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Conserved domains on  [gi|13443008|ref|NP_075964|]
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serine hydrolase-like protein [Mus musculus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 16-126 1.09e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.91  E-value: 1.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  16 IALKVWGSQKnPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHynPGLPYYQQNFVSEVRRVATAFKWNQ 95
Cdd:COG0596  14 LHYREAGPDG-PPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK--PAGGYTLDDLADDLAALLDALGLER 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 13443008  96 FTLLGHSFGGCVGGTFACMFPEMVDKLILLD 126
Cdd:COG0596  91 VVLVGHSMGGMVALELAARHPERVAGLVLVD 121
EntF2 super family cl43840
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 9-301 8.18e-08

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


The actual alignment was detected with superfamily member COG3319:

Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 53.55  E-value: 8.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   9 LAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDF-CYmamdfgghGLSSH-YNPGLP----------YY 76
Cdd:COG3319 584 AAAAALSPLVPLRAGGSGPPLFCVHPAGGNVLCYRPLARALGPDRpVY--------GLQAPgLDGGEPppasveemaaRY 655

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  77 qqnfVSEVRRVatafkwnQ----FTLLGHSFGGCVGgtF--ACMFPEM---VDKLILLDS-----TPFFLDSNEMENILT 142
Cdd:COG3319 656 ----VEAIRAV-------QpegpYHLLGWSFGGLVA--YemARQLEAQgeeVALLVLLDSyapgaLARLDEAELLAALLR 722

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 143 YRRRNIEHTLQVEAsqkksLRAVSPEEMLQgflnnnshldkdcgelilqrgttkvdagLVLNRDRRISWPENsfdfVSKE 222
Cdd:COG3319 723 DLARGVDLPLDAEE-----LRALDPEERLA----------------------------RLLERLREAGLPAG----LDAE 765

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 223 MFVHSAKSLQASVlmiKALQGY----YDVR----RANDADKAPMHFMVDTLRSTLKERFQFVEVPGNHYiHMNKPQVVAg 294
Cdd:COG3319 766 RLRRLLRVFRANL---RALRRYrprpYDGPvllfRAEEDPPGRADDPALGWRPLVAGGLEVHDVPGDHF-SMLREPHVA- 840


                ....*..
gi 13443008 295 VVGPFLQ 301
Cdd:COG3319 841 ELAAALR 847
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 16-126 1.09e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.91  E-value: 1.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  16 IALKVWGSQKnPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHynPGLPYYQQNFVSEVRRVATAFKWNQ 95
Cdd:COG0596  14 LHYREAGPDG-PPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK--PAGGYTLDDLADDLAALLDALGLER 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 13443008  96 FTLLGHSFGGCVGGTFACMFPEMVDKLILLD 126
Cdd:COG0596  91 VVLVGHSMGGMVALELAARHPERVAGLVLVD 121
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-137 1.81e-16

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 77.16  E-value: 1.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    27 PPVLCLHGWLDNANSFDRLIPLLPQD-FCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGG 105
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 13443008   106 CVGGTFACMFPEMVDKLILLDSTPFFLDSNEM 137
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEA 112
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 27-129 1.55e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 71.86  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    27 PPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEV-RRVATAFKWNQFTLLGHSFGG 105
Cdd:TIGR03695   3 PVLVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERYDFEEAAQLLlATLLDQLGIEPFFLVGYSMGG 82

                          90       100
                  ....*....|....*....|....
gi 13443008   106 CVGGTFACMFPEMVDKLILLDSTP 129
Cdd:TIGR03695  83 RIALYYALQYPERVQGLILESGSP 106
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 22-126 8.78e-09

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 56.04  E-value: 8.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   22 GSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSS--HYNPGLPYYQQNFVSEVRRVATAFKWNQFTLL 99
Cdd:PLN03084 123 GSNNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDkpQPGYGFNYTLDEYVSSLESLIDELKSDKVSLV 202

                         90       100
                 ....*....|....*....|....*..
gi 13443008  100 GHSFGGCVGGTFACMFPEMVDKLILLD 126
Cdd:PLN03084 203 VQGYFSPPVVKYASAHPDKIKKLILLN 229
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 9-301 8.18e-08

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 53.55  E-value: 8.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   9 LAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDF-CYmamdfgghGLSSH-YNPGLP----------YY 76
Cdd:COG3319 584 AAAAALSPLVPLRAGGSGPPLFCVHPAGGNVLCYRPLARALGPDRpVY--------GLQAPgLDGGEPppasveemaaRY 655

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  77 qqnfVSEVRRVatafkwnQ----FTLLGHSFGGCVGgtF--ACMFPEM---VDKLILLDS-----TPFFLDSNEMENILT 142
Cdd:COG3319 656 ----VEAIRAV-------QpegpYHLLGWSFGGLVA--YemARQLEAQgeeVALLVLLDSyapgaLARLDEAELLAALLR 722

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 143 YRRRNIEHTLQVEAsqkksLRAVSPEEMLQgflnnnshldkdcgelilqrgttkvdagLVLNRDRRISWPENsfdfVSKE 222
Cdd:COG3319 723 DLARGVDLPLDAEE-----LRALDPEERLA----------------------------RLLERLREAGLPAG----LDAE 765

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 223 MFVHSAKSLQASVlmiKALQGY----YDVR----RANDADKAPMHFMVDTLRSTLKERFQFVEVPGNHYiHMNKPQVVAg 294
Cdd:COG3319 766 RLRRLLRVFRANL---RALRRYrprpYDGPvllfRAEEDPPGRADDPALGWRPLVAGGLEVHDVPGDHF-SMLREPHVA- 840


                ....*..
gi 13443008 295 VVGPFLQ 301
Cdd:COG3319 841 ELAAALR 847
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 16-126 1.09e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 93.91  E-value: 1.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  16 IALKVWGSQKnPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHynPGLPYYQQNFVSEVRRVATAFKWNQ 95
Cdd:COG0596  14 LHYREAGPDG-PPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK--PAGGYTLDDLADDLAALLDALGLER 90

                        90       100       110
                ....*....|....*....|....*....|.
gi 13443008  96 FTLLGHSFGGCVGGTFACMFPEMVDKLILLD 126
Cdd:COG0596  91 VVLVGHSMGGMVALELAARHPERVAGLVLVD 121
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 27-137 1.81e-16

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 77.16  E-value: 1.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    27 PPVLCLHGWLDNANSFDRLIPLLPQD-FCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGG 105
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 13443008   106 CVGGTFACMFPEMVDKLILLDSTPFFLDSNEM 137
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGALDPPHELDEA 112
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 27-129 1.55e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 71.86  E-value: 1.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    27 PPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEV-RRVATAFKWNQFTLLGHSFGG 105
Cdd:TIGR03695   3 PVLVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERYDFEEAAQLLlATLLDQLGIEPFFLVGYSMGG 82

                          90       100
                  ....*....|....*....|....
gi 13443008   106 CVGGTFACMFPEMVDKLILLDSTP 129
Cdd:TIGR03695  83 RIALYYALQYPERVQGLILESGSP 106
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
15-127 3.59e-11

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 61.94  E-value: 3.59e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  15 HIALKVWGSQKNP--PVLCLHGWLDNANSFDRLIP-LLPQDFCYMAMDFGGHGLSS---HYNPGLPYYQQNfVSEVRRVA 88
Cdd:COG2267  15 RLRGRRWRPAGSPrgTVVLVHGLGEHSGRYAELAEaLAAAGYAVLAFDLRGHGRSDgprGHVDSFDDYVDD-LRAALDAL 93

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 13443008  89 TAFKWNQFTLLGHSFGGCVGGTFACMFPEMVDKLILLDS 127
Cdd:COG2267  94 RARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP 132
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 22-126 8.78e-09

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 56.04  E-value: 8.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   22 GSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSS--HYNPGLPYYQQNFVSEVRRVATAFKWNQFTLL 99
Cdd:PLN03084 123 GSNNNPPVLLIHGFPSQAYSYRKVLPVLSKNYHAIAFDWLGFGFSDkpQPGYGFNYTLDEYVSSLESLIDELKSDKVSLV 202

                         90       100
                 ....*....|....*....|....*..
gi 13443008  100 GHSFGGCVGGTFACMFPEMVDKLILLD 126
Cdd:PLN03084 203 VQGYFSPPVVKYASAHPDKIKKLILLN 229
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 24-131 4.14e-08

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 53.28  E-value: 4.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    24 QKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNP-GLPYYQQNFVSEVRRVATafkWnqftlLGHS 102
Cdd:TIGR01738   2 QGNVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPlSLADMAEAIAAQAPDPAI---W-----LGWS 73

                          90       100
                  ....*....|....*....|....*....
gi 13443008   103 FGGCVGGTFACMFPEMVDKLILLDSTPFF 131
Cdd:TIGR01738  74 LGGLVALHIAATHPDRVRALVTVASSPCF 102
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 9-301 8.18e-08

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 53.55  E-value: 8.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   9 LAVPWGHIALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDF-CYmamdfgghGLSSH-YNPGLP----------YY 76
Cdd:COG3319 584 AAAAALSPLVPLRAGGSGPPLFCVHPAGGNVLCYRPLARALGPDRpVY--------GLQAPgLDGGEPppasveemaaRY 655

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  77 qqnfVSEVRRVatafkwnQ----FTLLGHSFGGCVGgtF--ACMFPEM---VDKLILLDS-----TPFFLDSNEMENILT 142
Cdd:COG3319 656 ----VEAIRAV-------QpegpYHLLGWSFGGLVA--YemARQLEAQgeeVALLVLLDSyapgaLARLDEAELLAALLR 722

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 143 YRRRNIEHTLQVEAsqkksLRAVSPEEMLQgflnnnshldkdcgelilqrgttkvdagLVLNRDRRISWPENsfdfVSKE 222
Cdd:COG3319 723 DLARGVDLPLDAEE-----LRALDPEERLA----------------------------RLLERLREAGLPAG----LDAE 765

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008 223 MFVHSAKSLQASVlmiKALQGY----YDVR----RANDADKAPMHFMVDTLRSTLKERFQFVEVPGNHYiHMNKPQVVAg 294
Cdd:COG3319 766 RLRRLLRVFRANL---RALRRYrprpYDGPvllfRAEEDPPGRADDPALGWRPLVAGGLEVHDVPGDHF-SMLREPHVA- 840


                ....*..
gi 13443008 295 VVGPFLQ 301
Cdd:COG3319 841 ELAAALR 847
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 22-142 2.63e-07

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 51.45  E-value: 2.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   22 GSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSShynpglpyyQQNFVSEVRRVATAF------KWNQ 95
Cdd:PLN02894 101 SKEDAPTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSS---------RPDFTCKSTEETEAWfidsfeEWRK 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 13443008   96 ------FTLLGHSFGGCVGGTFACMFPEMVDKLILLDSTPFFLDSNEMENILT 142
Cdd:PLN02894 172 aknlsnFILLGHSFGGYVAAKYALKHPEHVQHLILVGPAGFSSESDDKSEWLT 224
PRK05855 PRK05855
SDR family oxidoreductase;
16-90 8.84e-07

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 49.98  E-value: 8.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 13443008   16 IALKVWGSQKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLPYYQQNFVSEVRRVATA 90
Cdd:PRK05855  15 LAVYEWGDPDRPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSAPKRTAAYTLARLADDFAAVIDA 89
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 29-133 1.53e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 48.24  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    29 VLCLHGWldnANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPGLpyyqqNFVSEVRRVATAFK-WNQFTLLGHSFGGCV 107
Cdd:pfam12697   1 VVLVHGA---GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDL-----ADLADLAALLDELGaARPVVLVGHSLGGAV 72

                          90       100
                  ....*....|....*....|....*.
gi 13443008   108 GGTFACMfpeMVDKLILLDSTPFFLD 133
Cdd:pfam12697  73 ALAAAAA---ALVVGVLVAPLAAPPG 95
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 29-131 3.17e-05

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 44.51  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008    29 VLCLHGWLDNANSFDRLIP-LLPQDFCYMAMDFGGHGLSshynPGLPYYQQNF-------VSEVRRVATAFKWNQFTLLG 100
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADaLAAQGFAVYAYDHRGHGRS----DGKRGHVPSFddyvddlDTFVDKIREEHPGLPLFLLG 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 13443008   101 HSFGGCVGGTFACMFPEMVDKLILldSTPFF 131
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLIL--SAPAL 111
PRK10673 PRK10673
esterase;
24-129 4.28e-05

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 44.34  E-value: 4.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   24 QKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHyNPGLPYyqQNFVSEVRRVATAFKWNQFTLLGHSF 103
Cdd:PRK10673  14 HNNSPIVLVHGLFGSLDNLGVLARDLVNDHDIIQVDMRNHGLSPR-DPVMNY--PAMAQDLLDTLDALQIEKATFIGHSM 90

                         90       100
                 ....*....|....*....|....*.
gi 13443008  104 GGCVGGTFACMFPEMVDKLILLDSTP 129
Cdd:PRK10673  91 GGKAVMALTALAPDRIDKLVAIDIAP 116
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 28-130 6.05e-05

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 41.35  E-value: 6.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  28 PVLCLHGWLDNANSFDRLIPLLPQD-FCYMAMDFGGHGLSshynpgLPYYQQNFVSEVRRVATAFKWNQFTLLGHSFGGC 106
Cdd:COG1075   7 PVVLVHGLGGSAASWAPLAPRLRAAgYPVYALNYPSTNGS------IEDSAEQLAAFVDAVLAATGAEKVDLVGHSMGGL 80

                        90       100
                ....*....|....*....|....*.
gi 13443008 107 VGGTFACMF--PEMVDKLILLdSTPF 130
Cdd:COG1075  81 VARYYLKRLggAAKVARVVTL-GTPH 105
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
24-131 2.32e-03

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 38.85  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   24 QKNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSSHYNPglpYYQQNFVSEVRRVATafkwNQFTLLGHSF 103
Cdd:PRK10349  11 QGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGA---LSLADMAEAVLQQAP----DKAIWLGWSL 83

                         90       100
                 ....*....|....*....|....*...
gi 13443008  104 GGCVGGTFACMFPEMVDKLILLDSTPFF 131
Cdd:PRK10349  84 GGLVASQIALTHPERVQALVTVASSPCF 111
PLN02578 PLN02578
hydrolase
 25-205 6.33e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 37.90  E-value: 6.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008   25 KNPPVLCLHGWLDNANSFDRLIPLLPQDFCYMAMDFGGHGLSS----HYNPGLPYYQ-QNFVSEVRRvatafkwNQFTLL 99
Cdd:PLN02578  85 EGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDkaliEYDAMVWRDQvADFVKEVVK-------EPAVLV 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13443008  100 GHSFGGCVGGTFACMFPEMVDKLILLDSTPFFLDSN--------EMENILT---------YRRRNIEHTLQVEASQKKSL 162
Cdd:PLN02578 158 GNSLGGFTALSTAVGYPELVAGVALLNSAGQFGSESrekeeaivVEETVLTrfvvkplkeWFQRVVLGFLFWQAKQPSRI 237

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 13443008  163 RAVspeemLQGFLNNNSHLDKDCGELILQRgTTKVDAGLVLNR 205
Cdd:PLN02578 238 ESV-----LKSVYKDKSNVDDYLVESITEP-AADPNAGEVYYR 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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