd15307  90 HLCTISVDRYLSLRYPMRfgrNKTRRRVTLKIV-FVWLLSIAMSLPLSLMYSKD-----HASVLVNGTCQIP-------D 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLSTLLILYVLPLGIISFSY---TRIWSKlknhvspgaasdhyHQRRH--------KTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15307 157 PVYKLVGSIVCFYIPLGVMLLTYcltVRLLAR--------------QRSRHgriirleqKATKVLGVVFFTFVILWSPFF 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 286 AFQLAVDIDSHVLDLKEYKlIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCE 343
Cdd:cd15307 223 VLNLLPTVCAECEERISHW-VFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
60-333 7.05e-12

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 65.24  E-value: 7.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLM-GEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15080  10 LILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFM-VFGGFTTTMYTSMhGYFVFGPTGCNLEGFFATLGGEIAL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHrCIVYHLESKISKQISFLIIGLAWG---VSALLASPLAIFREYslieiIPDFEIVACTEKWPGEEKSVY 215
Cdd:cd15080  89 WSLVVLAIERY-VVVCKPMSNFRFGENHAIMGVAFTwvmALACAAPPLVGWSRY-----IPEGMQCSCGIDYYTLKPEVN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDS 295
Cdd:cd15080 163 NESFVIYMFVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQ 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13027422 296 HVldlkEYKLIF-TVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15080 243 GS----DFGPIFmTIPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
51-340 9.11e-12

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 64.85  E-value: 9.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAISIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHL-----ESKISKQISFLIIglAWGVSALLASPLAIFREYSLIeiipdfEIVACte 205
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSNAVsyrnqQTATLRIVTQMVA--VWVLAFLVHGPAILVSDSWKT------EDGEC-- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 kwpgeEKSVYGTVYSLSTLLIL-YVLPLGIISFSYTRIWSKLknhvspgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15295 151 -----EPEFFSNWYILAITSVLeFLVPVILVAYFNTQIYWSL-----------WKRLRDRKLAKSLAIILGTFAICWAPY 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 285 HAFQLAVDIDSHVLDLKEYKLIFTVFHIiamcSTFANPLLYGWMNSNYRKAFLSAF 340
Cdd:cd15295 215 SLFTIIRAACEKHRGSPWYNFAFWLQWF----NSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
57-334 1.33e-11

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 64.39  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVP--YAQGLAV 134
Cdd:cd15184   7 YSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLF-LLTLPF-WAHYAANEWVFGNAMCKLLTglYHIGFFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIalDRHRCIVYHLESKISKQISFLII--GLAWGVSALLASPLAIF----REYSlieiipdfeIVACTEKWP 208
Cdd:cd15184  85 GIFFIILLTI--DRYLAIVHAVFALKARTVTFGVVtsVVTWVVAVFASLPGIIFtksqKEGS---------HYTCSPHFP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPgaasdhyhQRRHKTTKMLVCVVVVFAVSWLP----- 283
Cdd:cd15184 154 PSQYQFWKNFQTLKMNILGLVLPLLVMIICYSGILKTLLRCRNE--------KKRHKAVRLIFTIMIVYFLFWAPynivl 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 284 -LHAFQLAVDID----SHVLDLKeykliFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15184 226 lLNTFQEFFGLNncssSNRLDQA-----MQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
49-247 1.33e-11

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 64.43  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAYCsiilLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNtLCLPFTLTYTLMGE-WKMGPVLCHLVP 127
Cdd:cd15199   3 YASLLILEFG----LGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLL-ICLPFKAYFYLNGNrWSLGGGTCKALL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVyHLESKI---SKQISFLIIGLAWgvsaLLASPLAIfrEYSLIEIIPDFEivACT 204
Cdd:cd15199  78 FMLSLSRGVSIAFLTAVALDRYFRVV-HPRGKKnslSLQAAPYISFLVW----LLLVGLTI--PTLLASQPKNFT--ECN 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 13027422 205 EKWPGEEKSVYGTVYSLSTLLiLYVLPLGIISFSYTRIWSKLK 247
Cdd:cd15199 149 SFSPKDDEDFSDTWQEAVFFL-QFLLPFGLIVFCTVRIIRRLK 190
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
51-188 1.62e-11

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 64.33  E-value: 1.62e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15148   1 LPLAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLL-IICLPFRILYHVNNnQWTLGPLLCKVVGNL 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFRE 188
Cdd:cd15148  80 FYMNMYISIILLGFISLDRYLKINRSSRRQkfLTRKWSIVACGVLWAVALVGFVPMIVLTE 140
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-336 1.66e-11

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 64.48  E-value: 1.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTV---TNFFIANLAVADLLVNTLCLPFTLtYTLM---GEWKMGPVLCH 124
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLILLLAMPVEL-YNFIwvhHPWAFGDAACR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 125 LVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASP-LAIFREYSLIEIIPDFEIv 201
Cdd:cd15355  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIPmLFTMGEQNRSGTHPGGLI- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 202 aCTekwPGEEKSVYGTVYSLSTLLIlYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTT-------------- 267
Cdd:cd15355 159 -CT---PIVDTSTLKVVIQVNAFLS-FLFPMLVISVLNTLIANQLTVMVNQAEQENQVCTIGGQRTvlsvsmepgrvqsl 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 268 ----KMLVCVVVVFAVSWLPLHAFQLAVdidSHVLDLKEYKLIFTVFHIIAM-------CSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15355 234 rhgvLVLRAVVIAFVVCWLPYHVRRLMF---CYVSDEQWTTFLYDFYHYFYMltnvlfyVSSAINPILYNLVSANFRQIF 310
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
52-325 1.97e-11

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 63.92  E-value: 1.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYcsiiLLGVVGNSLVIHVVI-KFKSMRTVTnFFIANLAVADLLVNtLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15201   6 VLILEF----VLGLLGNGLALWIFCfHLKSWKSST-VYLFNLAVADFLLI-ICLPFRTDYYLRGkHWKFGDIPCRIVLFM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLaifreYSLIEIIPDFEIVACtEKW 207
Cdd:cd15201  80 LAMNRAGSIFFLTAVAVDRYFRVVHphHRINSISVRKAAIIACGLWLLTIAMTVYL-----LTKKHLFPRGNATQC-ESF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspGAASDHyHQRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15201 154 NICTGTDSSSNWHEAMFLLEFFLPLAIILYCSVRIIWQLR-----GRQLDR-HAKIKRAVQFIMVVAIVFIICFLPSNVT 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 288 QLAVDI--DSHVLDLKEYKLIFTVFHiIAMCSTFAN----PLLY 325
Cdd:cd15201 228 RIAIWIlkHTSNEDCQYYRSVDLAFY-ITISFTYFNsmldPVVY 270
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
57-358 2.17e-11

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 65.03  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   57 YCSIILLGVVGNSLVIHVVIKfKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:PHA02638 105 YIIIFILGLFGNAAIIMILFC-KKIKTITDIYIFNLAISDLIF-VIDFPF-IIYNEFDQWIFGDFMCKVISASYYIGFFS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  137 STITLTVIALDRHRCIVYHLESKISK--QISFLIIGLAWGVSALLASPLAIFREYSLI--------EIIPDFEIVACTEK 206
Cdd:PHA02638 182 NMFLITLMSIDRYFAILYPISFQKYRtfNIGIILCIISWILSLIITSPAYFIFEASNIifsaqdsnETISNYQCTLIEDN 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  207 wPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:PHA02638 262 -EKNNISFLGRILQFEINILGMFIPIIIFAFCYIKIILKLKQLKK---------SKKTKSIIIVSIIIICSLICWIPLNI 331
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  287 FQLAVD----------IDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRceqrldAIHSEVSMT 356
Cdd:PHA02638 332 VILFATmysfkgfnsiISEHICGFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFR------NIFTNAKFS 405

                 ..
gi 13027422  357 FK 358
Cdd:PHA02638 406 FR 407
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
57-336 2.44e-11

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 63.56  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIkFKsMR-----TVTNFfiaNLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQ 130
Cdd:cd15375   7 YSIIFIVGFPGNIIAIFVYL-FK-MRpwkssTIIML---NLALTDLLY-VTSLPFLIYYYINGEsWIFGEFMCKFIRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLES-KISKQI-SFLIIGLAWGVSALLASPLaifreYSLIEIIPDFEIVACTEKWP 208
Cdd:cd15375  81 HFNLYGSILFLTCFSIFRYVVIVHPLRAfQVQKRRwAIVACAVVWVISLAEVSPM-----TFLITTKEKNNRTICLDFTS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASdhyhqrRHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15375 156 SDNLNTI-WWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSAS------KQKARRLIILILLVFYVCFLPFHILR 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 289 LA-VDIDSHVLDLKEYKLIFTVFHI---IAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15375 229 VVrIETRLPPVSCCLKHQVHAIYIItrpLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
52-330 2.54e-11

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 64.05  E-value: 2.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAycSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTL-CLP---FTLTYTLMGEwkmgPVLCHLVP 127
Cdd:cd15386   4 IGVLA--AILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALFqVLPqliWEITYRFQGP----DLLCRAVK 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 128 YAQGLAVQVSTITLTVIALDRHRCIVYHLES--KISKQiSFLIIGLAWGVSALLASP-LAIFreySLIEIIPDFEIVACt 204
Cdd:cd15386  78 YLQVLSMFASTYMLIMMTVDRYIAVCHPLRTlqQPSRQ-AYLMIGATWLLSCILSLPqVFIF---SLREVDQGSGVLDC- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 ekWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL-KN-----------------HVSPGAASDHYHQRRHK- 265
Cdd:cd15386 153 --WADFGFPWGAKAYITWTTLSIFVLPVAILIVCYSLICYEIcKNlkgktqtsrsegggwrtQGMPSRVSSVRTISRAKi 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 266 -TTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNS 330
Cdd:cd15386 231 rTVKMTFVIVLAYIACWAPFFSVQMWSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSG 296
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
51-336 3.09e-11

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 63.24  E-value: 3.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15172   1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILF-VLTLPF-WAVYEAHQWIFGNFSCKLLRGIY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIV-----YHLESKiSKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFeivACTE 205
Cdd:cd15172  79 AINFYSGMLLLACISVDRYIAIVqatksFRLRSR-TLAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQY---VCEP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVYSLST-LLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPL 284
Cdd:cd15172 155 KYPKNSTAIMWKLLVLSLqVSLGFFIPLLVMIFCYSFIIKTLLQAQN---------SQRHKAVRVVVAVVLVFLVCQVPY 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 285 HAFQLAVDID----SHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15172 226 NIVLLIEAINlgeqQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
51-285 3.99e-11

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 63.35  E-value: 3.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTlCLPFTL-TYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd15379   1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVC-SLPLLIyNYTQKDYWPFGDFTCRLVRFQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLES---KISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEK 206
Cdd:cd15379  80 FYTNLHGSILFLTCISVQRYLGICHPLASwhkKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQR-----NRTVCYDL 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 207 WPGEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15379 155 SPPARSTAY-FPYGITLTRTGFLLPFAARLACYCSMATILCRVVIAVAVVAAPGEKRGKAARMIIVVAAVFLISFLPFH 232
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
60-182 4.46e-11

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 63.25  E-value: 4.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15005  10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSgWIYGALSCKVIAFLAVLFCFHSA 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 139 ITLTVIALDRHRCIVYH--LESKISKQISFLIIGLAWGVSALLASP 182
Cdd:cd15005  90 FTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
60-336 5.01e-11

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 62.36  E-value: 5.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15309  10 LIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESKI---SKQISFLIIGLAWGVSALLASPLAifreYSLIEIIPDFEIVActekwpgeeksvyG 216
Cdd:cd15309  90 NLCAISIDRYTAVAMPMLYNTrysSKRRVTVMISVVWVLSFAISCPLL----FGLNNTDQNECIIA-------------N 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLSTLLILYVLPLGIISFSYTRIWSKLknhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLavdIDSH 296
Cdd:cd15309 153 PAFVVYSSIVSFYVPFIVTLLVYVQIYIVL--------------QKEKKATQMLAIVLGVFIICWLPFFITHI---LNMH 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 13027422 297 VlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15309 216 C-DCNIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
63-336 5.70e-11

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 62.64  E-value: 5.70e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  63 LGVVGNSLVIHVVIKFKSMR-TVTNFFIANLAVADLL--VNTLCLPFTLTYT-----LMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd14980  13 LALIGNILVIIWHISSKKKKkKVPKLLIINLAIADFLmgIYLLIIAIADQYYrgryaQYSEEWLRSPPCLLACFLVSLSS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLAsplaifreyslieIIPdfeiVACTEKWPGEEK- 212
Cdd:cd14980  93 LMSVLMMLLITLDRYICIVYPFSNkRLSYKSAKIILILGWLFSIIFA-------------AIP----ILYSINQPGDNRl 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 213 ---------SVYGTVYSLSTLLILYVLPLG---IISFSYTRIWSKLKNhvSPGAASDHYHQRRHKTTKMLVCVVVVFAVS 280
Cdd:cd14980 156 ygyssicmpSNVSNPYYRGWLIAYLLLTFIawiIICILYILIFISVRK--SRKSARRSSSKRDKRIAIRLALILITDLIC 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 281 WLPLHAFQLAVDIDSHVLDLkeYKLIFTVFHIIAMCSTfANPLLYGWMNSNYRKAF 336
Cdd:cd14980 234 WLPYYIVIFSGLLTSTEIDI--HVLQFIAILALPLNSA-INPYLYTLTTPTFKRDF 286
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
60-183 8.81e-11

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 61.78  E-value: 8.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLP-FTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15308  10 LILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPlYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASI 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 139 ITLTVIALDRHRCIVYHLESKiSKQIS---FLIIGLAWGVSALLASPL 183
Cdd:cd15308  90 FNLCAISVDRFIAVSVPLNYN-RRQGSvrqLLLISATWILSFAVASPV 136
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
51-325 1.02e-10

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 61.72  E-value: 1.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd15968   1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLY-ALSLPLLIYNYAMRDrWLFGDFMCRLVRFL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLASPLAIFREYSLIEiipdfEIVACTEKW 207
Cdd:cd15968  80 FYFNLYGSILFLTCISVHRYLGICHPMRPwhKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIR-----NRTVCYDLA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLH-- 285
Cdd:cd15968 155 PPALFPHY-VPYGMALTVSGFLLPFSIILWCYCLVVRTLCR--TLGPAEPPAQARRRKSIRTIVTVTLLFALCFLPFHit 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 13027422 286 -----AFQLAVDIDSHVLDLkeYKLIFTVFHIIAMCSTFANPLLY 325
Cdd:cd15968 232 rtiylAVRVTPGVPCHVLEA--VAACYKITRPLASANSVLNPLLY 274
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
48-340 1.04e-10

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 62.23  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   48 EVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVtNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVP 127
Cdd:PHA02834  26 DVNYFVIVFYILLFIFGLIGNVLVIAVLIVKRFMFVV-DVYLFNIAMSDLML-VFSFPF-IIHNDLNEWIFGEFMCKLVL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  128 YAQGLAVQVSTITLTVIALDRHRCIVYHLESK-ISKQISFLIIGLAWGVSALLASPLAIfreysLIEIIPDFEIVACTEK 206
Cdd:PHA02834 103 GVYFVGFFSNMFFVTLISIDRYILVVNATKIKnKSISLSVLLSVAAWVCSVILSMPAMV-----LYYVDNTDNLKQCIFN 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  207 WPGEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasdHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:PHA02834 178 DYHENFSWS-AFFNFEINIFGIVIPLIILIYCYSKILYTLKN---------CKNKNKTRSIKIILTVVTFTVVFWVPFNI 247
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  287 FQLAVDIDS-HVLDLKEY--KLIFTVFHIIAMCSTF---ANPLLYGWMNSNYRKAFLSAF 340
Cdd:PHA02834 248 VLFINSLQSvGLIDIGCYhfKKIVYSIDIAELISFVhccVNPIIYAFVGKNFKKVFKNMF 307
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
57-266 1.23e-10

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 61.69  E-value: 1.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15162   7 YTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLL-VIWLPFKIAYHIHGNnWIFGEALCRLVTVAFYGNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIFReysLIEIIPDFEIVACTEKWPGEEKS 213
Cdd:cd15162  86 CSILLLTCISIDRYLAIVHPMGhrRLRARRYALGTCLAIWLLALLVTLPLYLVK---QTIFLPALDITTCHDVLPEQLLV 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLknhvspgAASDHYHQRRHKT 266
Cdd:cd15162 163 GDWFYYFLSLAIVGFLIPFILTASCYVATIRTL-------AALEDENSEKKKK 208
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
51-239 1.23e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 61.79  E-value: 1.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHlESKISKQISFLIIGLAWGVSALLASPLAIfreyslieiipDFEIVACTEKWP-- 208
Cdd:cd15403  81 WFFVLEGVAILLIISVDRFLIIVQR-QDKLNPHRAKVMIAISWVLSFCISFPSVV-----------GWTLVEVPARAPqc 148
                       170       180       190
                ....*....|....*....|....*....|...
gi 13027422 209 --GEEKSVYGTVYSLSTLLILYVLPLGIISFSY 239
Cdd:cd15403 149 vlGYTESPADRVYAVLLVVAVFFVPFSIMLYSY 181
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
60-226 1.59e-10

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 61.43  E-value: 1.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLG-VVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE---WKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15006   8 VIFVGsLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFCS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLAWgVSALLASpLAIFREYSLIEIipdFEIVACTEKWPGEEKS-V 214
Cdd:cd15006  88 VTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIW-AHAVVAS-VPVFAVTNVTDI---YAMSTCTESWGYSLGHlV 162
                       170
                ....*....|..
gi 13027422 215 YGTVYSLSTLLI 226
Cdd:cd15006 163 YVIIYNITTVIL 174
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
56-154 2.73e-10

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 60.50  E-value: 2.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  56 AYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLL-VNTlcLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLA 133
Cdd:cd15157   6 VYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMfVST--LPFRADYYLMGsHWVFGDIACRIMSYSLYVN 83
                        90       100
                ....*....|....*....|.
gi 13027422 134 VQVSTITLTVIALDRHRCIVY 154
Cdd:cd15157  84 MYCSIYFLTVLSIVRFLAIVH 104
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
60-342 3.02e-10

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 60.23  E-value: 3.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15306  10 VIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 139 ITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIfreySLIEIIPDF--EIVACTEKWPGEEKSV 214
Cdd:cd15306  90 MHLCAISLDRYIAIKKPIQASQynSRATAFIKITVVWLISIGIAIPVPI----KGIETDVDNpnNITCVLTKERFGDFIL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTvyslstlLILYVLPLGIISFSYTRIWSKLKNHVSpgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLA-VDI 293
Cdd:cd15306 166 FGS-------LAAFFTPLAIMIVTYFLTIHALRKQTI---------TNEQRASKVLGIVFFLFLLMWCPFFITNITsVLC 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 294 DShvLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRC 342
Cdd:cd15306 230 DS--CNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-336 3.14e-10

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 60.35  E-value: 3.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILA-YCSIILLGVVGNSLVIHVVIKFKSMRTVTN---FFIANLAVADLLVNTLCLPFTLtYTLMG---EWKMGPVLCH 124
Cdd:cd15130   1 VLVTAiYLALFVVGTVGNSVTLFTLARKKSLQSLQStvrYHLGSLALSDLLILLLAMPVEL-YNFIWvhhPWAFGDAGCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 125 LVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLA-IFREYSLIEIIPDFEIV 201
Cdd:cd15130  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPMLfTMGLQNESDDGTHPGGL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 202 ACTekwPGEEKSVYGTVYSLSTlLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyhQRRHKTTKMLVCVVVVFAVSW 281
Cdd:cd15130 160 VCT---PIVDTATLKVVIQVNT-FMSFLFPMLVTSILNTVIANKLV-------------QALRRGVLVLRAVVIAFVVCW 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13027422 282 LPLHAFQLAVdidSHVLDLKEYKLIFTVFHIIAM-------CSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15130 223 LPYHVRRLMF---CYISDEQWTTFLFDFYHYFYMltnalfyVSSAINPILYNLVSANFRQVF 281
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
51-335 4.46e-10

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 59.87  E-value: 4.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSalLASPLAIF----REYSLIEIIPDFEIVact 204
Cdd:cd15316  81 VSFCYASLFHLCFISVDRYIAVTDPLvyPTKFTVSVSGICISVSWIFS--LTYSFSVFytgvNDDGLEELVNALNCV--- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 205 ekwpGEEKSVYGTVYSLSTLLiLYVLPLGIISFSYTRIWSKLKNHV------------SPGAASDHYHQRRHKTTKMLVC 272
Cdd:cd15316 156 ----GGCQIILNQNWVLVDFL-LFFIPTFAMIILYGKIFLVAKQQArkiemtsskaesSSESYKDRVARRERKAAKTLGI 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 273 VVVVFAVSWLPlhaFQLAVDIDSHvLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15316 231 TVIAFLVSWLP---YLIDVLIDAF-MNFITPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
62-326 4.51e-10

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 60.09  E-value: 4.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVI-HVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15376  12 LVAVLGNGLALwLFVTRERRPWHTGVVFSFNLAVSDLLY-ALSLPLLAAYYYPPkNWRFGEAACKLERFLFTCNLYGSIF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVY------HLESKISKQISfliiGLAWGVSALLASPLAIFREYslieiipDFEIVACTEKWPGEEKS 213
Cdd:cd15376  91 FITCISLNRYLGIVHpfftrsHVRPKHAKLVS----LAVWLLVAALSAPVLSFSHL-------EVERHNKTECLGTAVDS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGT--VYSLSTLLILYVLPLGIISFSYTRI-WSKLKNH-VSPgaasdhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQ- 288
Cdd:cd15376 160 RLPTylPYSLFLAVVGCGLPFLLTLASYLAIvWAVLRSPgITT--------LEKRKVAALVAVVVALYAVSFVPYHILRn 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHI------IAMCstfANPLLYG 326
Cdd:cd15376 232 LNLYRRLQWLKAAASLRIYFAYQVtkglvtLNMC---IHPLLYM 272
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
47-331 4.61e-10

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 60.17  E-value: 4.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  47 VEVQVVLIlaycsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTlclpFTLTYTLMgeWKM-----GP- 120
Cdd:cd15388   2 VEIAVLAI-----IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAF----FQVLPQLV--WDItdrfrGPd 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 121 VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLI-IGLAWGVSALLASP-LAIFreySLIEIIPD- 197
Cdd:cd15388  71 VLCRLVKYLQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGpVCVAWAISLILSLPqVFIF---SKVEVAPGv 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 198 FEIVAC-TEKWpgeeksvyGT-VYSLSTLLILYVLPLGIISFSYTRIWSKLKN----------------HVSPGAASD-- 257
Cdd:cd15388 148 YECWACfIEPW--------GLkAYVTWITLVVFVLPTLIITVCQVLIFKEIHIniylksqiivavvkkkQLLSSRASSva 219
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 258 HYHQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAvdidsHVLDLKEYK--LIFTVFHIIAMCSTFANPLLYGWMNSN 331
Cdd:cd15388 220 EVSKAMIKTVKMTLVIVLVYVLCWAPFFLVQLW-----SVWDPKAPTegATFTILMLLASLNSCTNPWIYMAFSSS 290
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
51-336 8.22e-10

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 59.11  E-value: 8.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTV---TNFFIANLAVADLLVNTLCLPFTLtYTLMG---EWKMGPVLCH 124
Cdd:cd15356   1 VLFTAVYALIWALGAAGNALTIHLVLKKRSLRGLqgtVHYHLVSLALSDLLILLISVPIEL-YNFVWfhyPWVFGDLVCR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 125 LVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIF----REYSLIEIIPDF 198
Cdd:cd15356  80 GYYFVRDICSYATVLNIASLSAERYLAICQPLRAKrlLSKRRTKWLLALIWASSLGFALPMAFImgqkYELETADGEPEP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 199 EIVACTEKWPGEEKSVYGTVyslsTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhyHQRRHKTTKMLVCVVVVFA 278
Cdd:cd15356 160 SSRVCTVLVSRATLKVFIQV----NAFVSFVLPLALIAFLNGVTVSHLR------------IQSLQHSVQVLRAIVIAYV 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 279 VSWLPLHAFQLAVdidSHVLDLKEYKLIFTVFHIIAM-------CSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15356 224 ICWLPYHARRLMF---CYVPDDAWTDSLYNFYHYFYMltntlfyVSSAVNPLLYNVVSSSFRKLF 285
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
56-334 1.09e-09

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 58.99  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  56 AYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTL-MGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLC-VCTLPLRVVYYVhKGQWLFGDFLCRISSYALYVNL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVY---HLESKISKQISFLIIGLaWGVSALLASPLAIFREYSlieiiPDFEIVACTEKWPGEE 211
Cdd:cd15158  85 YCSIYFMTAMSFTRFLAIVFpvqNLNLVTVKKARIVCVGI-WIFVTLTSSPFLMSGSHD-----TETNKTKCFEPPQSNQ 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 KSVYGTVYSLSTLLILYVLPLGIISFSYTRI-WSKLKNHvspgAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHaFQLA 290
Cdd:cd15158 159 QLTKLLVLNYISLVVGFIIPFLVILICYAMIiRTLLKNT----MKARKQQSSRKKAIRMIIIVLLAFLVSFMPYH-IQRT 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 291 VDIdsHVLDLK----EYKLIFTVFHIIAMCSTFAN----PLLYGWMNSNYRK 334
Cdd:cd15158 234 IHL--HFLSRKdstcEEVLYMQKSVVITLCLAAANccfdPLLYFFSGENFRR 283
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
51-336 1.37e-09

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 58.65  E-value: 1.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKS----MRTVTNFFIAnLAVADLLVNTLCLPFTLtYTLMGE---WKMGPVLC 123
Cdd:cd15135   1 ITLTLLYSLILVAGILGNSATIKVTQVLQKkgylQKSVTDHMVS-LACSDLLVLLLGMPVEL-YSAIWDpfaTPSGNIAC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 124 HLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESK-ISKQISFLIIGLAWGVSALLASPL--AIFREYSLiEIIPDFEI 200
Cdd:cd15135  79 KIYNFLFEACSYATILNVATLSFERYIAICHPFKYKaLSGSRVRLLICFVWLTSALVALPLlfAMGTEDPL-EAFPSYRG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 201 VACTEKWPGEEKSV------YGTVYSLS--TLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAS---------DHYHQR- 262
Cdd:cd15135 158 TRHHCQDQKSNLTIctslssKWTVFQASifSAFVLYLLVLASVAFMCRRMMRALMGSKKGAVAVkgpggsvqlLRKHESa 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 263 -----RHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMC----STFANPLLYGWMNSNYR 333
Cdd:cd15135 238 egktaRKQTILFLGLIVGTLAVCWMPNQIRRIMAAAKPKDDWTRSYFRAYIILLPIADTffylSSVLNPLLYNLSSQQFR 317

                ...
gi 13027422 334 KAF 336
Cdd:cd15135 318 SVF 320
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
62-247 1.38e-09

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 58.14  E-value: 1.38e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNtLCLPFTLTYTLMGEWKMGPVLCHLVPYaQGLAVQVSTITL 141
Cdd:cd15072  12 LVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGIS-LNALVAASSSLLRRWPYGSEGCQAHGF-QGFFTALASICS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 142 TV-IALDRHrcIVYHLESKISKQISFLIIGLAWGVSALLAS-PLAIFREYslieiipDFEIV--ACTEKWPGEEKSVygT 217
Cdd:cd15072  90 SAaIAWDRY--HHYCTRSKLQWSTAISLVLFVWLFSAFWAAmPLLGWGEY-------DYEPLgtCCTLDYSKGDRNY--V 158
                       170       180       190
                ....*....|....*....|....*....|
gi 13027422 218 VYSLSTLLILYVLPLGIISFSYTRIWSKLK 247
Cdd:cd15072 159 SYLFTMAFFNFILPLFILLTSYSSIEQKLK 188
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
51-246 1.62e-09

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 58.24  E-value: 1.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLML-ACFLPFQIVYHIQRnHWIFGKPLCNVVTVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIG--LAWGVSALLASPLAifrEYSLIEIIPDFEIVACTE-- 205
Cdd:cd15368  80 FYANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAAciGMWLLVLTALSPLE---RTDLTYYVKELNITTCFDvl 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 13027422 206 KWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL 246
Cdd:cd15368 157 KWTMLPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKL 197
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
51-285 2.17e-09

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 57.87  E-value: 2.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLmgEWKMGPVLCHLVPYAQ 130
Cdd:cd15070   1 VTYISIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSL--GVTIHFYSCLFMSCLL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLA-SPLAIFREYslieiiPDFEIVACTEkW 207
Cdd:cd15070  79 VVFTHASIMSLLAIAVDRYLRVKLTVRYRIvtTQRRIWLALGLCWLVSFLVGlTPMFGWNRK------PSLESVNTTP-L 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVL-PLGIISFSYTRIWSKLKNHVSPGAA----SDHYHQRRHKTTKMLVCVVVVFAVSWL 282
Cdd:cd15070 152 QCQFTSVMRMDYMVYFSFFTWILiPLVIMCALYVDIFYIIRNKLSQNATgfreTGAFYGREFKTAKSLALVLFLFAVCWL 231

                ...
gi 13027422 283 PLH 285
Cdd:cd15070 232 PLS 234
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
51-335 2.33e-09

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 57.89  E-value: 2.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYtlmgEWKMGP-VLCHLVPYA 129
Cdd:cd15920   1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLL-VLCLPFRVAY----QNTAGPlSFCKIVGAF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLES-KI-SKQISFLIIGLAWGVSALLASPLaifreyslieIIPDFEIVACTEK- 206
Cdd:cd15920  76 FYLNMYASILFLSLISLDRYLKIIKPLQQfKIhTVPWSSAASGGVWLLLLACMIPF----------LFESRNEGPCDNKc 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYGTVYSLSTLLILYVLPLGIISFsYTRIWSKLKNhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15920 146 FHFRSKGLTAGGINLTAVVIFYILSLLFLYF-YAKISHKLYK-VSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHI 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 287 FQLA-VDIDSHVLDLKEYKLIFTVFHIIAMCSTFAN----PLLYGWMNSNYRKA 335
Cdd:cd15920 224 VRVPyVLAQIDVISSLPWKQTLHIANELVLCLSALNscldPIIYFFLSSSFRRA 277
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
57-333 3.94e-09

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 57.11  E-value: 3.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADlLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15153   7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVAD-LAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQISFLIIGLA-WGVSALLASPLAIFREYSLieiipDFEIVACTEKWPGEEKSVy 215
Cdd:cd15153  86 SICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAAvWIVVGLACLPFPLLRSKSL-----SNNNRSCFADLGMKKLNF- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVYSLSTL--LILYVLPLGIISFSytrIWsKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA---FQLA 290
Cdd:cd15153 160 GAAIAMMTVaeLFGFVIPLFIIAWC---TW-KTENSLRQRNKQQQSTSEKQKALRMVRMCAAVFFICFAPYHInflFYLM 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 291 VdIDSHVLDLKEYKLIFTvFHIIAMC----STFANPLLYGWMNSNYR 333
Cdd:cd15153 236 V-SESIITNCEVSQVILQ-FHPISLClaslNCCLDPILYYFMTSEFQ 280
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
63-336 4.60e-09

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 57.11  E-value: 4.60e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  63 LGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLT 142
Cdd:cd15082  26 LSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALWSLA 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 143 VIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPLAI-FREYSLIEIipdfeIVACTEKWpgeeksvYGTVYS 220
Cdd:cd15082 106 VLAFERFFVICRPLGNiRLQGKHAALGLLFVWTFSFIWTIPPVLgWSSYTVSKI-----GTTCEPNW-------YSGNMH 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 221 LSTLLIL-----YVLPLGIISFSYTRIWSKLK--NHVSPGAASDHYHQRrhKTTKMLVCVVVVFAVSWLPLHAFQLAV-- 291
Cdd:cd15082 174 DHTYIITffttcFILPLGVIFVSYGKLLQKLRkvSNTQGRLGNARKPER--QVTRMVVVMIVAFMVCWTPYAAFSILVta 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 13027422 292 ----DIDSHVLDLKEYkliftvfhiIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15082 252 hptiHLDPRLAAIPAF---------FSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
49-239 5.10e-09

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 56.39  E-value: 5.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAycsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPY 128
Cdd:cd15215   1 IRSVLIVI---FLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAifreYSLIEIIPDFEIVACTEK 206
Cdd:cd15215  78 LMHLFAFAGVNTIVVVSVDRYLAIIHPLSypTKMTPRRGYLLIYGTWIVSVLQSTPPL----YGWGQAAFDERNALCSVI 153
                       170       180       190
                ....*....|....*....|....*....|....*
gi 13027422 207 WpgeeksvyGTVYSLSTLLIL--YVLPLGIISFSY 239
Cdd:cd15215 154 W--------GSSYSYTILSVVssFVLPVIIMLACY 180
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
57-246 5.75e-09

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 56.70  E-value: 5.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFtLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15175   7 YSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILF-LLTLPF-WAASAAKKWVFGEEMCKAVYCLYKMSFFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIV-----YHLESK---ISKQISFLIiglaWGVSALLASPLAIFREYSLIEIIPDFEIVActekwp 208
Cdd:cd15175  85 GMLLLMCISIDRYFAIVqaasaHRHRSRavfISKVSSLGV----WVLAFILSIPELLYSGVNNNDGNGTCSIFT------ 154
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 13027422 209 gEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKL 246
Cdd:cd15175 155 -NNKQTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTL 191
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
60-336 6.39e-09

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 56.40  E-value: 6.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLT--------YTLMGEWKMGPVlCHLVPYAQG 131
Cdd:cd15360  10 INILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVdirtksqyYNYAIDWQTGAG-CAAAGFFTV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLAS-PLAIFREYSLIEIIPDFEIvactekwp 208
Cdd:cd15360  89 FASELSVYTLTVITLERWHTITYamQLDRKVRLRHAAVIMVGGWIFAFTVALlPIFGISSYMKVSICLPMDI-------- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 geeKSVYGTVYSLStLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDhyhqrrHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15360 161 ---ESPLSQAYIIF-ILVLNVLAFLIICACYIKIYLTVRNPNFVSSNSD------TKIAKRMAVLIFTDFLCMAPISFFA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHIIAMCstfANPLLYGWMNSNYRKAF 336
Cdd:cd15360 231 ISASLKVPLITVSKSKILLVLFYPINSC---ANPFLYAIFTKTFRRDF 275
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
61-325 8.46e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 55.93  E-value: 8.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTlCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15200  11 FVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLII-NLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIV--YHLESKISKQISFLIIGLAWGVSALLASPLAIFREYSlieiipdfEIVACTEKWPGEEKSVYGT 217
Cdd:cd15200  90 FLTAIALNRYLKVVhpHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQ--------SNSTCLSYDHGTDPSASDR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 218 VYSLsTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAsdhyhqRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSHV 297
Cdd:cd15200 162 WHRI-LFFLEFFLPLGIILFCIFSIILTLKQRKLAKQA------GPQRAVKVLAVIVLVYTVCFLPSILFALASLVAFKV 234
                       250       260       270
                ....*....|....*....|....*....|..
gi 13027422 298 LDLKEYKLIFTVFHiIAMCSTFAN----PLLY 325
Cdd:cd15200 235 SQCRSLDLCTQLFH-GSLAFTYLNsaldPVLY 265
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
62-334 9.10e-09

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 56.07  E-value: 9.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLT--------YTLMGEWKMGPVlCHLVPYAQGLA 133
Cdd:cd15964  12 LLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVdlhtrseyYNHAIDWQTGPG-CNTAGFFTVFA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 134 VQVSTITLTVIALDRHRCIVY--HLESKIS-KQISFLIIGlAWGVSALLA-SPLAIFREYSLIEIipdfeivaCTekwPG 209
Cdd:cd15964  91 SELSVYTLTVITLERWYAITFamRLDRKIRlRHASAIMLG-GWVFCFLLAlLPLVGVSSYAKVSI--------CL---PM 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 210 EEKSVYGTVYSLStLLILYVLPLGIISFSYTRIWSKLKNhvspgaasDHYH--QRRHKTTKMLVCVVVVFAVSWLPLHAF 287
Cdd:cd15964 159 DTETPLAQAYIVF-VLMLNIIAFVIICACYIKIYITVRN--------PQYKsgDKDTKIAKRMAVLIFTDFICMAPISFY 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 288 QLAVDIDSHVLDLKEYKLIFTVFHIIAMCstfANPLLYGWMNSNYRK 334
Cdd:cd15964 230 ALSAILNKPLITVSNSKILLVLFYPLNSC---ANPFLYAIFTKAFRR 273
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
51-336 9.11e-09

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 56.10  E-value: 9.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLmgEWKMGPVLCHLVPYAQ 130
Cdd:cd15068   1 SVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITIST--GFCAACHGCLFIACFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLA-SPLAIFREysliEIIPDFEIVACTEKW 207
Cdd:cd15068  79 LVLTQSSIFSLLAIAIDRYIAIRIPLRynGLVTGTRAKGIIAICWVLSFAIGlTPMLGWNN----CGQPKEGKNHSQGCG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLIL-----YVLPLGIISFSYTRIW-------SKLKNHVSPGAASDHYHQRRHKTTKMLVCVVV 275
Cdd:cd15068 155 EGQVACLFEDVVPMNYMVYFnffacVLVPLLLMLGVYLRIFlaarrqlKQMESQPLPGERARSTLQKEVHAAKSLAIIVG 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 276 VFAVSWLPLH---AFQLAVDIDSHVLDLKEYKLIftvfhIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15068 235 LFALCWLPLHiinCFTFFCPDCSHAPLWLMYLAI-----VLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
57-181 1.02e-08

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 55.70  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15155   7 YSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLF-VFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYG 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 137 STITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAW------GVSALLAS 181
Cdd:cd15155  86 SMLFLTCISVDRFLAIVYPFRSRTirTRRNSAIVCAGVWilvlsgGISASLFS 138
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
57-247 1.10e-08

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 55.57  E-value: 1.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVikFKSMRTV-TNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAV 134
Cdd:cd15371   7 YIIVVVLGVPSNAIILWML--FFRLRSVcTAIFYANLAISDLLF-CITLPFKIVYHLNGnNWVFGETMCRIITITFYGNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSALLASPLAIFREYSLieiIPDFEIVACTEKWPGEEK 212
Cdd:cd15371  84 YCSILLLTCISINRYLAIVHPFiyRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYY---LKELNITTCHDVLPECEQ 160
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 13027422 213 SVYGTVYSLSTLLIL-YVLPLGIISFSYTRIWSKLK 247
Cdd:cd15371 161 NSNFQFYYFISMAVFgFLIPLVITIFCYISIIRTLN 196
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
51-333 1.38e-08

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 55.56  E-value: 1.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKF-KSMRTVTNFFIANLAVADLLVnTLCLPFTLTYtLMGEWKMGPVLCHLVPYA 129
Cdd:cd15188   1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYvPKKKKMTEVYLLNLAVSDLLF-LVTLPFWAMY-VAWHWVFGSFLCKFVSTL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIFREyslIEIIPDFEIVaCTEKW 207
Cdd:cd15188  79 YTINFYSGIFFVSCMSLDKYLEIVHaqSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQ---THHTNNGVWV-CHADY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 pGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGaasdhyhQRRhkTTKMLVCVVVVFAVSWLP---- 283
Cdd:cd15188 155 -GGHHTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPG-------QGR--ALRFVAALVVVFFVLWFPynlt 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 284 --LHAFQlavdiDSHVLD----LKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15188 225 lfLHSLQ-----DLHVIGncerSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
60-285 1.99e-08

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 54.85  E-value: 1.99e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPvlCHLVPYAQGLAVQVSTI 139
Cdd:cd15071  10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQSSIL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHR--CIVYHLESKISKQISFLIIGLAWGVSALLA-SPL-------AIFREYSLIEIIPDFEIVACTEKWPG 209
Cdd:cd15071  88 ALLAIAVDRYLrvKIPTRYKSVVTPRRAAVAIAGCWILSFLVGlTPMfgwnnlnAVERAWAANSSMGELVIKCQFETVIS 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 210 EEKSVYGT--VYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaASDHYHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15071 168 MEYMVYFNffVWVLPPLLLMLLIYLEVFYLIRKQLNKKVSSSSS---DPQKYYGKELKIAKSLALILFLFALSWLPLH 242
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
60-336 2.43e-08

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 54.48  E-value: 2.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLT--------YTLMGEWKMGPVlCHLVPYAQG 131
Cdd:cd15359  10 INILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVdsqtksqyYNHAIDWQTGSG-CSTAGFFTV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLAS-PLAIFREYSLIEIIpdfeivactekWP 208
Cdd:cd15359  89 FASELSVYTLTVITLERWHTITYamQLDRKLRLRHAILIMLGGWVFSLLIAVlPLVGVSNYMKVSIC-----------LP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLsTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDhyhqrrHKTTKMLVCVVVVFAVSWLPLHAFQ 288
Cdd:cd15359 158 MDIETLLSQAYIL-LILVLNVIAFLVICACYIKIYLAVQNPELVAKNKD------TKIAKRMAILIFTDFTCMAPISFFA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 289 LAVDIDSHVLDLKEYKLIFTVFHIIAMCstfANPLLYGWMNSNYRKAF 336
Cdd:cd15359 231 ISAAFKVPLITVTNSKILLVLFYPINSC---ANPFLYAIFTKAFRRDF 275
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
60-154 3.34e-08

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 54.17  E-value: 3.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15214   9 IAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASML 88
                        90
                ....*....|....*
gi 13027422 140 TLTVIALDRHRCIVY 154
Cdd:cd15214  89 TLGAIAIDRYYAVLY 103
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
52-336 3.55e-08

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 54.01  E-value: 3.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIIllgVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLL------VNTLcLPFTLTYtlmgewKMGPVLCHL 125
Cdd:cd15102   5 VVFVAICCFI---VLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLLagaaylANIL-LSGARTL------RLSPAQWFL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 126 VPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKQIS-FLIIGLAWGVSALL-ASPLAIFREYSLIEiipdfeivAC 203
Cdd:cd15102  75 REGSMFVALSASVFSLLAIAIERHLTMAKMKPYGASKTSRvLLLIGACWLISLLLgGLPILGWNCLGALD--------AC 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 204 TEKWPgeeksVYGTVYSLSTLLILYVLPLGIISFsYTRIWSKlknhVSPGAASDHYHQRRHKTTKMLVCVVVVFA---VS 280
Cdd:cd15102 147 STVLP-----LYSKHYVLFCVTIFAGILAAIVAL-YARIYCL----VRASGRKATRASASPRSLALLKTVLIVLLvfiAC 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 13027422 281 WLPLHAFQLAvDIDSHVldlKEYKLIFTV--FHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15102 217 WGPLFILLLL-DVACPV---KTCPILYKAdwFLALAVLNSALNPIIYTLRSRELRRAV 270
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
65-180 4.27e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 54.13  E-value: 4.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  65 VVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLL--VNTLCLPFTLTYtLMG-------EWkMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15137  15 LLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLmgVYLLIIASVDLY-YRGvyikhdeEW-RSSWLCTFAGFLATLSSE 92
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 136 VSTITLTVIALDRHRCIVYHLE-SKISKQISFLIIGLAWGVSALLA 180
Cdd:cd15137  93 VSVLILTLITLDRFICIVFPFSgRRLGLRRAIIVLACIWLIGLLLA 138
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
57-334 4.46e-08

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 54.15  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTL-MGEWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15377   7 YILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLY-VLTLPALIFYYFnKTDWIFGDAMCKLQRFIFHVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLASPLAIFREYSlieiIPDFEIVACTEKWPGEEKS 213
Cdd:cd15377  86 GSILFLTCISVHRYTGVVHPLKSlgRLKKKNAICISVLVWLIVVVAISPILFYSGTG----VRKNKTITCYDTTSDEYLR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRhKTTKMLVCVVVVFAVSWLPLHAFQ---LA 290
Cdd:cd15377 162 SY-FIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRR-KSIYLVIIVLTVFAVSYLPFHVMKtlnLR 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 291 VDIDSHVLDLKEYK----LIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15377 240 ARLDFQTPAMCAFNdrvyATYQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
60-203 4.64e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 54.06  E-value: 4.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15385  10 IFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTY 89
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 140 TLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPLAIFreYSLIEIIPDFEIVAC 203
Cdd:cd15385  90 MLVMMTADRYIAICHPLKTlQQPTKRSYLMIGSAWALSFILSTPQYFI--FSLSEIENGSGVYDC 152
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
62-248 4.83e-08

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 53.95  E-value: 4.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVntLC-LPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTIT 140
Cdd:cd15378  12 VLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAF--LCtLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 141 LTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLaifreYSLIEIIPDFEIVACTEkWPGEEKSVYGTV 218
Cdd:cd15378  90 LTFISIDRYLLIKYPFREHIlqKKRSAVAISLAIWVLVTLELLPI-----LTFIGPNLKDNVTKCKD-YASSGDATNSLI 163
                       170       180       190
                ....*....|....*....|....*....|
gi 13027422 219 YSLSTLLILYVLPLGIISFSYTRIWSKLKN 248
Cdd:cd15378 164 YSLFLTVTGFLIPLCVMCFFYYKIALFLKN 193
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
51-255 5.02e-08

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 53.63  E-value: 5.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15364   1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLY-LGTLPLWTIYVSNNhKWPWGSLACKITGYI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKW 207
Cdd:cd15364  80 FFCNIYISILLLCCISIDRFVAVVYALESRgrRRQRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETLQMDTQV 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 208 PGeeksvygtvYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAA 255
Cdd:cd15364 160 AG---------FYYARFCIGFAIPLAILIFTNYRIFRSIQTSTSLTPH 198
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
53-336 5.36e-08

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 53.59  E-value: 5.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTN-FFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd14983   3 SLMVYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVF-ILSLPIKIVEALSSAWTLPAVLCPLYNLAHF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 132 LAVQVSTITLTVIALDRHRCIVYHLESKISKQ--ISFLIIGLAWGVSaLLASPLAIFREYS---LIEIIPDFEIVACTEK 206
Cdd:cd14983  82 STLYASTCFLTAISAGRYLGVAFPIKYQLYKKplYSCLVCVAIWALV-IFHVTLVFILETSggtLDINTPVGNSSTCYEN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYGTVySLSTLLILYVLPLGIISFSYTR-IWSKLKNHVSpgaasdhyHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd14983 161 FTPEQLALLAPV-RLELSLVLFFLPLAITAFCYVRcIRILVRSRLH--------ERRKRRAVRVAVSTLLTFVVCFGPYN 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 13027422 286 AFQLAVDIDSHVLDLKEYKLIFTVfhiiamCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd14983 232 ISHVVGFVRHESVWWRKLALLTST------CNAFLDPLIFYFLSSSMERGF 276
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
57-159 8.83e-08

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 52.84  E-value: 8.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLtYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15923   7 YIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLL-LISLPFKM-HSYRRESAGLQKLCNFVLSLYYINMYV 84
                        90       100
                ....*....|....*....|...
gi 13027422 137 STITLTVIALDRHRCIVYHLESK 159
Cdd:cd15923  85 SIFTITAISVDRYVAIRYPLRAR 107
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
57-247 1.16e-07

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 52.65  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVI-KFKSmRTVTNFFIANLAVADLLVntLC-LPFTLtYTLMGEWKMGPvLCHLVPYAQGLAV 134
Cdd:cd15164   7 YIPILFFGLLFNVLALWVFCcKMKK-WTETRVYMINLAVADCCL--LFsLPFVL-YFLKHSWPDDE-LCLVLQSIYFINR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFeivaCTEKwpgeeK 212
Cdd:cd15164  82 YMSIYIITAIAVDRYIAIKYPLKAKSlrSPRKAALTCGLLWVLVIISVSLRLAWEEQE-----ENF----CFGK-----T 147
                       170       180       190
                ....*....|....*....|....*....|....*
gi 13027422 213 SVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLK 247
Cdd:cd15164 148 STRPSKRTLIFSLLGFFIPLIILSFCSIQVIRSLK 182
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
62-335 1.39e-07

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 52.07  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTnfFIANLAVADLLVNTLCLPFTL--TYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15220  11 LTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGIlsSSPFFLGVVFGEAECRVYIFLSVCLVSASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWgVSALLASPLAIFREYSLIEIIPDFEiVACTEKW-PGEEKSVYG 216
Cdd:cd15220  89 TISAISVERYYYIVHPMryEVKMTIGLVAAVLVGVW-VKALLLGLLPVLGWPSYGGPAPIAA-RHCSLHWsHSGHRGVFV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 217 TVYSLstllILYVLPLGIISFSYTRIWSklknhVSPGAasdhyhqrrhKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSH 296
Cdd:cd15220 167 VLFAL----VCFLLPLLLILVVYCGVFK-----VFGGG----------KAALTLAAIVGQFLCCWLPYFAFHLYSALAAS 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 13027422 297 VLDLKEYKLIFTvfhIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15220 228 PVSGGEAEEVVT---WLAYSCFAVNPFFYGLLNRQIREE 263
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
53-183 2.09e-07

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 51.77  E-value: 2.09e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLmgewkMGPVLCH----LVPY 128
Cdd:cd15211   2 LSTVYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVADLLVCAFWMPQEAVLGS-----TGTLLVLgyrlFREG 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCI-----VYHleSKISKQISFLIIGLAWGVSALLASPL 183
Cdd:cd15211  77 LLFLGLTVSLLSHSLIALNRYVLItklpaVYQ--ALYQKRNTEWMIALSWALALGLLLPW 134
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
57-334 2.37e-07

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 51.75  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVP-YAQGLAVQ 135
Cdd:cd15171   7 CSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCF-LLTLPFWAHAAWHGGSLGNPTCKVLVAlSSVGLHSE 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 V-STITLTVIAldRHRCIVYHLESKISKQISFLII--GLAWGVSALLASPLAIFREYSLIEIIPDfeiVACTEKW--PGE 210
Cdd:cd15171  86 AlFNVLLTVQA--SRVFFHGRLASSARRVAPCGIIasVLAWLTAFLVTLPEFVFYKPQMDSQKSK---CAFSRPHflPAE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 EKSvYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvspgaasdhYHQRRHKTTKMLVCVVVVFAVSWLP------L 284
Cdd:cd15171 161 ETF-WKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQR-----------FRERQRDLSKLVFAIMVVFLLMWAPynialfL 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 285 HAFQ----LAVDIDSHVLDLKeykliFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15171 229 SAFKehfsLRDCKSSYHLDAS-----VQVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
60-333 3.01e-07

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 51.45  E-value: 3.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLvpyaQGLAVQVSTI 139
Cdd:cd15081  22 VVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVL----EGFTVSVCGI 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 140 T----LTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPlaifreyslieiipdfEIVACTEKWP-GEEKS 213
Cdd:cd15081  98 TglwsLTIISWERWVVVCKPFGNiKFDGKLAIVGIIFSWVWSAVWCAP----------------PIFGWSRYWPhGLKTS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLST-------LLILYV----LPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWL 282
Cdd:cd15081 162 CGPDVFSGSSdpgvqsyMIVLMItcciIPLAIIILCYLQVWLAIRAVAQQQKESESTQKAEKEVSRMVVVMIFAYCFCWG 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 283 PLHAFQ-LAVDIDSHVLdlkeYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15081 242 PYTFFAcFAAANPGYAF----HPLAAALPAYFAKSATIYNPIIYVFMNRQFR 289
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
57-334 4.64e-07

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 50.88  E-value: 4.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLvNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15152   7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLL-QVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQISFLIIGLA-WGVSALLASPLAIFREYSlieiipDFEIVACTEKWPGEEKSVY 215
Cdd:cd15152  86 SIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAgWLVVCVGCLPFPLLRQSQ------DTNPTCCFADLPLRNVGLT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 216 GTVySLSTL--LILYVLPLGIISFSYTRIWSKLKNHVSpgAASDhyHQRRHKTTKMLVCVVVVFAVSWLPLH-AFQLAVD 292
Cdd:cd15152 160 TSV-IMLTIaeLTGFVTPLLIVLYCSWKTVMSLREKTP--VLQD--LGEKKKALKMILTCAVVFLICFAPYHiSFPLDFL 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 293 IDSHVLDLKEYKLIFTVFHIIAMCSTFAN----PLLYGWMNSNYRK 334
Cdd:cd15152 235 VKSNKIKSCTARKVILIFHPVALCLASLNscldPVIYYFTTDEFKR 280
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
52-148 1.28e-06

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 49.48  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQG 131
Cdd:cd15126   3 ILLLALV-VFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLFFCLPVVVFNEITKKRLLGDVSCRVVPYMEV 81
                        90
                ....*....|....*..
gi 13027422 132 LAVQVSTITLTVIALDR 148
Cdd:cd15126  82 TSLGVTTFSLCALGIDR 98
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
60-182 1.41e-06

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 49.65  E-value: 1.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15218  10 IIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVKNGStWTYGTLTCKVIAFLGVLSCFHTA 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 139 ITLTVIALDRHRCIVYH--LESKISKQISFLIIGLAWGVSALLASP 182
Cdd:cd15218  90 FMLFCISVTRYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
51-333 2.20e-06

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 48.64  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCH-LVPY 128
Cdd:cd15370   1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLF-VIWFPLKIAYHINGnNWIYGEALCKvLIGF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGlAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIGLA-WGVSALLASPLAIFREYSLIeiiPDFEIVACTEKW 207
Cdd:cd15370  80 FYG-NMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAIGISLAiWLLILLVTIPLYLVKQTVFI---PALDITTCHDVL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 PGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSpgaaSDHYHQRRHKTTKMLVCVVVVFAVSWLPlhaf 287
Cdd:cd15370 156 PEQLLVGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSIN----DESIEKKRKRAIKLIVTVLVMYLICFTP---- 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 288 qlavdidSHVLDLKEYKLIFT-------VFHIIAMCSTFAN----PLLYGWMNSNYR 333
Cdd:cd15370 228 -------SNLLLVVHYFLLKNqgqssvyAFYITALCLSTLNscidPFVYYFVSHDFR 277
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
49-336 2.99e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.39  E-value: 2.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  49 VQVVLILAycsIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVL---CHL 125
Cdd:cd15069   2 TYVALELI---IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLflaCFV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 126 VpyaqgLAVQVSTITLTVIALDRHR--CIVYHLESKISKQISFLIIGLAWGVSALLA-SPLAIFREyslieiiPDFEIVA 202
Cdd:cd15069  79 L-----VLTQSSIFSLLAVAVDRYLaiKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNK-------AMSATNN 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 203 CTEKWPGEE-------KSVYGTVYSLSTLLIL-----YVLPLGIISFSYTRIWSKLKNHVSPGAASDHYH---QRRHKTT 267
Cdd:cd15069 147 STNPADHGTnhsccliSCLFENVVPMSYMVYFnffgcVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRttlQREIHAA 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 268 KMLVCVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFhIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15069 227 KSLAIIVGIFALCWLPVHILNCITLFQPEFSKSKPKWAMNVAI-LLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
57-321 3.22e-06

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 48.10  E-value: 3.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLtYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15165   7 YIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLL-LLSLPFKM-HSSKKQWPLGRTLCSFLESLYFVNMYG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 137 STITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLieiipdfEIVACTEKWpgeEKSV 214
Cdd:cd15165  85 SILIIVCISVDRYIAIRHPFLAKRlrSPRKAAIVCLTIWVFVWAGSIPIYSFHDKPT-------NNTRCFHGF---SNKT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAAsdhyHQRRHKTTKMLVCVVVVFAVSWLPLH-AFQLAVDI 293
Cdd:cd15165 155 WSKKVIVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQP----KVKQNKSVKIVLSNLVVFLVCFTPYHlGIFLQFLV 230
                       250       260
                ....*....|....*....|....*...
gi 13027422 294 DSHVLDLKEYKLIFTVFHIIAMCstFAN 321
Cdd:cd15165 231 KNDIINDCSTKQSIRLFVQVSMC--LAN 256
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
57-325 3.57e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 48.24  E-value: 3.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15365   7 YIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLY-IVILPLWIDYLWNGDnWTLSGFVCIFSAFLLYTNFY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKISKQISF-LIIGLAWGVSALLASPLAIFREYSLIEiipDFEIVACTEKWPGEEksv 214
Cdd:cd15365  86 TSTALLTCIALDRYLAVVHPLKFMHLRTIRTaLSVSVAIWLLEICFNAVILTWEDSFHE---SSSHTLCYDKFPLED--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 215 YGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKnhvSPGAASDhyhQRRHKTTKMLVCVVVVFAVSWLPLHAFQLAVDID 294
Cdd:cd15365 160 WQARLNLFRICLGYLLPLLIILFCYWKIYQAVR---SNQATED---QEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIV 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 13027422 295 SHVlDLKEYKLIFTVFHI---IAMCSTFANPLLY 325
Cdd:cd15365 234 EPC-DCRNAKWLYTLYKItvaLTSLNCIADPFLY 266
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
57-334 5.43e-06

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 47.45  E-value: 5.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15369   7 YTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLF-VLLLPFKIAYHFSGnDWLFGEAMCRVVTAAFYCNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIfREYSLIeiIPDFEIVACTEKWPGEEKS 213
Cdd:cd15369  86 CSILLMTCISVDRFLAVVYPMQSLSwrTLRRASFTCAAIWLLSIAGVVPLLL-SEQTIQ--IPDLGITTCHDVLNEQLLM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLknhvspgAASDHYHQRRHKTTKMLVCVVVVFA--VSWLPLHAFQLAV 291
Cdd:cd15369 163 GYYVYYFSIFSCLFFFVPLIITTVCYVSIIRCL-------SSSSDVANSSKKTRALFMAVAVFCVfvICFGPTNVLLLAH 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 13027422 292 DIDSHVLDLKEYK-LIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15369 236 YVRFAYTSTNDASyFAYLLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
60-159 6.42e-06

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 47.15  E-value: 6.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTI 139
Cdd:cd15156  10 VFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLF-VFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSIL 88
                        90       100
                ....*....|....*....|
gi 13027422 140 TLTVIALDRHRCIVYHLESK 159
Cdd:cd15156  89 FLTCISVDRFLAIVYPFRSK 108
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
60-182 8.74e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 47.25  E-value: 8.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  60 IILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGE-WKMGPVLCHLVPYAQGLAVQVST 138
Cdd:cd15217  10 IICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIRNGSaWTYSVLSCKIVAFMAVLFCFHAA 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 13027422 139 ITLTVIALDRHRCIVYHleSKISKQISF----LIIGLAWGVSALLASP 182
Cdd:cd15217  90 FMLFCISVTRYMAIAHH--RFYSKRMTFwtciAVICMVWTLSVAMAFP 135
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
51-188 9.86e-06

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 46.68  E-value: 9.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPF-TLTYTLMGEWKMGPVLCHLVPYA 129
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLY-VCSLPLlIVNYAMRDRWPFGDFLCKLVRFL 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIG--LAWGVSALLASPLAIFRE 188
Cdd:cd16001  80 FYTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGsaATWILVVLQLLPTLVYAR 140
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
51-178 1.06e-05

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 46.48  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSAL 178
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHplHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
51-336 1.37e-05

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 46.41  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILlgvvGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLclpFTLTYTLMGE--WKMGPVLCHLVPY 128
Cdd:cd15346   5 VVFIIICCFIIL----ENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVA---YTANLLLSGAttYKLTPTQWFLREG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIV---YHLESKISKqiSFLIIGLAWGVSALLASpLAIFrEYSLIEiipdfEIVACTE 205
Cdd:cd15346  78 SMFVALSASVFSLLAIAIERYITMLkmkLHNGSNSFR--SFLLISACWVISLILGG-LPIM-GWNCIS-----ALSSCST 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 206 KWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLH 285
Cdd:cd15346 149 VLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKASRSSEKSMALLKTVIIVLSVFIACWAPLF 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 13027422 286 AFqLAVDIDSHVldlKEYKLIFTV--FHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15346 229 IL-LLLDVGCKV---KTCSILFKAeyFLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
53-241 1.50e-05

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 46.10  E-value: 1.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILA-YCSIILLGVVGNSLVIHV-VIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYA 129
Cdd:cd15170   2 LVLAvYIITFLIGLPANLLAFYTfIRKVRRKPTPIDILLLNLTVSDLIF-LLFLPFKMAEAASGmIWPLPYFLCPLSSFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFLIIG--LAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKW 207
Cdd:cd15170  81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIAsvFFWVLAFSHCSIVYIVEYHIDSENTSVTNNSRCYDNF 160
                       170       180       190
                ....*....|....*....|....*....|....
gi 13027422 208 PGEEKSVYGTVySLSTLLILYVLPLGIISFSYTR 241
Cdd:cd15170 161 TPEQLKILLPV-RLELFLVLFCIPFLITCFCYIN 193
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
51-336 1.52e-05

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 45.94  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGvvgNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLpFTLTYTlmgewkmGPVLCHLVPYA- 129
Cdd:cd15342   4 VALGLTVSVIVLLT---NLLVIAAIFINRRFHYPIYYLLGNLAAADLFAGVAYL-FLMFHT-------GPWTAKLSLYQw 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 ---QGL---AVQVSTITLTVIALDRHRCIV-YHLESKISKQISFLIIGLAWGVSALLAsplaifreyslieIIPDF---- 198
Cdd:cd15342  73 flrQGLldtSLTASVANLLAIAVERHQTIFtMQLHSKMSNQRVVILIFGIWMVALILG-------------LIPAMgwnc 139
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 199 --EIVACTEKWPGEEKSvYGTVYSLSTLLIlYVLPLGIisfsYTRIWSKLKnHVSPGAASDHYHQRRHKTT-----KMLV 271
Cdd:cd15342 140 lcDLKRCSTMAPLYSRS-YLVFWALSNLLT-FLIMVAV----YTRIFIYVR-RKSQRMSEHHSSHPRYRETvlglmKTVV 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422 272 CVVVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVfhiIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15342 213 IILGAFVVCWTPGQVVLLLDGLGCESCNVLAYEKYFLL---LAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
51-158 2.07e-05

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 45.95  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGE-WKMGPVLCHLVPYA 129
Cdd:cd14996   1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLV-CSAMPFQAAYFLKGFyWKYQSTQCRIANFF 79
                        90       100       110
                ....*....|....*....|....*....|...
gi 13027422 130 QGLAVQ----VSTITLTVIALDRHRCIVYHLES 158
Cdd:cd14996  80 GTLVIHvsmcVSILILSWIAISRYATLMKHDSA 112
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
54-268 3.07e-05

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 45.14  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  54 ILAYCSIILLGV--VGNSLVIHVVIKFKSMRT-VTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15219   1 LLAVLLVVVLVVslLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLNMPFTLLGVVRNRQPFGDGFCQAVGFLE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVS------ALLASPLAIFREYSlieiipdfeivA 202
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPLSytSKMRYRDAALMVGYSWLHSltfslvALFLSWLGYSSLYA-----------S 149
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 203 CTEKWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYTRIwsklknhvspgaasdHYHQRRHKTTK 268
Cdd:cd15219 150 CTLHLPREEERRRFAVFTAFFHAFTFLLSLLVLCVTYLKV---------------LKVRRRQRATK 200
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
57-288 4.73e-05

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 44.68  E-value: 4.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPYAQGLAVQ 135
Cdd:cd15967   7 YILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLY-LLTLPFLVVYYLKGrKWIFGQVFCKITRFCFNLNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 136 VSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSAllasplaifreyslIEIIPDfeiVACTEKWPGEEKS 213
Cdd:cd15967  86 GSIGFLTCISVYRYLAIVHPMRVmgRITTTHSVVISALVWLLVV--------------IQSLPD---LFFSKTNSNGTKC 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 214 VYGT---------VYSLSTLLILYVLPLGIISFSYTRIWSKL--KNHVSPGAasdhyhqrRHKTTKMLVCVVVVFAVSWL 282
Cdd:cd15967 149 FDTTfndylesylTYSLGWTVTGFVIPLLIILGCYGHVVVVLcrNNNVDKGL--------KQRCLKLVIILIVLFSVCYI 220

                ....*.
gi 13027422 283 PLHAFQ 288
Cdd:cd15967 221 PYHVFR 226
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
57-108 6.67e-05

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 44.20  E-value: 6.67e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTL 108
Cdd:cd15221   7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKML 58
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
51-334 1.36e-04

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 43.25  E-value: 1.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPfTLTYTLM--GEWKMGPVLCHLVPY 128
Cdd:cd15374   1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLY-VLSLP-TLIYYYAdhNHWPFGVVACKIVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLES--KISKQISFLIIGLAWGVSALLASPLAIFREYSlieiiPDFEIVACTEK 206
Cdd:cd15374  79 LFYANLYCSILFLTCISVHRYVGICHPIRAlrWVKPRHAYLICASVWLVVTVCLVPNLIFVTTS-----RKDNITLCHDT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 207 WPGEEKSVYgTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHvSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15374 154 TRPEEFDHY-VHYSSAVMVLLFGIPCLVIVVCYGLMARRLCKP-RVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHI 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 13027422 287 ----FQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15374 232 trtlYYVARLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRR 283
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
63-333 1.49e-04

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 43.28  E-value: 1.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  63 LGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLpfTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLT 142
Cdd:cd14989  13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSL--IEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 143 VIALDRHRCIVYHLESKI--SKQISFLIIGLAWgvsalLASPLAIFREYSLIEIipdfeivacteKWPGEEKSVYGTVYS 220
Cdd:cd14989  91 WMSFDRYIALAKVMKSSPlrTMQHARLSCGLIW-----MASISATLLPFTAVQA-----------QHTGEVHFCFADVRE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 221 LSTLLIL--YVLPLGIISFSYTRIWSKLknhvspgaASDHYHQ----RRHKTTKMLVCVVVVFAVSWLPLHAF---QLAV 291
Cdd:cd14989 155 IQWLEVTlgFIIPFSIIGLCYSLIVRVL--------VRAQKHRrlrpRRQKALRMILVVVLVFFICWLPENVFisiQLLQ 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 292 DIDSHVLDLKE-----YKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd14989 227 GTQEPSESYDEsfrhnHPLTGHIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-247 1.77e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 42.88  E-value: 1.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  47 VEVQVVlilayCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLV 126
Cdd:cd15387   2 VEVTVL-----ALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVFQVLPQLIWDITFRFYGPDFLCRLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 127 PYAQGLAVQVSTITLTVIALDRHRCIVYHLESkISKQISFLIIGLAWGVSALLASP-LAIFreySLIEIIPdfEIVACte 205
Cdd:cd15387  77 KYLQVVGMFASTYMLLLMSIDRCLAICQPLRS-LHRRSDRVYVLFSWLLSLVFSIPqVHIF---SLREVGN--GVYDC-- 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 13027422 206 kWPGEEKSVYGTVYSLSTLLILYVLPLGIISFSYT----RIWSKLK 247
Cdd:cd15387 149 -WADFIQPWGPKAYITWITLSVYIIPVLILSVCYGlisfKIWQNVK 193
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
61-340 2.42e-04

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 42.20  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422    61 ILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQvSTIT 140
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAHLICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQ-GPLM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   141 LtVIALDRHRC----IVYHLESKISKQISFLIIGLAWGVSALLasplaifreYSLIEIIPDFeIVACTekwPGEekSVYG 216
Cdd:pfam10320  80 L-MIGIDRLIAvkfpIFYRLLSSSKYLFIQLIFPVIYSSFITV---------YGFLQRDDET-IIVCA---PPL--ALPG 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422   217 TVYSLSTLLILYVLPLGIISFSYTRIWSKLKNhvspgaasDHYHQRRHKTTKMLVCVVVVFAVSWLP---LHAFQLAVDI 293
Cdd:pfam10320 144 TAFTIFTLSSLFINVIVLIVYIILIIIFKNKK--------QSQNSDSKKVFKSLQVTVVIFIFGWFTstiANTVFLYLTE 215
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 13027422   294 DSHVLDLKEYKLIFTVfhIIAMCSTFanpLLYGWMNSNYRKAFLSAF 340
Cdd:pfam10320 216 DGEVEVIIQMYAGFFV--LLSFSQNF---FVTYWRSSEYRKAFRSLW 257
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
62-124 2.73e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 42.49  E-value: 2.73e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13027422  62 LLGVVGNSLVIHVVIKFKSMRTVTNFF--IANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCH 124
Cdd:cd15142  12 IFGVVGNLIAIVVLCKSRKEQKETTFYtlVCGLAVTDLLGTCLASPVTIATYLKGRWPGGQPLCE 76
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
52-336 3.39e-04

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 42.11  E-value: 3.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIIllgVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNtlcLPFTLTYTLMGE--WKMGPVLCHLVPYA 129
Cdd:cd15345   5 IFFLVICSFI---VLENLMVLIAIWKNNRFHNRMYFFIGNLALCDLLAG---IAYKVNILMSGKktFSLSPTQWFLREGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 130 QGLAVQVSTITLTVIALDRHRCIVYHLESKISKQIS-FLIIGLAWGVSALLASpLAIFrEYSLIEIIPDfeivaCTEKWP 208
Cdd:cd15345  79 MFVALGASTFSLLAIAIERHLTMIKMRPYDANKRYRvFLLIGTCWLISVLLGA-LPIL-GWNCLDNLPD-----CSTILP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 209 GEEKSVYGTVYSLSTLLILYVLPLgiisfsYTRIWSKLKNHvSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHAFq 288
Cdd:cd15345 152 LYSKKYVAFCISIFIAILVAIVIL------YARIYILVKSS-SRRVTNHRNSERSMALLRTVVIVVGVFIACWSPLFIL- 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 13027422 289 LAVDIDSHVldlKEYKLIFTV--FHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15345 224 LLIDVACEV---KQCPILYKAdwFIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
51-242 3.41e-04

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 41.83  E-value: 3.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQ 130
Cdd:cd15431   1 IILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 GLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIFREYSLI--EIIPDF--EI---- 200
Cdd:cd15431  81 LFLGITECLLLAVMAYDRFVAICNPLRYTLimSWRVCIQLAAGSWVSAFLLTVIPVLTMPLHFCgpNVINHFfcEVqall 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 13027422 201 -VACTekwpgeEKSVYGTVYSLSTLLILyVLPLGIISFSYTRI 242
Cdd:cd15431 161 kLACS------DTSLNEILMFATSIFTL-LLPFSFILVSYIRI 196
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
57-188 5.47e-04

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 41.35  E-value: 5.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  57 YCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQV 136
Cdd:cd15166   7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIF-ILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSI 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 137 STITLTVIALDRHRCIVYHLESKISKQIS--FLIIGLAWGVSALLASPLAIFRE 188
Cdd:cd15166  86 ALWLLAFISADRYMAIVQPKHAKELKNTPkaVLACVGVWIMTLASTFPLLFLYE 139
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
51-334 8.16e-04

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 40.89  E-value: 8.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHV-VIKFKSMRTVTNFFIaNLAVADLLVnTLCLPFTLTYTLMG-EWKMGPVLCHLVPY 128
Cdd:cd15373   1 ILLPVSYGIVFVVGLVLNILALYVfLFRTKPWNASTTYMF-NLAISDTLY-VLSLPLLVYYYADEnDWPFSEALCKIVRF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIF------------REYSLIEI 194
Cdd:cd15373  79 LFYTNLYCSILFLLCISVHRFLGVCYPVRSLrwLKVRYARIVSVVVWVIVLACQSPVLYFvttsdkggnitcHDTSSPEL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 195 IPDFeivactekwpgeeksvygTVYSLSTLLILYVLPLGIISFSYTRIWSKLknhVSPGAASDHYHQRRHKTTKMLVCVV 274
Cdd:cd15373 159 FDQF------------------VVYSSVMLVLLFCVPFVVILVCYALMVRKL---LKPSAGTSTNSRSKKKSVKMIIIVL 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 275 VVFAVSWLPLHAFQL------AVDIDSHVLDLkeYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRK 334
Cdd:cd15373 218 AVFILCFLPFHVTRTlyysfrSMDLSCGTLNA--INLAYKVTRPLASANSCLDPILYFLAGQSFRS 281
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
53-336 9.35e-04

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 40.74  E-value: 9.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  53 LILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGL 132
Cdd:cd15223   3 LSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 133 AVQVSTITLTVIALDRHRCIVYHLE--SKISKQISFLIIGLAWGVSALLASPLAIF---REYSLIEIIPDFEI------- 200
Cdd:cd15223  83 FTAMESSILLVMALDRYVAICKPLRypSIITKSFILKLVLFALIRSGLLVLPIVVLasqLSYCSSNVIEHCYCdhmalvs 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 201 VACTEkwpgeekSVYGTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTKMLVCVVVVFAVS 280
Cdd:cd15223 163 LACGD-------TTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSS 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 13027422 281 WlpLHAFQLAVDIDSHVLdlkeykliFTVFHIIAMCSTfaNPLLYGWMNSNYRKAF 336
Cdd:cd15223 236 L--TYRFGKTIPPDVHVL--------LSVLYILIPPAL--NPIIYGVRTKEIRQGF 279
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
48-186 1.53e-03

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 40.12  E-value: 1.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  48 EVQVVLILAYCsiiLLGVVGNSLVIHVvIKFKSMRTVTNFFIANLAVADLLVnTLCLPFTL---TYTLMGEWKMGPVLCH 124
Cdd:cd15108   1 EVLSALVMFTC---VCGMAGNGLVVWL-LSCRGRRTPFCVYVLHLAVADLLF-LLCMASTLsleTSPLVITHDLAYEVVR 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13027422 125 LVPYaqgLAVQVSTITLTVIALDRHRCIVYHLESKI--SKQISFLIIGLAWGVSALLASPLAIF 186
Cdd:cd15108  76 RVKY---FAYTASLSLLTAISTQRCLSVLFPIWYKChqPRHLSAVVCALLWALSLLMNVLASFF 136
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
51-333 2.32e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 39.39  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNtLCLPFTLTYTLMGEWKMGPVLCHLVPYAq 130
Cdd:cd15163   1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVG-LSLPTRIVMYYSAGNCLTCSFVHIFSYF- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 131 gLAVQVSTITLTVIALDRHRCIVYHLESKISKQISFliiglAWGVSALLAsplaifreysLIEIIPDFEIVACTEKWPGE 210
Cdd:cd15163  79 -VNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNY-----AKGICVFIW----------LFAIVVTFSILTTAIKFASC 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 211 eksvygtvySLSTLLIL----YVLPLGIISFSYTRIWSKLKNhvsPGAASDHyHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15163 143 ---------CLSKLFALtvfeFFLPLLIITFFTIRIMCALSR---PGLMHQS-RERRMRAVQLLITVLIIFMICFTPFHV 209
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 13027422 287 FQLAVDIDSHVlDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYR 333
Cdd:cd15163 210 RQVAVAFNPDI-PHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
47-336 3.56e-03

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 38.76  E-value: 3.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  47 VEVQVVLILAYCSIIllgvvGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMgPVLCHLV 126
Cdd:cd15354   2 IAAEVFLTLGIISLL-----ENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLLNNRHL-VIEDAFV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 127 PYAQG-------LAVQVSTITLTVIALDRHRCIVYHLESK--ISKQISFLIIGLAWGVSALLASPLAIFREyslieiipd 197
Cdd:cd15354  76 RHIDNvfdslicISVVASMCSLLAIAVDRYVTIFYALRYHniMTVRRAGIIIACIWTFCTGCGIIFILYSE--------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 198 feivactekwpgeeksvygTVYSLSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRHKTTK----MLVCV 273
Cdd:cd15354 147 -------------------STYVIICLITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMkgavTLTIL 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 13027422 274 VVVFAVSWLPLHAFQLAVDIDSHVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15354 208 LGIFIVCWAPFFLHLILMISCPQNLYCVCFMSHFNMYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
55-290 5.71e-03

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 38.19  E-value: 5.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  55 LAYCSIILLGVVGNSLVIHVvikFKSMRTVTNF-----FIANLAVADLLVnTLCLPFTLTYTL-MGEWKMGPVLCHLVPY 128
Cdd:cd15147   5 IVYSIIFVLGLIANCYVLWV---FARLYPSKKLneikiFMVNLTIADLLF-LITLPFWIVYYHnEGNWILPKFLCNVAGC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 129 AQGLAVQVSTITLTVIALDRHRCIVYHLES-KISKQISFLIIGLAWGVSALLASPLAIFREYSLIEIIPDFEIVACTEKW 207
Cdd:cd15147  81 LFFINTYCSVAFLGVISYNRYQAVTRPIKTaQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNTVKIDSGNFTRCFEGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 208 -PGEEKSVYGTVYSLSTLLILYVLplgIISFSYTRIWSKLknhVSPGAASDHYHQRRHKTTKMLVCVVVVFAVSWLPLHA 286
Cdd:cd15147 161 eKDNSKPVLIIHFIIIGLFFLVFL---LILVCNLVIARTL---LSQPVQGQRNAGVKRRALWMVCTVLAVFVICFVPHHV 234

                ....
gi 13027422 287 FQLA 290
Cdd:cd15147 235 VQGP 238
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
68-336 5.85e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 38.08  E-value: 5.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  68 NSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNT-LCLPFTLTYTLMGEWKMGPVLCHLVPyaqglAVQVSTITLTVIAL 146
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIgLILNFIFAYLLQSEAAKLVTVGLIVA-----SFSASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 147 DRHRCIVYHLESKISKQISF--LIIGLAWGVSALLA----SPLAIFREYSLIEIIPDFeivactekwpgeeksvygTVYS 220
Cdd:cd15961  93 DRYLSLYYALTYNSERTVTFtyVMLVLLWGASICLGllpvMGWNCLADESTCSVVRPL------------------TKNN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 221 LSTLLILYVLPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRH-----KTTKMLVCVVVVFAVSWLPLHAFQLAVDIds 295
Cdd:cd15961 155 AAILSVSFLLMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHyvttrKGVSTLAIILGTFAACWMPFTLYSLIADY-- 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 13027422 296 hvldlkEYKLIFTVFHII-AMCSTFANPLLYGWMNSNYRKAF 336
Cdd:cd15961 233 ------TYPSIYTYATLLpATYNSIINPVIYAFRNQEIQKAL 268
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-186 6.05e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 38.23  E-value: 6.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  51 VVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEwkmgpvlcHLVPYAq 130
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGD--------KTISFS- 71
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13027422 131 GLAVQ-------VST--ITLTVIALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLASPLAIF 186
Cdd:cd13954  72 GCLTQlyfffslGGTecFLLAVMAYDRYVAICHplHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVL 138
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
40-178 6.52e-03

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 38.19  E-value: 6.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  40 LIDSTKLVEVQVVLILAYCSIILLGVVGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMG 119
Cdd:cd15945   3 LLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIP 82
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13027422 120 PVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHL--ESKISKQISFLIIGLAWGVSAL 178
Cdd:cd15945  83 FYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLlyTTAMSRRVCYLLLVGAYLSGMA 143
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
52-181 7.30e-03

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 37.94  E-value: 7.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  52 VLILAYCSIILLGV-VGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNtlclpftLTYTLMgEWKMGPVLCHLVP--- 127
Cdd:cd15343   1 IIVLCVGTFCCLFIfVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFAG-------IAYVFL-MFNTGPVSKTLTVnrw 72
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 13027422 128 -YAQGL---AVQVSTITLTVIALDRHRCIV-YHLESKISKQISFLIIGLAWGVSALLAS 181
Cdd:cd15343  73 fLRQGLldtSLSASLTNLLVIAVERHISIMrMKVHSNLTKRRVTLLIALVWAIAIFMGA 131
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
58-335 9.43e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.51  E-value: 9.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422  58 CSII-LLGVVGNSLVIHVVIKFKSMRTVTNF-FIANLAVADLLVNTL-CLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAV 134
Cdd:cd15341   7 CTLCgLLCILENVAVLYLILSSPKLRRKPSYlFIGSLALADFLASVVfACSFVDFHVFHGVDSSAIFLLKLGGVTMSFTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 135 QVSTITLTviALDRHRCIVY--HLESKISKQISFLIIGLAWGVSALLAS-PLAIFREYSLIEiipdfeivACTEKWPgee 211
Cdd:cd15341  87 SLGSLLLM--AFDRYVCIYYpsEYKALVTRKRALVALAVMWVLTALIAYlPLMGWNCCPLNS--------PCSELFP--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13027422 212 ksVYGTVYSLSTLLILYVLPLGIIsFSYTRIWSKLKNHVS----------PGAASDHYHQRRHKTTKMLVCVVVVFAVSW 281
Cdd:cd15341 154 --LIPNDYLLSWLLLVAILLSGII-YTYGHVLWKAHKHVVymekhqdqqgPGNARMRLDVRLAKTLGLVLAVLLICWSPV 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 13027422 282 LPLHAFQLAVDIDSHVldlkeyKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKA 335
Cdd:cd15341 231 LALMMHSLFTSLSDHI------KKAFAFCSTLCLVNSMVNPIIYALRSRELRSS 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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