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Conserved domains on  [gi|19923096|ref|NP_071431|]
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cytokine receptor-like factor 2 isoform 1 precursor [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-207 1.16e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923096 119 PSSPKHVRFS-WHQDAVTVTCS--DLSYGDLL-YEVQYRSPFDTEWQ---SKQENTCNVTIEGLDAEKCYSFWVRVKAmE 191
Cdd:cd00063   1 PSPPTNLRVTdVTSTSVTLSWTppEDDGGPITgYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVN-G 79

                        90
                ....*....|....*.
gi 19923096 192 DVYGPdtyPSDWSEVT 207
Cdd:cd00063  80 GGESP---PSESVTVT 92
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-207 1.16e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923096 119 PSSPKHVRFS-WHQDAVTVTCS--DLSYGDLL-YEVQYRSPFDTEWQ---SKQENTCNVTIEGLDAEKCYSFWVRVKAmE 191
Cdd:cd00063   1 PSPPTNLRVTdVTSTSVTLSWTppEDDGGPITgYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVN-G 79

                        90
                ....*....|....*.
gi 19923096 192 DVYGPdtyPSDWSEVT 207
Cdd:cd00063  80 GGESP---PSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 119-188 5.67e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.67  E-value: 5.67e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19923096    119 PSSPKHVRFS-WHQDAVTVTCSDLSY-GDLLYEVQYR---SPFDTEWQ--SKQENTCNVTIEGLDAEKCYSFWVRVK 188
Cdd:smart00060   1 PSPPSNLRVTdVTSTSVTLSWEPPPDdGITGYIVGYRveyREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 119-207 1.16e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.56  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923096 119 PSSPKHVRFS-WHQDAVTVTCS--DLSYGDLL-YEVQYRSPFDTEWQ---SKQENTCNVTIEGLDAEKCYSFWVRVKAmE 191
Cdd:cd00063   1 PSPPTNLRVTdVTSTSVTLSWTppEDDGGPITgYVVEYREKGSGDWKeveVTPGSETSYTLTGLKPGTEYEFRVRAVN-G 79

                        90
                ....*....|....*.
gi 19923096 192 DVYGPdtyPSDWSEVT 207
Cdd:cd00063  80 GGESP---PSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 119-188 5.67e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 35.67  E-value: 5.67e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19923096    119 PSSPKHVRFS-WHQDAVTVTCSDLSY-GDLLYEVQYR---SPFDTEWQ--SKQENTCNVTIEGLDAEKCYSFWVRVK 188
Cdd:smart00060   1 PSPPSNLRVTdVTSTSVTLSWEPPPDdGITGYIVGYRveyREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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