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Conserved domains on  [gi|225903450|ref|NP_067530|]
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protein HGH1 homolog isoform 1 [Mus musculus]

Protein Classification

HGH1 family protein( domain architecture ID 10513361)

HGH1 family protein simmilar to protein HGH1, which is an armadillo repeat protein that binds to the dynamic central domain III of eukaryotic elongation factor 2 (eEF2) via a bipartite interface; contains both DUF383 and DUF384 domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


:

Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 225903450  267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


:

Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225903450  299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 225903450  267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225903450  299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
120-294 3.13e-79

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 241.68  E-value: 3.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  120 VLDPQWPWAEEAAAVLANLSREPAPCAALMEKLMAAEPERLG-----LERLVNALC---TPSYNAAAPLHYLGPLLSNLS 191
Cdd:pfam04063   2 ITDPKSPLADLACMLLSNLTKSDSICKSLLELKRSSEPEDLSssglaIDQLVDLFVkgaDGGYNKHANYDYLAYVFANLS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225903450  192 QQAEVRAFLLDP----DRCVVQRLLPLTQYtDSSVRRGGVVGTLRNCCFEHRHHKWLLGA-QVDILPFLLLPLAGPEEFS 266
Cdd:pfam04063  82 QLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNCCFDTEAHEWLLSEeEIDILPYLLLPLAGPEEYD 160

                         170       180
                  ....*....|....*....|....*...
gi 225903450  267 EEEMDQLPVDLQYLSPDKQREPDADIRK 294
Cdd:pfam04063 161 EEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
299-353 4.22e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.19  E-value: 4.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 225903450  299 AVMLLTATAPGRKQVRDQGAYLILRELHSWEPEPDVRMACEKLIQVLIGDEPEAG 353
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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