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Conserved domains on  [gi|153251913|ref|NP_065895|]
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probable tRNA methyltransferase 9B isoform 1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 2.29e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 100.84  E-value: 2.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  26 DLQSKAWPRVRQFLQE--QKPGSLIADIGCGTGKYLK--VNSQVHTVGCDYCGPLVEIARNRGCEA------MVCDNLNL 95
Cdd:COG2226    2 DRVAARYDGREALLAAlgLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERAAEAglnvefVVGDAEDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 153251913  96 PFRDEGFDAIISIGVIHHFSTKQrriRAIKEMARVLVPGGQLMIYVWA 143
Cdd:COG2226   82 PFPDGSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 2.29e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 100.84  E-value: 2.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  26 DLQSKAWPRVRQFLQE--QKPGSLIADIGCGTGKYLK--VNSQVHTVGCDYCGPLVEIARNRGCEA------MVCDNLNL 95
Cdd:COG2226    2 DRVAARYDGREALLAAlgLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERAAEAglnvefVVGDAEDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 153251913  96 PFRDEGFDAIISIGVIHHFSTKQrriRAIKEMARVLVPGGQLMIYVWA 143
Cdd:COG2226   82 PFPDGSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 6.75e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 92.63  E-value: 6.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   48 IADIGCGTGKYL-----KVNSQVhtVGCDYCGPLVEIARNRG------CEAMVCDNLNLPFRDEGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARV--TGVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 153251913  117 KQRRiRAIKEMARVLVPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 9-139 1.41e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 78.66  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   9 EKQH-VHNVYESTAP-YfsDL--------QSKAWPR-VRQFLQEqKPGSLIADIGCGTGKYL-----KVNSQVHTVGCDY 72
Cdd:PRK00216   8 EKQEkVAEMFDSIAPkY--DLmndllsfgLHRVWRRkTIKWLGV-RPGDKVLDLACGTGDLAialakAVGKTGEVVGLDF 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 153251913  73 CGPLVEIARNR--------GCEAMVCDNLNLPFRDEGFDAI-ISIG---VIHhfstkqrRIRAIKEMARVLVPGGQLMI 139
Cdd:PRK00216  85 SEGMLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFDAVtIAFGlrnVPD-------IDKALREMYRVLKPGGRLVI 156
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 1.27e-12

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 66.90  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   13 VHNVYESTAPYFSDL-------QSKAW-PRVRQFLQEQKpGSLIADIGCGTG----KYLKVNSQVHTV-GCDYCGPLVEI 79
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLWrRRAVKLIGVFK-GQKVLDVACGTGdlaiELAKSAPDRGKVtGVDFSSEMLEV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153251913   80 ARNRGC-----EAMVCDNLNLPFRDEGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLVPGGQLMI 139
Cdd:TIGR01934  80 AKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVTDIQK---ALREMYRVLKPGGRLVI 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 8.35e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 8.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  48 IADIGCGTGKY---LKVNSQVHTVGCDYCGPLVEIARNR-------GCEAMVCDNLNLPF-RDEGFDAIISIGVIHHFST 116
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|...
gi 153251913 117 KQRRIraIKEMARVLVPGGQLMI 139
Cdd:cd02440   82 DLARF--LEEARRLLKPGGVLVL 102
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 26-143 2.29e-25

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 100.84  E-value: 2.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  26 DLQSKAWPRVRQFLQE--QKPGSLIADIGCGTGKYLK--VNSQVHTVGCDYCGPLVEIARNRGCEA------MVCDNLNL 95
Cdd:COG2226    2 DRVAARYDGREALLAAlgLRPGARVLDLGCGTGRLALalAERGARVTGVDISPEMLELARERAAEAglnvefVVGDAEDL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 153251913  96 PFRDEGFDAIISIGVIHHFSTKQrriRAIKEMARVLVPGGQLMIYVWA 143
Cdd:COG2226   82 PFPDGSFDLVISSFVLHHLPDPE---RALAEIARVLKPGGRLVVVDFS 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 48-135 6.75e-23

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 92.63  E-value: 6.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   48 IADIGCGTGKYL-----KVNSQVhtVGCDYCGPLVEIARNRG------CEAMVCDNLNLPFRDEGFDAIISIGVIHHFST 116
Cdd:pfam13649   1 VLDLGCGTGRLTlalarRGGARV--TGVDLSPEMLERARERAaeaglnVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*....
gi 153251913  117 KQRRiRAIKEMARVLVPGG 135
Cdd:pfam13649  79 PDLE-AALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-139 1.91e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 85.79  E-value: 1.91e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   50 DIGCGTGKYLKVNSQV--HTVGCDYCGPLVEIAR----NRGCEAMVCDNLNLPFRDEGFDAIISIGVIHHFstkQRRIRA 123
Cdd:pfam08241   2 DVGCGTGLLTELLARLgaRVTGVDISPEMLELARekapREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHV---EDPERA 78

                          90
                  ....*....|....*.
gi 153251913  124 IKEMARVLVPGGQLMI 139
Cdd:pfam08241  79 LREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 29-139 2.85e-18

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 80.45  E-value: 2.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  29 SKAW-PRVRQFLQEQ-KPGSLIADIGCGTGKYLKV----NSQVhtVGCDYCGPLVEIARNR----GCEAMVCDNLNLPFR 98
Cdd:COG2227    7 RDFWdRRLAALLARLlPAGGRVLDVGCGTGRLALAlarrGADV--TGVDISPEALEIARERaaelNVDFVQGDLEDLPLE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 153251913  99 DEGFDAIISIGVIHHFstkQRRIRAIKEMARVLVPGGQLMI 139
Cdd:COG2227   85 DGSFDLVICSEVLEHL---PDPAALLRELARLLKPGGLLLL 122
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 23-152 5.67e-18

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 81.89  E-value: 5.67e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  23 YFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGKYL-----KVNSQVhtVGCDYCGPLVEIARNRgCEAMVCDNLNL-- 95
Cdd:COG0500    5 YYSDELLPGLAALLALLERLPKGGRVLDLGCGTGRNLlalaaRFGGRV--IGIDLSPEAIALARAR-AAKAGLGNVEFlv 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153251913  96 -------PFRDEGFDAIISIGVIHHFStKQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRHFE 152
Cdd:COG0500   82 adlaeldPLPAESFDLVVAFGVLHHLP-PEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 9-139 1.41e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 78.66  E-value: 1.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   9 EKQH-VHNVYESTAP-YfsDL--------QSKAWPR-VRQFLQEqKPGSLIADIGCGTGKYL-----KVNSQVHTVGCDY 72
Cdd:PRK00216   8 EKQEkVAEMFDSIAPkY--DLmndllsfgLHRVWRRkTIKWLGV-RPGDKVLDLACGTGDLAialakAVGKTGEVVGLDF 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 153251913  73 CGPLVEIARNR--------GCEAMVCDNLNLPFRDEGFDAI-ISIG---VIHhfstkqrRIRAIKEMARVLVPGGQLMI 139
Cdd:PRK00216  85 SEGMLAVGREKlrdlglsgNVEFVQGDAEALPFPDNSFDAVtIAFGlrnVPD-------IDKALREMYRVLKPGGRLVI 156
PRK08317 PRK08317
hypothetical protein; Provisional
 34-182 3.51e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 77.67  E-value: 3.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  34 RVRQFLQEQkPGSLIADIGCGTG---KYLK--VNSQVHTVGCDYCGPLVEIARNRGCEA-----MVCDNL-NLPFRDEGF 102
Cdd:PRK08317  10 RTFELLAVQ-PGDRVLDVGCGPGndaRELArrVGPEGRVVGIDRSEAMLALAKERAAGLgpnveFVRGDAdGLPFPDGSF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913 103 DAIISIGVIHHFSTKQRrirAIKEMARVLVPGGQLMI-------YVWAMEQKNRhfeKQDVLVPWNRALCsqlfseSSQS 175
Cdd:PRK08317  89 DAVRSDRVLQHLEDPAR---ALAEIARVLRPGGRVVVldtdwdtLVWHSGDRAL---MRKILNFWSDHFA------DPWL 156

                        170
                 ....*....|..
gi 153251913 176 GRK-----RQCG 182
Cdd:PRK08317 157 GRRlpglfREAG 168
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 43-141 5.61e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 69.19  E-value: 5.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  43 KPGSLIADIGCGTG---KYLKVNSQVHTVGCDYCGPLVEIARNRGCEA--------MVCDNLNLPFrDEGFDAIISIGVI 111
Cdd:COG2230   50 KPGMRVLDIGCGWGglaLYLARRYGVRVTGVTLSPEQLEYARERAAEAgladrvevRLADYRDLPA-DGQFDAIVSIGMF 128

                         90       100       110
                 ....*....|....*....|....*....|
gi 153251913 112 HHFSTKQRRiRAIKEMARVLVPGGQLMIYV 141
Cdd:COG2230  129 EHVGPENYP-AYFAKVARLLKPGGRLLLHT 157
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
12-155 2.26e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 68.10  E-value: 2.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  12 HVHNVYESTAPYF-----SDLQSKAWPRVRQFLQEQ---KPGSLIADIGCGTG---KYLKvNSQVHTVGCDYCGPLVEIA 80
Cdd:COG4976    6 YVEALFDQYADSYdaalvEDLGYEAPALLAEELLARlppGPFGRVLDLGCGTGllgEALR-PRGYRLTGVDLSEEMLAKA 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153251913  81 RNRGCEA--MVCDNLNLPFRDEGFDAIISIGVIHHFSTKQrriRAIKEMARVLVPGGQLMIYVWAMEQKNRHFEKQD 155
Cdd:COG4976   85 REKGVYDrlLVADLADLAEPDGRFDLIVAADVLTYLGDLA---AVFAGVARALKPGGLFIFSVEDADGSGRYAHSLD 158
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
44-141 7.35e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 64.46  E-value: 7.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  44 PGSLIADIGCGTGKYLKV----NSQVHTVGCDYCGPLVEIARNR--GCEAMVCDNLNLPFrDEGFDAIISIGVIHHFstk 117
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALlaerFPGARVTGVDLSPEMLARARARlpNVRFVVADLRDLDP-PEPFDLVVSNAALHWL--- 76

                         90       100
                 ....*....|....*....|....
gi 153251913 118 QRRIRAIKEMARVLVPGGQLMIYV 141
Cdd:COG4106   77 PDHAALLARLAAALAPGGVLAVQV 100
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 13-139 1.27e-12

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 66.90  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   13 VHNVYESTAPYFSDL-------QSKAW-PRVRQFLQEQKpGSLIADIGCGTG----KYLKVNSQVHTV-GCDYCGPLVEI 79
Cdd:TIGR01934   1 VQEMFDRIAPKYDLLndllsfgLHRLWrRRAVKLIGVFK-GQKVLDVACGTGdlaiELAKSAPDRGKVtGVDFSSEMLEV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 153251913   80 ARNRGC-----EAMVCDNLNLPFRDEGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLVPGGQLMI 139
Cdd:TIGR01934  80 AKKKSElplniEFIQADAEALPFEDNSFDAVtIAFG-LRNVTDIQK---ALREMYRVLKPGGRLVI 141
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 50-137 4.04e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.39  E-value: 4.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   50 DIGCGTG----KYLKVNSQVHTVGCDYCGPLVEIARNR--GCEAMVCDNLNLPFRDEG------FDAIISIGVIHHFSTK 117
Cdd:pfam08242   2 EIGCGTGtllrALLEALPGLEYTGLDISPAALEAARERlaALGLLNAVRVELFQLDLGeldpgsFDVVVASNVLHHLADP 81

                          90       100
                  ....*....|....*....|
gi 153251913  118 QrriRAIKEMARVLVPGGQL 137
Cdd:pfam08242  82 R---AVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 48-139 8.35e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 58.60  E-value: 8.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  48 IADIGCGTGKY---LKVNSQVHTVGCDYCGPLVEIARNR-------GCEAMVCDNLNLPF-RDEGFDAIISIGVIHHFST 116
Cdd:cd02440    2 VLDLGCGTGALalaLASGPGARVTGVDISPVALELARKAaaalladNVEVLKGDAEELPPeADESFDVIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|...
gi 153251913 117 KQRRIraIKEMARVLVPGGQLMI 139
Cdd:cd02440   82 DLARF--LEEARRLLKPGGVLVL 102
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 50-161 1.55e-10

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 59.35  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   50 DIGCGTGKYL-----KVNSQVHTVGCDYCGPLVEIARNR-------GCEAMVCDNLNLP--FRDEGFDAIISIGVIHHFS 115
Cdd:pfam13847   9 DLGCGTGHLSfelaeELGPNAEVVGIDISEEAIEKARENaqklgfdNVEFEQGDIEELPelLEDDKFDVVISNCVLNHIP 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 153251913  116 TKQrriRAIKEMARVLVPGGQLMI-YVWAMEQKNRHFEKQDVLVPWN 161
Cdd:pfam13847  89 DPD---KVLQEILRVLKPGGRLIIsDPDSLAELPAHVKEDSTYYAGC 132
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
11-137 9.34e-08

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 52.83  E-value: 9.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   11 QHVHNVYESTAPYFSDL-------QSKAWPRVRQFLQEQKPGSLIADIGCGTG----KYLK-VNSQVHTVGCDYCGPLVE 78
Cdd:pfam01209   2 QRVGDVFSSVASKYDLMndvisfgIHRLWKDFTMKCMGVKRGNKFLDVAGGTGdwtfGLSDsAGSSGKVVGLDINENMLK 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 153251913   79 IARNRGCEA------MVCDN-LNLPFRDEGFDAI-ISIGvIHHFSTKQRrirAIKEMARVLVPGGQL 137
Cdd:pfam01209  82 EGEKKAKEEgkynieFLQGNaEELPFEDDSFDIVtISFG-LRNFPDYLK---VLKEAFRVLKPGGRV 144
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 24-138 1.03e-07

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 52.67  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   24 FSDLQSKAWPRVRQFLQE---QKPGSlIADIGCGTG----KYLKVNSQVHTVGCDYCGPLVEIARNRGCE--AMVCDNL- 93
Cdd:TIGR02072  12 HAKIQREMAKRLLALLKEkgiFIPAS-VLDIGCGTGyltrALLKRFPQAEFIALDISAGMLAQAKTKLSEnvQFICGDAe 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 153251913   94 NLPFRDEGFDAIISIGVIHHFSTKQrriRAIKEMARVLVPGGQLM 138
Cdd:TIGR02072  91 KLPLEDSSFDLIVSNLALQWCDDLS---QALSELARVLKPGGLLA 132
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
59-141 7.33e-07

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 48.71  E-value: 7.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  59 LKVNsqvhtVGC--DYCGPLVEIARNRGCEAMVCDNLN--LPFRDEGFDAIISIGVIHHFsTKQRRIRAIKEMARVLVPG 134
Cdd:COG4627    5 LKLN-----IGCgpKRLPGWLNVDIVPAPGVDIVGDLTdpLPFPDNSVDAIYSSHVLEHL-DYEEAPLALKECYRVLKPG 78


                 ....*..
gi 153251913 135 GQLMIYV 141
Cdd:COG4627   79 GILRIVV 85
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 27-150 1.12e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 48.19  E-value: 1.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   27 LQSKAWPRVRQFLQEQ-----KPGSLIaDIGCGTGKYLKVnsqVHTVGCDYCGplVEIARNRGCEAMVC------DNLNL 95
Cdd:pfam13489   1 YAHQRERLLADLLLRLlpklpSPGRVL-DFGCGTGIFLRL---LRAQGFSVTG--VDPSPIAIERALLNvrfdqfDEQEA 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 153251913   96 PFRDEGFDAIISIGVIHHFstkQRRIRAIKEMARVLVPGGQLMIYVWAMEQKNRH 150
Cdd:pfam13489  75 AVPAGKFDVIVAREVLEHV---PDPPALLRQIAALLKPGGLLLLSTPLASDEADR 126
PLN02244 PLN02244
tocopherol O-methyltransferase
 41-164 1.12e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 47.43  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  41 EQKPGSLIADIGCGTG---KYL--KVNSQVHTVGCDycgPlVEIARNRG----------CEAMVCDNLNLPFRDEGFDAI 105
Cdd:PLN02244 115 DEKRPKRIVDVGCGIGgssRYLarKYGANVKGITLS---P-VQAARANAlaaaqglsdkVSFQVADALNQPFEDGQFDLV 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913 106 ISIGVIHHFSTKQRrirAIKEMARVLVPGGQLMIYVWAmeqkNRHFEK-QDVLVPWNRAL 164
Cdd:PLN02244 191 WSMESGEHMPDKRK---FVQELARVAAPGGRIIIVTWC----HRDLEPgETSLKPDEQKL 243
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 43-135 4.19e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 43.78  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  43 KPGSLIADIGCGTG------KYLKVNSqvhtVGCDYCGPLVEIAR-------NRGCEAMVCDNLNLPFRDEGFDAIIS-- 107
Cdd:COG1041   25 KEGDTVLDPFCGTGtilieaGLLGRRV----IGSDIDPKMVEGARenlehygYEDADVIRGDARDLPLADESVDAIVTdp 100

                         90       100       110
                 ....*....|....*....|....*....|..
gi 153251913 108 -IGVIHHFSTKQRRI---RAIKEMARVLVPGG 135
Cdd:COG1041  101 pYGRSSKISGEELLElyeKALEEAARVLKPGG 132
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 16-139 8.64e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 44.11  E-value: 8.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  16 VYESTAPYFSDLQSKAWPRVRQFLQEQKPGSLIADIGCGTGK--YL---KVNSQVHTVGCDYCGPLVEIARNR-GCEAMV 89
Cdd:PLN02233  45 VYDNLNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDlaFLlseKVGSDGKVMGLDFSSEQLAVAASRqELKAKS 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 153251913  90 C---------DNLNLPFRDEGFDAIiSIGviHHFSTKQRRIRAIKEMARVLVPGGQLMI 139
Cdd:PLN02233 125 CykniewiegDATDLPFDDCYFDAI-TMG--YGLRNVVDRLKAMQEMYRVLKPGSRVSI 180
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 43-139 1.38e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 43.97  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  43 KPGSLIADIGCGTGK---YLKVNSQVHTVGCDYCGPLVEIA------RNRGCEAMVCDNLNLPFRDEGFDAIISIGVIHH 113
Cdd:PLN02336 265 KPGQKVLDVGCGIGGgdfYMAENFDVHVVGIDLSVNMISFAleraigRKCSVEFEVADCTKKTYPDNSFDVIYSRDTILH 344

                         90       100
                 ....*....|....*....|....*.
gi 153251913 114 FSTKQRRIRAikeMARVLVPGGQLMI 139
Cdd:PLN02336 345 IQDKPALFRS---FFKWLKPGGKVLI 367
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
32-137 2.59e-04

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 42.92  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  32 WPRVRQFLQEQKpGSLIADIGCGTG-------------------------------KYLKVNSQVHtvgcdyCGPL-VEi 79
Cdd:PRK15068 111 WDRVLPHLSPLK-GRTVLDVGCGNGyhmwrmlgagaklvvgidpsqlflcqfeavrKLLGNDQRAH------LLPLgIE- 182

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  80 arnrgceamvcdnlNLPFrDEGFDAIISIGVIHHfstkqRR--IRAIKEMARVLVPGGQL 137
Cdd:PRK15068 183 --------------QLPA-LKAFDTVFSMGVLYH-----RRspLDHLKQLKDQLVPGGEL 222
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 41-139 3.49e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 42.26  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  41 EQKPGSLIADIGCGTG---KYLKVNSQVHTVGCDYCGPLVEIA--RNRG-----CEAMvcDNLNLPFRDEGFDAIISIGV 110
Cdd:PTZ00098  49 ELNENSKVLDIGSGLGggcKYINEKYGAHVHGVDICEKMVNIAklRNSDknkieFEAN--DILKKDFPENTFDMIYSRDA 126

                         90       100
                 ....*....|....*....|....*....
gi 153251913 111 IHHFSTKQRRiRAIKEMARVLVPGGQLMI 139
Cdd:PTZ00098 127 ILHLSYADKK-KLFEKCYKWLKPNGILLI 154
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 37-150 5.65e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.94  E-value: 5.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  37 QFLQEQKPGSlIADIGCGTG----KYLKVNSQVHTVGCDYCGPLVEIAR-N------RGCEAMVCDNLNlPFRDEGFDAI 105
Cdd:COG2813   43 EHLPEPLGGR-VLDLGCGYGviglALAKRNPEARVTLVDVNARAVELARaNaaanglENVEVLWSDGLS-GVPDGSFDLI 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 153251913 106 IS-----IGVIHHFSTKQRRIRAIkemARVLVPGGQLMIyVWameqkNRH 150
Cdd:COG2813  121 LSnppfhAGRAVDKEVAHALIADA---ARHLRPGGELWL-VA-----NRH 161
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 34-137 1.39e-03

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 40.28  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  34 RVRQFLQEQKPGS--LIADIGCGTGKY----LKVNSQVHTV---GCDYCGPLVEIARNR--GCEAMVCDNLNLPFRDEGF 102
Cdd:PRK11088  73 AVANLLAERLDEKatALLDIGCGEGYYthalADALPEITTMqlfGLDISKVAIKYAAKRypQVTFCVASSHRLPFADQSL 152

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 153251913 103 DAIIsigvihhfstkqrRIRA---IKEMARVLVPGGQL 137
Cdd:PRK11088 153 DAII-------------RIYApckAEELARVVKPGGIV 177
arsM PRK11873
arsenite methyltransferase;
39-139 3.13e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 39.16  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913  39 LQEQKPGSLIADIGCGTGK--YL---KVNSQVHTVGCDYCGPLVEIARNRGCEAMVcDNL--------NLPFRDEGFDAI 105
Cdd:PRK11873  72 LAELKPGETVLDLGSGGGFdcFLaarRVGPTGKVIGVDMTPEMLAKARANARKAGY-TNVefrlgeieALPVADNSVDVI 150

                         90       100       110
                 ....*....|....*....|....*....|....
gi 153251913 106 ISIGVIHHFSTKQRrirAIKEMARVLVPGGQLMI 139
Cdd:PRK11873 151 ISNCVINLSPDKER---VFKEAFRVLKPGGRFAI 181
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 43-139 5.98e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 38.46  E-value: 5.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   43 KPGSLIADIGCGTG---KYLKVNSQVHTVGcdycgplVEIARN--RGCEAMVcDNLNLPFR-----------DEGFDAII 106
Cdd:pfam02353  60 KPGMTLLDIGCGWGglmRRAAERYDVNVVG-------LTLSKNqyKLARKRV-AAEGLARKvevllqdyrdfDEPFDRIV 131

                          90       100       110
                  ....*....|....*....|....*....|...
gi 153251913  107 SIGVIHHFStKQRRIRAIKEMARVLVPGGQLMI 139
Cdd:pfam02353 132 SVGMFEHVG-HENYDTFFKKLYNLLPPGGLMLL 163
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 48-150 9.30e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 36.80  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153251913   48 IADIGCGTG----KYLKVNSQVHTVGCDYCGPLVEIAR-----NR--GCEAMVCDNLNlPFRDEGFDAIISIGVIH---- 112
Cdd:pfam05175  35 VLDLGCGAGvlgaALAKESPDAELTMVDINARALESARenlaaNGleNGEVVASDVYS-GVEDGKFDLIISNPPFHagla 113

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 153251913  113 -HFSTKQrriRAIKEMARVLVPGGQLMIyVWameqkNRH 150
Cdd:pfam05175 114 tTYNVAQ---RFIADAKRHLRPGGELWI-VA-----NRF 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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