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Conserved domains on  [gi|15042949|ref|NP_067632|]
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PR domain zinc finger protein 12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 84-213 7.61e-98

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


:

Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 286.18  E-value: 7.61e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTY 163
Cdd:cd19196   1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIP 213
Cdd:cd19196  81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 1.81e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 15042949   257 NLRSHMRIHTLDKPFVCRFCNRRFSQ 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 6.80e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 6.80e-05
                          10        20
                  ....*....|....*....|....*
gi 15042949   286 LRNHVRLHTGERPYKCQVCQSAYSQ 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 244-265 3.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.78e-04
                          10        20
                  ....*....|....*....|..
gi 15042949   244 RCVICHRGFNSRSNLRSHMRIH 265
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 84-213 7.61e-98

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 286.18  E-value: 7.61e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTY 163
Cdd:cd19196   1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIP 213
Cdd:cd19196  81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 99-203 8.62e-12

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 61.38  E-value: 8.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949    99 GLGIFSKTWIKAGTEMGPFTGR-VIAPEHVDICKNNNLMWEVFNEDGT--------VRYFIDASQEDHRSWMTYI--KCA 167
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPylftldedSEYCIDARALYYGNWARFInhSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15042949   168 RNEQEQnLEVVQIGTSIFYKAIEMIPPDQELLVWYG 203
Cdd:pfam00856  81 PNCEVR-VVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 86-207 4.48e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.18  E-value: 4.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949     86 AEVIIAQSsiPGEGLGIFSKTWIKAGTEMGPFTGRVI-------APEHVDI-CKNNNLMWEVFNEdgtvrYFIDASqeDH 157
Cdd:smart00317   1 NKLEVFKS--PGKGWGVRATEDIPKGEFIGEYVGEIItseeaeeRPKAYDTdGAKAFYLFDIDSD-----LCIDAR--RK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 15042949    158 RSWMTYIKCARNEQEQNLEVVQIGTS-IFYKAIEMIPPDQELLVWYGNSHN 207
Cdd:smart00317  72 GNLARFINHSCEPNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYA 122
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 15042949   257 NLRSHMRIHTLDKPFVCRFCNRRFSQ 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 6.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 6.80e-05
                          10        20
                  ....*....|....*....|....*
gi 15042949   286 LRNHVRLHTGERPYKCQVCQSAYSQ 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-294 2.34e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.34e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15042949 244 RCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNR--RFSQSSTLRNHVRLHT 294
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 244-265 3.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.78e-04
                          10        20
                  ....*....|....*....|..
gi 15042949   244 RCVICHRGFNSRSNLRSHMRIH 265
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-301 6.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15042949 244 RCVICHRGFNSRSNLRSHMR--IHTL--DKPFVCRF--CNRRFSQSSTLRNHVRLHTGERPYKC 301
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354
ZnF_C2H2 smart00355
zinc finger;
244-265 7.20e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.20e-03
                           10        20
                   ....*....|....*....|..
gi 15042949    244 RCVICHRGFNSRSNLRSHMRIH 265
Cdd:smart00355   2 RCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 84-213 7.61e-98

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 286.18  E-value: 7.61e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTY 163
Cdd:cd19196   1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIP 213
Cdd:cd19196  81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 81-212 6.10e-39

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 135.05  E-value: 6.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  81 SLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEhvdICKNNNLMWEVFNEDGtVRYFIDASQEDHRSW 160
Cdd:cd19193   1 RLTLPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDE---EAADSGYSWQIYKGGK-LSHYIDAKDESKSNW 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15042949 161 MTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGI 212
Cdd:cd19193  77 MRYVNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDEYAKELGI 128
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 84-210 3.71e-38

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 132.99  E-value: 3.71e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNL-MWEVFNEDGTVRYFIDASQEDHRSWMT 162
Cdd:cd19191   1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVRNTQhLWEIYDQEGTLQHFIDGGDPSKSSWMR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15042949 163 YIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFL 210
Cdd:cd19191  81 YIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDSYTSFF 128
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 82-213 1.85e-37

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 131.37  E-value: 1.85e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  82 LVLPAEVIIAQSSIPG-EGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFnEDGTVRYFIDASQEDHrSW 160
Cdd:cd19198   1 LDLPEGLRVLQTSFGGtPHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIF-EDGKLSHFIDGRGSTG-NW 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 15042949 161 MTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIP 213
Cdd:cd19198  79 MSYVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWYGDCYLQFMGIP 131
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 84-203 2.30e-29

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 108.44  E-value: 2.30e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRViapehvdicknnnlmwevfnedgtvryfidasqedhrSWMTY 163
Cdd:cd10534   1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYG 203
Cdd:cd10534  44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 82-200 1.26e-28

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 108.22  E-value: 1.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  82 LVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTG--RVIApehvdicKNNNLMWEVFNEDGTVRYFIDASQEDHRS 159
Cdd:cd19200   8 IPIPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVGvqRSSV-------KDPTYAWEIVDEFGKVKFWIDASEPGTGN 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 15042949 160 WMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLV 200
Cdd:cd19200  81 WMKYIRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 81-207 5.58e-26

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 100.59  E-value: 5.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  81 SLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVdicKNNNLMWEVFNedGTVRYF-IDASQEDHRS 159
Cdd:cd19188   1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQV---KNNVYMWEIYG--PKRGWMcVDASDPTKGN 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 15042949 160 WMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHN 207
Cdd:cd19188  76 WLRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 84-201 7.53e-26

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 101.55  E-value: 7.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGrviapEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTY 163
Cdd:cd19214  30 IPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVG-----EQRSNLKDPSYGWEVLDEFGNVKFCIDASQPDVGSWLKY 104

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVW 201
Cdd:cd19214 105 IRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLF 142
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 84-203 1.98e-25

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 99.32  E-value: 1.98e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNeDGTVRYFIDASQEDHRSWMTY 163
Cdd:cd19187   3 LPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYS-NGEFYHYIDGFDPSKSNWMRY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15042949 164 IKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYG 203
Cdd:cd19187  82 VNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYC 121
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 84-201 2.31e-23

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 94.94  E-value: 2.31e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGrviapEHVDICKNNNLMWEVFNED-----------------GTV 146
Cdd:cd19213  20 IPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTG-----VQRSTLKDTNFGWEQILNDvevssqegcitkivddlGNE 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15042949 147 RYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVW 201
Cdd:cd19213  95 KFCVDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 92-205 3.94e-23

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 93.13  E-value: 3.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  92 QSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQ 171
Cdd:cd19190  12 KSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNWLRFVHEAPSQE 91

                        90       100       110
                ....*....|....*....|....*....|....
gi 15042949 172 EQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNS 205
Cdd:cd19190  92 QKNLAAIQEGENIFYLAVDDIETDTELLIGYLDS 125
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 82-211 1.81e-21

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 89.06  E-value: 1.81e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  82 LVLPAEVIIaQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVD--ICKNNNLMWEVFNEDGTVrYFIDASQEDHRS 159
Cdd:cd19189   4 LSLPRQLYL-RQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVAdwTDKAAPHIWKIYHNDVLE-FCIITTDENECN 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 15042949 160 WMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLG 211
Cdd:cd19189  82 WMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQLG 133
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 108-205 8.56e-20

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 83.33  E-value: 8.56e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949 108 IKAGTEMGPFTGRVIAPEHVDICKNNNLmwEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQ--IGTSIF 185
Cdd:cd19197   1 IPAGLRLGPVPGIFKLGKYLSDRKEPGN--KKKVRRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIAdlPGGQIF 78

                        90       100
                ....*....|....*....|
gi 15042949 186 YKAIEMIPPDQELLVWYGNS 205
Cdd:cd19197  79 YRALRDIQPGEELTVWYSNS 98
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 100-211 1.24e-19

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 83.55  E-value: 1.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949 100 LGIFSKTWIKAGTEMGPFTGRVIA-PEHVDICKNNNLMWEVFNEDgtvrYFIDASQEDHRSWMTYIKCARNEQEQNLEVV 178
Cdd:cd19194  20 GGVFAKRRIPKRTQFGPLEGPLVKkSELKDNKIHPLELEEDDGED----LYFDLSDENKCNWMMFVRPAQNHLEQNLVAY 95

                        90       100       110
                ....*....|....*....|....*....|...
gi 15042949 179 QIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLG 211
Cdd:cd19194  96 QYGQEIYFTTIKNIEPKQELKVWYAASYAEFLG 128
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 84-203 5.32e-19

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 82.08  E-value: 5.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEVIIAQssIPGEGLGIFSKTWIKAGTEMGPFTGRVIA---PEHVDICKnnnlmweVFNEDGTVRYFiDASQEDHRSW 160
Cdd:cd19199   7 LPDNLEIRQ--LEDGSEGVFALVPLVKRTQFGPFEAKRVArldGFAVFPLK-------VFEKDGSVVYL-DTSNEDDCNW 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15042949 161 MTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYG 203
Cdd:cd19199  77 MMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYA 119
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 84-202 4.28e-16

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 73.92  E-value: 4.28e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  84 LPAEV-IIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIA---PEHVDicknnnlmWEVFNEDGTVR-YFIDASqEDHR 158
Cdd:cd19201   3 LPGELeLRKPSQDAGRSGGVWAKQPLPEGTRFGPYPGKLVKeplDPSYE--------WKVEAQGSKGGeGLLLLT-EDSG 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 15042949 159 SWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWY 202
Cdd:cd19201  74 TWLKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVL 117
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 99-203 8.62e-12

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 61.38  E-value: 8.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949    99 GLGIFSKTWIKAGTEMGPFTGR-VIAPEHVDICKNNNLMWEVFNEDGT--------VRYFIDASQEDHRSWMTYI--KCA 167
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLELRLWGPylftldedSEYCIDARALYYGNWARFInhSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15042949   168 RNEQEQnLEVVQIGTSIFYKAIEMIPPDQELLVWYG 203
Cdd:pfam00856  81 PNCEVR-VVYVNGGPRIVIFALRDIKPGEELTIDYG 115
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 119-202 1.06e-09

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 56.02  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949 119 GRVIAPEHVDICKNNN----LMWEVFNEDGTVRyFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPP 194
Cdd:cd19195  31 GHIFGPYEGQICTQDKssgfFSWLIVDKNNRYK-SIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYFRACRDIRP 109


                ....*...
gi 15042949 195 DQELLVWY 202
Cdd:cd19195 110 GEKLRVWY 117
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 90-204 1.66e-08

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 52.43  E-value: 1.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  90 IAQSSIPGEGLGIFSKTW----IKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIK 165
Cdd:cd19192   6 LWRGGSKSVLTDIFTSVVtttdIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVVPYIFRVDTGACNGSSEPSDWLRLVQ 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15042949 166 CARNEQEQNLEVVQIGTS-IFYKAIEMIPPDQELLVWYGN 204
Cdd:cd19192  86 PARDRHEQNLEAFRKNEGqVYFRTLRRIRKGEELLVWYSD 125
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 86-207 4.48e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 51.18  E-value: 4.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949     86 AEVIIAQSsiPGEGLGIFSKTWIKAGTEMGPFTGRVI-------APEHVDI-CKNNNLMWEVFNEdgtvrYFIDASqeDH 157
Cdd:smart00317   1 NKLEVFKS--PGKGWGVRATEDIPKGEFIGEYVGEIItseeaeeRPKAYDTdGAKAFYLFDIDSD-----LCIDAR--RK 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 15042949    158 RSWMTYIKCARNEQEQNLEVVQIGTS-IFYKAIEMIPPDQELLVWYGNSHN 207
Cdd:smart00317  72 GNLARFINHSCEPNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYA 122
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 93-203 1.02e-06

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 47.34  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  93 SSIPG---EGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDicknNNLMWEVFN----EDGTVRYFIDASQedHRSWMTYIk 165
Cdd:cd10522   5 SMIPNlshNGLGLFAAETIAKGEFVGEYTGEVLDRWEED----RDSVYHYDPlypfDLNGDILVIDAGK--KGNLTRFI- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15042949 166 carNEQEQ-NLEVVQIGTS----IFYKAIEMIPPDQELLVWYG 203
Cdd:cd10522  78 ---NHSDQpNLELIVRTLKgeqhIGFVAIRDIKPGEELFISYG 117
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 97-201 1.73e-05

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 43.56  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15042949  97 GEGLGIfsktW-----IKAGTEMGPFTGRViapEHVDICKNNNLMWEVFNEDGTVRYFIDASqedhrSWMTYIKCARNEQ 171
Cdd:cd10520  18 EERLGV----WcvgdaLQKGTFLGPLEEEL---ESHDLTEGGSPRQEESGQSGDVLACEQSS-----KWMRFACRARSEE 85

                        90       100       110
                ....*....|....*....|....*....|
gi 15042949 172 EQNLEVVQIGTSIFYKAIEMIPPDQELLVW 201
Cdd:cd10520  86 ESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 1.81e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.81e-05
                          10        20
                  ....*....|....*....|....*.
gi 15042949   257 NLRSHMRIHTLDKPFVCRFCNRRFSQ 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-310 6.80e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 6.80e-05
                          10        20
                  ....*....|....*....|....*
gi 15042949   286 LRNHVRLHTGERPYKCQVCQSAYSQ 310
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-294 2.34e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.34e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15042949 244 RCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNR--RFSQSSTLRNHVRLHT 294
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 244-265 3.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.78e-04
                          10        20
                  ....*....|....*....|..
gi 15042949   244 RCVICHRGFNSRSNLRSHMRIH 265
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-301 6.49e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 6.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15042949 244 RCVICHRGFNSRSNLRSHMR--IHTL--DKPFVCRF--CNRRFSQSSTLRNHVRLHTGERPYKC 301
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE 354
ZnF_C2H2 smart00355
zinc finger;
244-265 7.20e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 33.59  E-value: 7.20e-03
                           10        20
                   ....*....|....*....|..
gi 15042949    244 RCVICHRGFNSRSNLRSHMRIH 265
Cdd:smart00355   2 RCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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