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Conserved domains on  [gi|157823982|ref|NP_067321|]
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zinc finger protein 318 isoform 2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10648429)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270|GO:0003700
PubMed:  11179890|11361095|10940247|22803940|12665246
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 18-142 4.99e-08

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGR-----PVGASSG--PTRRPSSPPPPSCSSLRLPARRhRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASP 90
Cdd:PHA03307  285 ASSSSSPRERspspsPSSPGSGpaPSSPRASSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPS 363

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157823982   91 SPTRGRRASPSPPRGRRGSPSPPRAR-RGSPSPPRSRRHYPPGLGGFRGSIRG 142
Cdd:PHA03307  364 SPRKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATGRFPAGRPRPSP 416
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 1085-1114 3.35e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 47.63  E-value: 3.35e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 157823982   1085 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQ 1114
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKK 30
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 899-1031 5.98e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   899 KKISDEKNRASQKQKVIEER-EKLKTEQEArqkkmfyLTTELERLHKQQGEMLRKKRREKDGHKDPLLMEVsrlQDSIMK 977
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKiSSLKEKIEK-------LESEKKEKESKISDLEDELNKDDFELKKENLEKE---IDEKNK 568

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982   978 DIAELHKETEEAEKKQSELDKVAQILGIDIFD-------KSLKSSNDSKEsTEKPEKEKSK 1031
Cdd:TIGR04523  569 EIEELKQTQKSLKKKQEEKQELIDQKEKEKKDlikeieeKEKKISSLEKE-LEKAKKENEK 628
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 18-142 4.99e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGR-----PVGASSG--PTRRPSSPPPPSCSSLRLPARRhRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASP 90
Cdd:PHA03307  285 ASSSSSPRERspspsPSSPGSGpaPSSPRASSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPS 363

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157823982   91 SPTRGRRASPSPPRGRRGSPSPPRAR-RGSPSPPRSRRHYPPGLGGFRGSIRG 142
Cdd:PHA03307  364 SPRKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATGRFPAGRPRPSP 416
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 1085-1114 3.35e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 47.63  E-value: 3.35e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 157823982   1085 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQ 1114
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKK 30
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 899-1031 5.98e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   899 KKISDEKNRASQKQKVIEER-EKLKTEQEArqkkmfyLTTELERLHKQQGEMLRKKRREKDGHKDPLLMEVsrlQDSIMK 977
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKiSSLKEKIEK-------LESEKKEKESKISDLEDELNKDDFELKKENLEKE---IDEKNK 568

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982   978 DIAELHKETEEAEKKQSELDKVAQILGIDIFD-------KSLKSSNDSKEsTEKPEKEKSK 1031
Cdd:TIGR04523  569 EIEELKQTQKSLKKKQEEKQELIDQKEKEKKDlikeieeKEKKISSLEKE-LEKAKKENEK 628
PTZ00121 PTZ00121
MAEBL; Provisional
 899-1031 1.30e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKViEEREKLKTEQEARQkkmfylttelERLHKQQGEMLRKKRREKDGHKDPLLMEVSRlqdsiMKD 978
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKA-EEENKIKAAEEAKK----------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEE-----AKK 1703

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157823982  979 IAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTE--KPEKEKSK 1031
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEakKDEEEKKK 1758
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 904-1035 1.41e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.89  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   904 EKNRASQKQ-KVIEEREKLKteQEARQKKMfylttELERLHKQQGEMLRKKRREKDGhkdpLLMEVSRLQDSIMKDIAEL 982
Cdd:pfam05557   48 DRNQELQKRiRLLEKREAEA--EEALREQA-----ELNRLKKKYLEALNKKLNEKES----QLADAREVISCLKNELSEL 116

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 157823982   983 HKETEEAE----KKQSELDKVAQILgiDIFDKSLKSSNDSKESTEKPEKEKSKSPEK 1035
Cdd:pfam05557  117 RRQIQRAElelqSTNSELEELQERL--DLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
QWRF pfam04484
QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also ...
 18-150 2.52e-04

QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also includes microtubule-associated protein ENDOSPERM DEFECTIVE 1 and SNOWY COTYLEDON 3. AUG8 binds the microtubule plus-end and participates in the reorientation of microtubules in hypocotyls (the stem of a germinating seedling).


Pssm-ID: 461327 [Multi-domain]  Cd Length: 304  Bit Score: 44.66  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982    18 GSASGPPPGRPVGA-----SSGPTRRPSSPPPPSCSSLRLPARRHRSPSghrgrwASPSPPRGRRGS-PSPPRGRRASPS 91
Cdd:pfam04484    5 GSSSGTPRGIVVPArflqeTSSRLRRLSDPGSPTSSSSKVPSKKSRLDG------APSSSPRSRANSrASPGRGSSRALS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823982    92 PTRGRRASPSPPrgrRGSPSPPRARRGSPSPPRSrrhyPPGLGGFRGSIRGESrADFAR 150
Cdd:pfam04484   79 PSKLGSSTSSPS---RGLPSPSRPRSSSSSKASS----SAGSGKGVPSVLSFG-ADVRR 129
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
899-1036 3.30e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.13  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKVIEEREKLK-TEQEARQKKMfylttELERLHKQqgemLRKKRREKDGHKDpLLMEVSRLQDSIMK 977
Cdd:COG1340   140 EKIKELEKELEKAKKALEKNEKLKeLRAELKELRK-----EAEEIHKK----IKELAEEAQELHE-EMIELYKEADELRK 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982  978 DIAELHKETEEAEKKQSELDKVAQILGIDI--FDKSLKSSNDSKESTEKPEKEKSKSPEKE 1036
Cdd:COG1340   210 EADELHKEIVEAQEKADELHEEIIELQKELreLRKELKKLRKKQRALKREKEKEELEEKAE 270
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 899-996 7.13e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKvieeREKLKTEQEARQKKMFyltTELERLHKQQGEMLRKKRREKdghKDPLLMEVSRLQDSIMKD 978
Cdd:cd16269   198 KEIEAERAKAEAAEQ----ERKLLEEQQRELEQKL---EDQERSYEEHLRQLKEKMEEE---RENLLKEQERALESKLKE 267

                          90       100
                  ....*....|....*....|
gi 157823982  979 IAELHKE--TEEAEKKQSEL 996
Cdd:cd16269   268 QEALLEEgfKEQAELLQEEI 287
 
Name Accession Description Interval E-value
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 18-142 4.99e-08

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 57.49  E-value: 4.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGR-----PVGASSG--PTRRPSSPPPPSCSSLRLPARRhRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASP 90
Cdd:PHA03307  285 ASSSSSPRERspspsPSSPGSGpaPSSPRASSSSSSSRESSSSSTS-SSSESSRGAAVSPGPSPSRSPSPSRPPPPADPS 363

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157823982   91 SPTRGRRASPSPPRGRRGSPSPPRAR-RGSPSPPRSRRHYPPGLGGFRGSIRG 142
Cdd:PHA03307  364 SPRKRPRPSRAPSSPAASAGRPTRRRaRAAVAGRARRRDATGRFPAGRPRPSP 416
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 17-128 2.03e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.56  E-value: 2.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   17 DGSASGPPPGRPVGASSGPTRRPSSPPPPSCsslrlPARRHRSPSGHRGRWASPSPPRGRRGSPSPpRGRRASPSPTRGR 96
Cdd:PHA03307  276 NGPSSRPGPASSSSSPRERSPSPSPSSPGSG-----PAPSSPRASSSSSSSRESSSSSTSSSSESS-RGAAVSPGPSPSR 349

                          90       100       110
                  ....*....|....*....|....*....|..
gi 157823982   97 RASPSPPRGRRGSPSPPRARRGSPSPPRSRRH 128
Cdd:PHA03307  350 SPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 1085-1114 3.35e-07

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 47.63  E-value: 3.35e-07
                            10        20        30
                    ....*....|....*....|....*....|
gi 157823982   1085 AGSHWCKDCNTTCGTMFDFFTHMHNKKHTQ 1114
Cdd:smart00451    1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKK 30
PHA03247 PHA03247
large tegument protein UL36; Provisional
 24-128 1.11e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   24 PPGRPVGASSGPTRRPSSPPPPSCSSlrlpARRHRSPSGHRGRWASPSPPrgrrgSPSPPRGRRASPSPTRGRRASPSPP 103
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQ----SARPRAPVDDRGDPRGPAPP-----SPLPPDTHAPDPPPPSPSPAANEPD 2639

                          90       100
                  ....*....|....*....|....*
gi 157823982  104 RGRRGSPSPPRARRGSPSPPRSRRH 128
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGRVSRP 2664
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-122 2.42e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   16 KDGSASGPPPGRPVGASSGP-------TRRPSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRA 88
Cdd:PHA03307  302 SPGSGPAPSSPRASSSSSSSresssssTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAAS 381

                          90       100       110
                  ....*....|....*....|....*....|....
gi 157823982   89 SPSPTRgRRASPSPPRGRRGSPSPPRARRGSPSP 122
Cdd:PHA03307  382 AGRPTR-RRARAAVAGRARRRDATGRFPAGRPRP 414
PHA03378 PHA03378
EBNA-3B; Provisional
 20-135 4.79e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 4.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   20 ASGPPPGRPVGASSGPTRRPSSPPPPSCSSLRLPARRhRSPSGHRGRWASPS-------PPRGRRGSPSPPRGRRASPSP 92
Cdd:PHA03378  698 PRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRA-RPPAAAPGRARPPAaapgrarPPAAAPGRARPPAAAPGAPTP 776

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 157823982   93 TRGRRASPSPPRGRRGSPSPPRARRGSPSPPRSRRHYPPGLGG 135
Cdd:PHA03378  777 QPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQG 819
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 899-1031 5.98e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.32  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   899 KKISDEKNRASQKQKVIEER-EKLKTEQEArqkkmfyLTTELERLHKQQGEMLRKKRREKDGHKDPLLMEVsrlQDSIMK 977
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKiSSLKEKIEK-------LESEKKEKESKISDLEDELNKDDFELKKENLEKE---IDEKNK 568

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982   978 DIAELHKETEEAEKKQSELDKVAQILGIDIFD-------KSLKSSNDSKEsTEKPEKEKSK 1031
Cdd:TIGR04523  569 EIEELKQTQKSLKKKQEEKQELIDQKEKEKKDlikeieeKEKKISSLEKE-LEKAKKENEK 628
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 18-127 8.37e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 8.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGrPVGASSGPTRRPSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRG----SPSPPRGRRASPSPT 93
Cdd:PHA03307  112 SSPDPPPPT-PPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQaalpLSSPEETARAPSSPP 190

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 157823982   94 RGRRASPSPPRG-----RRGSPSPPRARRGSPSPPRSRR 127
Cdd:PHA03307  191 AEPPPSTPPAAAsprppRRSSPISASASSPAPAPGRSAA 229
PHA03247 PHA03247
large tegument protein UL36; Provisional
 18-133 9.96e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 9.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPG--RPVGASSGPTRRPS-SPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTR 94
Cdd:PHA03247 2774 APAAGPPRRltRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG 2853

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 157823982   95 GRRAsPSPPRGRRGSPSPPRARRGSPSPPRSRRHYPPGL 133
Cdd:PHA03247 2854 GSVA-PGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAV 2891
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 18-131 1.15e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.70  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGR--PVGASSGPTRRPSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSP-------PRGRRGSPSPPRGRRA 88
Cdd:PHA03307  187 SSPPAEPPPStpPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSEssgcgwgPENECPLPRPAPITLP 266

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 157823982   89 SPSPTRGRRASPSPPRGRRGSPSPPRARRGSPSPPRSRRHYPP 131
Cdd:PHA03307  267 TRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAP 309
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 20-130 1.16e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   20 ASGPPPGRPVGASSGPTRRPSSPPPPSCsslrlPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGRRAS 99
Cdd:PRK07764  407 AAAPAPAAAAPAAAAAPAPAAAPQPAPA-----PAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPA 481

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157823982  100 PSPPRGRRGSPSPPRARRGSPSPPRS-----RRHYP 130
Cdd:PRK07764  482 PAPPAAPAPAAAPAAPAAPAAPAGADdaatlRERWP 517
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 16-132 1.24e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   16 KDGSASGPPPGRPVGASSGPTRRPSSPPPPscsslRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRG 95
Cdd:PHA03307  826 PDGGSESSGPARPPGAAARPPPARSSESSK-----SKPAAAGGRARGKNGRRRPRPPEPRARPGAAAPPKAAAAAPPAGA 900

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 157823982   96 RRASPSPPRGRRGSPSPPrarrGSPSPPRSRRHYPPG 132
Cdd:PHA03307  901 PAPRPRPAPRVKLGPMPP----GGPDPRGGFRRVPPG 933
PTZ00121 PTZ00121
MAEBL; Provisional
 899-1031 1.30e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKViEEREKLKTEQEARQkkmfylttelERLHKQQGEMLRKKRREKDGHKDPLLMEVSRlqdsiMKD 978
Cdd:PTZ00121 1640 KKEAEEKKKAEELKKA-EEENKIKAAEEAKK----------AEEDKKKAEEAKKAEEDEKKAAEALKKEAEE-----AKK 1703

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157823982  979 IAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTE--KPEKEKSK 1031
Cdd:PTZ00121 1704 AEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEakKDEEEKKK 1758
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 904-1035 1.41e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.89  E-value: 1.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   904 EKNRASQKQ-KVIEEREKLKteQEARQKKMfylttELERLHKQQGEMLRKKRREKDGhkdpLLMEVSRLQDSIMKDIAEL 982
Cdd:pfam05557   48 DRNQELQKRiRLLEKREAEA--EEALREQA-----ELNRLKKKYLEALNKKLNEKES----QLADAREVISCLKNELSEL 116

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 157823982   983 HKETEEAE----KKQSELDKVAQILgiDIFDKSLKSSNDSKESTEKPEKEKSKSPEK 1035
Cdd:pfam05557  117 RRQIQRAElelqSTNSELEELQERL--DLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
PHA03270 PHA03270
envelope glycoprotein C; Provisional
 68-141 1.76e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165528 [Multi-domain]  Cd Length: 466  Bit Score: 45.31  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   68 ASPSPPRGRRGSPS--PPRGR-------RASPSPTRGRRASPSPprgrrGSPSPPRARRGSPSPPRSRRHYPPGLGGFRG 138
Cdd:PHA03270   21 AGAGAPRGAVSNASeaPTSGSpgsaegpRTTPTPTRGKGTPTGP-----ASPPKSGPPKSPPAPFRCKRPDVLARYGSRV 95


                  ...
gi 157823982  139 SIR 141
Cdd:PHA03270   96 QIR 98
QWRF pfam04484
QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also ...
 18-150 2.52e-04

QWRF family; AUG8 belongs to the plant QWRF motif-containing protein family, which also includes microtubule-associated protein ENDOSPERM DEFECTIVE 1 and SNOWY COTYLEDON 3. AUG8 binds the microtubule plus-end and participates in the reorientation of microtubules in hypocotyls (the stem of a germinating seedling).


Pssm-ID: 461327 [Multi-domain]  Cd Length: 304  Bit Score: 44.66  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982    18 GSASGPPPGRPVGA-----SSGPTRRPSSPPPPSCSSLRLPARRHRSPSghrgrwASPSPPRGRRGS-PSPPRGRRASPS 91
Cdd:pfam04484    5 GSSSGTPRGIVVPArflqeTSSRLRRLSDPGSPTSSSSKVPSKKSRLDG------APSSSPRSRANSrASPGRGSSRALS 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823982    92 PTRGRRASPSPPrgrRGSPSPPRARRGSPSPPRSrrhyPPGLGGFRGSIRGESrADFAR 150
Cdd:pfam04484   79 PSKLGSSTSSPS---RGLPSPSRPRSSSSSKASS----SAGSGKGVPSVLSFG-ADVRR 129
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 20-147 2.77e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   20 ASGPPPGRPVGASSGPTRRPSSPPPPScsslrlPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGRRAS 99
Cdd:PRK07764  616 AAPAAPAAPAAPAPAGAAAAPAEASAA------PAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAA 689

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157823982  100 PSPPRGRRGSPSPPRARRGSPSPPRSRRHYPPGLGGFRGSIRGESRAD 147
Cdd:PRK07764  690 PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADD 737
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
899-1036 3.30e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.13  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKVIEEREKLK-TEQEARQKKMfylttELERLHKQqgemLRKKRREKDGHKDpLLMEVSRLQDSIMK 977
Cdd:COG1340   140 EKIKELEKELEKAKKALEKNEKLKeLRAELKELRK-----EAEEIHKK----IKELAEEAQELHE-EMIELYKEADELRK 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982  978 DIAELHKETEEAEKKQSELDKVAQILGIDI--FDKSLKSSNDSKESTEKPEKEKSKSPEKE 1036
Cdd:COG1340   210 EADELHKEIVEAQEKADELHEEIIELQKELreLRKELKKLRKKQRALKREKEKEELEEKAE 270
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 891-1034 4.54e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.43  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  891 PSLIKYNPKKISDEKNRASQkqkVIEEREKLKTEQEARQKKMFYLTTELERLHKQqgemLRKKRREKDGHKDPLLmevSR 970
Cdd:PRK00409  501 ENIIEEAKKLIGEDKEKLNE---LIASLEELERELEQKAEEAEALLKEAEKLKEE----LEEKKEKLQEEEDKLL---EE 570

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  971 LQDSIMKDIAELHKETEEAEKKQSELDK------VAQILgIDIfDKSLKSSNDSKESTEKPEKEKSKSPE 1034
Cdd:PRK00409  571 AEKEAQQAIKEAKKEADEIIKELRQLQKggyasvKAHEL-IEA-RKRLNKANEKKEKKKKKQKEKQEELK 638
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 16-135 4.57e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 4.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   16 KDGSASGPPPGRPVGASSGPTRRPSSPPPPSCSSLRLPARRHRSPSGHRGR---WASPSPPRGRRGSPSPPRGRRASPSP 92
Cdd:PRK07764  624 PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGgaaPAAPPPAPAPAAPAAPAGAAPAQPAP 703

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157823982   93 TRGRRASPSPPRGRRGSPSPPRARRGSPS-------PPRSRRHYPPGLGG 135
Cdd:PRK07764  704 APAATPPAGQADDPAAQPPQAAQGASAPSpaaddpvPLPPEPDDPPDPAG 753
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 19-178 4.82e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.39  E-value: 4.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   19 SASGPPPGRPVGASSGPTRRPSSPPPPSCsslrlPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGRR- 97
Cdd:PHA03307   97 PASPAREGSPTPPGPSSPDPPPPTPPPAS-----PPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRq 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   98 ---ASPSPPRGRRGSPSPPRARRGSPSPPRsRRHYPPGLGGFRGSIRGESRADFARDGRGDHPGGGGGSRRRSPGLCSDS 174
Cdd:PHA03307  172 aalPLSSPEETARAPSSPPAEPPPSTPPAA-ASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWG 250


                  ....
gi 157823982  175 SLEE 178
Cdd:PHA03307  251 PENE 254
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 24-131 6.82e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 6.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   24 PPGRPVGASSGPTRRPSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPR---------GRRASPSPTR 94
Cdd:PHA03307  777 PAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSESSGPARppgaaarppPARSSESSKS 856

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157823982   95 GRRASPSPPRGRRG----SPSPPRARRGSPSPPRSRRHYPP 131
Cdd:PHA03307  857 KPAAAGGRARGKNGrrrpRPPEPRARPGAAAPPKAAAAAPP 897
PHA03247 PHA03247
large tegument protein UL36; Provisional
 19-139 9.44e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 9.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   19 SASGPPPGRPVGASSGPTRRPSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGRRA 98
Cdd:PHA03247 2595 SARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA 2674

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157823982   99 SPS-PPRGRR--------GS-------PSPPRARRGSPSPPRSRRHYPPGLGGFRGS 139
Cdd:PHA03247 2675 QASsPPQRPRrraarptvGSltsladpPPPPPTPEPAPHALVSATPLPPGPAAARQA 2731
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
905-999 1.03e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.51  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  905 KNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLHKQQGEMLRK----KRREKDGHKDPLLMEVSRLQ-------- 972
Cdd:PRK03918  608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKyseeEYEELREEYLELSRELAGLRaeleelek 687

                          90       100
                  ....*....|....*....|....*....
gi 157823982  973 --DSIMKDIAELHKETEEAEKKQSELDKV 999
Cdd:PRK03918  688 rrEEIKKTLEKLKEELEEREKAKKELEKL 716
PHA03247 PHA03247
large tegument protein UL36; Provisional
 23-122 1.10e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   23 PPPGRPVG---ASSGPTRR---PSSPPPPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGR 96
Cdd:PHA03247 2846 PPPSLPLGgsvAPGGDVRRrppSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP 2925

                          90       100
                  ....*....|....*....|....*.
gi 157823982   97 RASPSPPRGRRGSPSPPRARRGSPSP 122
Cdd:PHA03247 2926 PPQPQPPPPPPPRPQPPLAPTTDPAG 2951
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 892-1031 1.49e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.70  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   892 SLIKYNpkkiSDEKNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLHKQQGEM------LRKKRREKDGHKDPLL 965
Cdd:TIGR04523  104 DLSKIN----SEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLnnkyndLKKQKEELENELNLLE 179

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   966 MEVSRLQdSIMKDI---------------------AELHKETEEAEKKQSELDKVAQILGIDIFDKSLK-SSNDSKESTE 1023
Cdd:TIGR04523  180 KEKLNIQ-KNIDKIknkllklelllsnlkkkiqknKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEiSNTQTQLNQL 258


                   ....*...
gi 157823982  1024 KPEKEKSK 1031
Cdd:TIGR04523  259 KDEQNKIK 266
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 892-1037 2.01e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   892 SLIKYNPKKISDEKNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLHKQQGEMLRKKRREKDG---HKDPLLMEV 968
Cdd:TIGR04523  433 ETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKlneEKKELEEKV 512

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157823982   969 SRL---QDSIMKDIAELHKETEEAEKKQSELDKvaQILGIDiFDksLKSSNDSKESTEKPEK-EKSKSPEKEL 1037
Cdd:TIGR04523  513 KDLtkkISSLKEKIEKLESEKKEKESKISDLED--ELNKDD-FE--LKKENLEKEIDEKNKEiEELKQTQKSL 580
PTZ00121 PTZ00121
MAEBL; Provisional
 895-1034 2.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  895 KYNPKKISDEKNRASQKQKVIEEREKLKTEQEARQKKmfylttELERLHKQQGEMLRKKRREKDgHKDpllmEVSRLQDS 974
Cdd:PTZ00121 1285 KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAK------KKAEEAKKKADAAKKKAEEAK-KAA----EAAKAEAE 1353

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982  975 IMKDIAELHKETEEA-EKKQSELDKVAqilgiDIFDKSLKSSNDSKESTEKPEKEKSKSPE 1034
Cdd:PTZ00121 1354 AAADEAEAAEEKAEAaEKKKEEAKKKA-----DAAKKKAEEKKKADEAKKKAEEDKKKADE 1409
Gag_spuma pfam03276
Spumavirus gag protein;
54-145 2.69e-03

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 41.66  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982    54 ARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRrasPSPTRGRRASPSPPRGRRGSPSPPRARRGspsppRSRRHYPPGL 133
Cdd:pfam03276  475 AARGPQIRASRGPGPGPSAGEGRGGPANEGRGG---PCNAGGGNDCGANGQNDGGENIQNGGQEL-----RSQGGQNLRS 546

                           90
                   ....*....|..
gi 157823982   134 GGFRGSIRGESR 145
Cdd:pfam03276  547 GGGQGQRWGEGR 558
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 18-150 3.89e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   18 GSASGPPPGRPVGASSGPTRrpsspppPSCSSLRLPARRHRSPSGHRGRWASPSPPRGRRgSPSPPRGRRASPSPTRGRR 97
Cdd:PHA03307  340 AVSPGPSPSRSPSPSRPPPP-------ADPSSPRKRPRPSRAPSSPAASAGRPTRRRARA-AVAGRARRRDATGRFPAGR 411

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157823982   98 ASPSPPRGRRGSPSPPRARR----------GSPSPPRSRRHYpPGLGGFRGSIRGESRADFAR 150
Cdd:PHA03307  412 PRPSPLDAGAASGAFYARYPlltpsgepwpGSPPPPPGRVRY-GGLGDSRPGLWDAPEVREAA 473
PTZ00121 PTZ00121
MAEBL; Provisional
 895-1034 3.99e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  895 KYNPKKISDEKNRASQKQKVIEEREK---LKTEQEARQKKMFYLTTELERlhKQQGEMLRKKRREKDGhkdpllMEVSRL 971
Cdd:PTZ00121 1367 EAAEKKKEEAKKKADAAKKKAEEKKKadeAKKKAEEDKKKADELKKAAAA--KKKADEAKKKAEEKKK------ADEAKK 1438

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157823982  972 QDSIMKDIAELHKETEEAEKKQSELDKVAQILGIDIFDKSLKSSNDSKESTEKPEKEKSKSPE 1034
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
899-1033 4.00e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLHK--QQGEMLRKKRREKDGHKdpllmevSRLQDsim 976
Cdd:PRK03918  314 KRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEErhELYEEAKAKKEELERLK-------KRLTG--- 383

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157823982  977 KDIAELHKETEEAEKKQSELDKvaQILGIDIFDKSLKS-SNDSKESTEKPEKEKSKSP 1033
Cdd:PRK03918  384 LTPEKLEKELEELEKAKEEIEE--EISKITARIGELKKeIKELKKAIEELKKAKGKCP 439
PTZ00121 PTZ00121
MAEBL; Provisional
 904-1036 4.72e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  904 EKNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELERLH--KQQGEMLRKKRREKDGHKDpllmEVSRLQDSIMKDIAE 981
Cdd:PTZ00121 1590 EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEeeKKKVEQLKKKEAEEKKKAE----ELKKAEEENKIKAAE 1665

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157823982  982 LHKETEEAEKKQSELDKVAQilgidifDKSLKSSNDSKESTEKPEKEKSKSPEKE 1036
Cdd:PTZ00121 1666 EAKKAEEDKKKAEEAKKAEE-------DEKKAAEALKKEAEEAKKAEELKKKEAE 1713
PTZ00121 PTZ00121
MAEBL; Provisional
 899-1036 4.97e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKVIEER--EKLKTEQEARQKKMFYLTTELERLHKQQGEMLRKKRREKDGHKDPLLMEVSRLQDsiM 976
Cdd:PTZ00121 1230 KKAEEAKKDAEEAKKAEEERnnEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADE--A 1307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  977 KDIAELHKETEEAEKKQSELDKVAQILGIDIFDKslKSSNDSKESTEKPEKEKSKSPEKE 1036
Cdd:PTZ00121 1308 KKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEA--KKAAEAAKAEAEAAADEAEAAEEK 1365
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 64-133 5.18e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 40.26  E-value: 5.18e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   64 RGRWASPSPPRgrrgSPSPPRgRRASPSPTRGRRASPSPPRGRrGSPSPPRARRGSPSPPRSRRHYPPGL 133
Cdd:PHA03201    3 RARSRSPSPPR----RPSPPR-PTPPRSPDASPEETPPSPPGP-GAEPPPGRAAGPAAPRRRPRGCPAGV 66
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 899-996 7.13e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 39.87  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  899 KKISDEKNRASQKQKvieeREKLKTEQEARQKKMFyltTELERLHKQQGEMLRKKRREKdghKDPLLMEVSRLQDSIMKD 978
Cdd:cd16269   198 KEIEAERAKAEAAEQ----ERKLLEEQQRELEQKL---EDQERSYEEHLRQLKEKMEEE---RENLLKEQERALESKLKE 267

                          90       100
                  ....*....|....*....|
gi 157823982  979 IAELHKE--TEEAEKKQSEL 996
Cdd:cd16269   268 QEALLEEgfKEQAELLQEEI 287
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
892-1037 7.20e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.27  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  892 SLIKYNPKKISDEKNRASQKQKVIEEREKLKTEQEARQKKMFYLTTELER----LHKQQGEMLRKKRREKDGHKdpllmE 967
Cdd:COG4372    14 SLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQleeeLEQARSELEQLEEELEELNE-----Q 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157823982  968 VSRLQDSIMKDIAELHKETEEAEKKQSELDKV-AQILGIDIFDKSLKSSNDSKESTEKPEKEKSKSPEKEL 1037
Cdd:COG4372    89 LQAAQAELAQAQEELESLQEEAEELQEELEELqKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQL 159
PTZ00121 PTZ00121
MAEBL; Provisional
 895-1036 7.58e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 7.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982  895 KYNPKKISDEKNRASQKQKVIEER--EKLKTEQEARQKKMFYLTTELERLHKQQGEMLRKKRREKdghkdplLMEVSRLQ 972
Cdd:PTZ00121 1529 KAEEAKKADEAKKAEEKKKADELKkaEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEAR-------IEEVMKLY 1601

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823982  973 DSIMKDIAELHKETEEAEKKQSELDKVAQIlgidifdKSLKSSNDSKESTEKPEKEKSKSPEKE 1036
Cdd:PTZ00121 1602 EEEKKMKAEEAKKAEEAKIKAEELKKAEEE-------KKKVEQLKKKEAEEKKKAEELKKAEEE 1658
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
61-123 7.72e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 7.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157823982   61 SGHRGRW--ASPSPPRGRRGSPSPPRGRRASPSPTRGRRASPSPPRGRRGSPSPPRARRGSPSPP 123
Cdd:PRK07003  564 SSDRGARaaAAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPP 628
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 17-132 8.34e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 8.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   17 DGSASGPPPGRPVGASSGPTRRPSSPPPpscsslrlPARRHRSPSGHRGRWASPSPPRGRRGSPSPPRGRRASPSPTRGR 96
Cdd:PRK07764  665 GGDGWPAKAGGAAPAAPPPAPAPAAPAA--------PAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAD 736

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 157823982   97 RASPSPPRGRRGsPSPPRARRGSPSPPRSRRHYPPG 132
Cdd:PRK07764  737 DPVPLPPEPDDP-PDPAGAPAQPPPPPAPAPAAAPA 771
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 903-1035 8.51e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 40.39  E-value: 8.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823982   903 DEKNRASQKQKVIEEREKLKTEQEARQKKmfyLTTELERLHKQqgemlrkkrREKDGHKdpllmEVSRLQDSIMKDIAEL 982
Cdd:TIGR04523  264 KIKKQLSEKQKELEQNNKKIKELEKQLNQ---LKSEISDLNNQ---------KEQDWNK-----ELKSELKNQEKKLEEI 326

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 157823982   983 HKETEEAEKKQSEL-DKVAQIlgidifDKSLKSSNDSKESTEKPEKEKSKSPEK 1035
Cdd:TIGR04523  327 QNQISQNNKIISQLnEQISQL------KKELTNSESENSEKQRELEEKQNEIEK 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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