heparanase precursor [Rattus norvegicus]
Protein Classification
glycosyl hydrolase family 79 N-terminal domain-containing protein( domain architecture ID 5168)
glycosyl hydrolase family 79 N-terminal domain-containing protein similar to Homo sapiens heparanase, which acts as an endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Glyco_hydro_79n super family | cl04201 | Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or ... |
177-363 | 4.51e-24 | ||||
Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. The actual alignment was detected with superfamily member pfam03662: Pssm-ID: 461010 Cd Length: 318 Bit Score: 102.69 E-value: 4.51e-24
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| Name | Accession | Description | Interval | E-value | ||||
| Glyco_hydro_79n | pfam03662 | Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or ... |
177-363 | 4.51e-24 | ||||
Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. Pssm-ID: 461010 Cd Length: 318 Bit Score: 102.69 E-value: 4.51e-24
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| Name | Accession | Description | Interval | E-value | ||||
| Glyco_hydro_79n | pfam03662 | Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or ... |
177-363 | 4.51e-24 | ||||
Glycosyl hydrolase family 79, N-terminal domain; Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesized as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity. Pssm-ID: 461010 Cd Length: 318 Bit Score: 102.69 E-value: 4.51e-24
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| Blast search parameters | ||||
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