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Conserved domains on  [gi|24371248|ref|NP_076423|]
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FUN14 domain-containing protein 2 [Homo sapiens]

Protein Classification

FUN14 domain-containing protein( domain architecture ID 10522754)

FUN14 domain-containing protein similar to Homo sapiens FUN14 domain-containing protein 1 that acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control

Gene Ontology:  GO:0005741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FUN14 pfam04930
FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although ...
 87-173 2.86e-27

FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although the function of these proteins is not known they may contain transmembrane helices.


:

Pssm-ID: 461487  Cd Length: 95  Bit Score: 98.83  E-value: 2.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24371248    87 LFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVrskaeeVV 166
Cdd:pfam04930   1 LGFGGVLGLCAGYALKKVGKLAAVAVGGGFLLLQYLAYQGYITVNWDKVEKDVESALDRNGDGKIDTKDAKV------LL 74


                  ....*..
gi 24371248   167 SFVKKNV 173
Cdd:pfam04930  75 DFLTANL 81
 
Name Accession Description Interval E-value
FUN14 pfam04930
FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although ...
 87-173 2.86e-27

FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although the function of these proteins is not known they may contain transmembrane helices.


Pssm-ID: 461487  Cd Length: 95  Bit Score: 98.83  E-value: 2.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24371248    87 LFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVrskaeeVV 166
Cdd:pfam04930   1 LGFGGVLGLCAGYALKKVGKLAAVAVGGGFLLLQYLAYQGYITVNWDKVEKDVESALDRNGDGKIDTKDAKV------LL 74


                  ....*..
gi 24371248   167 SFVKKNV 173
Cdd:pfam04930  75 DFLTANL 81
COG2383 COG2383
Uncharacterized membrane protein, Fun14 family [Function unknown];
82-181 4.62e-03

Uncharacterized membrane protein, Fun14 family [Function unknown];


Pssm-ID: 441949  Cd Length: 107  Bit Score: 35.23  E-value: 4.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24371248  82 SVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIrksnqiptEVRSK 161
Cdd:COG2383  11 QLGLQLGFGAVIGFAVGYALKKVAKIVLVLVGLYLASLFYLESQGIITVNWDALQALLDGATQQARG--------AGGSL 82

                        90       100
                ....*....|....*....|
gi 24371248 162 AEEVVSfvkkNVLVTGGFFG 181
Cdd:COG2383  83 LDGLLS----NLPFGAGFAA 98
 
Name Accession Description Interval E-value
FUN14 pfam04930
FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although ...
 87-173 2.86e-27

FUN14 family; This family of short proteins are found in eukaryotes and some archaea. Although the function of these proteins is not known they may contain transmembrane helices.


Pssm-ID: 461487  Cd Length: 95  Bit Score: 98.83  E-value: 2.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24371248    87 LFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIRKSNQIPTEVrskaeeVV 166
Cdd:pfam04930   1 LGFGGVLGLCAGYALKKVGKLAAVAVGGGFLLLQYLAYQGYITVNWDKVEKDVESALDRNGDGKIDTKDAKV------LL 74


                  ....*..
gi 24371248   167 SFVKKNV 173
Cdd:pfam04930  75 DFLTANL 81
COG2383 COG2383
Uncharacterized membrane protein, Fun14 family [Function unknown];
82-181 4.62e-03

Uncharacterized membrane protein, Fun14 family [Function unknown];


Pssm-ID: 441949  Cd Length: 107  Bit Score: 35.23  E-value: 4.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24371248  82 SVATQLFIGGVTGWCTGFIFQKVGKLAATAVGGGFFLLQLANHTGYIKVDWQRVEKDMKKAKEQLKIrksnqiptEVRSK 161
Cdd:COG2383  11 QLGLQLGFGAVIGFAVGYALKKVAKIVLVLVGLYLASLFYLESQGIITVNWDALQALLDGATQQARG--------AGGSL 82

                        90       100
                ....*....|....*....|
gi 24371248 162 AEEVVSfvkkNVLVTGGFFG 181
Cdd:COG2383  83 LDGLLS----NLPFGAGFAA 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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