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Conserved domains on  [gi|2065532653|ref|NP_065105|]
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solute carrier family 22 member 17 isoform a [Homo sapiens]

Protein Classification

solute carrier family 22 member 17( domain architecture ID 13024576)

solute carrier family 22 member 17 (SLC22A17) is cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
174-605 0e+00

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 174 APPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCG 253
Cdd:cd17445     1 TQTGVRHCDAGWNYTGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 254 VGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITA 333
Cdd:cd17445    81 VLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 334 PCILFLFYGWPGLflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssfsfasllnyr 413
Cdd:cd17445   161 PLSLFLCYGCPGV------------------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 414 niwKNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASL 491
Cdd:cd17445   174 ---KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 492 VLLGLWDCehpifptvwaqqgnpnrdLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLS 571
Cdd:cd17445   251 ILLGLMDY------------------LNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLS 312
                         410       420       430
                  ....*....|....*....|....*....|....
gi 2065532653 572 GPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17445   313 SPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
 
Name Accession Description Interval E-value
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
174-605 0e+00

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 174 APPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCG 253
Cdd:cd17445     1 TQTGVRHCDAGWNYTGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 254 VGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITA 333
Cdd:cd17445    81 VLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 334 PCILFLFYGWPGLflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssfsfasllnyr 413
Cdd:cd17445   161 PLSLFLCYGCPGV------------------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 414 niwKNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASL 491
Cdd:cd17445   174 ---KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 492 VLLGLWDCehpifptvwaqqgnpnrdLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLS 571
Cdd:cd17445   251 ILLGLMDY------------------LNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLS 312
                         410       420       430
                  ....*....|....*....|....*....|....
gi 2065532653 572 GPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17445   313 SPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
181-614 1.03e-45

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 169.81  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNGLPVLTTNAIgQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 260
Cdd:TIGR00898 100 CLDGWEYSYDTFSSTIVT-EWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLF 340
Cdd:TIGR00898 179 NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFL 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 341 YGWpgLFLESARWLIVKRQIEEAQSVLRILAERNRPHgQMLGEEAQEALQDLENTCPLPatssfSFASLLNYRNIWKNLL 420
Cdd:TIGR00898 259 LSW--FVPESPRWLISQGRIEEALKILQRIAKINGKK-LPAEVLSLSLEKDLSSSKKQY-----SFLDLFRTPNLRKTTL 330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 421 ILgftNFIAHAIRHCYQ--PVGGGGSPSDFYLcSLLASGTAALACVFLG-VTVDRFGRRGILLLSMTLTGIASLVLLGLw 497
Cdd:TIGR00898 331 CL---MMLWFTTAFSYYglVLDLGNLGGNIYL-DLFISGLVELPAKLITlLLIDRLGRRYTMAASLLLAGVALLLLLFV- 405
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 498 dcehPIFPTVWaqqgnpnrdlneaaITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRL 577
Cdd:TIGR00898 406 ----PVDLYFL--------------RTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY 467
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2065532653 578 HMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPE 614
Cdd:TIGR00898 468 LGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_1 pfam07690
Major Facilitator Superfamily;
217-573 3.95e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.75  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LR---VALAGELVGVGGHFLFLGLALVSKDWRFLqrmITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAER 373
Cdd:pfam07690 120 GRalgLVSAGFGLGAALGPLLGGLLASLFGWRAA---FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 NRPHGQMLGeeaqealqdlentcplpATSSFSFASLLNYRNIWKNLLILGFtnfiahairhcyqpvggGGSPSDFYLCSL 453
Cdd:pfam07690 197 LLRDPVLWL-----------------LLALLLFGFAFFGLLTYLPLYQEVL-----------------GLSALLAGLLLG 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 454 LASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdceHPIFPTVWaqqgnpnrdlneaAITTFSVLGLFS 533
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL----SLTLSSLW-------------LLLALLLLGFGF 305
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2065532653 534 SqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP 573
Cdd:pfam07690 306 G-LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
217-569 4.26e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.00  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:COG2814    53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRVALAGELVGVGGHFL--FLGLALVSK-DWRflqrmitapcILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRilaer 373
Cdd:COG2814   133 GRALGLLGAGLGLGPALgpLLGGLLADLfGWR----------WVFLVNAVLALLALLLLLRLLPESRPAARARLR----- 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 nrphgqmlgeeaqealqdlentcplpatssFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGG---GGSPSDFYL 450
Cdd:COG2814   198 ------------------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQevlGLSASAAGL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 451 CSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLlglwdcehPIFPTVWaqqgnpnrdlneaAITTFSVLG 530
Cdd:COG2814   248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL--------ALAGSLW-------------LLLLALFLL 306
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2065532653 531 LFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGG 569
Cdd:COG2814   307 GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
xylE PRK10077
D-xylose transporter XylE; Provisional
319-563 4.39e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 49.69  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 319 LVSKDWR--FLQRMITAPCILFLFYGWPglflESARWLIVKRQIEEAQSVLRILaernrphgqMLGEEAQEALQDLENTC 396
Cdd:PRK10077  188 LNTDGWRymFASEAIPALLFLMLLYFVP----ETPRYLMSRGKQEQAEGILRKI---------MGNTLATQALQEIKHSL 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 397 PLPATSS---FSFASLLnyrnIWKNLLILGFTNFIAHAIRHCYQP--VGGGGSPSDFYLCSLLASGTAALACVFLGV-TV 470
Cdd:PRK10077  255 DHGRKTGgklLMFGVGV----IVIGVMLSVFQQFVGINVVLYYAPeiFKTLGASTDIALLQTIIVGVINLTFTVLAImTV 330
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 471 DRFGRRGILLlsmtltgIASLVLlglwdcehpifptvwaqqgnpnrdlneaAITTFSVLGLFSSQAAAILSTL------- 543
Cdd:PRK10077  331 DKFGRKPLQI-------IGALGM----------------------------AIGMFSLGTAFYTQAPGIVALLsmlfyva 375
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2065532653 544 ------------LAAEVIPTTVRGRGLGLIMA 563
Cdd:PRK10077  376 afamswgpvcwvLLSEIFPNAIRGKALAIAVA 407
 
Name Accession Description Interval E-value
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
174-605 0e+00

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 525.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 174 APPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCG 253
Cdd:cd17445     1 TQTGVRHCDAGWNYTGLPGLTNNIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 254 VGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITA 333
Cdd:cd17445    81 VLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 334 PCILFLFYGWPGLflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssfsfasllnyr 413
Cdd:cd17445   161 PLSLFLCYGCPGV------------------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 414 niwKNLLILGFTNFIAHAIRHCYQPVGGG--GSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASL 491
Cdd:cd17445   174 ---KNLLILGFTTFIAHAISHCYQSFSDDvrGTPSTFYLSYLLSTGTAGLACLFLCATVDRFGRRGILLLAMTLTGIASL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 492 VLLGLWDCehpifptvwaqqgnpnrdLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLS 571
Cdd:cd17445   251 ILLGLMDY------------------LNDAAIKTFSILGLFSSQAAASLSILFAAEVIPTVIRGSGLGLIMALGSLGGLS 312
                         410       420       430
                  ....*....|....*....|....*....|....
gi 2065532653 572 GPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17445   313 SPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
185-605 1.09e-172

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 495.50  E-value: 1.09e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 185 WDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTG 264
Cdd:cd17373     1 WDYGIRAGLVQNAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 265 VMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWP 344
Cdd:cd17373    81 FSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 345 GLflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssfsfasllnyrniwKNLLILGF 424
Cdd:cd17373   161 FP----------------------------------------------------------------------KNILILGF 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 425 TNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIF 504
Cdd:cd17373   171 NSLTGYGIRHCFARSMMGHEPENFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGLASLLLLGLLNLIGKYS 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 505 PTVWAQqgnPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAF 584
Cdd:cd17373   251 QHPDSG---MSDSVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYF 327
                         410       420
                  ....*....|....*....|.
gi 2065532653 585 LQHVVLAACALLCILSIMLLP 605
Cdd:cd17373   328 LQHVVFACCALLCILCILLLP 348
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
180-605 2.87e-74

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 241.99  E-value: 2.87e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 180 HCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAA 259
Cdd:cd17443     7 LCTGGWPFSAAAGLGSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 260 GSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFL 339
Cdd:cd17443    87 ASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLLL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 340 FYgwpglflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssFSFASllnyrniwKNL 419
Cdd:cd17443   167 LY--------------------------------------------------------------WCFPS--------RNG 176
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 420 LILGFTNFIAHAIRHCYQPVGGGGSPSdFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdc 499
Cdd:cd17443   177 LILGFTAFIGGGIRYCFARNLAPFVPT-FYLPYFLQAGLEALACIFLCLTVDRCGRRGVLLLGTIVTGLSSLLLLAL--- 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 500 ehpifptvwaqqgnpNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHM 579
Cdd:cd17443   253 ---------------TQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQN 317
                         410       420
                  ....*....|....*....|....*.
gi 2065532653 580 GHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17443   318 KQGYFLHHVVFASFAVLSVLCILLLP 343
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
185-605 4.01e-74

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 241.33  E-value: 4.01e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 185 WDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTG 264
Cdd:cd17317     1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 265 VMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWp 344
Cdd:cd17317    81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLW- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 345 glflesarwlivkrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcPLPatssfsfasllnyrniwKNLLILGF 424
Cdd:cd17317   160 ----------------------------------------------------WLP-----------------RRTIIVGL 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 425 TNFIAHAIRHCYQPVGGGGSPsDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPif 504
Cdd:cd17317   171 IWFVTSLVYYGLSLNSSNLGG-NLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENT-- 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 505 ptvwaqqgnpnrdlneaAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAF 584
Cdd:cd17317   248 -----------------LALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPL 310
                         410       420
                  ....*....|....*....|.
gi 2065532653 585 LQHVVLAACALLCILSIMLLP 605
Cdd:cd17317   311 LPLIIFGVLALLGGLLTLLLP 331
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
175-605 1.57e-54

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 190.45  E-value: 1.57e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 175 PPDFNHCL-KDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCG 253
Cdd:cd17444     1 TENASSCQcTERDYRIRAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 254 VGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITA 333
Cdd:cd17444    81 LTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIIC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 334 PCILFLFYgwpglflesarWLIVKrqieeaqsvlrilaernrphgqmlgeeaqealqdlentcplpatssfsfasllnyr 413
Cdd:cd17444   161 PFLLMLSY-----------WCIFP-------------------------------------------------------- 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 414 niwKNLLILGFTNFIAHAIRHCY-----QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGI 488
Cdd:cd17444   174 ---KNIVVLCVNSLTGYGIHHCFaksmmDHEMKGSFLHNFYAEYYTMAVIALASCLAMCPVVGFLGRRGGLLLFMILTAL 250
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 489 ASLVLLGLWDCehpIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALG 568
Cdd:cd17444   251 ASLLQLGLLNL---IGKYSQHPDSGMSDEVKDKFSVTFSIVGMFSSHAVGSLSVFFCAEITPTVIRGGGLGLVLASAGFG 327
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2065532653 569 GLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17444   328 MLTAPIMELHNQKGYFLHHIIFACCTLICIICILLLP 364
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
181-614 1.03e-45

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 169.81  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNGLPVLTTNAIgQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 260
Cdd:TIGR00898 100 CLDGWEYSYDTFSSTIVT-EWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP 178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLF 340
Cdd:TIGR00898 179 NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFL 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 341 YGWpgLFLESARWLIVKRQIEEAQSVLRILAERNRPHgQMLGEEAQEALQDLENTCPLPatssfSFASLLNYRNIWKNLL 420
Cdd:TIGR00898 259 LSW--FVPESPRWLISQGRIEEALKILQRIAKINGKK-LPAEVLSLSLEKDLSSSKKQY-----SFLDLFRTPNLRKTTL 330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 421 ILgftNFIAHAIRHCYQ--PVGGGGSPSDFYLcSLLASGTAALACVFLG-VTVDRFGRRGILLLSMTLTGIASLVLLGLw 497
Cdd:TIGR00898 331 CL---MMLWFTTAFSYYglVLDLGNLGGNIYL-DLFISGLVELPAKLITlLLIDRLGRRYTMAASLLLAGVALLLLLFV- 405
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 498 dcehPIFPTVWaqqgnpnrdlneaaITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRL 577
Cdd:TIGR00898 406 ----PVDLYFL--------------RTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY 467
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 2065532653 578 HMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPE 614
Cdd:TIGR00898 468 LGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPE 504
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
176-605 4.51e-27

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 112.77  E-value: 4.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 176 PDFNHCLKDWDYNGlPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVG 255
Cdd:cd17374     3 ADTEPCVDGWVYDR-SKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 256 GAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRlrvALAGELVGVG---GHFLFLGLALVSKDWRFLQRMIT 332
Cdd:cd17374    82 AAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHR---ALAITLTSCFfsiGQMLLAGLAYAIRDWRLLQLVVS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 333 APCILFLFYGWpglflesarWLiVKRqieeaqsvlrilaernrphgqmlgeeaqealqdlenTCPLpatSSFSFASLLNY 412
Cdd:cd17374   159 VPFFLFFLYSW---------WL-PKR------------------------------------TLIL---SFVWFANSFSY 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 413 RNIWKNLLILGftnfiahairhcyqpvggggspSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLV 492
Cdd:cd17374   190 YGLSLDLQHLG----------------------LNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 493 LLGLwDCEHPIFPTVWAqqgnpnrdlneaaittfsVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSG 572
Cdd:cd17374   248 NIFV-PQEMQTLRTVLA------------------VLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILA 308
                         410       420       430
                  ....*....|....*....|....*....|...
gi 2065532653 573 PAQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17374   309 PLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
181-343 5.15e-19

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 88.95  E-value: 5.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNGLpvlTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 260
Cdd:cd17379     8 CQDGWVYNTP---RSSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLF 340
Cdd:cd17379    85 NYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLL 164

                  ...
gi 2065532653 341 YGW 343
Cdd:cd17379   165 YYW 167
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
181-605 4.57e-17

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 82.86  E-value: 4.57e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNGLPVLTTNAIgQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTlgLVGPCGVGGAAAG 260
Cdd:cd17447     8 CQNGWVYDHSTFSSTIAT-EWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVA--YVLSLVFGLASAF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVM--ALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILF 338
Cdd:cd17447    85 SVSYVMfaITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 339 LFYGWpglflesarWLivkrqieeaqsvlrilaernrPHGQMLgeeaqealqdlentcplpaTSSFSFASLLNYRNIWKN 418
Cdd:cd17447   165 IITWW---------WV---------------------PKISLC-------------------TGIVWFGVAFTYYGISFN 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 419 LLILG----FTNFIAHAIRhcyqpvggggSPSDFylcsllasgtaalaCVFlgVTVDRFGRRGILLLSMTLTGIASLVLL 494
Cdd:cd17447   196 ISGFGlnvyLTQFIYGAIE----------LPAKL--------------LAY--LLLDRIGRRLTQAGSLILTGLSIGINI 249
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 495 glwdcehpIFPTVWAqqgnpnrdlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 574
Cdd:cd17447   250 --------LIPSEFT-----------VVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPL 310
                         410       420       430
                  ....*....|....*....|....*....|.
gi 2065532653 575 QRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17447   311 VILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
181-343 5.59e-17

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 82.85  E-value: 5.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNgLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 260
Cdd:cd17446     6 CTDGWVYD-KSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSP 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCdPTqRLRvALAGELVGVG---GHFLFLGLALVSKDWRFLQRMITAPCIL 337
Cdd:cd17446    85 SFPIYCVFRFLTGMALSGIVLNSVSLNVEWM-PT-RVR-AVVGTLLGYCytlGQLILAGVAYAIRDWRWLQLAVSLPFFI 161

                  ....*.
gi 2065532653 338 FLFYGW 343
Cdd:cd17446   162 FFLYSW 167
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
219-574 1.54e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 75.86  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 219 ILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR-- 296
Cdd:TIGR00895  62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgt 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 -LRVALAGELVGVGGHFLFLGLALVSKDWRflqrmitapcILFLFYGWPGLFL---------ESARWLIVKRQIEEAQSV 366
Cdd:TIGR00895 142 aVGLMFCGYPIGAAVGGFLAGWLIPVFGWR----------SLFYVGGIAPLLLllllmrflpESIDFLVSKRPETVRRIV 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 367 LRILAERNRPHGQMLGEEAQEAlQDLENTCPLPATSSFSFASLLnyrnIWknlLILGFTNFIAHAIRHC--YQPVGGGGS 444
Cdd:TIGR00895 212 NAIAPQMQAEAQSALPEQKSTQ-GTKRSVFKALFQGKTARITVL----LW---LLYFMLLVGVYFLTNWlpKLMVELGFS 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 445 PSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMtLTGIaslvllglwdcehpIFPTVWAQQGNPNRDLNEAAIT 524
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL-LGAV--------------FAVLVGSTLFSPTLLLLLGAIA 348
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 2065532653 525 TFSVLGLFSSQAAailstlLAAEVIPTTVRGRGLGLIMALGALGGLSGPA 574
Cdd:TIGR00895 349 GFFVNGGQSGLYA------LMALFYPTAIRATGVGWAIGIGRLGAIIGPI 392
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
220-614 7.91e-13

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 70.68  E-value: 7.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 220 LGFASGYLFLGYPADRFGRRGIVLLTlglVGPCGVGGAAAGSSTGVMAL---RFLLGFL--LAGVDLGVYLMrlELCDPT 294
Cdd:cd17358    52 LGALIGALLSGKLADRIGRKRTLLIS---AIPCILGWLLIAFAKDVWMLylgRFLAGFGggAASVVVPVYIA--EIAPKN 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 295 QRLRVALAGELVGVGGHFL--FLGLALvskDWRFLQRMITAPCILFLfygwPGLFL--ESARWLIVKRQIEEAQSVLRIL 370
Cdd:cd17358   127 VRGALGSLNQLLVNIGILLgyVLGSFL---PWRTLALIGAIPPVVFL----ILLFFipESPRWLAKKGREEEAEKSLQFL 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 371 aeRNRPHGqmLGEEAQEALQDLENTCPLPATSSFSfasLLNYRNIWKNLLI-------------LGFTNFIAHAIRHcyq 437
Cdd:cd17358   200 --RGKDAD--ISKEAAEIQEELAELEKEAKESSFS---DLFQRKYLKPLVIglglmlfqqlsgiNAVIFYASSIFDE--- 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 438 pvGGGGSPSDfyLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVL---LGLWDCEHPIFPTVWaqqgnp 514
Cdd:cd17358   270 --AGSGLDPN--TATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALglyFYLQEHGALLSSVSW------ 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 515 nrdlneaaITTFSVLGLFSSQAAAILST--LLAAEVIPTTVRGRGLGLIMALGALGG----LSGPAQRLHMG-HGAFLqh 587
Cdd:cd17358   340 --------LPLVGLVIYIISFSIGLGPLpwVIMSEIFPAKIKGLAGSLVTLVNWLFAfivtKTFPFLTLAWGaSGTFW-- 409
                         410       420
                  ....*....|....*....|....*...
gi 2065532653 588 vVLAACALLCIL-SIMLLPETKRKLLPE 614
Cdd:cd17358   410 -IFAGICGLALVfVLLFVPETKGKSLEE 436
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
203-603 1.13e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 69.94  E-value: 1.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 203 LVCDLGWQVILEQILFI-----LGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLA 277
Cdd:cd17316    25 LAAEFSLGLSLLQTGLLfaagfLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIG 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 278 GVDLGVYLMRLELCDPTQRLRVAL-------AGELVGVGGHFLFLGLALVSKDWRflqrmitapcILFLFYGWPGLFLes 350
Cdd:cd17316   105 GEYPGASTYVAEFAPSKRRGFALGllqsgwaLGALLAALVASLLIPLLSGDWGWR----------ILFLIGALPALLA-- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 351 arWLIVKRqieeaqsVLRILAernrphgqmlgeeaqealqdlentcplpatssFSFASLLNYrniwkNLLILGFTNFIAH 430
Cdd:cd17316   173 --LLLRRR-------TLLLIL--------------------------------LWFFISFGY-----YGLTTFLPTYLQT 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 431 airhcyqpvGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdcehpifptvwaq 510
Cdd:cd17316   207 ---------VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYL-------------- 263
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 511 qgnpnRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP--AQRLHMGHGAFLQHV 588
Cdd:cd17316   264 -----LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPplIALLLASTGGTGVPA 338
                         410
                  ....*....|....*
gi 2065532653 589 VLAACALLCILSIML 603
Cdd:cd17316   339 LILALLAIVALIVAL 353
MFS_1 pfam07690
Major Facilitator Superfamily;
217-573 3.95e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 64.75  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LR---VALAGELVGVGGHFLFLGLALVSKDWRFLqrmITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAER 373
Cdd:pfam07690 120 GRalgLVSAGFGLGAALGPLLGGLLASLFGWRAA---FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 NRPHGQMLGeeaqealqdlentcplpATSSFSFASLLNYRNIWKNLLILGFtnfiahairhcyqpvggGGSPSDFYLCSL 453
Cdd:pfam07690 197 LLRDPVLWL-----------------LLALLLFGFAFFGLLTYLPLYQEVL-----------------GLSALLAGLLLG 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 454 LASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdceHPIFPTVWaqqgnpnrdlneaAITTFSVLGLFS 533
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL----SLTLSSLW-------------LLLALLLLGFGF 305
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 2065532653 534 SqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP 573
Cdd:pfam07690 306 G-LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
217-569 4.26e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.00  E-value: 4.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:COG2814    53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRVALAGELVGVGGHFL--FLGLALVSK-DWRflqrmitapcILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRilaer 373
Cdd:COG2814   133 GRALGLLGAGLGLGPALgpLLGGLLADLfGWR----------WVFLVNAVLALLALLLLLRLLPESRPAARARLR----- 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 nrphgqmlgeeaqealqdlentcplpatssFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGG---GGSPSDFYL 450
Cdd:COG2814   198 ------------------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQevlGLSASAAGL 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 451 CSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLlglwdcehPIFPTVWaqqgnpnrdlneaAITTFSVLG 530
Cdd:COG2814   248 LLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL--------ALAGSLW-------------LLLLALFLL 306
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 2065532653 531 LFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGG 569
Cdd:COG2814   307 GFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
217-604 1.04e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.98  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:cd06174    39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERER 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRVALAGELVGVGGhfLFLGLALVSkdwrflqrmitaPCILFLFYGWPGLFLESARWLIVkrqieeaQSVLRILAERNRP 376
Cdd:cd06174   119 GRALGLLQAFGSVG--GILGPLLGG------------ILASSLGFGWRAVFLIAAALALL-------AAILLLLVVPDPP 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 377 HGqmlgeeaqealQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIrHCYQPV----GGGGSPSDFYLCS 452
Cdd:cd06174   178 ES-----------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSF-STLLPLflldLGGLSVAVAGLLL 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 453 LLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCehpifptvwaqqgnpnrdlNEAAITTFSVLGLF 532
Cdd:cd06174   246 SLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS-------------------LLLLLLLLLLLGFG 306
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2065532653 533 SSqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIMLL 604
Cdd:cd06174   307 LG-GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
Sugar_tr pfam00083
Sugar (and other) transporter;
217-615 7.81e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 61.52  E-value: 7.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGL--VGPCGVGGAAAGSSTGVMAL-RFLLGFLLAGVDLGVYLMRLELCDP 293
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLfvIGAVLQGAAKGKWSVYQLIVgRVLVGIGVGGASVLAPMYISEIAPK 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 294 TQRlrvalaGELVG----------VGGHFLFLGLALVSKD--WRFLQRMITAPCILFLFYGWpglFL-ESARWLIVKRQI 360
Cdd:pfam00083 134 KLR------GALGSlyqlaitfgiLLAYIFGLGLNKTSNSdgWRIPLGLQLVPALLLIIGLL---FLpESPRWLVEKGRL 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 361 EEAQSVLRILAERNRPHGQMLGE-EAQEALQDLENTcplpatssfSFASLLNYRNIWKNLLI----LGFTNFIAHAIRHC 435
Cdd:pfam00083 205 EEAREVLAKLRGVPDVDRELDEIkDSLEAGQEAEKA---------SWKELFSTKTRRQRLLIgvmlQIFQQLTGINAIFY 275
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 436 YQP-----VGgggsPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGlwdcehPIFPTVWAQ 510
Cdd:pfam00083 276 YSTtifenLG----LSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGI------VALLGVSKS 345
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 511 QGNPNrdlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALG----ALGGLSGPAQRLHMGHGAFlq 586
Cdd:pfam00083 346 DWAGI-----VAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANwlanFLIGFLFPIITDAIGLGYT-- 418
                         410       420       430
                  ....*....|....*....|....*....|
gi 2065532653 587 HVVLAACALLCILSIML-LPETKRKLLPEV 615
Cdd:pfam00083 419 FFIFAGLLVLFIIFVFFfVPETKGRTLEEI 448
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
217-610 1.03e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.65  E-value: 1.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:COG2271    53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKER 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LR---VALAGELVGVGGHFLFLGLALVSKDWRflqrmitapcILFLFYGWPGLFLesarwlivkrqieeaqSVLRILAer 373
Cdd:COG2271   133 GRalgIFNAGGPLGGALAPPLLGWLLAAFGWR----------AAFLILGLPGLLL----------------ALLRFWL-- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 nrphgqmlgeeaqealqdlentcplpatssFSFASLLNYrniwknLLILGFTNFIAHAIRHCYqpvggGGSPSDFYLCSL 453
Cdd:COG2271   185 ------------------------------LALAYFLVY------FALYGFLTWLPTYLVEVR-----GLSLAQAGLLLS 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 454 LASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWdcehpiFPTVWAqqgnpnrdlneaaITTFSVLGLFS 533
Cdd:COG2271   224 LPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL------LPSPAL-------------AIALLFLAGFG 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 534 SQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLqhvVLAACALLCILSIMLLPET 607
Cdd:COG2271   285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPllvgylLDATGY-QAAFL---LLAALALLAALLALLLLRE 360

                  ...
gi 2065532653 608 KRK 610
Cdd:COG2271   361 TRK 363
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
197-343 1.09e-08

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 57.45  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 197 AIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLL 276
Cdd:cd17375    23 IVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVS 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 277 AGVDLGVYLMRLELCDPTQR---------------LRVALAGELVgvgghflflglalvsKDWRFLQRMITAPCILFLFY 341
Cdd:cd17375   103 SGYLVVVFVYVTEFTGIKARtwasmhvhaffavgiMVVALVGYLV---------------RTWWIYQIILSLVTIPFILC 167

                  ..
gi 2065532653 342 GW 343
Cdd:cd17375   168 CW 169
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
218-603 1.45e-08

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 57.15  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 218 FILGFAS---GYLFLGYPADRFGRRGIVLLTLGLVGpcgVGGAAAG-----SSTGVMA------LRFLLGFLLAGVDLGV 283
Cdd:cd17369    50 FGVGFLArplGGVVFGHFGDRIGRKKTLVLTLLLMG---IATFLIGllptyAQIGILApillvlLRLLQGLALGGEWGGA 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 284 YLMRLELCDPTQRlrvALAGELVGVGGHF-LFLGLALVSkdwrFLQRMITAPciLFLFYGWPGLFLESARWLIV----KR 358
Cdd:cd17369   127 VLMAVEHAPPKRR---GFYGSFPQLGAPVgLLLATGVFL----LLSALLSDE--AFLSWGWRIPFLLSAVLVAVglyiRL 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 359 QIEEAQSVLRILAERNRPhgqmlgeeaqealqdlentcPLPATSSFsfasllnyRNIWKNLLI---------LGFTNFIA 429
Cdd:cd17369   198 RLEETPVFRRAKEAGQVV--------------------RAPLVEVL--------RRHWRALLLaiglrlaenVLFYLFTT 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 430 HAIRHCYQPVGGggSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIAslvllglwdcehpIFPTVWA 509
Cdd:cd17369   250 FALSYATQTLGV--DRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALF-------------AFPFFWL 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 510 QQGNPNrdlneAAITTFSVLGLFSSQAA--AILSTLLaAEVIPTTVRGRGLGLIMALGA-LGGLSGP---AQRLHMGHGA 583
Cdd:cd17369   315 LDTGST-----WLIVLAAVVVLGVLHGMmyGPQAAFL-AELFPTRVRYTGASLGYQLGAiLGGGFAPliaTALVAATGSW 388
                         410       420
                  ....*....|....*....|
gi 2065532653 584 FLQHVVLAACALLCILSIML 603
Cdd:cd17369   389 WPVALYLAALAVISLVAALF 408
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
216-610 1.72e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 57.20  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 216 ILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQ 295
Cdd:COG2223    47 AIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 296 R---LRVALAGELVGVGGHFLFLGLALVSKDWRflqrmitapcILFLFYGWPGLFLESARWLIVKRqieeaqsvlriLAE 372
Cdd:COG2223   127 RglaLGLAAGGGNLGAAVAAFLAPLLIAAFGWR----------NAFLILGILLLVVAVLAWLFLRD-----------PPA 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 373 RNRPHGQMLGEEAQEALQDlentcplPATSSFSFASLLNYrniwknLLILGFTNFIAHAIRHCYqpvggGGSPSDFYLCS 452
Cdd:COG2223   186 GAAAAAKASLRDQLEALRD-------PRFWLLSLLYFGTF------GSFIGFSSWLPPYLVDQF-----GLSAATAGLLA 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 453 LLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdcehpiFPTVWaqqgnpnrdlneAAITTFSVLGLF 532
Cdd:COG2223   248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALA-------LGSLW------------LFLVLFLLLGLA 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 533 SSQAAAILSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGP----AQRLHMG--HGAFLqhvVLAACALLCILSIMLLPE 606
Cdd:COG2223   309 LGGGNGAVFALV-PDIFPTKNAGAVYGLVGAAGGLGGFLGPllfgALLDATGsyTAAFL---VFAVLALVALVLTLLLYR 384

                  ....
gi 2065532653 607 TKRK 610
Cdd:COG2223   385 RPRR 388
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
181-343 1.79e-08

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 56.71  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 181 CLKDWDYNGLPVLTTnAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAG 260
Cdd:cd17376     8 CLDGWEYSQDVYLST-IVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSP 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 261 SSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVG-GHFLFLGLALVSKDWRFLQRMITAPCILFL 339
Cdd:cd17376    87 SWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIFYAiGYMLLPLFAYFIRDWRMLLLALTLPGVLCV 166

                  ....
gi 2065532653 340 FYGW 343
Cdd:cd17376   167 PLWW 170
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
200-615 2.76e-08

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 56.58  E-value: 2.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 200 QWDLVCDLGWQVILEqiLFILGFASGYLFLGYPADRFGRRGIVLLT--LGLVGPCGVGGAAAGSSTGVMAL-RFLLGFll 276
Cdd:TIGR00879  64 NSDSYSSSLWGLVVS--IFLVGGFIGALFAGWLSDRFGRKKSLLIIalLFVIGAILMGLAAFALSVEMLIVgRVLLGI-- 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 277 aGVDLGVYLMRL---ELCDPTQRLRVALAGELVGVGGHFL--FLGLALVSKDWRFLQRMITAPCILF--LFYGWPGLFLE 349
Cdd:TIGR00879 140 -GVGIASALVPMylsEIAPKALRGALTSLYQLAITFGILVayGFGSGKVSLNNTLGWRIPLGLQLIPagLLFLGLFFLPE 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 350 SARWLIVKRQIEEAQSVL-RILAERNRPHGQMLGEEAQEALQDLENTCPLPATSS-FSFASLLNYRnIWKNLLILGFTNF 427
Cdd:TIGR00879 219 SPRWLVGKGRVEEARKSLaRLRGTSGEDKELLDELELIDIKRSIEKRSVQPSWGSlFSSTRRIRRR-LFLGVVLQWFQQF 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 428 IAHAIRHCYQPV---GGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSmtltgiASLVLLGLWDCEHPIF 504
Cdd:TIGR00879 298 TGINAIMYYSPTifeNAGVSTDHAFLVSIIVGAVNFAFTFVAIFLVDRFGRRPLLLIG------AAGMAICLFVLGILGA 371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 505 PTVWAQQgnpnRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTtvRGRGLGLIMALGA------LGGLSGPAQRLH 578
Cdd:TIGR00879 372 SFVTGSS----KSSGNVAIVFILLFIAFFAMGWGPVPWVIVSEIFPL--SLRPKGISIAVAAnwlanfIVGFLFPTMLES 445
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 2065532653 579 MGHGAFlqHVVLAA-CALLCILSIMLLPETKRKLLPEV 615
Cdd:TIGR00879 446 IGVGGV--FIFFGGlNVLGLIFVYFFLPETKGRTLEEI 481
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
185-605 5.36e-08

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 55.06  E-value: 5.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 185 WDYNGLPVLTTnaIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPAD-RFGRRGIVLLTLGLVGpcgVGGAAAGSST 263
Cdd:cd17378    11 WEWDGGSKVSI--VSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMA---LSGIATAFSP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 264 GV---MALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLA-LVSKDWRFLQRMITAPCILFL 339
Cdd:cd17378    86 NYwvyAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAyLNGSSWRVLYFWTSIPALIYC 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 340 FYGWPglflesarwlivkrqieeaqSVLRILAernrphgqmlgeeaqealqdlentcplpatssfsfasllnyrniwknL 419
Cdd:cd17378   166 ILVYL--------------------FARRLLA-----------------------------------------------V 178
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 420 LILGFTNFIAHairhcY-QPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWd 498
Cdd:cd17378   179 MVIGFGIGMVY-----YgIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLS- 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 499 cehpIFPTVWAQQGnpnrdlneaaittFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLH 578
Cdd:cd17378   253 ----IGGTTSLQIA-------------LELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSL 315
                         410       420
                  ....*....|....*....|....*..
gi 2065532653 579 MGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17378   316 GRKNAALSFGVFGVAILLLGLFALGLP 342
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
413-629 1.22e-07

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 413 RNIWKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 486
Cdd:COG2814     6 RRRWLALLALALGAFLSGLGIGIVLPALPliaadlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 487 GIASLVLlglwdcehPIFPTVWaqqgnpnrdlneaAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGA 566
Cdd:COG2814    86 ALGSLLC--------ALAPSLW-------------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 567 LGGLSGP------AQRLHMgHGAFLqhVVLAACALLCILSIMLLPETKRKLLPEVLRD-GELCRRPSLLR 629
Cdd:COG2814   145 LGPALGPllggllADLFGW-RWVFL--VNAVLALLALLLLLRLLPESRPAARARLRGSlRELLRRPRLLL 211
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
217-604 9.03e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 51.42  E-value: 9.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:cd17320    42 AYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAEL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRVaLAgelvgvgghFLFLGLALVskdwrflqrMITAPCI---LFLFYGWPGLFlesarWLIVKRQIEEAQSVLRILAEr 373
Cdd:cd17320   122 AKI-FS---------LLMMILAIA---------PALAPLLgglLLLFFGWRAIF-----VFLALLGLLLLLLVLLFLPE- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 nrphgqmlgeeaqealqdlenTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIA--HAIRHCYQPVGG-------GGS 444
Cdd:cd17320   177 ---------------------TLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGlsFAGLFAYLAAAPfiyieqlGLS 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 445 PSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWAqqgnpnrdlneAAIT 524
Cdd:cd17320   236 PAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVA-----------PLFL 304
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 525 TFSVLGLFSSQAAAilstlLAAEVIPtTVRGRGLGLIMALG-ALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIML 603
Cdd:cd17320   305 IFFGFGLIFPNATS-----LALEPFP-HVAGTASALLGFLQfLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378

                  .
gi 2065532653 604 L 604
Cdd:cd17320   379 L 379
xylE PRK10077
D-xylose transporter XylE; Provisional
319-563 4.39e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 49.69  E-value: 4.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 319 LVSKDWR--FLQRMITAPCILFLFYGWPglflESARWLIVKRQIEEAQSVLRILaernrphgqMLGEEAQEALQDLENTC 396
Cdd:PRK10077  188 LNTDGWRymFASEAIPALLFLMLLYFVP----ETPRYLMSRGKQEQAEGILRKI---------MGNTLATQALQEIKHSL 254
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 397 PLPATSS---FSFASLLnyrnIWKNLLILGFTNFIAHAIRHCYQP--VGGGGSPSDFYLCSLLASGTAALACVFLGV-TV 470
Cdd:PRK10077  255 DHGRKTGgklLMFGVGV----IVIGVMLSVFQQFVGINVVLYYAPeiFKTLGASTDIALLQTIIVGVINLTFTVLAImTV 330
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 471 DRFGRRGILLlsmtltgIASLVLlglwdcehpifptvwaqqgnpnrdlneaAITTFSVLGLFSSQAAAILSTL------- 543
Cdd:PRK10077  331 DKFGRKPLQI-------IGALGM----------------------------AIGMFSLGTAFYTQAPGIVALLsmlfyva 375
                         250       260       270
                  ....*....|....*....|....*....|..
gi 2065532653 544 ------------LAAEVIPTTVRGRGLGLIMA 563
Cdd:PRK10077  376 afamswgpvcwvLLSEIFPNAIRGKALAIAVA 407
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
206-610 5.06e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 49.18  E-value: 5.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 206 DLGWQVILeQILFIlGFASGYLFLGYPADRFGRRGIVLL-TLGLVGPCGVGGAA--AGSSTGVMALRFLLGfLLAGVDLG 282
Cdd:cd17357    48 DLLWSLIV-SIFFI-GGAIGSFISAFLANRFGRKNGLLIsNALLVVSSLLMFLSksAKSPELLIFGRFLVG-IACGLSTG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 283 VYLMRLELCDPTQrLRVALaGELVGVGGHF-----LFLGLALV---SKDWRFLQRMITAPCILFLFYgWPgLFLESARWL 354
Cdd:cd17357   125 FVPMYLQEISPSE-LRGAL-GSLTQIGVTLgillgQVFGLPSVlgtETLWPYLLFFPGIPALLQLAA-LP-FFPESPKFL 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 355 -IVKRQIEEAQSVLRILaernRPHGQMLGEEAQEALQDLENtcpLPATSSFSFASLLNYRNIWKNLLIL----------G 423
Cdd:cd17357   201 lISKGDEEEAEKSLKFL----RGIEDDVDQELEEIKKESEQ---MGDQKQVSLMQLLRDPSLRLPLLLVlvvsasqqfsG 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 424 FTNFIAHAIrhcyqpvggggspsDFYLCSLLASGTAALACVFLGVT-----------VDRFGRRGILLLSMTLTGIASLV 492
Cdd:cd17357   274 INAIFFYST--------------FIFENAGFSPQLAEWANLGIGIVnvlstivgpflIEKVGRRPLLLISLSVCAVALLL 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 493 LlglwdcehpifpTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALG---- 568
Cdd:cd17357   340 M------------SVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSnfiv 407
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 2065532653 569 GLSGPAQRLHMGHGAFLQHVVLaaCALLCILSIMLLPETKRK 610
Cdd:cd17357   408 GMAFPPLQSIGGGFVFIIFAIP--CALFLLYLYRYLPETKGR 447
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
219-605 6.98e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 48.74  E-value: 6.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 219 ILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR-L 297
Cdd:cd17365    44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRsL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 298 RVALAGELVGVGGHFL-FLGLALV-SKDWRflqrmitapcILFLFYGWPGLFLesarwlivkrqieeaqsvlrilaernr 375
Cdd:cd17365   124 AVTLMFCGYPLGAALGgFLAAALIpAFGWR----------SVFLLGGVPPLIL--------------------------- 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 376 phgqmlgeeaqeaLQDLENTCPLPATssfSFASLlnyrniwknLLILGFTNFIAHAIRhcyqpvGGGGSPSDFYLCSLLA 455
Cdd:cd17365   167 -------------LPLLRGTLLLWVT---FFMGL---------LLVYLLNSWLPKLMV------EAGYSLSQALTITLLL 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 456 SGTAALACVFLGVTVDRFGRRGILLLSMTLTGiASLVLLGLwdcehpiFPTVWAqqgnpnrdlneAAITTFSVLGLFSSq 535
Cdd:cd17365   216 NIGGVIGSLLLGWLADRFGPKRVLALFFALGA-VSLALLGV-------SPASLV-----------LLYVLVFLAGACVN- 275
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2065532653 536 AAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP---AQRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd17365   276 GAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPllgGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
469-618 2.26e-05

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 47.42  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 469 TVDRFGRRGILLLSMTLTGIASLVLLGLWdceHPIFPtvwaqqgnpnrdlnEAAITTFSVLGLFSSQAAAILSTLLAAEV 548
Cdd:TIGR00887 358 LVDIIGRKPIQLMGFFILTVLFFVLGFAY---NHLST--------------HGFLAIYVLAQFFANFGPNATTFIVPGEV 420
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 549 IPTTVRGRGLGLIMALGALGGLSG----------PAQRLHMGHGAFLQHV--VLAACALLCILSIMLLPETKRKLLPEVL 616
Cdd:TIGR00887 421 FPTRYRSTAHGISAASGKAGAIIGqfgflylaqhGDPTKGYPTGIWMGHVleIFALFMFLGILFTLLIPETKGKSLEELS 500

                  ..
gi 2065532653 617 RD 618
Cdd:TIGR00887 501 GE 502
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
436-608 2.33e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 47.27  E-value: 2.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 436 YQPVGGGGSPSDFYLCSLLASGTAALACV-------FLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDceHPIFPTVw 508
Cdd:cd17364   223 ISAIGFSKTMNAYQELFNIAVGQLIIALAgtvpgywFTVFLIDRIGRKKIQMMGFFGMTIFLLILAGPYD--HWKISTI- 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 509 aqqgnpnrdlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSG----PAQRLHMGHGAF 584
Cdd:cd17364   300 ------------GFFVLYGLTFFFSNFGPNTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGsflfLSLTQNIGVRNV 367
                         170       180
                  ....*....|....*....|....
gi 2065532653 585 LqhVVLAACALLCILSIMLLPETK 608
Cdd:cd17364   368 L--IILAGVALLGIILTLLFPEEK 389
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
217-604 3.52e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 3.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFAsgyLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:cd17473    46 LFIALFA---PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEER 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRV-ALAGELVGVGGH-FLFLGLALVSKDWRflqrmitAPcilFLFYGWPGLFLESARWLIVKRQIEEaqsvlrilAERN 374
Cdd:cd17473   123 AKMlGLQSAAMSLGGVvFLLLGGALAEIGWR-------AP---FLVYLLALPVLILVLLFLPEPARKS--------KSAA 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 375 RPHGQMLGEEAQEALQdlentcpLPATSSFsFASLLNYrniwknlLILGFTNFIAHAIrhcyqpvgGGGSPSDFYLCSLL 454
Cdd:cd17473   185 SPGAATAAALPWKRVL-------PIYFLAF-LAMLLFY-------VIPIQLPFLLQER--------GGGSAALIGLALAI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 455 ASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIAsLVLLGLWdcehpifPTVWAqqgnpnrdlneaaittfSVLGLFSS 534
Cdd:cd17473   242 ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG-FLLLALA-------SGLWV-----------------VLLGAILA 296
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 535 QAAA--ILSTLL--AAEVIPTTVRGRGLGLIMALGALGG-----LSGPAQRLHMGH-GAFLqhVVLAACALLCILSIMLL 604
Cdd:cd17473   297 GLGFglLLPTLNswAMSLVPPELRGRAMGIVTSAFFLGQflsplVLGPLVNLTGGLsGAFL--ILGVLALVLAIVLLLLR 374
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
220-359 5.30e-05

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 46.02  E-value: 5.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 220 LGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFL--LAGVDLGVYLMrlELCDPTQRL 297
Cdd:cd17359    47 LGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvgGASALVPMYIA--EVAPAEIRG 124
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2065532653 298 RVALAGELVGVGGHFL-----------FLGLALVSKDWRFLQRMITAPCILFLFygwpGLFL--ESARWLIVKRQ 359
Cdd:cd17359   125 RLVSLNQLMIVFGQLLayivnylianaGGADWLGAEGWRWMLGLEAIPAILFLL----GMLFipESPRWLVSKGK 195
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
227-599 7.53e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 227 LFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRV---ALAG 303
Cdd:cd17325    49 PPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAmgiFSSA 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 304 ELVGVGGHFLFLGLALVSKDWRFLqrmitapcilFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPhgqmlge 383
Cdd:cd17325   129 IGLGFLIGPLLGGLLADALGYRAP----------FLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSG------- 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 384 eaqealqdlentcplpatssfsFASLLNYRNIWKnLLILGFTNFIAHAIRHCYQPV----GGGGSPSDFYLCSLLASGTA 459
Cdd:cd17325   192 ----------------------LRLLLRDRRLLA-LFLAIFVLAFAFGALEPFLPLyaaeLGGLSPAQIGLLFGAQGLAS 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 460 ALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLlglwdcehPIFPTVWaqqgnpnrdlneAAITTFSVLGLFSSQAAAI 539
Cdd:cd17325   249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL--------PLATSFW------------LLLLLLALLGLGLGLVFPA 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2065532653 540 LSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMGHGAFLQHVVLAACALLCIL 599
Cdd:cd17325   309 TLALL-ADIVPPEGRGTAMGLFNTAFSLGMVLGPllggflYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
209-604 1.36e-04

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 44.45  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 209 WQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLmRL 288
Cdd:cd17372    34 WQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASW-YL 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 289 ELCDPTQRLRVALAGELVGVGGHFLFLGLALV---SKDWRFLQRMITAPCILFL----FYGWPGLFLesarWLIVKRQIE 361
Cdd:cd17372   113 EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLvmpRLGWRWLLAFSSVPSSLLLvfyrWTPKTTLLL----WVIWFGNAF 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 362 EAQSVLRILAERNRPHGQMLGEEAQEAlqdLENTCPLpatsSFSFASLLNYRNIwknllilgftnFIAhairhcyqpvgg 441
Cdd:cd17372   189 AYYGVVLLTTELNNSHNVCGSKSDSDS---GESPTEK----QCRNSNDVDYRDV-----------FIA------------ 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 442 ggSPSDFYLCSLLASGtaalacvflgvtVDRFGRRgillLSMTLT-GIASLVLLGLWDCEHPifptvwaqqgnpnrdlne 520
Cdd:cd17372   239 --TFAEFPGLLISAAM------------IDRLGRK----ASMASMlFTCCIFLLLLLICQSP------------------ 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 521 aAITTFSVLGLFSSQAAAILST-LLAAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVL-AACALLCI 598
Cdd:cd17372   283 -FILTVLLFGGRACISAAFTVVyIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALLLfSVVCLVSA 361

                  ....*.
gi 2065532653 599 LSIMLL 604
Cdd:cd17372   362 ICVCLL 367
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
217-274 1.56e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 44.52  E-value: 1.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGF 274
Cdd:PRK11102   34 AYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL 91
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
217-287 1.85e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 44.30  E-value: 1.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLL-AGVDLGVYLMR 287
Cdd:TIGR00710  48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAsAGSVISQALVR 119
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
419-605 3.05e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 419 LLILGFTNFIAHAIRHCYQPV---GGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLG 495
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPAllqSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 496 LwdcehPIFPTVWAqqgnpnrdlneaaitTFSVLGLFSSQAAAILSTLLaAEVIPTTVRGRGLGLIMALGALGGLSGP-A 574
Cdd:cd06174    81 A-----PSFWLLLL---------------GRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGLLQAFGSVGGILGPlL 139
                         170       180       190
                  ....*....|....*....|....*....|.
gi 2065532653 575 QRLHMGHGAFLQHVVLAACALLCILSIMLLP 605
Cdd:cd06174   140 GGILASSLGFGWRAVFLIAAALALLAAILLL 170
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
222-596 3.10e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.39  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 222 FASGYLFLGYPAD----RFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVD------LGVYLMRLELC 291
Cdd:cd17327    50 FYVGYIIFELPGNlllqRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFpgfilyLGMWYKREEQA 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 292 dptqrLRVAL---AGELVGVGGHFLFLGLALVS-----KDWRFL---QRMITAPCILFLFYGWPGLflESARWLIVKRqi 360
Cdd:cd17327   130 -----KRIAFfyaAAGLGSIFGGLLAYGVFKILgvgglAGWRWLfiiEGLITIIIGLVIFFWLPDN--PSKAWFLTEE-- 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 361 EEAQSVLRIlAERNRPHGQMLGEEAQ--EALQD--------LENTCPLPATSSFSFASLlnyrnIWKNLlilGFTNFIAh 430
Cdd:cd17327   201 EKELAVERL-RANQTGKGDQKFKWKQikEAFKDprtwllflFFFCSQITNNGISNFLPL-----ILKSL---GFYSLQT- 270
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 431 airhcyqpvggggspsdfylcSLLASGTAALACV-FLGVTV--DRFGRRGILLLSMTLTGIASLVLLGLWdcehpifptv 507
Cdd:cd17327   271 ---------------------NLLSVPIGALGAVsLLIAALlsDRFKKRGLFAIFACVLALVGSIILLAA---------- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 508 waqqgnpnrDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP-------AQRLHMG 580
Cdd:cd17327   320 ---------PNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPqifragdAPRYIPG 390
                         410
                  ....*....|....*.
gi 2065532653 581 HGAFLQHVVLAACALL 596
Cdd:cd17327   391 NIALLVCACVSIVLSV 406
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
454-614 3.48e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 43.37  E-value: 3.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 454 LASGTAALACVFLGVTVDRFGRRGILLLSMTLTGiASLVLLGLWdceHPIFPTVWAqqgnpnrdlneAAITTFSVlGLFS 533
Cdd:cd17329    43 LSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRA-LGFALLGFA---HSPWLFAIA-----------LVLTGFGG-GLFE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 534 SQAAAILstllaAEVIPTTVRGRGLGLIMALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCILSIML--LPETKRKL 611
Cdd:cd17329   107 PASEAMI-----ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLflLPETRPKR 181

                  ...
gi 2065532653 612 LPE 614
Cdd:cd17329   182 RAA 184
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
211-274 3.64e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 43.33  E-value: 3.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2065532653 211 VILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGF 274
Cdd:cd17323    36 ANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGF 99
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
416-574 5.20e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.93  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 416 WKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIA 489
Cdd:COG2271     9 WRILALLFLAYFLNYLDRSNLSVAAPplqadlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 490 SLVllglwdceHPIFPTVWaqqgnpnrdlneAAITTFSVLGLFSSqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGG 569
Cdd:COG2271    89 TLL--------FGFATSFW------------QLLLLRFLLGLGEA-GFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147

                  ....*
gi 2065532653 570 LSGPA 574
Cdd:COG2271   148 ALAPP 152
MFS_1 pfam07690
Major Facilitator Superfamily;
442-632 5.53e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.79  E-value: 5.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 442 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLglwdcehpIFPTVWAqqgnpnrdlnea 521
Cdd:pfam07690  28 GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL--------FASSLWL------------ 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 522 AITTFSVLGLFSSqAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLQHVVLAACAL 595
Cdd:pfam07690  88 LLVLRVLQGLGAG-ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPllggllASLFGW-RAAFLILAILSLLAA 165
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2065532653 596 LCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPP 632
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV 202
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
217-608 6.35e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 42.67  E-value: 6.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAG-VDLGVYLMrlELCDPTQ 295
Cdd:cd17371    42 VTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGeWAAGAALM--AEYVPAR 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 296 RLRVALA--------GELVGVGGHFLFLGLALVSKDWR--FLQRMITAPCILFLFYGWPglflESARWLIV--KRQIEEA 363
Cdd:cd17371   120 HRGKALGyvqsgwavGWLLATLLAALLFPLLPPEIAWRvlFLLGALPALLVLFIRRFVK----EPPQWQAAraARRHFAD 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 364 QSVLRILAERNrphgqMLGEEAQEALqdlentcpLPATSSFSFASLLNyrniWKNLLILGFTNFIAHairhcyqpvGGGG 443
Cdd:cd17371   196 RPSLRELFSPP-----LLRTTLLASL--------LATGALGGYYGITT----WLPSYLTGERGLSFE---------GSAG 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 444 SPSDFYLCSLLAsgtaalaCVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLwdcehPIFPTVWAQQGnpnrdlneaAI 523
Cdd:cd17371   250 YLVVTILGGFLG-------YLAGGFLADRIGRRNNFALFALGSAISILLYFFL-----PLSPTLILILG---------FP 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 524 TTFSVLGLFSSQAAailstlLAAEVIPTTVRGRGLGLIMALGALGGLSGPaqrlhMGHGAFLQH-------VVLAACALL 596
Cdd:cd17371   309 LGFFASGPFSGMGA------YLTELFPTAVRATAQGFCYNVGRIIGALFP-----FLVGFLATSgslgtaiAVFAAVYYI 377
                         410
                  ....*....|..
gi 2065532653 597 CILSIMLLPETK 608
Cdd:cd17371   378 AGLVLALLLPET 389
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
217-325 7.43e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.11  E-value: 7.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:COG0477    57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARER 136
                          90       100       110
                  ....*....|....*....|....*....|..
gi 2065532653 297 LR-VALAGELVGVGGHF--LFLGLALVSKDWR 325
Cdd:COG0477   137 GRaLGLWGAAIGLGLALgpLLGGLLVAALGWR 168
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
458-633 7.96e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.18  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 458 TAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLglwdcehpIFPTVWaqqgnpnrdlneaAITTFSVLGLFSSQAA 537
Cdd:cd17325    43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA--------FATSYW-------------QLLLARFLQGLASAAV 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 538 AILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLqhvVLAACALLC-ILSIMLLPETKRK 610
Cdd:cd17325   102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPllggllADALGY-RAPFL---VCAALALLAlVLALLLLPEPRPP 177
                         170       180
                  ....*....|....*....|...
gi 2065532653 611 LLPEVLRDGELCRRPSLLRQPPP 633
Cdd:cd17325   178 PNKRAVSAARLRSGLRLLLRDRR 200
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
225-567 8.73e-04

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 41.98  E-value: 8.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 225 GYLFLGYPADRFGRRGIVLLTLGLVGpCGVGG-------AAAGSSTGVMAL--RFLLGFlLAGVDLG---VYLMrlELCD 292
Cdd:cd17368    56 GAIVLGAYADRIGRKPAMTLTLAIMA-LGTLLialaptyATIGIAAPLLVLlaRLLQGF-AAGGEVGgvtAYLV--EAAP 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 293 PTQR-----------LRVALAGELVGVGGHFLFLGLALVSKDWR--FLQRMITAPCILFLfygwpglflesarwlivKRQ 359
Cdd:cd17368   132 PGRRgfytswqsasqQVAIVAGALVGYLLSLTLTAEALAEWGWRipFFIGLLIIPLGLWL-----------------RRS 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 360 IEEAQSVLRILAernRPHGQMLGEEAQEALQDLENTCPLPATSSFSFasllnyrniwknLLILGFTNFIAHAIRHCYQPv 439
Cdd:cd17368   195 LEETEAFLERKA---RPTRRELFALLANNRRIILLGMLLVAGSTVTF------------YFTTVYTPTYAKTVLGLSAR- 258
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 440 ggggspsDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSmTLTGIASLVLLGLWDCEHPIFPTVWAQQGnpnrdln 519
Cdd:cd17368   259 -------DSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVI-TLAALVTLYPVFAWLTAAPSFGRLLLVLL------- 323
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 2065532653 520 eaaittfsVLGLFSSQAAAILSTLLaAEVIPTTVRGRGLGLIMALGAL 567
Cdd:cd17368   324 --------VLSFFFGMYGGAMVVAL-VELFPVRVRSTGFSLVYALAVA 362
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
195-339 1.05e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 41.69  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 195 TNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGF 274
Cdd:cd17377    25 TSIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2065532653 275 LLAGVDLGVYLMRLELCDPTQRlrvALAGELvgvGGHFLFLGLALVS------KDWRFLQRMITAPCILFL 339
Cdd:cd17377   105 MNGGMSLVAFVLLNECVGKSYW---ALAGSL---GGLFFAVGIAQYAllgyfiRSWRTLAVVVNLQGTLVF 169
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
217-604 1.39e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.40  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQR 296
Cdd:cd17319    46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARER 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 297 LRVA---LAGELVGVGGHFLFLGLALVSKDWRFLqrmitapcilFLFYGWPGLFLESARWLIVKRQIeeaqsvlrilaer 373
Cdd:cd17319   126 GRATglfNSGAPLGAAIGPPLSGWLLLLFGWRWA----------FIIEGLLGLLLAVLWWFYLRQVW------------- 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 374 nrphGQMLGEeaqealqdlentcplpatssFSFASLLNYRNIWknllilgFTNFIAHAirhcyqpvgGGGSPSDFYLCSL 453
Cdd:cd17319   183 ----GLALGY--------------------FGINYALYGLLTW-------LPTYLKQA---------RGFSLKQVGLLAA 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 454 LASGTAALACVFLGVTVDRF---GRRGILLLSMTLTGIASLVLlglwdcehPIFPTVWAQqgnpnrdlneaaiTTFSVLG 530
Cdd:cd17319   223 IPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLA--------YLTTSPVVA-------------VILLSLA 281
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 531 LFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSGPA------QRLHMGHGAFLqhvVLAACALLCILSIMLL 604
Cdd:cd17319   282 GFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLligylvDATGSYTAAFL---FLAAVALLAALLVLLL 358
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
436-606 1.63e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 41.08  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 436 YQPVGGGGSPSdfyLCSLLASGTAALACVFLGV-TVDRFGRRGILL---LSMTLTGIASLVLLGLWDCEHPIFPTVWAQq 511
Cdd:cd17361   227 FQTLGFGSDAS---LISAVITGAVNVVSTLVSIyLVDRFGRRFLLLeggVQMLASQVAIGILLAVKFGDGGELPKAYAI- 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 512 gnpnrdlneAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLI----MALGALGGLSGPAQRLHMGHGAFLqh 587
Cdd:cd17361   303 ---------AVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAGQSLTvavnFLFTFVIAQAFLSMLCAMKFGIFL-- 371
                         170       180
                  ....*....|....*....|
gi 2065532653 588 vVLAACALLCIL-SIMLLPE 606
Cdd:cd17361   372 -FFAGWVVVMSLfVYFLLPE 390
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
204-497 1.76e-03

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.10  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 204 VCDLGWQVILEQILfILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGV 283
Cdd:cd17360    31 VLSTGWQELIVSST-VAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTV 109
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 284 YLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLAL----VSKDWRFLQRMITAPCILFLFYGwpgLFL-ESARWLIVKR 358
Cdd:cd17360   110 PLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGafsyLPGGWRWMLGLAAVPAVLQFIGL---LFLpESPRWPSTRR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 359 QieeaqsvLRIlaernrphGQMLgeeaqEALQDLE--NTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIahairhcy 436
Cdd:cd17360   187 A-------LIV--------GCGL-----QAFQQFSgiNTVMYYSATILQMAGFKDNQNAIWLSLIVAGTNFI-------- 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2065532653 437 qpvggggspsdfylcsllasGTaaLACVFLgvtVDRFGRRGILLLSMTLTgIASLVLLGLW 497
Cdd:cd17360   239 --------------------FT--IVGMYL---IDKFGRRKLLLISLFGV-IVALVVLAVW 273
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
413-607 3.36e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 413 RNIWKNLLILGFTNFIAHAIRHCYQPVGG------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLT 486
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPplaeefGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 487 GIAsLVLLGLwdcehpiFPTVWaqqgnpnrdlneaAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALGA 566
Cdd:COG2223    81 GIG-LLLLAL-------AVSYW-------------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGN 139
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 2065532653 567 LGGLSG--PAQRLHMGHG---AFLqhVVLAACALLCILSIMLLPET 607
Cdd:COG2223   140 LGAAVAafLAPLLIAAFGwrnAFL--ILGILLLVVAVLAWLFLRDP 183
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
442-635 4.97e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 442 GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDCEHPIFPTVWaqqgnpnrdlneA 521
Cdd:cd06173    30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLL------------V 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 522 AITTFSVLG-LFSSQAAAILSTLLAAEVIPttvrgRGLGLIMALGALGGLSGPA-----QRLHMGHGAFLQHVVLAACAL 595
Cdd:cd06173    98 LAFLLGIASaFFGPARQALLPELVPKEQLV-----RANALNSLATQLARIIGPAlggllVALLGPGGAFAINALSFLLSA 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2065532653 596 LCILSImLLPETKRKLLPEVLRDGELCRRPSLLRQPPPTR 635
Cdd:cd06173   173 LLLLFI-RRPPPAAPGESSSLLLRDLREGLRYLRRSPLLR 211
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
397-610 5.88e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 397 PLPATSSFSFASLLnyRNIWKN-----LLILGFTNFIAHAIRHCYQPVGG----GGSPSDFYLCSLLASGTAALACVFLG 467
Cdd:COG2211   208 PVPEEEKVSLKESL--KALLKNrpfllLLLAYLLFFLALALVAALLLYYFkyvlGLSAALVGLLLALYFLAALLGAPLWP 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 468 VTVDRFGRRGILLLSMTLTGIASLVLLglwdcehpifptvWAQQGNPnrdlneAAITTFSVLGLFSSQAAAILSTLLAAE 547
Cdd:COG2211   286 RLAKRFGKKKAFIIGLLLAALGLLLLF-------------FLGPGNL------WLLLVLAALAGIGLGAILVLPWAMLAD 346
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 548 VIP-----TTVRGRG-----------LGLIMA-------LGALGGLSGPAQRLHMGHGAFLQHVVL-AACALLCILSIML 603
Cdd:COG2211   347 VVDydewkTGRRREGlyfgiftfaikLGQALAgalagllLALFGYVAGAAQSPSALTGIRLLFFLLpAVLLLLAALLLLF 426

                  ....*..
gi 2065532653 604 LPETKRK 610
Cdd:COG2211   427 YPLTRER 433
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
217-610 6.34e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 6.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPA----DRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVD--LGVYLMRLEL 290
Cdd:COG0738    47 LLLFAFFLGYLLASLPAgrliDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDvaANPYVAALGP 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 291 CDPTQRLRVALA----GELVG--VGGHFLFLGLALvskDWRFLQRMITAPCILFLFYGWpglflesarwlivkrqieeaq 364
Cdd:COG0738   127 ETAASRLNLLHAffslGALLGplLGGLLILLGLSL---SWHLPYLILAVLLLLLALLFL--------------------- 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 365 svLRILAERNRPHGQMLGEEAqealqdlentcplpatssfSFASLLNYRNIWKNLLIL--------GFTNFIAHAIRHcy 436
Cdd:COG0738   183 --RSKLPEIEEEEEEAAGSAA-------------------SLKSLLKNPRLLLGGLAIflyvgaegAIGDWLPLYLKD-- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 437 qpvGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLglwdcehpIFPTVWaqqgnpnr 516
Cdd:COG0738   240 ---VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--------LAPGPW-------- 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 517 dlneAAITTFSVLGLFssqAAAILSTL--LAAEVIPTTvRGRGLGLIMALGALGGLSGP------AQRLHMgHGAFLqhV 588
Cdd:COG0738   301 ----LALIGLALVGLG---LSLMFPTIfsLALDGLGKR-TAAAVSAVLIMGIVGGAIGPpligflADAFGL-RAAFL--V 369
                         410       420
                  ....*....|....*....|..
gi 2065532653 589 VLAACALLCILSIMLLPETKRK 610
Cdd:COG0738   370 PLVCYLLILLLALALKRKRRKK 391
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
217-493 6.40e-03

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 39.52  E-value: 6.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 217 LFILGFASGYLFLGYPADRFGRRGIVLL--TLGLVGPCGVG-GAAAGSSTGVMALRFLLGFlLAGVDLGVYLMRLELCDP 293
Cdd:cd17432    58 IFPLGGLFGSLLVGPLVIRLGRKGTLLLnnIFAIVAAILMGlSKIAKSFEMIIVGRFLVGI-NAGISLNVVPMYLGESAP 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 294 tQRLR--VALAGELVGVGGHFL--FLGL-ALVSKD--WRFLQRMITAPCIL-FLFYGWpglFLESARW-LIVKRQIEEAQ 364
Cdd:cd17432   137 -KNLRgaVGLVPAIFITLGILLgqVLGLrELLGNEegWPLLLALTGVPALLqLLTLPF---FPESPRYlLIEKGDEEAAR 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 365 SVLRILAERNRPHGQMlgEEAQEALQDLENTCPLPATSSFSFASLLnyrniWKNLLILgftnfiahAIRHCYQPvgGGGS 444
Cdd:cd17432   213 KALQRLRGKEDVDDEM--EEMLEEQRAEKGVGTVSVLELFRDRSVR-----WQLISII--------VLMAGQQL--CGIN 275
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2065532653 445 PSDFYLCSLLAS-------------GTAA---LACVFLGVTVDRFGRRGILLLSMTLTGIASLVL 493
Cdd:cd17432   276 AIYFYADSIFLEagipedkiqyvtvGTGAcevLATITCVLVIERLGRRPLLIGGFGLMAVWCAVL 340
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
218-608 8.44e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 38.82  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 218 FILGFAS---GYLFLGYPADRFGRRGIVLLTLGL--VGPCGVGGAAAGSSTGVMA-LRFLLGFLLAGVDLG-------VY 284
Cdd:cd17367    46 FAVGFLMrpiGGWLFGRLADRIGRRAALTLSVSLmaAGSLVIAVTPTYATIGIWApIILLLARLLQGLSVGgeygtsaTY 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 285 LMrlELCDPTQRLRVALAGELVGVGGHFLFLGLALVskdwrfLQRMITAPC-------ILFLFYGWPGLFLesarwLIVK 357
Cdd:cd17367   126 LS--EVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV------LQHTLGEDQmaawgwrIPFLLGGVLAVVV-----LWLR 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 358 RQIEEAQSVLRIlAERNRPHGQMLGEeaqealqdlentcplpatssfsfasLLNYRNiwKNLLILGFTnfIAHAIRHCYQ 437
Cdd:cd17367   193 RGLEETESFEAI-AESNEASAGTLRE-------------------------LRRHPR--ELLLVVGLT--AGGTLAFYTW 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 438 PVGG--------GGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLlsmtLTGIASLVLLglwdceHPIFPTVwa 509
Cdd:cd17367   243 TTYLqkflvntaGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLL----FFGIGGTLAT------VPLLSAL-- 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2065532653 510 qqgnpnrDLNEAAITTFSVL--GLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIMALG-ALGGLSGPA-----QRLHMGH 581
Cdd:cd17367   311 -------DHTDSPYTAFALVlvGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAvAIFGGTAPYvalwlKSIGHEW 383
                         410       420
                  ....*....|....*....|....*..
gi 2065532653 582 GAFLQHVVLAACALLCILsimLLPETK 608
Cdd:cd17367   384 VFFWYVAGLIAISLVVYL---RMPETR 407
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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