involucrin [Rattus norvegicus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Involucrin_N super family | cl11208 | Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of ... |
16-67 | 2.19e-11 | ||
Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis. The downstream part of the protein is represented by the family Involucrin, pfam00904. The actual alignment was detected with superfamily member pfam10583: Pssm-ID: 431372 Cd Length: 69 Bit Score: 59.89 E-value: 2.19e-11
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
253-293 | 7.72e-04 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. : Pssm-ID: 429235 Cd Length: 41 Bit Score: 37.45 E-value: 7.72e-04
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
156-194 | 3.35e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. : Pssm-ID: 429235 Cd Length: 41 Bit Score: 35.91 E-value: 3.35e-03
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
377-416 | 7.98e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. : Pssm-ID: 429235 Cd Length: 41 Bit Score: 34.76 E-value: 7.98e-03
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| Name | Accession | Description | Interval | E-value | ||
| Involucrin_N | pfam10583 | Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of ... |
16-67 | 2.19e-11 | ||
Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis. The downstream part of the protein is represented by the family Involucrin, pfam00904. Pssm-ID: 431372 Cd Length: 69 Bit Score: 59.89 E-value: 2.19e-11
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
253-293 | 7.72e-04 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 37.45 E-value: 7.72e-04
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
156-194 | 3.35e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 35.91 E-value: 3.35e-03
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
377-416 | 7.98e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 34.76 E-value: 7.98e-03
|
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| Name | Accession | Description | Interval | E-value | ||
| Involucrin_N | pfam10583 | Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of ... |
16-67 | 2.19e-11 | ||
Involucrin of squamous epithelia N-terminus; This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis. The downstream part of the protein is represented by the family Involucrin, pfam00904. Pssm-ID: 431372 Cd Length: 69 Bit Score: 59.89 E-value: 2.19e-11
|
||||||
| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
253-293 | 7.72e-04 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 37.45 E-value: 7.72e-04
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
156-194 | 3.35e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 35.91 E-value: 3.35e-03
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
268-307 | 4.68e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 35.53 E-value: 4.68e-03
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
377-416 | 7.98e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 34.76 E-value: 7.98e-03
|
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| Involucrin2 | pfam06994 | Involucrin; This family represents a conserved region approximately 60 residues long, multiple ... |
238-278 | 8.38e-03 | ||
Involucrin; This family represents a conserved region approximately 60 residues long, multiple copies of which are found within eukaryotic involucrin, and which is rich in glutamine and glutamic acid residues. Involucrin forms part of the insoluble cornified cell envelope (a specialized protective barrier) of stratified squamous epithelia. Members of this family seem to be restricted to mammals. Pssm-ID: 429235 Cd Length: 41 Bit Score: 34.76 E-value: 8.38e-03
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| Blast search parameters | ||||
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