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Conserved domains on  [gi|117676363|ref|NP_075708|]
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solute carrier family 5 member 4B [Mus musculus]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 27-660 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11486:

Pssm-ID: 444915  Cd Length: 636  Bit Score: 1024.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 347 VPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 427 RIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 507 GTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLDAEELETQEEAGG 586
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDQDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117676363 587 ALEEDS-EQSRGCLKRACCLLCGL-QNTGPKLTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11486  561 MIETDEmREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-660 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1024.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 347 VPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 427 RIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 507 GTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLDAEELETQEEAGG 586
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDQDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117676363 587 ALEEDS-EQSRGCLKRACCLLCGL-QNTGPKLTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11486  561 MIETDEmREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 1.03e-160

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 467.59  E-value: 1.03e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363   58 FFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  138 GKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  218 LMGFAFAEVGGYESFTEKYMNAIPSVVegDNLTispkcytpqPDSFHVFRDPVTGDIPWPGLIFGMTILaiwywcadQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  298 VQRCLCGKnmshvKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVVPseceKQCGTAVGCTNYAYPTLVLELMPDG 377
Cdd:pfam00474 222 LQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  378 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVPLVQVSQNGqLFHYIG 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 117676363  458 SVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 3.78e-152

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 445.98  E-value: 3.78e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363   61 AGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFG-KR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  141 LQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMG 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  221 FAFAEVGGYESFTEKYMNAIPSVVEGDnltispkcytpqpDSFHVFRDPVTGDIPWPGLIFGMTILAIWYWcADQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTNPSPD-------------DLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  301 CLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDkvacVVPSEcekqCGTAVGCTNYAYPTLVLELMPDGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTD----IDPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  381 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVplVQVSQNGQLFHYIGSVS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 117676363  461 SYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-500 5.87e-141

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 418.39  E-value: 5.87e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  25 NAADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWN 104
Cdd:COG4146    4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 105 ALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFgGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFIL 184
Cdd:COG4146   84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 185 LAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesftekymnaiPSVVEG-DNLTISPkcytpqPDSF 263
Cdd:COG4146  163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 264 HVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKV 343
Cdd:COG4146  225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 344 AcvvpsecekqcgtavgCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASEREL 422
Cdd:COG4146  305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKyFNPNASEKQL 368

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117676363 423 MIAGRIFGMVLIAVSILWVPLVQVSqnGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRL 500
Cdd:COG4146  369 VKVGRIATVVLAVIAILIAPLIGNA--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILLK 444
PRK10484 PRK10484
putative transporter; Provisional
 32-547 4.19e-66

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 226.30  E-value: 4.19e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  32 IVIYFIVVLAVGL--WSMVR-SNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLM 108
Cdd:PRK10484   4 ILSFLGFTLLVAVisWWKTRkTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 109 VLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIyLSVLSLFIMVALQTSSIIFSGAI-----F-IQLALGLNLYLAVF 182
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 183 ILL----AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesftekymnaipsvveGDNLTISPKCYTP 258
Cdd:PRK10484 163 LLVwligIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 259 QPDSFHVFrDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSI-GGATDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 339 YTDKVAcvvpsecekqcgtavgCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKIRKKA 417
Cdd:PRK10484 305 YGDGLP----------------NADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 418 SERELMIAGRIFGMVLIAVSILWVPLVQVSQNGqLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVvgl 497
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGII--- 444

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 117676363 498 irliaefVYGTGSCVAPSncpkiicGVHYMYFAIILFFVSIIVILGVSFL 547
Cdd:PRK10484 445 -------LYIIINFVLKF-------DIHFLYVLAILFVINVVVMLIIGKI 480
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-660 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1024.49  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11486    1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11486   81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVF 266
Cdd:cd11486  161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACV 346
Cdd:cd11486  241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 347 VPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAG 426
Cdd:cd11486  321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 427 RIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVY 506
Cdd:cd11486  401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 507 GTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLDAEELETQEEAGG 586
Cdd:cd11486  481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETEDQDSNS 560

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 117676363 587 ALEEDS-EQSRGCLKRACCLLCGL-QNTGPKLTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11486  561 MIETDEmREEPGCCKKAYNWFCGLdQGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
 27-660 0e+00

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 793.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11487    1 ADISVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11487   81 FVVLLLGWLFVPVYLTAGVITMPQYLKKRFGGQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLT---ISPKCYTPQPDSF 263
Cdd:cd11487  161 ITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSEDPAvgnISSSCYRPRPDSY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 264 HVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKV 343
Cdd:cd11487  241 HLLRDPVTGDLPWPALILGLTIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 344 ACVVPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELM 423
Cdd:cd11487  321 ACVEPSVCLRVCGTEVGCSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKELL 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 424 IAGRIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAE 503
Cdd:cd11487  401 LVGRVWVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMGLCRMVPE 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 504 FVYGTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLdaeeletqee 583
Cdd:cd11487  481 FSFGSGSCVAPSSCPAIICGVHYLYFAILLFFCSGLLVLIVSLCTPPIPRKHLHRLVFSLRHSKEEREDL---------- 550

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 117676363 584 aggaleedseqsrgclkraccllcglqntgpkltkeeeaalrqkFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11487  551 --------------------------------------------LPDISEDPKWARVVNLNALIMMAVAVFLWGFYA 583
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
 28-660 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 758.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11488    1 DIAVVVVYFVFVLAVGIWSSIRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAI 187
Cdd:cd11488   81 VLIALGWIFVPVYIAAGVVTMPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 188 TAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNltispKCYTPQPDSFHVFR 267
Cdd:cd11488  161 TALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIPALTVPNT-----TCHLPRSDAFHIFR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 268 DPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVV 347
Cdd:cd11488  236 DPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEVGCVD 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 348 PSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGR 427
Cdd:cd11488  316 PDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQELMVVGR 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 428 IFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVYG 507
Cdd:cd11488  396 VFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMIMEFVYG 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 508 TGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLWNNTEERIDLdaeeletqeeagga 587
Cdd:cd11488  476 APSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL-------------- 541

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117676363 588 leedseqsrgCLKRACCLLCGL-QNTGPKLTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11488  542 ----------WWKRLGMWFCGLsQTPEQDLSEEERQALEKKLTSIEEDPLWRTVCNINALILLAINVFLWGYFA 605
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
 28-660 0e+00

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 708.21  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11490    1 DIVVLVLYFLFVLAVGLWSMWKTKRSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAI 187
Cdd:cd11490   81 MVLVLAWLFLPIYIASRVTTMPEYLKKRFGGKRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDLYLAVVGLLGI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 188 TAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNltispKCYTPQPDSFHVFR 267
Cdd:cd11490  161 TALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSPNS-----TCGIPREDAFHIFR 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 268 DPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVV 347
Cdd:cd11490  236 DPVTSDLPWPGVLLGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACAD 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 348 PSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGR 427
Cdd:cd11490  316 PEVCKEICGNPSGCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRASEWELMIVGR 395

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 428 IFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVYG 507
Cdd:cd11490  396 VFVLVLVVVSILWIPLVQASQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLDFIYV 475

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 508 TGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSlwnnteERIDLDAEELEtqeeagga 587
Cdd:cd11490  476 TPQCDQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLATEPPSKEMISRLTWF------TRFDAVVESEE-------- 541

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 117676363 588 leedseqsrgcLKRACCLLCGLQNTGPKlTKEEEAALRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11490  542 -----------LKKAILWLCGMEKQTEK-SSSSPAPPEAAMVSLEEEPLMKHVLNANLIICVSVAVFLWAYFA 602
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
 29-660 0e+00

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 706.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  29 ISVIVIYFIVVLAVGLWSMvRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLM 108
Cdd:cd10329    1 IVIIAVYFVAVIAIGLWSS-RKKRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGNYEWNAAFV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 109 VLVLGWVFLPIYIKAGVLTMPEYLRKRFGGkRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAIT 188
Cdd:cd10329   80 LLLLGWVFLPFYIRSGVSTMPEFLEKRFGG-RSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLVIT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 189 AFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesFTEKYMNAIPSVVegdnltispkcytpqpdSFHVFRD 268
Cdd:cd10329  159 AIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGG---GWSAYMAAIPSGT-----------------AFHLFRP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 269 PVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVVP 348
Cdd:cd10329  219 PDDPDLPWPGLLLGYPILGIWYWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVP 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 349 secekqCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRI 428
Cdd:cd10329  299 ------CGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPEASEKELVRVGRI 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 429 FGMVLIAVSILWVPLVQvSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVYGt 508
Cdd:cd10329  373 ATLVVVVISILWAPIIQ-AQGGSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYG- 450

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 509 gscvAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCWSLwnnteeridldaeeletqeeaggal 588
Cdd:cd10329  451 ----EPDTRPAIIGGIHFLYFAFLLFVVSVIVTVIVSLLTPPPPAEKLAGLTWST------------------------- 501

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117676363 589 eedseqsrgclkraccllcglqntgpkltkeeeaaLRQKFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd10329  502 -----------------------------------RLTKETSTLERPPWYKNVRILAILLLALTIFLYGYFA 538
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
 27-660 0e+00

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 673.58  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11489    3 ADIIVIGVYFALNVAVGIWSSCRVSRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11489   83 YALLALAWVFVPVYISSGIVTMPEYLQRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSvvegdNLTISPKCYTPQPDSFHVF 266
Cdd:cd11489  163 VTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPS-----KIIPNTTCHLPRADAMHLF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACV 346
Cdd:cd11489  238 RDPVTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVACV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 347 VPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAG 426
Cdd:cd11489  318 DPEECLRVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLLVG 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 427 RIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVY 506
Cdd:cd11489  398 RLVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLEFAH 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 507 GTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCW-SLWNNTEeridldaeeletqeeag 585
Cdd:cd11489  478 PAPRCGVPDTRPSVLRSMHYLHFAVALCALSGAVVVAGSLLTPPPQSVQIRNLTWwTLAQDTP----------------- 540

                        570       580       590       600       610       620       630
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117676363 586 gaLEEDSEQSRGCLKRACCLLCGLQNTGPKLTKeeeaalrqkFSDTSEKPLWRTVMNINAVLLLGVAVFVHAYFA 660
Cdd:cd11489  541 --LGIKLGDGQTLSRRTDGCESVRFASGTPPPI---------IHSTTEHPFWARVCGVNAILLMCVNIFFYAYFA 604
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
 28-561 0e+00

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 620.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11491    1 DIAVVALYFILVMCIGIYAMWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAI 187
Cdd:cd11491   81 LLQLLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLLGL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 188 TAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSV----VEGDNLTISPKCYTPQPDSF 263
Cdd:cd11491  161 TALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVtsilLTYNLSNTNSCCVHPKKDAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 264 HVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKV 343
Cdd:cd11491  241 KLLRDPTDEDVPWPGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRILFPDDI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 344 ACVVPSECEKQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELM 423
Cdd:cd11491  321 ACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKASSRELM 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 424 IAGRIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAE 503
Cdd:cd11491  401 IVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGAVRLILA 480

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117676363 504 FVYGTGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYRLCW 561
Cdd:cd11491  481 FAYRAPECGQPDNRPGIIKDIHYMYFATALFWITGLITVIVSLLTPPPTKENIRTTTF 538
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 1.03e-160

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 467.59  E-value: 1.03e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363   58 FFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  138 GKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  218 LMGFAFAEVGGYESFTEKYMNAIPSVVegDNLTispkcytpqPDSFHVFRDPVTGDIPWPGLIFGMTILaiwywcadQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  298 VQRCLCGKnmshvKAACILCGYLKLLPMFLMVMPGMISRILYTDKVACVVPseceKQCGTAVGCTNYAYPTLVLELMPDG 377
Cdd:pfam00474 222 LQRCLAAK-----DAKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  378 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVPLVQVSQNGqLFHYIG 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 117676363  458 SVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 3.78e-152

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 445.98  E-value: 3.78e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363   61 AGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFG-KR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  141 LQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMG 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  221 FAFAEVGGYESFTEKYMNAIPSVVEGDnltispkcytpqpDSFHVFRDPVTGDIPWPGLIFGMTILAIWYWcADQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTNPSPD-------------DLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  301 CLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDkvacVVPSEcekqCGTAVGCTNYAYPTLVLELMPDGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTD----IDPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  381 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELMIAGRIFGMVLIAVSILWVplVQVSQNGQLFHYIGSVS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 117676363  461 SYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-500 5.87e-141

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 418.39  E-value: 5.87e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  25 NAADISVIVIYFIVVLAVGLWSMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWN 104
Cdd:COG4146    4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 105 ALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFgGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFIL 184
Cdd:COG4146   84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 185 LAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesftekymnaiPSVVEG-DNLTISPkcytpqPDSF 263
Cdd:COG4146  163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 264 HVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKV 343
Cdd:COG4146  225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 344 AcvvpsecekqcgtavgCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASEREL 422
Cdd:COG4146  305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKyFNPNASEKQL 368

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117676363 423 MIAGRIFGMVLIAVSILWVPLVQVSqnGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRL 500
Cdd:COG4146  369 VKVGRIATVVLAVIAILIAPLIGNA--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILLK 444
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
25-553 1.32e-84

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 274.00  E-value: 1.32e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  25 NAADISVIVIYFIVVLAVGLWSMVRSNrgTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWN 104
Cdd:COG0591    2 STLDLIIIILYLLLLLGIGLYASRRTK--SLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 105 ALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKRLQIYLSVLSLFIMVALqTSSIIFSGAIFIQLALGLNLYLAVFIL 184
Cdd:COG0591   80 YALGALLLALFFAPRLRRLGALTIPEFLEKRFG-RGLRLLAAIIILLFLLGY-LAAQLVALGKLLEALFGIPYWLGILIG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 185 LAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKymnaipsvvegdnltispkcyTPQPDSFH 264
Cdd:COG0591  158 ALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAA---------------------LPAPGLLS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 265 VFRDPVTGDIPWpglIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDkva 344
Cdd:COG0591  217 LFPGLGFTGWLA---FLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPD--- 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 345 cvvpsecekqcgTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASERELM 423
Cdd:COG0591  291 ------------LPLADPDLALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPfIKPKASDKQLL 358

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 424 IAGRIFGMVLIAVSILWVplvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIrliae 503
Cdd:COG0591  359 RVSRLAVLVVGLLALLLA----LLFPSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLL----- 429

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 117676363 504 FVYGTGScvapsncpkiICGVHYMYFAIILFFVSIIVILGVSFLTEPIPD 553
Cdd:COG0591  430 WKLLGGP----------LGPFGWLYPILPGLLVSLLVFVVVSLLTKPPSE 469
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
 31-498 2.04e-83

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 272.26  E-value: 2.04e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  31 VIVIYFIVVLAVGLWsmVRSNRGT----VGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd10325    2 IFIVYVILIIGLGLW--VSREKKGgekdATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASYEWMAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGkRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd10325   80 ITLIIVAKFFLPIFLKNGIYTMPQFLEERYDG-RVRTIMAVFWLLLYVFVNLTSVLYLGALAIETITGIPLTYSIIGLAL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESftekymnaipsvvegdNLTISPKCYTPQPDSFHVF 266
Cdd:cd10325  159 FAAAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGEG----------------VFAGFTLLAAEAPEHFHMI 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RDPVTG-----DIPWPG-LIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYT 340
Cdd:cd10325  223 LDKSNPedaykDLPGIAvLLGGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLAS 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 341 DKVACVVPSECEKqcgtavgctNYAYPTLvLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASE 419
Cdd:cd10325  303 NLLLPAATGIEKP---------DQAYPWL-LRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKyIPKKASE 372

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117676363 420 RELMIAGRIFGMVLIAVSILWVPLvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLI 498
Cdd:cd10325  373 KQLVNVGRLAAVIALIIAALIAPP--LLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSAL 449
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-553 2.23e-74

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 247.59  E-value: 2.23e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGlWSMVRSNRgTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEW-NAL 106
Cdd:cd11478    2 DYLIVAVYFVFVLGIG-FYLKRKVK-TSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWiGAI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGK-RLqiyLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11478   80 PAMVFLGIVMMPFYYGSKVRSVPEYLKLRFNKStRL---LNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKymnaipsVVEGDNLTISPKCYTPQPDSFHv 265
Cdd:cd11478  157 AIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEK-------IDANGPPGWNGLSWGPQGSQST- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 frDPVTgdiPWPGLIFGMT-ILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVA 344
Cdd:cd11478  229 --NPMG---VNLGLVFGLGfVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVPELGA 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 345 CVVPSecekqcgtavgcTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKIRKKASERELM 423
Cdd:cd11478  304 SGGLD------------YNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYqTYIVKDAPDKHYL 371

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 424 IAGRIFGMVLIAVSILWVPLvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG----LVVGLIR 499
Cdd:cd11478  372 KVGRIATVVGVLISIGTAYI--ASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGtasaIVLYGLY 449

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 117676363 500 LIAEFVYGTGSCVApsncpkiicgvhyMYFAIILFFVSIIVILGVSFLTEPIPD 553
Cdd:cd11478  450 ELGLIVYHSDMAPN-------------FYGAWWAFVVCFVVTVLVSLLTKPKPE 490
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 28-545 5.65e-73

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 242.46  E-value: 5.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSmvRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd10322    2 DLIIVVVYLALLLGIGLYA--SKKVKSSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALqTSSIIFSGAIFIQLALGLNLYLAVFILLAI 187
Cdd:cd10322   80 GALLLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPY-LALQLIGGGYILSTLLGIPYTVAVIIAAVI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 188 TAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYEsftekyMNAIPSVVEGDNLTispkcytpqpdsfhvfr 267
Cdd:cd10322  159 VILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGG------FSALAAALPALLLA----------------- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 268 dPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVAcvv 347
Cdd:cd10322  216 -LGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLEN--- 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 348 psecekqcgtavgcTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASERELMIAG 426
Cdd:cd10322  292 --------------PDLALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPlINPKASDKKLLRVS 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 427 RIFGMVLIAVSILWVPLVQvsqngQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIRLIAEFVy 506
Cdd:cd10322  358 RIAVVVVGVLALLLALLPP-----SILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLA- 431

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 117676363 507 gtgscvapsncpkiicGVHYMYFAIILFFVSIIVILGVS 545
Cdd:cd10322  432 ----------------SPLGIDPIIPALLVSLIVFVVVS 454
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
 34-545 5.33e-69

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 232.43  E-value: 5.33e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  34 IYFIVVLAVGLWSMVRSNR-GTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLMVLVL 112
Cdd:cd10328    2 LLFTALVALISWYKTRGDDlSSSDGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALIIL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 113 GWVFLPIYIKAGVLTMPEYLRKRFgGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLN----------LYLAVF 182
Cdd:cd10328   82 ALVFLPRYLKGGITTIPEFLEERY-DETTRRIVSILFLLGYVVILLPIVLYSGALALNSLFDVSellgisyfqaLWLLVW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 183 ILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesftekymnaiPSVVEGDNltispKCYTPQPDS 262
Cdd:cd10328  161 LIGIIGAIYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGD------------GSFLAGLD-----TLLTAHPEK 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 263 FHVFRDPvTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYtdk 342
Cdd:cd10328  224 LNAIGGA-DSPVPFSTLFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLY--- 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 343 vacvvpsecekqcGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASERE 421
Cdd:cd10328  300 -------------GDGLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPiINKNATDKQ 366

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 422 LMIAGRIFGMVLIAVSILWVPLVQVSQNGqLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAfwglMVGLVVGLIrli 501
Cdd:cd10328  367 LVKVGKIFGIVLALISMIIAPFIAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAA----KIALIFGVI--- 438

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 117676363 502 aefVYGTGSCVAPSncpkiicGVHYMYFAIILFFVSIIVILGVS 545
Cdd:cd10328  439 ---LYALLQFVFLV-------PIHFLHVLAILFVICVAIMLIIG 472
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-498 5.53e-67

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 227.10  E-value: 5.53e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMvRSNRGtVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11494    2 DWIVLVGYLLGILVYGVYKG-RGQKN-QEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFgGKRLQIYLSVlsLFIMV-ALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11494   80 AMIFLCITFVPVFYKLKVYTAYEYLERRF-GLKTRLLTSI--LFLISrGLATGVTIYAPAIILSTILGWSLWLTILLIGG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAE--VGGYESFtekymnaipsVVEGDNLTISPKCYTPQPDSFH 264
Cdd:cd11494  157 ITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLlpVGFVDAL----------LVAGKSGRLNALDFSFDLSDTY 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 265 VFrdpvtgdipWPGLIfGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDKVA 344
Cdd:cd11494  227 TF---------WSGLI-GGFFLYLSYFGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFNPF 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 345 CVVPSECEkqcgTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASERELM 423
Cdd:cd11494  297 PVSFNPAE----DETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRfFKKDASDEHYL 372

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117676363 424 IAGRIFGMVLIAVSIlwVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLI 498
Cdd:cd11494  373 KVSRLLTVFWGLLAI--VFALFAGLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIV 445
PRK10484 PRK10484
putative transporter; Provisional
 32-547 4.19e-66

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 226.30  E-value: 4.19e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  32 IVIYFIVVLAVGL--WSMVR-SNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLM 108
Cdd:PRK10484   4 ILSFLGFTLLVAVisWWKTRkTDTSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 109 VLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIyLSVLSLFIMVALQTSSIIFSGAI-----F-IQLALGLNLYLAVF 182
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 183 ILL----AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyesftekymnaipsvveGDNLTISPKCYTP 258
Cdd:PRK10484 163 LLVwligIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 259 QPDSFHVFrDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSI-GGATDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 339 YTDKVAcvvpsecekqcgtavgCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKIRKKA 417
Cdd:PRK10484 305 YGDGLP----------------NADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 418 SERELMIAGRIFGMVLIAVSILWVPLVQVSQNGqLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVvgl 497
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGII--- 444

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 117676363 498 irliaefVYGTGSCVAPSncpkiicGVHYMYFAIILFFVSIIVILGVSFL 547
Cdd:PRK10484 445 -------LYIIINFVLKF-------DIHFLYVLAILFVINVVVMLIIGKI 480
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-558 4.01e-57

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 200.89  E-value: 4.01e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNRGTvGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11477    2 DWLVIALYFLLMLGIGLWFSKRASKST-SDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGK---RLQIYLSVLSLFIMVALqTSSIIFSGAIFI-QLALGLNLYLAVFI 183
Cdd:cd11477   81 AGLIGAFVFARRWRRLRVLTDGEFPEERYGGRygaPLRQFYAVYFALLSNVD-ILAWVFLAAIKVsAVFGPWDPWLTILI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 184 LLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYmnaipsvvegdnltispkcytpqPDSf 263
Cdd:cd11477  160 LGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQL-----------------------PEG- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 264 HVFRDPVTGDIPWPGLIFGMTILAIWYWCA----DQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILY 339
Cdd:cd11477  216 HLDLFGSGLGASGFYITFFFILFFGWYPLSysggGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLY 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 340 TDKVACVVPSEcekqcgtavgctnYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKAS 418
Cdd:cd11477  296 PDLDDPEADFE-------------LAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRfIKPNAS 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 419 ERELMIAGRIFGMVLIAVSILWVplVQVSQNGQLFHYIGSVSSYLGPPLgavfMLAIFFKRVNEQGAFWGLMVGLVVGLi 498
Cdd:cd11477  363 EKHLLKVGRLATVLFGLLSIVVA--LASDSIGGAFWIVLALGAGLGGPL----ILPWLWWRFNAWTEIWAMIASIIVGL- 435

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 499 rliaefvygtgscVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSFLTEPIPDVHLYR 558
Cdd:cd11477  436 -------------VVSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAVTLLTPPTDEETLVA 482
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 26-547 2.78e-48

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 176.19  E-value: 2.78e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  26 AADISVIVIYFIVVLAVGLWSMVRSNrgTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNA 105
Cdd:cd11495    3 WLDYLVLVIYLLAMLGIGLYFSKKQK--STDDYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 106 LLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKRLQIYLSVLSLFIMVAlQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11495   81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRFG-PWARVYGSLLFILFQLG-RMGIVLYLPALALSAVTGINPYIIIILMG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyeSFTEKYMNAIpsvvEGDNLTISpkcytpqpDSFHV 265
Cdd:cd11495  159 VLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPG--GFGEVFDIAI----ANGKFSLG--------DFSFS 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 FRDPVTgdipwPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKL------------LPMFLMVMPGM 333
Cdd:cd11495  225 LTESTI-----WVIFIGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALpvallffgigtaLYVFYQQHPEL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 334 ISRILYTDKVacvvpsecekqcgtavgctnyaYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKI 413
Cdd:cd11495  300 LPAGINGDAV----------------------FPYFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRL 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 414 RKKASERELMIAGRIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAfwglMVGL 493
Cdd:cd11495  358 SPDPSDKQYLKVARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGA----LVGI 433

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 117676363 494 VVGLIRLIAEFVYGTgscvapsncpkiicGVHYMYFAIILFFVSIIVILGVSFL 547
Cdd:cd11495  434 IVSIIVIFWISLLYT--------------PIHFFLYSVIGTLVCFVVGYVVSLL 473
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 28-507 7.65e-44

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 163.88  E-value: 7.65e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNrgTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd10326    1 DWAVVVVYFLILLAISYYTSRRNA--DNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKrlqIYLSVLSLFIM-VALQTSSIIFSGAI----FIQLALGLNLYLAVF 182
Cdd:cd10326   79 GYLIIAFVLLPLYYRLNLTSIYEYLEDRFGVS---SRKTGAVFFLLsRILGAGIRLYLVALvlqqFLFDSLGIPFWLTVL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 183 ILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGyeSFTEkymnAIPSVVEGDNLTIspkcytpqpds 262
Cdd:cd10326  156 ITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGL--GFGE----AISAAGESGYSRI----------- 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 263 fhVFRDPVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMisrILYTDK 342
Cdd:cd10326  219 --FNFDDDNSRRTFWKQFLGGIFITIAMTGLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGV---LLYTYA 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 343 VACVVPsecekqcgTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRK---KASE 419
Cdd:cd10326  294 QKNGIA--------LPAKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRkseKKSE 365

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 420 RELMIAGRIFGMVLIAVSILWvplvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQ--GAFWGLMVGLVVGL 497
Cdd:cd10326  366 RKYVHIAFSLTFVLGILVFGS-----ASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDkwVPLVGLLAPVLSYL 440

                        490
                 ....*....|
gi 117676363 498 IRLIAEFVYG 507
Cdd:cd10326  441 LVSNSEGFFG 450
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-498 9.99e-44

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 163.54  E-value: 9.99e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMvRSNRGTVGgFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALL 107
Cdd:cd11493    1 DLAVIVLYLLGLPLLGLWLS-GRQKSTAD-YFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYIL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 MVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKrLQIYLSVLSLfIMVALQTSSIIFSGAIFIQLALGLNLY-----LAVF 182
Cdd:cd11493   79 GRIIVAFVLLPRYFRGEVVSAYELLGQRFGGG-MQKTASVTFL-VTRLLADGVRLFAAAIPVSMILGADGValsyiASIL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 183 ILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPqpds 262
Cdd:cd11493  157 IISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYTF---- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 263 fhvfrdpvtgdipWPGLIfGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDK 342
Cdd:cd11493  233 -------------WAAII-GGALLSMASHGTDQLMVQRLLACRNLRDAQKALIGSGVVVFPQFALFLLIGLLLYVYYGGA 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 343 VACvvpsecekqcGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKI-RKKASERE 421
Cdd:cd11493  299 SLA----------ALGLGSPDEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWkRRRLSDEK 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 422 LMIAGR----IFGMVLIAVSILwvplvQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGL 497
Cdd:cd11493  369 LLRASRlltlVWAVVLVGIALL-----FQYTDQPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFLVML 443


                 .
gi 117676363 498 I 498
Cdd:cd11493  444 L 444
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
 29-547 1.28e-43

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 163.06  E-value: 1.28e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  29 ISVIVIYFIVVLAVGLWSMVRSNrgTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAaveWNALLM 108
Cdd:cd11475    1 LITFIVYLLLMLGIGIYSYRKTK--TLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAI---WIAIGL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 109 VL--VLGWVF----LPIY-IKAGVLTMPEYLRKRFGGKRLQI-YLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLA 180
Cdd:cd11475   76 ILgaYLNWLFvakrLRRYtEKNDSITLPDYLENRFRDKSKLLrILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 181 VFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAIPSvvegdnltispkcytpqp 260
Cdd:cd11475  156 LLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDPG------------------ 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 261 dsfhvFRDPVTGDIPWPGLIFGMTILAIWYWCADQV-IVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILY 339
Cdd:cd11475  218 -----LLSPFGGDLGAGGLLAIISLLAWGLGYFGQPhILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALF 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 340 TDkvacvvpsecekqcgTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKAS 418
Cdd:cd11475  293 PD---------------GLLGDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAfLRKEAS 357

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 419 ERELMIAGRIfGMVLIAVSILWVPLvqvSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLI 498
Cdd:cd11475  358 DKELVWVSRL-AVLVIALIALLIAL---NPPSSVFSLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTVVV 433

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*....
gi 117676363 499 rliaefvygtgscvapsnCPKIICGVHYMYFAIILFFVSIIVILGVSFL 547
Cdd:cd11475  434 ------------------WKLLGLGIFGLYEIVPGFLASLLAIVVVSLL 464
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
25-550 9.10e-37

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 143.83  E-value: 9.10e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  25 NAADISVIVIYFIVVLAVGLWSMVRSNRGT-VGGFFLAGHDMAWWPMGASLFASNIGSNHFV---GLAGTGAASGIAIAA 100
Cdd:COG4145    3 NLAILIPLLIYLLLVLGIGIYASRKRSKGSfLEEYFLGSRSMGGFVLAMTLAATYTSASSFIggpGAAYKYGLGWVLLAM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 101 VE-WNALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIfSGAIFIQLALGLNLYL 179
Cdd:COG4145   83 IQvPTAFLTLGVLGKKFAILGRKYNAVTLADWLRARYQSKALVLLAALLLLLFFIAFMVAQFV-GGARLLETVTGISYTT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 180 AVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNaipsvvegdnltISPKCYTPQ 259
Cdd:COG4145  162 GLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAA------------IDPNLVSPT 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 260 -PDSFhvfrdpvtgdIPWPGLIFGMTILAIWYWCADQVIVqRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRIL 338
Cdd:COG4145  230 gPDGF----------LPRPFVISFWILVGFGVIGLPHTAV-RCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGRAV 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 339 YTDkvacvvpsecekqcgtaVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKA 417
Cdd:COG4145  299 LPD-----------------LTVPDQVIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLNyINPKA 361

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 418 S--ERELMIAGRIFGMVLIAVSIL--WVP--LVQVSqngQLFHYIGSVSSYLGPplgavFMLAIFFKRVNEQGAFWGLMV 491
Cdd:COG4145  362 SenEKKLKRLSKLVTLVLGLIVFLlaLNPpdLIIWL---NLFAFGGLEAAFFWP-----LVLGLYWKRANATGAIASMLV 433

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 492 GLVVglirLIAEFVYGTGscvapsncpkiICGVHymyfAIIL-FFVSIIVILGVSFLTEP 550
Cdd:COG4145  434 GVAS----YFLLYYGNPK-----------IFGFH----AIVPsLLISLIAFLIGSLLGKP 474
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 29-552 1.18e-34

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 137.27  E-value: 1.18e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  29 ISVIVIYFIVVLAVGLWSMVRsnRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNALLM 108
Cdd:cd11474    1 LIGVILYYLLILGIGLWASRR--VKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDPFGYAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 109 VLVLGWVFL--PIYiKAGVLTMPEYLRKRFGgKRLQIYLSVLSLFimvalqtSSIIFSGAIFIQLA------LGLNLYLA 180
Cdd:cd11474   79 CLILGGLFFakPMR-RMGLLTLGDFFRQRYG-RRVEVLLSIPAVL-------SYLGWVAAQLVALGlvlsviLGLPVETG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 181 VFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYEsftekymnaIPSVVEGDNLTISPKcyTPQP 260
Cdd:cd11474  150 ILISAAIVLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVD---------IASAAAAGKLRFFPW--LGTK 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 261 DSFHVFRD----PVTGDIPWpglifgmtilaiwywcadQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISR 336
Cdd:cd11474  219 SDWLIWIDawltLGLGSIPQ------------------QDVFQRVLSAKSEKTAQRLSLLAGVGYLLFAIPPLLIGLAAA 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 337 ILYTDKVACVVPSEcekqcgtavgcTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKIRK 415
Cdd:cd11474  281 SIDPSLTQYGLEED-----------AQLILPLLLQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYkPPFRP 349

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 416 KASERELMIAGRIfGMVLIAVSILWVPLvQVSQNGQLFHYIGSVSSY-LGPPLGAVfmlaIFFKRVNEQGAFWGLMVGLV 494
Cdd:cd11474  350 KASDRELLWVMRI-SVVVFGAIATLMAL-TVESIYGLVELASDLVLVgLFVPLLAG----LYWKRANTYGALAAIIVGLV 423

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117676363 495 VgliRLIAEFVYGTGSCVAPSNcpkiicgvhymyfaIILFFVSIIVILGVSFLTEPIP 552
Cdd:cd11474  424 L---RLLGGELLLGLPADIPPQ--------------LQGFPFSTLAMVIGSLLPLAVS 464
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 27-547 5.21e-33

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 133.38  E-value: 5.21e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLW-SMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNA 105
Cdd:cd11492    1 VDYVVFVAMLLISAAIGIYfGFFGGKQKTTEEYLLGGRNMSVFPVALSLIASFISGITLLGTPAEIYYYGTQYWLIVIAY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 106 LLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKRLQIYLSVLSLFIMVaLQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11492   81 VLVGPITAYIFLPVFYNLQLTSVYEYLELRFN-RRVRLLASFLFILQML-LYLPIVIYAPALALSQVTGINLHIIILVVG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKymnaipsVVEGDNLTISPkcYTPQPDSFHV 265
Cdd:cd11492  159 IVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEI-------AEEGGRLEFFN--FDPDPTVRHT 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 FrdpvtgdipWpGLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMI----------- 334
Cdd:cd11492  230 F---------W-SLVIGGTFTWLSLYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGLViyakyhdcdpl 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 335 --SRILYTDKVacvvpsecekqcgtavgctnyaYPTLVLELMPD--GLRGLMLS-VMLASLmSSLTSIFNSASTLFTIDL 409
Cdd:cd11492  300 taGLIKKPDQL----------------------LPYFVMDVLGHlpGLPGLFVAgIFSAAL-STLSSGLNSLAAVILEDF 356

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 410 YTKIRKK-ASERELMIAGRIFGMVLIAVSILWVPLVQVSqnGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWG 488
Cdd:cd11492  357 IKPFFKKkLSERQATNIMKLLVVVFGLLCIGLAFLVEKL--GGVLQLSLSIFGITGGPLLGIFTLGMFFPWANSKGALVG 434

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 489 LMVGLVVGL-IRLIAEFVYGTGSCVAPSnCPKIICG-----------------------------VHYMYFAIILFFVSI 538
Cdd:cd11492  435 LLVGLIFMLwIGIGGQIAIAPGPLSFPP-LPTSTEGcnytntttittsttttttedesepfplyrISYLWYSLIGFLITV 513


                 ....*....
gi 117676363 539 IVILGVSFL 547
Cdd:cd11492  514 VVGLIVSLL 522
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-552 1.50e-27

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 116.16  E-value: 1.50e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRSNrgTVGGFFLAGHDMAWW----PMGASLF--ASNIGS---NHFVGLAGTgaasgiai 98
Cdd:cd11479    2 DYGVIALYFAAMIAIGWWGMRRAK--TSEDYLVAGRRLGPGlylgTMAAVVLggASTIGGvglGYQYGISGM-------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  99 aaveWNAL---LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGkrlqiYLSVLSLFIMVA----LQTSSIIFSGAIFIQL 171
Cdd:cd11479   72 ----WLVVaigLGILALSLLLAKRIARLKVYTVSEVLELRYGP-----SARVISALVMLAytlmVAVTSTIAIGTVFSVL 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 172 aLGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLG-SLILMGFAFAEVGGYESFTEKYmnaipsvvegdnlt 250
Cdd:cd11479  143 -FGLPRTLSILVGGGIVVLYSVLGGMWSITLTDIIQFVIKTIGiFLLLLPLALSKAGGLSGLQEKL-------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 251 ispkcytpqPDSFHVFrdpvtGDIPWPGLI-------FGMTIlaiwywcaDQVIVQRCLCGKNMSHVKAACILCGYLKLL 323
Cdd:cd11479  208 ---------PASYFDL-----TSIGWDTIVtyfllyfFGILI--------GQDIWQRVFTARSEKVARWGGVAAGLYCVL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 324 PMFLMVMPGMISRILYTDkvacvvpsecekqcgtaVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSAST 403
Cdd:cd11479  266 YGVAGALIGMAAAVLLPD-----------------LANPQNAFATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASST 328

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 404 LFTIDLYTKIRKK-ASERELMIAGRIFGMVLIAVSILWVPLVQVSQNGQLFHYIGSVSSYLGPPLGavfmlAIFFKRVNE 482
Cdd:cd11479  329 VLTNDVLPRLRRKnESERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAILVGGLLVPILG-----GLFWKRATG 403

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 483 QGAFWGLMVGLVVGLIRLiaeFVYGTgscvaPSNCPkiicgvhyMYFAIIlffVSIIVILGVSFLTEPIP 552
Cdd:cd11479  404 AGALASMVAGSVVVLAGM---AVDGL-----LANTP--------IYYGLA---VSLVAFVAVSLLTRPTP 454
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
 27-515 3.77e-27

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 116.13  E-value: 3.77e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  27 ADISVIVIYFIVVLAVGLWSMVRS-NRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNA 105
Cdd:cd11504    4 ADYVVFSLLLVISAGIGLYYACTGgKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 106 LLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGgKRLQIYLSVLSLFIMVaLQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11504   84 FLGLLIPAHVFIPVFYRLELTSAYEYLELRFN-KTVRICGTVTFIFQMV-IYMGVVLYAPALALNAVTGFNLWISVLAMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNAipSVVEGDNLtispkcyTPQPDSFHV 265
Cdd:cd11504  162 VVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAGGIARVWRVAAES--DRIDGFNL-------SPDPTIRHT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 FrdpvtgdipWPgLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYtdkvac 345
Cdd:cd11504  233 F---------WT-LVVGGVFNMLALYGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARY------ 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 346 vvpSECEKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELM 423
Cdd:cd11504  297 ---HECDPLKNGIVARSDQLVPYFVMDVLDGlpGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPKFPDMTEERAT 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 424 IAGRI----FGMVLIAVSILwvplvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIR 499
Cdd:cd11504  374 LLSKGlavgYGLLCLLMAYL------ASTMGQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGLFMAFWI 447

                        490
                 ....*....|....*.
gi 117676363 500 LIAEFVYGTGSCVAPS 515
Cdd:cd11504  448 GIGSKVFPPYSPTKST 463
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
 127-498 1.47e-23

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 104.59  E-value: 1.47e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 127 TMPEYLRKRFGGKRLQIYLsVLSLFIMVaLQTSSIIFSGAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSV 206
Cdd:cd11476  106 TLLEIVRARYGTAAHLVFL-VFALFTNV-IVLAMLLLGGSAVVNALTGMPIVAASFLIPLGVLLYTLFGGLRATFLTDYI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 207 QTFIMLLGSLILMGFAF--AEVGGYESFTEKYMNAIPSVVEGDNltispkcytpqPDSFHVFRDPvtgdipwPGLIFGMT 284
Cdd:cd11476  184 HTVIILIILLVFAFAVYtsSDIGSPSKVYDLLQEAAPDLPVEGN-----------QGSYLTFKSK-------AGLIFGII 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 285 -ILAIW-YWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLPMFLMVMPGMISRILYTDkvacvvPSECEKQCGTAVgct 362
Cdd:cd11476  246 nIVGNFgTVFLDQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAALALGLN------PTFEEVSAGLVL--- 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 363 nyayPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKIRKKASERELMIAGRIFGMVL-IAVSILW 440
Cdd:cd11476  317 ----PYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYrTYINPNATGKQLLRVSRIAVIGFgLFMGGLA 392

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 117676363 441 VPLVQVSQN-GQLFHYIGSVssyLGPPLGAVFmLAIFFKRVNEQGAFWGLMVGLVVGLI 498
Cdd:cd11476  393 VGLNYIGISlGWLLLFMGIL---IGSAVFPVA-LGLYWRRQTGTAAVVSPIAGLVAGLA 447
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
 28-506 4.33e-23

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 103.43  E-value: 4.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLW-SMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11505    8 DYVVFAAMLFISAGIGIYyAFAGGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFggKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLA 186
Cdd:cd11505   88 FVVLISSEVFLPVFYRLGITSTYEYLELRF--NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 187 ITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNaipsvveGDNLTISPkcYTPQPDSFHVF 266
Cdd:cd11505  166 VCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILNDSYN-------GSRLNFWD--FDPNPLRRHTF 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 267 RD-PVTGDIPWPGlIFGMtilaiwywcaDQVIVQRCLCGKNMSHVKAACilcgYLKLLPMFLM----VMPGMISRILYTD 341
Cdd:cd11505  237 WTiTVGGTFTWTG-IYGV----------NQSQVQRYISCKTRFQAKLSL----YFNLLGLWAIlvcaVFSGLAMYSHYKD 301

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 342 kvacvvpseCEKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASE 419
Cdd:cd11505  302 ---------CDPWTAKIVSAPDQLMPYLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSE 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 420 RELMIAGR----IFGMVLIAVSILwvplvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVV 495
Cdd:cd11505  373 KLSSWISKglslLYGAMCIGMAVA------ASLMGGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLTGFAI 446

                        490
                 ....*....|.
gi 117676363 496 GLIRLIAEFVY 506
Cdd:cd11505  447 SLWVGIGAQIY 457
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
 28-497 3.13e-22

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 101.07  E-value: 3.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLW-SMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11503    2 DYGVFAAMLLVSTGIGLFvGLARGGQRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFG-GKRLqiyLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11503   82 LNSLMTAVLFMPVFYRLGITSTYQYLEMRFSrAVRL---CGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEkymnaipsvVEGDNLTISPKCYTPQPDSFHV 265
Cdd:cd11503  159 IICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLE---------IAQNHSRINFMDFDPDPRRRYT 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 FrdpvtgdipWPgLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACIlcgyLKLLPMFLMVMPGMISRIlytdkVAC 345
Cdd:cd11503  230 F---------WT-FVVGGTLVWLSMYGVNQAQVQRYVACRTEKQAKLALL----VNQVGLCLIVSSAATCGI-----VMF 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 346 VVPSECEKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASERELM 423
Cdd:cd11503  291 VYYSNCDPLLIGRISAPDQYMPYLVLDIFEDlpGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLPTIAPRKLV 370

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117676363 424 IAGR----IFGMVLIAVSILWVPLVQVSQNGQlFHYIGSVSsylGPPLGAvFMLAIFFKRVNEQGAFWGLMVGLVVGL 497
Cdd:cd11503  371 FISKglslIYGSACITVAALSSLLGGGVLQGS-FTVMGVIS---GPLLGA-FALGMFLPACNTPGVFSGLAVGLALSL 443
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
 29-552 8.53e-22

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 98.82  E-value: 8.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  29 ISVIVIYFIVVLAVGLWSMvRSNRGTVGGF----FLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAasgiaiaavewn 104
Cdd:cd10327    2 LLPIIIYLVILLGIGFYAR-RSKKRRSGDFleeyFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAY------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 105 allmVLVLGWVFLP------IYIKAGVL--------------TMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIfS 164
Cdd:cd10327   69 ----KIGLGWVLLAmiqvptGFLTLGVLgkkfaiiarkinavTIIDYLRARYNSKALVVLSSLALIVFFIAAMVAQFI-G 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 165 GAIFIQLALGLNLYLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNaipsvv 244
Cdd:cd10327  144 GARLLEAVTGLSYVTGLLIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAE------ 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 245 egdnltISPKCYTPqpdsfhvfrdPVTGDIPWPgLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACILCGYLKLLP 324
Cdd:cd10327  218 ------IDPNLLTP----------FGPGFLSPP-YILSFWVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFL 280

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 325 MFLMVMPGMISRILYTDkvacvvpsecekqcgTAVGctNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTL 404
Cdd:cd10327  281 MLGMHLAGVLGRAVLPD---------------LEVP--DKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSA 343

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 405 FTIDLYTKIR---KKASEREL----MIAGRIFGMVLIAVS------ILWVplvqvsqngQLFHYIGSVSSYLGPPLgavf 471
Cdd:cd10327  344 IVKDLYLNYKnkeKKTSEKKVkrisLIITIILGLLVFLLAinppdlIVWL---------NLFAFGGLEAAFFWPLV---- 410

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 472 mLAIFFKRVNEQGAFWGLMVGLVvglirliaefvygtgSCVAPSNCPKIICGVHYMYFAIILffvSIIVILGVSFLTEPI 551
Cdd:cd10327  411 -LGLYWKRANATGALASMVVGLV---------------SYILITYLKIKILGLHPIVPSLLL---SLIAFIIVSLATKKP 471


                 .
gi 117676363 552 P 552
Cdd:cd10327  472 D 472
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
 26-506 1.12e-20

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 96.07  E-value: 1.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  26 AADISVIVIYFIVVLAVGLWSMVRS-NRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWN 104
Cdd:cd11520    6 AWDYVVFAGLFLVSSGIGVFFAIKErKKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 105 ALLMVLVLGWVFLPIYIKAGVLTMPEYLRKRFggKRLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFIL 184
Cdd:cd11520   86 YTFVIIFTSELFLPVFYRSGITSTYEYLELRF--NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 185 LAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNaipsvveGDNLTIspkcytpqpdsFH 264
Cdd:cd11520  164 GIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGGFTNVWETAYN-------GSRLNI-----------FD 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 265 VFRDPVTGDIPWPgLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKAACilcgYLKLLPMFLMVMPGMIS-RILYTDKv 343
Cdd:cd11520  226 FDVDPLRRHTFWT-ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLAL----YLNLLGLWIILVCAVFSgLIMYSHY- 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 344 acvvpSECEKQCGTAVGCTNYAYPTLVLEL---MPdGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASER 420
Cdd:cd11520  300 -----KDCDPWTSGFISAPDQLMPYFVMEIfstMP-GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSEK 373

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 421 elmIAGRIFGMVLIAVSILWVPL-VQVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGLIR 499
Cdd:cd11520  374 ---LSTWISKGLCILFGVMCTSMaVAASLMGGVVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGITLSFWV 450


                 ....*..
gi 117676363 500 LIAEFVY 506
Cdd:cd11520  451 GIGAFIY 457
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
 28-497 4.39e-19

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 91.06  E-value: 4.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  28 DISVIVIYFIVVLAVGLWSMVRS-NRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGAASGIAIAAVEWNAL 106
Cdd:cd11519    8 DYVVFAGMLLISAGIGIYYAFAGgGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 107 LMVLVLGWVFLPIYIKAGVLTMPEYLRKRFGGKrlqIYLSVLSLFIM-VALQTSSIIFSGAIFIQLALGLNLYLAVFILL 185
Cdd:cd11519   88 IVVVISAEVFLPVFYRLGITSTYEYLELRFNKC---VRLIGTSLFIVqTALYTGIVIYAPALALNQVTGFDLWGAVVATG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 186 AITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYESFTEKYMNaipsvveGDNLTISPkcYTPQPDSFHV 265
Cdd:cd11519  165 VVCTFYCTLGGLKAVIWTDVFQVGIMVAGFVSVIIRAVVLQGGIGTILNDSYY-------GGRLNFWD--FDPNPLQRHT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 266 FrdpvtgdipWPgLIFGMTILAIWYWCADQVIVQRCLCGKNMSHVKaaciLCGYLKLLPMFLMVMPGMISRI-LYTdkva 344
Cdd:cd11519  236 F---------WT-IVIGGTFTWTSIYGVNQSQVQRYISCKTRFQAK----MSLYVNLVGLWAILSCAVLSGLaMYS---- 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 345 cvVPSECEKQCGTAVGCTNYAYPTLVLELMPD--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKIRKKASEREL 422
Cdd:cd11519  298 --IYKDCDPWTAKDVSAPDQLMPYLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQL 375

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 117676363 423 ----MIAGRIFGMVLIAVSILwvplvqVSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLVVGL 497
Cdd:cd11519  376 swisMGMSVFYGALCIGMAGL------ASLMGALLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGFAISL 448
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 33-547 1.01e-12

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 70.61  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363  33 VIYFIVVLAVGLW--SMVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGLAGTGaasgiaiaavewnALL--- 107
Cdd:cd11480    1 IGLFFVFVTITLYitIWAARRTRSTSDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLI-------------ALSgyd 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 108 -MVLVLGW--------VFLPIYI-KAGVLTMPEYLRKRFGGKRLQIYLSVLSLFIMVALQTSSIIFSGAIFiQLALGLNL 177
Cdd:cd11480   68 gLAYAIGWtggyvlllLLVAEPLrNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLL-SLLLGIPY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 178 YLAVFILLAITAFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYeSFTEKYMNAIPSVVEGDNLTisPKCYT 257
Cdd:cd11480  147 EVGVVVVGALMIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGN-PLGAGPGLLGLAAAAASGAG--EAYLA 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 258 PqpdsFHVFRDPvtgdIPWPGLIFGMTILAIwywCADQVIVqRCLCGKNMSHVKA----ACILCGYLKLLPMFLmvmpGM 333
Cdd:cd11480  224 P----GLLLTDP----LDVISLTLALMLGTA---GLPHVLM-RFYTVPDARAARKsvvwALGFIGLFYLLAPAL----GF 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 334 ISRILYTDKVACVVPSecekqcGTAVGCTNYAYPTLVLEL-MPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK 412
Cdd:cd11480  288 GARALVGPDVIGAPIA------GELDGGGDMAVLLLPEIAgLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAG 361

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 413 -IRKKASERELMIAGRIFGMVLIAVSI---LWVPLVQVSQngqlfhyigSVSsyLGPPLGA-----VFMLAIFFKRVNEQ 483
Cdd:cd11480  362 vIRPGASERREVRVARIAAVVVGVIAIllaLLFPPQNVAF---------LVA--LAFAIAAsaffpVLVLGIFWRRFTTR 430

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117676363 484 GAFWGLMVGLVVGLIRLIAEFVYGTGSCVAPSNcpkiicGVHYMYFAIILFFVSIIVILGVSFL 547
Cdd:cd11480  431 GAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFA------GFPLTNPGLVSVPLGFLVAIVVSLL 488
PRK15419 PRK15419
sodium/proline symporter PutP;
110-508 2.11e-10

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 63.50  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 110 LVLGWVFLPIYIKAGVLTMPEYLRKRFGGK-RLQIYLSVLSLFIMVALQTSSIIFSGAIFIQLALGLNLYLAVFILLAIT 188
Cdd:PRK15419  92 LVAGRLRVHTEYNNNALTLPDYFTGRFEDKsRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAAT 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 189 AFYTVAGGLASVIYTDSVQTFIMLLGSLILMGFAFAEVGGYEsftekymnaipsvvegdnltispkcytpqpDSFHVFRD 268
Cdd:PRK15419 172 ILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFG------------------------------DSLEVIKQ 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 269 PVTGDIpwpGLIFGMTILAI-----W---YWCADQVIVQRCLCGKNMSHVKAACILCGYLkLLPMFLMVMPGMISRILYT 340
Cdd:PRK15419 222 KSIENV---DMLKGLNFVAIislmgWglgYFGQPHILARFMAADSHHSIVHARRISMTWM-ILCLAGAVAVGFFGIAYFN 297

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 341 DKVAcvvpsecekQCGTAVGCTNYAYPTLVLELMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-IRKKASE 419
Cdd:PRK15419 298 EHPA---------VAGAVNQNAERVFIELAQILFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAfLRKHASQ 368

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117676363 420 RELMIAGRifgMVLIAVSILWVPLVQVSQNgQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVGLV----- 494
Cdd:PRK15419 369 KELVWVGR---VMVLVVALVAIALAANPEN-RVLGLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIGALtvivw 444

                        410
                 ....*....|....*....
gi 117676363 495 -----VGLIRLIAEFVYGT 508
Cdd:PRK15419 445 kqfgwLGLYEIIPGFIFGS 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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