|
Name |
Accession |
Description |
Interval |
E-value |
| GCP6_N |
pfam19340 |
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal ... |
28-342 |
0e+00 |
|
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal alpha-helical region of Gamma-tubulin complex component 6 (GCP6), a protein indispensable for assembly of the gamma-tubulin complex and for microtubule nucleation. It is located at the centrioles and the pericentriolar material, being required for centriole formation and reduplication. It has been shown that the N-terminal domains define the functional identity of gamma-tubulin complex proteins. GCP6 carries a large internal insertion phosphorylated by Plk4 and contains a domain of interaction with keratins.
:
Pssm-ID: 466048 Cd Length: 315 Bit Score: 551.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 28 VNRKRAKRSLKKVAYNALFTNLFQDETQQLQPDMSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEV 107
Cdd:pfam19340 1 VSRPRFKRALKKAAYGALFEKLFQEETAKWPSELAKTPVRNKLLMLSFDLRVAGLGDEADRLEELVEKLEAGPSSPLAEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 108 GSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPG 187
Cdd:pfam19340 81 EAVLDLLVQLAGSGPPQPLSFKRDYFRREKHVLRRVPLLGYDSYDLRVLEADAWSLVCREEWLFLHYIQYTLQLMEAAPG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 188 TGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLT 267
Cdd:pfam19340 161 TGLPTLGLFSLQLEAEDRFEKETRVSLFGALVHSRTYDMDVRLDLPPVPSNADLSGLAIKVPQSLDQSEDEGFQSASNLT 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1519314140 268 PDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAP 342
Cdd:pfam19340 241 PDSQSEPSMTPDIDVWEAALTYEPSKRRCWERVGCPPGKREEPYLTEAGREAFDQLYRLREGELQVLSSPLLQLP 315
|
|
| GCP_C_terminal |
pfam04130 |
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components ... |
1513-1816 |
1.74e-65 |
|
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains.
:
Pssm-ID: 461187 Cd Length: 297 Bit Score: 224.42 E-value: 1.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1513 LEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGagqTPGELLNPLVLNSVLSKALQCSlhgdtpHASNLSLA-LKYLPEVF 1591
Cdd:pfam04130 1 LLDHLRALKRYLLLGQGDFISRLMDALFDELW---KPASSLLRHNLTGLLEEAIRSS------NAQRDLPDvLRRLDARL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1592 APNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVcfHLKRTALLSHmagSVQFRQLQLFKH 1671
Cdd:pfam04130 72 DPDSLGGWDFLTLEYKVPWPLSLVLTPEALTKYQRLFRFLLRLKRVEFVLSSL--WRRRQMSGSR---SVLWHRARLLRQ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1672 EMQHFVKVIQGYIANQILHVTWCEFRARLAT-VGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQ 1750
Cdd:pfam04130 147 EMIHFVSQLQYYVMFEVIEPSWREFEEKLQKaASDLDDLIEAHEDFLDRILKKCFLTSPQQPLLKLLEEILSLILDFAEA 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519314140 1751 LISQAWGPPGGPRGAEHPNFALMQQS-----YNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYY 1816
Cdd:pfam04130 227 LDGLYLSVSESARAEAEDELPELERErlrrlEKQFRKKVSLLLKVLRGLKSHPDESHLRQLLLRLDFNGYY 297
|
|
| GCP_N_terminal |
pfam17681 |
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components ... |
353-633 |
6.11e-36 |
|
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1.
:
Pssm-ID: 465456 Cd Length: 298 Bit Score: 139.34 E-value: 6.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 353 VKDVLNVLIGVVSATFSLCQPAQAFVVKrgVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPvldSLYSKGLVFQAF 432
Cdd:pfam17681 1 LRDLLFALQGISGSYIRFDESDSRIVDD--IRIPGILPPSLRSLLSRLLELGLLYRRLRKFVESS---SSFEYGLVLQAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 433 TSGLRRYLQ-YYRACV-------LSTPPTLSLLTIGFLFKKLGRQLRYLAELcgVGAVLPGTCGGGpraafptgvKLLSY 504
Cdd:pfam17681 76 CAALQEELTeYYRLIAqlesqllEASDSILTLLRLVVWLQPPLLLLRVLSNL--VEAVEKQNLKGG---------ALLSL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 505 LYQEALHNcSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKL--YWTHGYVLiskeVED 582
Cdd:pfam17681 145 LHEATSHG-DPFVRELLSRLLQRVSRPYLEMLERWIYEGELDDPYNEFFVEENPSVAKESLTSddLWEDKYTL----RPE 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 583 CVPVFL-KHIAHDIYVCGKTINLLKLCCPRHY--------LCWSDVPVPRISVIFSLEEL 633
Cdd:pfam17681 220 MLPSFLsPDLAEKILLTGKSLNFLRECCGDSWriedtaseLEYGDDLSESSIFSLSLEEL 279
|
|
| DUF5401 super family |
cl38662 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
630-834 |
1.69e-07 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
The actual alignment was detected with superfamily member pfam17380:
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 56.29 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERV------ARHSSVSKEEKELRMEIAKQELIA------HAREAASRVLSALSDRQMsERMA 697
Cdd:pfam17380 374 ISRMRELERLQMERQQKNERVrqeleaARKVKILEEERQRKIQQQKVEMEQiraeqeEARQREVRRLEEERAREM-ERVR 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 698 LDARKRE-QFQRLKEQ--------FVKDQERRQAARQEELDddfSYARELRDRERRLKSLEEELERK-------ARQ-AL 760
Cdd:pfam17380 453 LEEQERQqQVERLRQQeeerkrkkLELEKEKRDRKRAEEQR---RKILEKELEERKQAMIEEERKRKllekemeERQkAI 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 761 VDHYSKLSAEAARREQKAL---WRIQ---------RHRLESAR-----LRFLLEDEKHIQEM-----LKAVSEAHQPQ-- 816
Cdd:pfam17380 530 YEEERRREAEEERRKQQEMeerRRIQeqmrkateeRSRLEAMEreremMRQIVESEKARAEYeattpITTIKPIYRPRis 609
|
250 260
....*....|....*....|....*.
gi 1519314140 817 --EPPDV------LLSVHPQVTSPGP 834
Cdd:pfam17380 610 eyQPPDVeshmirFTTQSPEWATPSP 635
|
|
| DUF4573 super family |
cl25719 |
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ... |
1041-1208 |
4.71e-03 |
|
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
The actual alignment was detected with superfamily member pfam15140:
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 39.81 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1041 SEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGEN 1120
Cdd:pfam15140 18 REIEPPQPGGKDDPLGAEEKKKDLRAVTEVEPLKGVAEIEPLGPVSEIQPLRAVSERDPLGAVEEIEPPQAASEMKPLGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1121 VSDVAPTRPRWNTHGHvsnasirvgENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE 1200
Cdd:pfam15140 98 AENILPLEAAREIHPL---------EAVGKIEPLQLVETIPKENESPEIHPLEGSQEIEPLEPVQLIEPLGEVEQIQPLE 168
|
....*...
gi 1519314140 1201 SVSDMAPT 1208
Cdd:pfam15140 169 TVPKENPT 176
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GCP6_N |
pfam19340 |
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal ... |
28-342 |
0e+00 |
|
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal alpha-helical region of Gamma-tubulin complex component 6 (GCP6), a protein indispensable for assembly of the gamma-tubulin complex and for microtubule nucleation. It is located at the centrioles and the pericentriolar material, being required for centriole formation and reduplication. It has been shown that the N-terminal domains define the functional identity of gamma-tubulin complex proteins. GCP6 carries a large internal insertion phosphorylated by Plk4 and contains a domain of interaction with keratins.
Pssm-ID: 466048 Cd Length: 315 Bit Score: 551.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 28 VNRKRAKRSLKKVAYNALFTNLFQDETQQLQPDMSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEV 107
Cdd:pfam19340 1 VSRPRFKRALKKAAYGALFEKLFQEETAKWPSELAKTPVRNKLLMLSFDLRVAGLGDEADRLEELVEKLEAGPSSPLAEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 108 GSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPG 187
Cdd:pfam19340 81 EAVLDLLVQLAGSGPPQPLSFKRDYFRREKHVLRRVPLLGYDSYDLRVLEADAWSLVCREEWLFLHYIQYTLQLMEAAPG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 188 TGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLT 267
Cdd:pfam19340 161 TGLPTLGLFSLQLEAEDRFEKETRVSLFGALVHSRTYDMDVRLDLPPVPSNADLSGLAIKVPQSLDQSEDEGFQSASNLT 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1519314140 268 PDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAP 342
Cdd:pfam19340 241 PDSQSEPSMTPDIDVWEAALTYEPSKRRCWERVGCPPGKREEPYLTEAGREAFDQLYRLREGELQVLSSPLLQLP 315
|
|
| GCP_C_terminal |
pfam04130 |
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components ... |
1513-1816 |
1.74e-65 |
|
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains.
Pssm-ID: 461187 Cd Length: 297 Bit Score: 224.42 E-value: 1.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1513 LEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGagqTPGELLNPLVLNSVLSKALQCSlhgdtpHASNLSLA-LKYLPEVF 1591
Cdd:pfam04130 1 LLDHLRALKRYLLLGQGDFISRLMDALFDELW---KPASSLLRHNLTGLLEEAIRSS------NAQRDLPDvLRRLDARL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1592 APNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVcfHLKRTALLSHmagSVQFRQLQLFKH 1671
Cdd:pfam04130 72 DPDSLGGWDFLTLEYKVPWPLSLVLTPEALTKYQRLFRFLLRLKRVEFVLSSL--WRRRQMSGSR---SVLWHRARLLRQ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1672 EMQHFVKVIQGYIANQILHVTWCEFRARLAT-VGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQ 1750
Cdd:pfam04130 147 EMIHFVSQLQYYVMFEVIEPSWREFEEKLQKaASDLDDLIEAHEDFLDRILKKCFLTSPQQPLLKLLEEILSLILDFAEA 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519314140 1751 LISQAWGPPGGPRGAEHPNFALMQQS-----YNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYY 1816
Cdd:pfam04130 227 LDGLYLSVSESARAEAEDELPELERErlrrlEKQFRKKVSLLLKVLRGLKSHPDESHLRQLLLRLDFNGYY 297
|
|
| GCP_N_terminal |
pfam17681 |
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components ... |
353-633 |
6.11e-36 |
|
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1.
Pssm-ID: 465456 Cd Length: 298 Bit Score: 139.34 E-value: 6.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 353 VKDVLNVLIGVVSATFSLCQPAQAFVVKrgVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPvldSLYSKGLVFQAF 432
Cdd:pfam17681 1 LRDLLFALQGISGSYIRFDESDSRIVDD--IRIPGILPPSLRSLLSRLLELGLLYRRLRKFVESS---SSFEYGLVLQAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 433 TSGLRRYLQ-YYRACV-------LSTPPTLSLLTIGFLFKKLGRQLRYLAELcgVGAVLPGTCGGGpraafptgvKLLSY 504
Cdd:pfam17681 76 CAALQEELTeYYRLIAqlesqllEASDSILTLLRLVVWLQPPLLLLRVLSNL--VEAVEKQNLKGG---------ALLSL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 505 LYQEALHNcSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKL--YWTHGYVLiskeVED 582
Cdd:pfam17681 145 LHEATSHG-DPFVRELLSRLLQRVSRPYLEMLERWIYEGELDDPYNEFFVEENPSVAKESLTSddLWEDKYTL----RPE 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 583 CVPVFL-KHIAHDIYVCGKTINLLKLCCPRHY--------LCWSDVPVPRISVIFSLEEL 633
Cdd:pfam17681 220 MLPSFLsPDLAEKILLTGKSLNFLRECCGDSWriedtaseLEYGDDLSESSIFSLSLEEL 279
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
630-834 |
1.69e-07 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 56.29 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERV------ARHSSVSKEEKELRMEIAKQELIA------HAREAASRVLSALSDRQMsERMA 697
Cdd:pfam17380 374 ISRMRELERLQMERQQKNERVrqeleaARKVKILEEERQRKIQQQKVEMEQiraeqeEARQREVRRLEEERAREM-ERVR 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 698 LDARKRE-QFQRLKEQ--------FVKDQERRQAARQEELDddfSYARELRDRERRLKSLEEELERK-------ARQ-AL 760
Cdd:pfam17380 453 LEEQERQqQVERLRQQeeerkrkkLELEKEKRDRKRAEEQR---RKILEKELEERKQAMIEEERKRKllekemeERQkAI 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 761 VDHYSKLSAEAARREQKAL---WRIQ---------RHRLESAR-----LRFLLEDEKHIQEM-----LKAVSEAHQPQ-- 816
Cdd:pfam17380 530 YEEERRREAEEERRKQQEMeerRRIQeqmrkateeRSRLEAMEreremMRQIVESEKARAEYeattpITTIKPIYRPRis 609
|
250 260
....*....|....*....|....*.
gi 1519314140 817 --EPPDV------LLSVHPQVTSPGP 834
Cdd:pfam17380 610 eyQPPDVeshmirFTTQSPEWATPSP 635
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
631-826 |
1.13e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 50.71 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVGRMERVARhsSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLK 710
Cdd:COG1196 323 EELAELEEELEELEEELEELEE--ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 711 -----EQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRH 785
Cdd:COG1196 401 qleelEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1519314140 786 RLES------ARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVH 826
Cdd:COG1196 481 ELLEelaeaaARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVA 527
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
630-817 |
8.47e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELR--------MEIAKQELIAHAREA--ASRVLSALSDRQMSE-RMAL 698
Cdd:PTZ00121 1142 AEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKkaeaarkaEEVRKAEELRKAEDArkAEAARKAEEERKAEEaRKAE 1221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 699 DARKREQFQRLKEQFVKDQERRQA--ARQEELDDDFSYARELRDRERRLKSLEEElERKARQALVDHYSKLSAEAARREQ 776
Cdd:PTZ00121 1222 DAKKAEAVKKAEEAKKDAEEAKKAeeERNNEEIRKFEEARMAHFARRQAAIKAEE-ARKADELKKAEEKKKADEAKKAEE 1300
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1519314140 777 KalwriqrHRLESARLRflLEDEKHIQEMLKAVSEAHQPQE 817
Cdd:PTZ00121 1301 K-------KKADEAKKK--AEEAKKADEAKKKAEEAKKKAD 1332
|
|
| DUF4573 |
pfam15140 |
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ... |
1041-1208 |
4.71e-03 |
|
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 39.81 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1041 SEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGEN 1120
Cdd:pfam15140 18 REIEPPQPGGKDDPLGAEEKKKDLRAVTEVEPLKGVAEIEPLGPVSEIQPLRAVSERDPLGAVEEIEPPQAASEMKPLGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1121 VSDVAPTRPRWNTHGHvsnasirvgENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE 1200
Cdd:pfam15140 98 AENILPLEAAREIHPL---------EAVGKIEPLQLVETIPKENESPEIHPLEGSQEIEPLEPVQLIEPLGEVEQIQPLE 168
|
....*...
gi 1519314140 1201 SVSDMAPT 1208
Cdd:pfam15140 169 TVPKENPT 176
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
631-816 |
4.91e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.97 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVGRMERV-ARHSSVSKEE-------KELRMEIAKQEL-IAHAREAASRVLSALSdrQMSERMALDAR 701
Cdd:TIGR02168 253 EELEELTAELQELEEKLEELrLEVSELEEEIeelqkelYALANEISRLEQqKQILRERLANLERQLE--ELEAQLEELES 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 702 KREQFQRLKEQfVKDQERRQAARQEELDDDFS-YARELRDRERRLKSLEEELERkARQALVDHYSKLSAEAARREQKalw 780
Cdd:TIGR02168 331 KLDELAEELAE-LEEKLEELKEELESLEAELEeLEAELEELESRLEELEEQLET-LRSKVAQLELQIASLNNEIERL--- 405
|
170 180 190
....*....|....*....|....*....|....*.
gi 1519314140 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQ 816
Cdd:TIGR02168 406 EARLERLEDRRERLQQEIEELLKKLEEAELKELQAE 441
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GCP6_N |
pfam19340 |
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal ... |
28-342 |
0e+00 |
|
Gamma-tubulin complex component 6 N-terminus; This family represents the N-terminal alpha-helical region of Gamma-tubulin complex component 6 (GCP6), a protein indispensable for assembly of the gamma-tubulin complex and for microtubule nucleation. It is located at the centrioles and the pericentriolar material, being required for centriole formation and reduplication. It has been shown that the N-terminal domains define the functional identity of gamma-tubulin complex proteins. GCP6 carries a large internal insertion phosphorylated by Plk4 and contains a domain of interaction with keratins.
Pssm-ID: 466048 Cd Length: 315 Bit Score: 551.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 28 VNRKRAKRSLKKVAYNALFTNLFQDETQQLQPDMSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEV 107
Cdd:pfam19340 1 VSRPRFKRALKKAAYGALFEKLFQEETAKWPSELAKTPVRNKLLMLSFDLRVAGLGDEADRLEELVEKLEAGPSSPLAEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 108 GSVLDLLVQLAGSGPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQVMEAAPG 187
Cdd:pfam19340 81 EAVLDLLVQLAGSGPPQPLSFKRDYFRREKHVLRRVPLLGYDSYDLRVLEADAWSLVCREEWLFLHYIQYTLQLMEAAPG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 188 TGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNADLSGLAIKVPPSVDQWEDEGFQSASNLT 267
Cdd:pfam19340 161 TGLPTLGLFSLQLEAEDRFEKETRVSLFGALVHSRTYDMDVRLDLPPVPSNADLSGLAIKVPQSLDQSEDEGFQSASNLT 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1519314140 268 PDSQSEPSVTPDVDLWEAALTYEASKRRCWERVGCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAP 342
Cdd:pfam19340 241 PDSQSEPSMTPDIDVWEAALTYEPSKRRCWERVGCPPGKREEPYLTEAGREAFDQLYRLREGELQVLSSPLLQLP 315
|
|
| GCP_C_terminal |
pfam04130 |
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components ... |
1513-1816 |
1.74e-65 |
|
Gamma tubulin complex component C-terminal; This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Structure-based sequence analysis revealed the existence of an exposed surface area conserved in all human GCPs and in GCP4 orthologs. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains.
Pssm-ID: 461187 Cd Length: 297 Bit Score: 224.42 E-value: 1.74e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1513 LEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGagqTPGELLNPLVLNSVLSKALQCSlhgdtpHASNLSLA-LKYLPEVF 1591
Cdd:pfam04130 1 LLDHLRALKRYLLLGQGDFISRLMDALFDELW---KPASSLLRHNLTGLLEEAIRSS------NAQRDLPDvLRRLDARL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1592 APNAPDVLSCLELRYKVDWPLNIVITEGCVSKYSGVFSFLLQLKLMMWALKDVcfHLKRTALLSHmagSVQFRQLQLFKH 1671
Cdd:pfam04130 72 DPDSLGGWDFLTLEYKVPWPLSLVLTPEALTKYQRLFRFLLRLKRVEFVLSSL--WRRRQMSGSR---SVLWHRARLLRQ 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1672 EMQHFVKVIQGYIANQILHVTWCEFRARLAT-VGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSIFSLVLKFRSQ 1750
Cdd:pfam04130 147 EMIHFVSQLQYYVMFEVIEPSWREFEEKLQKaASDLDDLIEAHEDFLDRILKKCFLTSPQQPLLKLLEEILSLILDFAEA 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1519314140 1751 LISQAWGPPGGPRGAEHPNFALMQQS-----YNTFKYYSHFLFKVVTKLVNRGYQPHLEDFLLRINFNNYY 1816
Cdd:pfam04130 227 LDGLYLSVSESARAEAEDELPELERErlrrlEKQFRKKVSLLLKVLRGLKSHPDESHLRQLLLRLDFNGYY 297
|
|
| GCP_N_terminal |
pfam17681 |
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components ... |
353-633 |
6.11e-36 |
|
Gamma tubulin complex component N-terminal; This is the N-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing center in yeast. Furthermore, family members such as human GCP4 (Gamma-tubulin complex component 4) have been structurally elucidated. Functional studies have shown that the N-terminal domain defines the functional identity of GCPs, suggesting that all GCPs are incorporated into the helix of gamma-tubulin small complexes (gTURCs) via lateral interactions between their N-terminal domains. Thereby, they define the direct neighbors and position the GCPs within the helical wall of gTuRC. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains. In addition to the conserved sequences, the N-terminal domains carry specific insertions of various sizes depending on the GCP, i.e. internal insertions or N-terminal extensions. These insertions may equally contribute to the function of individual GCPs as they have been implied in specific interactions with regulatory or structural proteins. For instance, GCP6 carries a large internal insertion phosphorylated by Plk4 and containing a domain of interaction with keratins, whereas the N-terminal extension of GCP3 interacts with the recruitment protein MOZART1.
Pssm-ID: 465456 Cd Length: 298 Bit Score: 139.34 E-value: 6.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 353 VKDVLNVLIGVVSATFSLCQPAQAFVVKrgVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPvldSLYSKGLVFQAF 432
Cdd:pfam17681 1 LRDLLFALQGISGSYIRFDESDSRIVDD--IRIPGILPPSLRSLLSRLLELGLLYRRLRKFVESS---SSFEYGLVLQAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 433 TSGLRRYLQ-YYRACV-------LSTPPTLSLLTIGFLFKKLGRQLRYLAELcgVGAVLPGTCGGGpraafptgvKLLSY 504
Cdd:pfam17681 76 CAALQEELTeYYRLIAqlesqllEASDSILTLLRLVVWLQPPLLLLRVLSNL--VEAVEKQNLKGG---------ALLSL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 505 LYQEALHNcSNEHYPVLLSLLKTSCEPYTRFIHDWVYSGVFRDAYGEFMIQVNHEYLSFRDKL--YWTHGYVLiskeVED 582
Cdd:pfam17681 145 LHEATSHG-DPFVRELLSRLLQRVSRPYLEMLERWIYEGELDDPYNEFFVEENPSVAKESLTSddLWEDKYTL----RPE 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 583 CVPVFL-KHIAHDIYVCGKTINLLKLCCPRHY--------LCWSDVPVPRISVIFSLEEL 633
Cdd:pfam17681 220 MLPSFLsPDLAEKILLTGKSLNFLRECCGDSWriedtaseLEYGDDLSESSIFSLSLEEL 279
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
630-834 |
1.69e-07 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 56.29 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERV------ARHSSVSKEEKELRMEIAKQELIA------HAREAASRVLSALSDRQMsERMA 697
Cdd:pfam17380 374 ISRMRELERLQMERQQKNERVrqeleaARKVKILEEERQRKIQQQKVEMEQiraeqeEARQREVRRLEEERAREM-ERVR 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 698 LDARKRE-QFQRLKEQ--------FVKDQERRQAARQEELDddfSYARELRDRERRLKSLEEELERK-------ARQ-AL 760
Cdd:pfam17380 453 LEEQERQqQVERLRQQeeerkrkkLELEKEKRDRKRAEEQR---RKILEKELEERKQAMIEEERKRKllekemeERQkAI 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 761 VDHYSKLSAEAARREQKAL---WRIQ---------RHRLESAR-----LRFLLEDEKHIQEM-----LKAVSEAHQPQ-- 816
Cdd:pfam17380 530 YEEERRREAEEERRKQQEMeerRRIQeqmrkateeRSRLEAMEreremMRQIVESEKARAEYeattpITTIKPIYRPRis 609
|
250 260
....*....|....*....|....*.
gi 1519314140 817 --EPPDV------LLSVHPQVTSPGP 834
Cdd:pfam17380 610 eyQPPDVeshmirFTTQSPEWATPSP 635
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
631-808 |
2.53e-07 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 54.92 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKdcavyvgRMERVARHssvsKEEKELRMEIAKQELIAHAREAASRVLSAlsdrQMSERMALDARKREQFQRLK 710
Cdd:pfam13868 36 AEEKEEER-------RLDEMMEE----ERERALEEEEEKEEERKEERKRYRQELEE----QIEEREQKRQEEYEEKLQER 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 711 EQFVKDQER----------RQAARQEELDDDFSYARELRDRErrlKSLEEELERKARQALVDHYSKLSAEAARREQKALW 780
Cdd:pfam13868 101 EQMDEIVERiqeedqaeaeEKLEKQRQLREEIDEFNEEQAEW---KELEKEEEREEDERILEYLKEKAEREEEREAEREE 177
|
170 180 190
....*....|....*....|....*....|.
gi 1519314140 781 RIQRHRLESARLRFLLE---DEKHIQEMLKA 808
Cdd:pfam13868 178 IEEEKEREIARLRAQQEkaqDEKAERDELRA 208
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
631-809 |
4.57e-07 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 54.15 E-value: 4.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVG-RMERVARhssvsKEEKELRMEIAKQELIAHAREAASRVL-------SALSDRQMSER------- 695
Cdd:pfam13868 148 EEEREEDERILEYLKeKAEREEE-----REAEREEIEEEKEREIARLRAQQEKAQdekaerdELRAKLYQEEQerkerqk 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 696 -MALDARKREQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARR 774
Cdd:pfam13868 223 eREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRRMKRLEHRRELEKQIEER 302
|
170 180 190
....*....|....*....|....*....|....*
gi 1519314140 775 EQKALWRIQRHRLESARLRfllEDEKHIQEMLKAV 809
Cdd:pfam13868 303 EEQRAAEREEELEEGERLR---EEEAERRERIEEE 334
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
635-817 |
1.07e-06 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 53.59 E-value: 1.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 635 EIEKDCAVYVGR----MERVARHSSVSKEEKELRMEIAKQELIAHAREAasrvLSALSDRQMsERMALDARKREQFQRLK 710
Cdd:pfam17380 328 EMDRQAAIYAEQermaMERERELERIRQEERKRELERIRQEEIAMEISR----MRELERLQM-ERQQKNERVRQELEAAR 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 711 EQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERK---------ARQALVDHY---------SKLSAEAA 772
Cdd:pfam17380 403 KVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREmervrleeqERQQQVERLrqqeeerkrKKLELEKE 482
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1519314140 773 RREQKALWRIQRHRLE---SARLRFLLED-------EKHIQEMLKAVSEAHQPQE 817
Cdd:pfam17380 483 KRDRKRAEEQRRKILEkelEERKQAMIEEerkrkllEKEMEERQKAIYEEERRRE 537
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
631-826 |
1.13e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 50.71 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVGRMERVARhsSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLK 710
Cdd:COG1196 323 EELAELEEELEELEEELEELEE--ELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAA 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 711 -----EQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALWRIQRH 785
Cdd:COG1196 401 qleelEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA 480
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1519314140 786 RLES------ARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVH 826
Cdd:COG1196 481 ELLEelaeaaARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVA 527
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
630-817 |
8.33e-05 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 47.45 E-value: 8.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMER----VARHSSVSKEEKELRmeiAKQELIAHAREAASRVLSALSDRQmsERMALDARKR-- 703
Cdd:COG4717 70 LKELKELEEELKEAEEKEEEyaelQEELEELEEELEELE---AELEELREELEKLEKLLQLLPLYQ--ELEALEAELAel 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 704 -EQFQRLKEQF--VKDQERRQAARQEELDDdfsyarelrdrerrlksLEEELERKARQALVDHYSKLSaEAARREQKALW 780
Cdd:COG4717 145 pERLEELEERLeeLRELEEELEELEAELAE-----------------LQEELEELLEQLSLATEEELQ-DLAEELEELQQ 206
|
170 180 190
....*....|....*....|....*....|....*..
gi 1519314140 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQE 817
Cdd:COG4717 207 RLAELEEELEEAQEELEELEEELEQLENELEAAALEE 243
|
|
| CCDC34 |
pfam13904 |
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ... |
700-808 |
1.06e-04 |
|
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.
Pssm-ID: 464032 [Multi-domain] Cd Length: 221 Bit Score: 45.47 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 700 ARKREQFQ--RLKEQFVKDQERRQAARQEELDDdfsyarelrdrerrlKSLEEELERKARQALVDHYSKLSAEAARREQK 777
Cdd:pfam13904 62 AAKQRQRQkeLQAQKEEREKEEQEAELRKRLAK---------------EKYQEWLQRKARQQTKKREESHKQKAAESASK 126
|
90 100 110
....*....|....*....|....*....|.
gi 1519314140 778 ALWRIQRHRLESARLRFLLEDEKHIQEMLKA 808
Cdd:pfam13904 127 SLAKPERKVSQEEAKEVLQEWERKKLEQQQR 157
|
|
| DUF4200 |
pfam13863 |
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil ... |
690-828 |
5.78e-04 |
|
Domain of unknown function (DUF4200); This family is found in eukaryotes. It is a coiled-coil domain of unknwon function.
Pssm-ID: 464003 [Multi-domain] Cd Length: 119 Bit Score: 41.40 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 690 RQMSE-RMALDArKREQFQRLKEQFvKDQERRQAARQEELDDDFsyarelrdrERRLKSLeEELERKARQALvdhySKLS 768
Cdd:pfam13863 6 REMFLvQLALDA-KREEIERLEELL-KQREEELEKKEQELKEDL---------IKFDKFL-KENDAKRRRAL----KKAE 69
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 769 AEAARREQKALwRIQRHRLESARLRflledeKHIQEMLKAVSEaHQPQEppDVLLSVHPQ 828
Cdd:pfam13863 70 EETKLKKEKEK-EIKKLTAQIEELK------SEISKLEEKLEE-YKPYE--DFLEKVVPK 119
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
631-812 |
7.52e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 44.54 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAvyvgrmERVARHSSVSKEEKELRMEIAK-----QELIAHAREAASRVLSALSDRQMSERMALDARKR-- 703
Cdd:COG1196 246 AELEELEAELE------ELEAELAELEAELEELRLELEElelelEEAQAEEYELLAELARLEQDIARLEERRRELEERle 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 704 ---EQFQRLKEQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEElERKARQALVDHYSKLSAEAARREQKALW 780
Cdd:COG1196 320 eleEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEA-EAELAEAEEELEELAEELLEALRAAAEL 398
|
170 180 190
....*....|....*....|....*....|..
gi 1519314140 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEA 812
Cdd:COG1196 399 AAQLEELEEAEEALLERLERLEEELEELEEAL 430
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
631-812 |
7.98e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 44.54 E-value: 7.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEkdcavyvgRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDAR---KREQFQ 707
Cdd:COG1196 220 EELKELE--------AELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEleeAQAEEY 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 708 RLK---EQFVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKAlwriQR 784
Cdd:COG1196 292 ELLaelARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEE----AL 367
|
170 180
....*....|....*....|....*...
gi 1519314140 785 HRLESARLRFLLEDEKHIQEMLKAVSEA 812
Cdd:COG1196 368 LEAEAELAEAEEELEELAEELLEALRAA 395
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
630-814 |
8.40e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 44.54 E-value: 8.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERVarhssvskEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSErmALDARKREQFQRL 709
Cdd:COG1196 294 LAELARLEQDIARLEERRREL--------EERLEELEEELAELEEELEELEEELEELEEELEEAE--EELEEAEAELAEA 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 710 KEQfVKDQERRQAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVD---HYSKLSAEAARREQKALWRIQRHR 786
Cdd:COG1196 364 EEA-LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERlerLEEELEELEEALAELEEEEEEEEE 442
|
170 180
....*....|....*....|....*...
gi 1519314140 787 LESARLRFLLEDEKHIQEMLKAVSEAHQ 814
Cdd:COG1196 443 ALEEAAEEEAELEEEEEALLELLAELLE 470
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
648-803 |
8.42e-04 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 43.87 E-value: 8.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 648 ERVARHSSVSKEEKELRMEIAKQELIAHA--REAASRVLSALSDRQMSERMALDARKREQFQRLKE-----QFVKDQERR 720
Cdd:pfam15558 66 EKEQRKARLGREERRRADRREKQVIEKESrwREQAEDQENQRQEKLERARQEAEQRKQCQEQRLKEkeeelQALREQNSL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 721 QAARQEELdddfsyA-------RELRDRERRLKSLEEELERKARQALVDHYSKlSAEAARR---EQKALWRIQRH-RLES 789
Cdd:pfam15558 146 QLQERLEE------AchkrqlkEREEQKKVQENNLSELLNHQARKVLVDCQAK-AEELLRRlslEQSLQRSQENYeQLVE 218
|
170
....*....|....*...
gi 1519314140 790 ARLRFL----LEDEKHIQ 803
Cdd:pfam15558 219 ERHRELrekaQKEEEQFQ 236
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
630-817 |
8.47e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 44.36 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 630 LEELKEIEKDCAVYVGRMERVARHSSVSKEEKELR--------MEIAKQELIAHAREA--ASRVLSALSDRQMSE-RMAL 698
Cdd:PTZ00121 1142 AEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKkaeaarkaEEVRKAEELRKAEDArkAEAARKAEEERKAEEaRKAE 1221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 699 DARKREQFQRLKEQFVKDQERRQA--ARQEELDDDFSYARELRDRERRLKSLEEElERKARQALVDHYSKLSAEAARREQ 776
Cdd:PTZ00121 1222 DAKKAEAVKKAEEAKKDAEEAKKAeeERNNEEIRKFEEARMAHFARRQAAIKAEE-ARKADELKKAEEKKKADEAKKAEE 1300
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1519314140 777 KalwriqrHRLESARLRflLEDEKHIQEMLKAVSEAHQPQE 817
Cdd:PTZ00121 1301 K-------KKADEAKKK--AEEAKKADEAKKKAEEAKKKAD 1332
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
631-811 |
1.22e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 43.98 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVGRMERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLK 710
Cdd:PTZ00121 1555 EELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKK 1634
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 711 EQFVKDQERRQAARQEELDDDfsyARELRDRERRLKSLEEELERKARQAlvdhysKLSAEAARREQKALWRIQRHRLESA 790
Cdd:PTZ00121 1635 VEQLKKKEAEEKKKAEELKKA---EEENKIKAAEEAKKAEEDKKKAEEA------KKAEEDEKKAAEALKKEAEEAKKAE 1705
|
170 180
....*....|....*....|.
gi 1519314140 791 RLRFLLEDEKHIQEMLKAVSE 811
Cdd:PTZ00121 1706 ELKKKEAEEKKKAEELKKAEE 1726
|
|
| PRK12704 |
PRK12704 |
phosphodiesterase; Provisional |
659-775 |
1.59e-03 |
|
phosphodiesterase; Provisional
Pssm-ID: 237177 [Multi-domain] Cd Length: 520 Bit Score: 43.23 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 659 EEKELRMEIAKQELIAHAREAASRVLSALsDRQMSERmaldarkREQFQRL------KEQFVKDQERRQAARQEELDDDF 732
Cdd:PRK12704 45 EEAKKEAEAIKKEALLEAKEEIHKLRNEF-EKELRER-------RNELQKLekrllqKEENLDRKLELLEKREEELEKKE 116
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1519314140 733 SYARELRDRERRLKSLEEELERKARQALvDHYSKLSAEAARRE 775
Cdd:PRK12704 117 KELEQKQQELEKKEEELEELIEEQLQEL-ERISGLTAEEAKEI 158
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
648-760 |
2.54e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 42.62 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 648 ERVARHSSVSKEEKELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERRQAARQEE 727
Cdd:COG1196 665 GSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE 744
|
90 100 110
....*....|....*....|....*....|....*
gi 1519314140 728 LDDDFSYARELRDRERRLKSLEEELER--KARQAL 760
Cdd:COG1196 745 EELLEEEALEELPEPPDLEELERELERleREIEAL 779
|
|
| DUF4573 |
pfam15140 |
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins ... |
1041-1208 |
4.71e-03 |
|
Domain of unknown function (DUF4573); This family of proteins is found in eukaryotes. Proteins in this family are typically approximately 360 amino acids in length.
Pssm-ID: 434493 [Multi-domain] Cd Length: 176 Bit Score: 39.81 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1041 SEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTHGHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGEN 1120
Cdd:pfam15140 18 REIEPPQPGGKDDPLGAEEKKKDLRAVTEVEPLKGVAEIEPLGPVSEIQPLRAVSERDPLGAVEEIEPPQAASEMKPLGT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 1121 VSDVAPTRPRWNTHGHvsnasirvgENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE 1200
Cdd:pfam15140 98 AENILPLEAAREIHPL---------EAVGKIEPLQLVETIPKENESPEIHPLEGSQEIEPLEPVQLIEPLGEVEQIQPLE 168
|
....*...
gi 1519314140 1201 SVSDMAPT 1208
Cdd:pfam15140 169 TVPKENPT 176
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
631-816 |
4.91e-03 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 41.97 E-value: 4.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVYVGRMERV-ARHSSVSKEE-------KELRMEIAKQEL-IAHAREAASRVLSALSdrQMSERMALDAR 701
Cdd:TIGR02168 253 EELEELTAELQELEEKLEELrLEVSELEEEIeelqkelYALANEISRLEQqKQILRERLANLERQLE--ELEAQLEELES 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 702 KREQFQRLKEQfVKDQERRQAARQEELDDDFS-YARELRDRERRLKSLEEELERkARQALVDHYSKLSAEAARREQKalw 780
Cdd:TIGR02168 331 KLDELAEELAE-LEEKLEELKEELESLEAELEeLEAELEELESRLEELEEQLET-LRSKVAQLELQIASLNNEIERL--- 405
|
170 180 190
....*....|....*....|....*....|....*.
gi 1519314140 781 RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQ 816
Cdd:TIGR02168 406 EARLERLEDRRERLQQEIEELLKKLEEAELKELQAE 441
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
646-817 |
5.25e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.05 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 646 RMERVARHSSVSKEEKELRMeiAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKE-----QFVKDQERR 720
Cdd:PTZ00121 1225 KAEAVKKAEEAKKDAEEAKK--AEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEkkkadEAKKAEEKK 1302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 721 QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQA-LVDHYSKLSAEAARREQKAlwriQRHRLESARLRfLLEDE 799
Cdd:PTZ00121 1303 KADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAkKAAEAAKAEAEAAADEAEA----AEEKAEAAEKK-KEEAK 1377
|
170
....*....|....*...
gi 1519314140 800 KHIQEMLKAVSEAHQPQE 817
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADE 1395
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
657-817 |
5.46e-03 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 41.18 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 657 SKEEKELRMEIAKQELiAHAREAASRVLSAlSDRQMSERmaldARKRE-QFQRLKEQfvkdQERRQAARQEELdddfsya 735
Cdd:pfam15558 191 AKAEELLRRLSLEQSL-QRSQENYEQLVEE-RHRELREK----AQKEEeQFQRAKWR----AEEKEEERQEHK------- 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 736 relrdrerrlKSLEEELERKARQALvDHYSKLSAEAARreqkalwRIQRHRLESARLRFLL------EDEKHIQEMLKAV 809
Cdd:pfam15558 254 ----------EALAELADRKIQQAR-QVAHKTVQDKAQ-------RARELNLEREKNHHILklkvekEEKCHREGIKEAI 315
|
....*...
gi 1519314140 810 SEAHQPQE 817
Cdd:pfam15558 316 KKKEQRSE 323
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
631-817 |
7.11e-03 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 41.21 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 631 EELKEIEKDCAVY----------VGRMERVARHSSVSKEEKELRM---EIAKQELIAHAREAAsrvlsaLSDRQMSERMA 697
Cdd:TIGR02169 758 SELKELEARIEELeedlhkleeaLNDLEARLSHSRIPEIQAELSKleeEVSRIEARLREIEQK------LNRLTLEKEYL 831
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314140 698 LDARKREQFQRLkeqfvkDQERRQAARQEELDDDfsyarelrdrERRLKSLEEELERKARQA--LVDHYSKLSAEaaRRE 775
Cdd:TIGR02169 832 EKEIQELQEQRI------DLKEQIKSIEKEIENL----------NGKKEELEEELEELEAALrdLESRLGDLKKE--RDE 893
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1519314140 776 QKALWRIQRHRLESARLRflLEDEKHIQEMLKAVSEAHQPQE 817
Cdd:TIGR02169 894 LEAQLRELERKIEELEAQ--IEKKRKRLSELKAKLEALEEEL 933
|
|
| |
