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Conserved domains on  [gi|12597661|ref|NP_075066|]
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large ribosomal subunit protein mL44 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DSRM_MRPL44 cd19874
double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and ...
 225-307 1.30e-47

double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins; MRPL44 (also known as L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. MRPL44 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


:

Pssm-ID: 380703  Cd Length: 84  Bit Score: 155.06  E-value: 1.30e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 225 GKELFEMWKIINPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKL 304
Cdd:cd19874   2 GKDLNEIWTPANPMGLLVEILQKRGLPPPEPRLIRQSGANTVLPVYFVGLYSDKKLIGEGPGESILIAEEMAARDALRRL 81


                ...
gi 12597661 305 YGF 307
Cdd:cd19874  82 FGT 84
Rnc super family cl33956
dsRNA-specific ribonuclease [Transcription];
138-304 5.15e-05

dsRNA-specific ribonuclease [Transcription];


The actual alignment was detected with superfamily member COG0571:

Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 43.93  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 138 TQFLEDEYPDMPtEG----IKN-LVDfltgEEVVCHVARNLAVEQ---LTLSEE---FPVPPAVLQQTFFAVIGALLQSS 206
Cdd:COG0571  56 AEYLYRRFPDAP-EGelskLRAaLVS----EETLAEIARELGLGDylrLGKGEEksgGRRRPSILADAFEALIGAIYLDG 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 207 GPERTALFIRDFLITQMTGKELFEMWKiiNPMGLLVEELKKRNVSAPESRLTRQSGGTTAlPLYFVGLYCDKKLIAEGPG 286
Cdd:COG0571 131 GLEAARKFVLRLFEPRLEEIAPGGAGK--DYKTALQEWLQARGLPLPEYEVVEEEGPDHA-KTFTVEVLVGGKVLGEGTG 207

                       170
                ....*....|....*...
gi 12597661 287 ETVLVAEEEAARVALRKL 304
Cdd:COG0571 208 RSKKEAEQAAAKAALEKL 225
 
Name Accession Description Interval E-value
DSRM_MRPL44 cd19874
double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and ...
 225-307 1.30e-47

double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins; MRPL44 (also known as L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. MRPL44 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380703  Cd Length: 84  Bit Score: 155.06  E-value: 1.30e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 225 GKELFEMWKIINPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKL 304
Cdd:cd19874   2 GKDLNEIWTPANPMGLLVEILQKRGLPPPEPRLIRQSGANTVLPVYFVGLYSDKKLIGEGPGESILIAEEMAARDALRRL 81


                ...
gi 12597661 305 YGF 307
Cdd:cd19874  82 FGT 84
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
138-304 5.15e-05

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 43.93  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 138 TQFLEDEYPDMPtEG----IKN-LVDfltgEEVVCHVARNLAVEQ---LTLSEE---FPVPPAVLQQTFFAVIGALLQSS 206
Cdd:COG0571  56 AEYLYRRFPDAP-EGelskLRAaLVS----EETLAEIARELGLGDylrLGKGEEksgGRRRPSILADAFEALIGAIYLDG 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 207 GPERTALFIRDFLITQMTGKELFEMWKiiNPMGLLVEELKKRNVSAPESRLTRQSGGTTAlPLYFVGLYCDKKLIAEGPG 286
Cdd:COG0571 131 GLEAARKFVLRLFEPRLEEIAPGGAGK--DYKTALQEWLQARGLPLPEYEVVEEEGPDHA-KTFTVEVLVGGKVLGEGTG 207

                       170
                ....*....|....*...
gi 12597661 287 ETVLVAEEEAARVALRKL 304
Cdd:COG0571 208 RSKKEAEQAAAKAALEKL 225
Ribonuclease_3 pfam00636
Ribonuclease III domain;
123-207 2.95e-04

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 39.57  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661   123 QELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEF----------------PV 186
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFPDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELdirrrnnalgkgpkraDG 80

                          90       100
                  ....*....|....*....|.
gi 12597661   187 PPAVLQQTFFAVIGALLQSSG 207
Cdd:pfam00636  81 KEKVLADAFEALIGALYLDGG 101
RIBOc smart00535
Ribonuclease III family;
117-222 3.13e-04

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 39.89  E-value: 3.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661    117 LNLKSNQELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQL------TLSEEFPVPPAV 190
Cdd:smart00535  14 NEHEHNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFirlgrgEAISGGRDKPKI 93

                           90       100       110
                   ....*....|....*....|....*....|..
gi 12597661    191 LQQTFFAVIGALLQSSGPERTALFIRDFLITQ 222
Cdd:smart00535  94 LADVFEALIGAIYLDSGLEAAREFIRDLLGPR 125
 
Name Accession Description Interval E-value
DSRM_MRPL44 cd19874
double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and ...
 225-307 1.30e-47

double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins; MRPL44 (also known as L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. MRPL44 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380703  Cd Length: 84  Bit Score: 155.06  E-value: 1.30e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 225 GKELFEMWKIINPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKL 304
Cdd:cd19874   2 GKDLNEIWTPANPMGLLVEILQKRGLPPPEPRLIRQSGANTVLPVYFVGLYSDKKLIGEGPGESILIAEEMAARDALRRL 81


                ...
gi 12597661 305 YGF 307
Cdd:cd19874  82 FGT 84
DSRM_mL44_subfamily cd20315
double-stranded RNA binding motif of mL44 subfamily proteins; The mitochondrion-specific ...
 236-305 4.62e-30

double-stranded RNA binding motif of mL44 subfamily proteins; The mitochondrion-specific ribosomal protein mL44 subfamily is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). MRPL3 (also known as mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL44 (also called L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Members of this family contain a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380747  Cd Length: 71  Bit Score: 109.13  E-value: 4.62e-30
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 236 NPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLY 305
Cdd:cd20315   2 NPTRELAEILRREGIEKPVSRLIAESGRLTKSPVYIVGVYCDEETIGEGYGYSIKEAKAEAATDALMKLF 71
DSRM_MRPL3_like cd19873
double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal ...
 230-306 5.89e-16

double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal protein L3 (MRPL3) and similar proteins; MRPL3 (also called mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL3 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380702  Cd Length: 84  Bit Score: 71.87  E-value: 5.89e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12597661 230 EMWKIINPMGLLVEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKLYG 306
Cdd:cd19873   7 DLIKLENPKRTLSALLKREGLEPPVSRLLKESGRASHTPTFVVGVYSGSQKLGEGAGSSIKMAEIRAARDALRKHYL 83
DSRM_RNAse_III_family cd10845
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ...
 235-304 3.04e-10

double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380682 [Multi-domain]  Cd Length: 69  Bit Score: 55.58  E-value: 3.04e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 235 INPMGLLVEELKKRNVSAPESRLTRQSGgTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKL 304
Cdd:cd10845   1 KDYKTALQEYLQKRGLPLPEYELVEEEG-PDHNKTFTVEVKVNGKVIGEGTGRSKKEAEQAAAKAALEKL 69
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
138-304 5.15e-05

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 43.93  E-value: 5.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 138 TQFLEDEYPDMPtEG----IKN-LVDfltgEEVVCHVARNLAVEQ---LTLSEE---FPVPPAVLQQTFFAVIGALLQSS 206
Cdd:COG0571  56 AEYLYRRFPDAP-EGelskLRAaLVS----EETLAEIARELGLGDylrLGKGEEksgGRRRPSILADAFEALIGAIYLDG 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 207 GPERTALFIRDFLITQMTGKELFEMWKiiNPMGLLVEELKKRNVSAPESRLTRQSGGTTAlPLYFVGLYCDKKLIAEGPG 286
Cdd:COG0571 131 GLEAARKFVLRLFEPRLEEIAPGGAGK--DYKTALQEWLQARGLPLPEYEVVEEEGPDHA-KTFTVEVLVGGKVLGEGTG 207

                       170
                ....*....|....*...
gi 12597661 287 ETVLVAEEEAARVALRKL 304
Cdd:COG0571 208 RSKKEAEQAAAKAALEKL 225
Ribonuclease_3 pfam00636
Ribonuclease III domain;
123-207 2.95e-04

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 39.57  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661   123 QELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEF----------------PV 186
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFPDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELdirrrnnalgkgpkraDG 80

                          90       100
                  ....*....|....*....|.
gi 12597661   187 PPAVLQQTFFAVIGALLQSSG 207
Cdd:pfam00636  81 KEKVLADAFEALIGALYLDGG 101
RIBOc smart00535
Ribonuclease III family;
117-222 3.13e-04

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 39.89  E-value: 3.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661    117 LNLKSNQELSEQGTSFSQTCLTQFLEDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQL------TLSEEFPVPPAV 190
Cdd:smart00535  14 NEHEHNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFirlgrgEAISGGRDKPKI 93

                           90       100       110
                   ....*....|....*....|....*....|..
gi 12597661    191 LQQTFFAVIGALLQSSGPERTALFIRDFLITQ 222
Cdd:smart00535  94 LADVFEALIGAIYLDSGLEAAREFIRDLLGPR 125
DSRM_EIF2AK2-like cd19875
double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 ...
 235-304 9.50e-04

double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins; The family includes EIF2AK2 and adenosine deaminase domain-containing proteins, ADAD1 and ADAD2. EIF2AK2 (EC 2.7.11.1/EC 2.7.10.2; also known as interferon-induced, double-stranded RNA-activated protein kinase, eIF-2A protein kinase 2, interferon-inducible RNA-dependent protein kinase, P1/eIF-2A protein kinase, protein kinase RNA-activated (PKR), protein kinase R, tyrosine-protein kinase EIF2AK2, or p68 kinase) acts as an IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. ADAD1 (also called testis nuclear RNA-binding protein (TENR)) and ADAD2 (also called testis nuclear RNA-binding protein-like (TENRL)) are phylogenetically related to a family of adenosine deaminases involved in RNA editing. ADAD1 plays an essential function in spermatid morphogenesis. It may be involved in testis-specific nuclear post-transcriptional processes such as heterogeneous nuclear RNA (hnRNA) packaging, alternative splicing, or nuclear/cytoplasmic transport of mRNAs. ADAD2 is a double-stranded RNA binding protein with unclear biological function. Members of this group contains varying numbers of double-stranded RNA binding motifs (DSRMs). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380704  Cd Length: 67  Bit Score: 37.25  E-value: 9.50e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12597661 235 INPMGLLVEELKKRNVSAPesrLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLVAEEEAARVALRKL 304
Cdd:cd19875   1 KNPVSALNEYCQKRGLSLE---FVDVSVGPDHCPGFTASATIDGIVFASATGTSKKEAKRAAAKLALKKL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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