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Conserved domains on  [gi|1937891262|ref|NP_064472|]
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neurogenic locus notch homolog protein 3 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1620-1711 5.65e-51

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411987  Cd Length: 90  Bit Score: 174.94  E-value: 5.65e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1620 ERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1699
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1937891262 1700 GQDALGMKNMTK 1711
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2028 1.71e-40

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.42  E-value: 1.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1820 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1899
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1900 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1979
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1937891262 1980 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2028
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1507-1562 8.05e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 8.05e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1937891262 1507 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1562
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1579-1639 1.53e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.64  E-value: 1.53e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937891262 1579 VIGSVVMLEIDNRLCLKSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1639
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 160-197 1.02e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.72  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  160 DIDECRAGASCRHGGTCINTPGSFHCLCPLGYTGLLCE 197
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-848 3.76e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  812 DVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFC 848
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1423-1460 9.22e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 52.71  E-value: 9.22e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1423 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1460
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1476-1502 1.90e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.90e-08
                           10        20
                   ....*....|....*....|....*..
gi 1937891262 1476 YCADHFADGRCDQGCNTEECGWDGLDC 1502
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1382-1419 2.27e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.27e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1382 EVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDC 1419
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  471 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 507
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2029-2316 8.08e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 8.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGLGPLLC---PPGaflpglkavQSGTKKSRRPPGKTGL----GPQGTRGRGKKLTLAcPGPLADSSVTL 2101
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladPPP---------PPPTPEPAPHALVSATplppGPAAARQASPALPAA-PAPPAVPAGPA 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2102 SPVDSLDSPRP--FGGPPAS-PGGFPLEGPyATTATTVSLAQLGASR-AGPLGRQPPggcvlslgllnPVAVPLDWARLP 2177
Cdd:PHA03247  2750 TPGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPA-----------DPPAAVLAPAAA 2817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2178 PPAPPGPSFLLPLAPGSQllnPATPVSPHERPPPYLA-----APG-----HGEEYPAAGTHSSPTKARFLRVPSehPYLT 2247
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAQ---PTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVS 2892

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1937891262 2248 PSPESpehWASPSPPSLSDWSDSTPSPATATSATAAGALPaQPHPisvPSLPQSQTQLGPQPEVTPKRQ 2316
Cdd:PHA03247  2893 RSTES---FALPPDQPERPPQPQAPPPPQPQPQPPPPPQP-QPPP---PPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 393-431 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1937891262  393 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 431
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-545 6.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  509 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 545
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 851-886 6.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  851 DIDDCD-PNPCLNGGSCQDGVGSFSCSCLSGFAGPRC 886
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 433-469 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  433 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTFCE 469
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1173-1205 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1937891262 1173 DSGLRCLHNGTCVDLVGGFRCNCPPGYTGLHCE 1205
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-962 2.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.04e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  931 SPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQ 962
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 276-313 3.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  276 DVDECQlQPNACHNGGTCFNLLGGHSCVCVNGWTGESC 313
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1124-1160 3.05e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262 1124 DVDECASQ-PCQNGGSCIDLVAHYLCSCPPGTLGVLCE 1160
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-924 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  889 DVDECLS-SPCGP-GTCTDHVASFTCTCPPGYGGFHCE 924
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1087-1122 1.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262 1087 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYSGDSCE 1122
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-274 1.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  238 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 274
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 585-620 6.27e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  585 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 620
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-582 7.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  547 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 582
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 660-688 9.76e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 9.76e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1937891262  660 INECAS-SPCGEGGSCVDGENGFHCLCPPG 688
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-1000 4.39e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 4.39e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  965 VDPCFSR-PCLHGGICNPTHSGFECTCREGFTGNQCQ 1000
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 738-772 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1937891262  738 DACESQ-PCQAGGTCTSDGIGFHCTCAPGFQGHQCE 772
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 622-656 3.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  622 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 656
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 316-351 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  316 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 351
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-731 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1937891262  698 NHPCAHkpcsHGVCHDAPGGFQCVCEPGWSGPRC 731
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1620-1711 5.65e-51

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 174.94  E-value: 5.65e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1620 ERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1699
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1937891262 1700 GQDALGMKNMTK 1711
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2028 1.71e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.42  E-value: 1.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1820 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1899
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1900 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1979
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1937891262 1980 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2028
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1507-1562 8.05e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 8.05e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1937891262 1507 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1562
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1579-1639 1.53e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.64  E-value: 1.53e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937891262 1579 VIGSVVMLEIDNRLCLKSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1639
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1912-2004 4.74e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 4.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1912 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1991
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1937891262 1992 LLLDHFANREITD 2004
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1781-1994 2.10e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.69  E-value: 2.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1781 GMDVNVRGPDGFTPL--MLASFCggalepmpaeedeaddTSASIISDLICQGAQLGARtDRTGETALH--LAARYARADA 1856
Cdd:PHA03095   107 GADVNAKDKVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLAvlLKSRNANVEL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1857 AKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV--EGMVEELIASHA 1932
Cdd:PHA03095   170 LRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGI 248

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1933 DVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1994
Cdd:PHA03095   249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 160-197 1.02e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.72  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  160 DIDECRAGASCRHGGTCINTPGSFHCLCPLGYTGLLCE 197
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-848 3.76e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  812 DVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFC 848
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
160-197 7.20e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.02  E-value: 7.20e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   160 DIDECRAGASCRHGGTCINTPGSFHCLCPLGYT-GLLCE 197
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1423-1460 9.22e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 52.71  E-value: 9.22e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1423 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1460
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1427-1460 1.62e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1937891262 1427 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1460
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1476-1502 1.90e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.90e-08
                           10        20
                   ....*....|....*....|....*..
gi 1937891262 1476 YCADHFADGRCDQGCNTEECGWDGLDC 1502
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1382-1419 2.27e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.27e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1382 EVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDC 1419
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1386-1420 2.98e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.37  E-value: 2.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1937891262 1386 EPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCS 1420
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
812-849 7.40e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 7.40e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   812 DVDECAGASPCGPHGTCTNLPGSFRCICHGGYT-GPFCD 849
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  471 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 507
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2029-2316 8.08e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 8.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGLGPLLC---PPGaflpglkavQSGTKKSRRPPGKTGL----GPQGTRGRGKKLTLAcPGPLADSSVTL 2101
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladPPP---------PPPTPEPAPHALVSATplppGPAAARQASPALPAA-PAPPAVPAGPA 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2102 SPVDSLDSPRP--FGGPPAS-PGGFPLEGPyATTATTVSLAQLGASR-AGPLGRQPPggcvlslgllnPVAVPLDWARLP 2177
Cdd:PHA03247  2750 TPGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPA-----------DPPAAVLAPAAA 2817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2178 PPAPPGPSFLLPLAPGSQllnPATPVSPHERPPPYLA-----APG-----HGEEYPAAGTHSSPTKARFLRVPSehPYLT 2247
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAQ---PTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVS 2892

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1937891262 2248 PSPESpehWASPSPPSLSDWSDSTPSPATATSATAAGALPaQPHPisvPSLPQSQTQLGPQPEVTPKRQ 2316
Cdd:PHA03247  2893 RSTES---FALPPDQPERPPQPQAPPPPQPQPQPPPPPQP-QPPP---PPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 393-431 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1937891262  393 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 431
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1474-1502 3.77e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.77e-07
                            10        20
                    ....*....|....*....|....*....
gi 1937891262  1474 KKYCADHFADGRCDQGCNTEECGWDGLDC 1502
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-545 6.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  509 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 545
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 851-886 6.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  851 DIDDCD-PNPCLNGGSCQDGVGSFSCSCLSGFAGPRC 886
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
393-431 8.83e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.83e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1937891262   393 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 431
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 433-469 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  433 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTFCE 469
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-507 1.31e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   471 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSTCQ 507
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1173-1205 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1937891262 1173 DSGLRCLHNGTCVDLVGGFRCNCPPGYTGLHCE 1205
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-962 2.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.04e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  931 SPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQ 962
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 276-313 3.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  276 DVDECQlQPNACHNGGTCFNLLGGHSCVCVNGWTGESC 313
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1124-1160 3.05e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262 1124 DVDECASQ-PCQNGGSCIDLVAHYLCSCPPGTLGVLCE 1160
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
433-469 4.59e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.59e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   433 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFT-GTFCE 469
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-545 5.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.47e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   509 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCE 545
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1124-1160 1.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262  1124 DVDECAS-QPCQNGGSCIDLVAHYLCSCPPG-TLGVLCE 1160
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-924 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  889 DVDECLS-SPCGP-GTCTDHVASFTCTCPPGYGGFHCE 924
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1087-1122 1.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262 1087 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYSGDSCE 1122
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2014-2313 1.32e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2014 AQERLHQDIVRLLDQPSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQS-GTKKSRRPPGKT--GLGPQGTRGRGKKLT--- 2087
Cdd:pfam03154  162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTqsTAAPHTLIQQTPTLHpqr 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2088 LACPGPlADSSVTLSPVDSLDSPRPFGGP----PASPGGFPLEG-----PYATTATTVSLAQLGASRAGPLGRQPpggcv 2158
Cdd:pfam03154  242 LPSPHP-PLQPMTQPPPPSQVSPQPLPQPslhgQMPPMPHSLQTgpshmQHPVPPQPFPLTPQSSQSQVPPGPSP----- 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2159 lslgllnpvAVPLDWARLPPPAPPGPSFLLPLAPGSQLLNPATPVSPHERPPPYLAAPghgeEYPAAGTHSSPTKarfLR 2238
Cdd:pfam03154  316 ---------AAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIP----QLPNPQSHKHPPH---LS 379

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937891262 2239 VPSehPYLTPSpespehwASPSPPSLSDWSDSTPSPatatsataagalPAQPHPISVPSLPQSQtQLGPQPEVTP 2313
Cdd:pfam03154  380 GPS--PFQMNS-------NLPPPPALKPLSSLSTHH------------PPSAHPPPLQLMPQSQ-QLPPPPAQPP 432
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-274 1.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  238 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 274
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
851-886 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262   851 DIDDC-DPNPCLNGGSCQDGVGSFSCSCLSGF-AGPRC 886
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1874-2010 4.75e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1874 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1938
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937891262 1939 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDH---LDRLP 2010
Cdd:cd22192    131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA smart00179
Calcium-binding EGF-like domain;
1178-1205 5.23e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.23e-05
                            10        20
                    ....*....|....*....|....*....
gi 1937891262  1178 CLHNGTCVDLVGGFRCNCPPGYT-GLHCE 1205
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 585-620 6.27e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  585 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 620
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-962 7.16e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 7.16e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1937891262   931 SPSSCFNGGTCVDGVNSFSCLCRPGYT-GTHCQ 962
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-582 7.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  547 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 582
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-313 7.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 7.24e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   276 DVDECQlQPNACHNGGTCFNLLGGHSCVCVNGWT-GESC 313
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 660-688 9.76e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 9.76e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1937891262  660 INECAS-SPCGEGGSCVDGENGFHCLCPPG 688
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
659-688 1.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.22e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1937891262   659 EINECAS-SPCGEGGSCVDGENGFHCLCPPG 688
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
889-924 1.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.38e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   889 DVDECLS-SPCGPG-TCTDHVASFTCTCPPGY-GGFHCE 924
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1086-1122 3.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.25e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262  1086 EVDPC-TAQPCQHGGTCRGYMGGYVCECPAGYS-GDSCE 1122
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-1000 4.39e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 4.39e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  965 VDPCFSR-PCLHGGICNPTHSGFECTCREGFTGNQCQ 1000
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
393-424 5.36e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.36e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  393 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 424
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 855-885 6.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1937891262  855 CDPNPCLNGGSCQDGVGSFSCSCLSGFAGPR 885
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-274 6.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.87e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   238 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWT-GQFCT 274
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
585-620 8.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.70e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262   585 VDECRS-QPCRYGGKCLDLVDKYLCRCPPG-TTGVNCE 620
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
160-190 9.76e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 9.76e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  160 DIDECRAG-ASCRHGGTCINTPGSFHCLCPLG 190
Cdd:pfam07645    1 DVDECATGtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
276-307 1.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  276 DVDECQLQPNACHNGGTCFNLLGGHSCVCVNG 307
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1090-1119 1.10e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1937891262 1090 CTAQPCQHGGTCRGYMGGYVCECPAGYSGD 1119
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
547-582 1.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.47e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   547 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GIRCE 582
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 242-270 1.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|....*....
gi 1937891262  242 CPGHRCLNGGTCVDGVNTYNCQCPPEWTG 270
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 513-541 2.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.79e-03
                           10        20
                   ....*....|....*....|....*....
gi 1937891262  513 CASTPCRNGAKCVDQPDGYECRCAEGFEG 541
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1177-1203 3.14e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.14e-03
                           10        20
                   ....*....|....*....|....*..
gi 1937891262 1177 RCLHNGTCVDLVGGFRCNCPPGYTGLH 1203
Cdd:pfam00008    5 PCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 738-772 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1937891262  738 DACESQ-PCQAGGTCTSDGIGFHCTCAPGFQGHQCE 772
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 622-656 3.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  622 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 656
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 316-351 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  316 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 351
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-731 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1937891262  698 NHPCAHkpcsHGVCHDAPGGFQCVCEPGWSGPRC 731
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 818-845 6.39e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....*...
gi 1937891262  818 GASPCGPHGTCTNLPGSFRCICHGGYTG 845
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-580 8.91e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.91e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1937891262  551 CSPDPCHH-GRCVDGIASFSCACAPGYTGIR 580
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-345 9.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 9.52e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1937891262   316 NIDDCATA-VCFHGATCHDRVASFYCACPMG 345
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPG 31
 
Name Accession Description Interval E-value
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1620-1711 5.65e-51

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 174.94  E-value: 5.65e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1620 ERLDFPYPLRDVRGEPLEPPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKDIAagHKGRREPV 1699
Cdd:cd21704      1 ERLEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESS--NKNRREPV 78

                           90
                   ....*....|..
gi 1937891262 1700 GQDALGMKNMTK 1711
Cdd:cd21704     79 GQDALGMKHIAK 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2028 1.71e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 152.42  E-value: 1.71e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1820 ASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRsT 1899
Cdd:COG0666     33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAG-A 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1900 DLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLF 1979
Cdd:COG0666    112 DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLH 191

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1937891262 1980 LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLDQ 2028
Cdd:COG0666    192 LAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1815-2026 2.45e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.56  E-value: 2.45e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1815 ADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILI 1894
Cdd:COG0666     61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1895 RNRStDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKE 1974
Cdd:COG0666    141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1975 ETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2026
Cdd:COG0666    220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1822-2026 7.96e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 127.38  E-value: 7.96e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1822 IISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDL 1901
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLL-AAGADI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1902 DARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1981
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1937891262 1982 AREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2026
Cdd:COG0666    161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1625-1709 9.68e-32

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 119.79  E-value: 9.68e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1625 PYPLRDVRGEPLE--PPEQSVPLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKdiAAGHKGRREPVGQD 1702
Cdd:cd21701      1 PYPIYSVRSEPGPatKTTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRRHGTLWFPEGFPRTR--ASRRSRRRDPVGQD 78


                   ....*..
gi 1937891262 1703 ALGMKNM 1709
Cdd:cd21701     79 SVGLKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1759-2009 1.07e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 1.07e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1759 AADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGgalepmpaeedeaddtSASIISDLICQGAQLGARtD 1838
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG----------------DLEIVKLLLEAGADVNAR-D 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1839 RTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIrNRSTDLDARMADGSTALILAARL 1918
Cdd:COG0666    118 KDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL-EAGADVNARDNDGETPLHLAAEN 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1919 AVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFA 1998
Cdd:COG0666    197 GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276

                          250
                   ....*....|.
gi 1937891262 1999 NREITDHLDRL 2009
Cdd:COG0666    277 LLAAALLDLLT 287
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1625-1709 1.90e-29

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 113.32  E-value: 1.90e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1625 PYPLRDVRGEPLEPPEQSvpLLPLLVAGAVFLLVIFVLGVMVARRKREHSTLWFPEGFALHKDiAAGHKgRREPVGQDAL 1704
Cdd:cd21703      2 PYPLVSVTSEPLKETKFN--LLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKE-NSNRK-RREPVGQDAV 77


                   ....*
gi 1937891262 1705 GMKNM 1709
Cdd:cd21703     78 GMKNL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1779-1978 7.73e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.96  E-value: 7.73e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1779 ADGMDVNVRGPDGFTPLMLASFCGgalepmpaeedeaddtSASIISDLICQGAQLGARtDRTGETALHLAARYARADAAK 1858
Cdd:COG0666    108 EAGADVNARDKDGETPLHLAAYNG----------------NLEIVKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVK 170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1859 RLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVD 1938
Cdd:COG0666    171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1937891262 1939 ELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPL 1978
Cdd:COG0666    250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1507-1562 8.05e-22

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 90.65  E-value: 8.05e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1937891262 1507 PALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDARGQAMVFPYHR 1562
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1579-1639 1.53e-21

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 89.64  E-value: 1.53e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937891262 1579 VIGSVVMLEIDNRLCLKSAenDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPLEPP 1639
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1631-1707 2.07e-17

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 78.68  E-value: 2.07e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1937891262 1631 VRGEPLEPPEQSvPLLPLLVAGAVFLLVIFV-LGVMVAR-RKREHSTLWFPEGFalhKDIAAGHKGRREPVGQDALGMK 1707
Cdd:cd21702      2 VKSETVEPPPPS-QLYPMYVVLAALVLLAFVgVGVLVSRkRRREHGQLWFPEGF---KVSEPSKKKRREPVGEDSVGLK 76
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1912-2004 4.74e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 78.23  E-value: 4.74e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1912 LILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNgANKDMQDSKeETPLFLAAREGSYEAAK 1991
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1937891262 1992 LLLDHFANREITD 2004
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1781-1994 2.10e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.69  E-value: 2.10e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1781 GMDVNVRGPDGFTPL--MLASFCggalepmpaeedeaddTSASIISDLICQGAQLGARtDRTGETALH--LAARYARADA 1856
Cdd:PHA03095   107 GADVNAKDKVGRTPLhvYLSGFN----------------INPKVIRLLLRKGADVNAL-DLYGMTPLAvlLKSRNANVEL 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1857 AKRLLDAGADTNAQDHSGRTPLHT-AVTADA-QGVFQILIRnRSTDLDARMADGSTALILAARLAV--EGMVEELIASHA 1932
Cdd:PHA03095   170 LRLLIDAGADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGI 248

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1933 DVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1994
Cdd:PHA03095   249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1624-1707 1.37e-15

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 73.97  E-value: 1.37e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1624 FPYPLRDVRGEPLEPPEQSV------PLLPLLVAGAVFLLVIFVLGVMVAR-RKREHSTLWFPEGFALHKDiAAGHKgRR 1696
Cdd:cd21705      1 LPFPLLAVTVEEAEKDPQLVaaqlpwPLVCSSVAGVLALVLGALLGVQLIRrRQREHGALWLPPGFARHRD-PNPHR-RR 78

                           90
                   ....*....|.
gi 1937891262 1697 EPVGQDALGMK 1707
Cdd:cd21705     79 EPVGEDAIGLK 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1945-2026 7.32e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.99  E-value: 7.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1945 LHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDhlDRLPRDVAQERLHQDIVR 2024
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78


                   ..
gi 1937891262 2025 LL 2026
Cdd:pfam12796   79 LL 80
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 1625-1712 1.72e-12

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 64.97  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1625 PYPLRDVRGE--PLEPPEQSVPLLPLLVAGAVFLLVI-FVLGVMV-ARRKREHSTLWFPEGFALHK-DIAAGHKGRREPV 1699
Cdd:cd21706      1 DFPIYQVRGEdpPDPPPEPPPSNLTYVVIGVVVVLLIgLLLGVLVtTQRKRARGITWFPEGFFTTSsSQRRRRSRRRGPD 80

                           90
                   ....*....|...
gi 1937891262 1700 GQDalgMKNMTKG 1712
Cdd:cd21706     81 GQE---MRNLKKQ 90
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1811-2001 9.49e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 69.91  E-value: 9.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1811 EEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVF 1890
Cdd:PHA02878   138 KKSKDDIIEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIV 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1891 QILIRNRSTdLDARMADGSTAL-ILAARLAVEGMVEELIASHADVNAVDE-LGKSALHwaAAVNNVEATLALLKNGANKD 1968
Cdd:PHA02878   218 HILLENGAS-TDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADIN 294

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1937891262 1969 MQDSKEETPLFLAAREGS-YEAAKLLLDHFANRE 2001
Cdd:PHA02878   295 SLNSYKLTPLSSAVKQYLcINIGRILISNICLLK 328
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1860-2001 4.24e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 68.55  E-value: 4.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGM-VEELIASHADVNAVD 1938
Cdd:PHA02876   259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAAD 338

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1937891262 1939 ELGKSALHWAAAVN-NVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANRE 2001
Cdd:PHA02876   339 RLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIE 402
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1860-1971 6.34e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 6.34e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAvtadaqgvfqilIRNRSTDldarmadgstalilaarlavegMVEELIaSHADVNAVDE 1939
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLA------------AKNGHLE----------------------IVKLLL-EHADVNLKDN 60

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1937891262 1940 lGKSALHWAAAVNNVEATLALLKNGANKDMQD 1971
Cdd:pfam12796   61 -GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1860-1999 5.32e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 64.28  E-value: 5.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAV---TADAQGVFQILIRNrSTDLDARMADGSTALILAARLA-VEGMVEELIASHADVN 1935
Cdd:PHA03095    33 LLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGADVN 111

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937891262 1936 AVDELGKSALHWAAAVNNVEATL--ALLKNGANKDMQDSKEETPL--FLAAREGSYEAAKLLLDHFAN 1999
Cdd:PHA03095   112 AKDKVGRTPLHVYLSGFNINPKVirLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1860-2026 7.56e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.47  E-value: 7.56e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVT-ADAQGVFQILIRNRSTDlDARMADGSTALILAARLAVEGMVEELIASHADVNAVD 1938
Cdd:PHA02875    54 LMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFAD-DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPN 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1939 ELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANreiTDHLDRLPrDV----- 2013
Cdd:PHA02875   133 TDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN---IDYFGKNG-CVaalcy 208

                          170
                   ....*....|...
gi 1937891262 2014 AQERLHQDIVRLL 2026
Cdd:PHA02875   209 AIENNKIDIVRLF 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 160-197 1.02e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.72  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  160 DIDECRAGASCRHGGTCINTPGSFHCLCPLGYTGLLCE 197
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 812-848 3.76e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.79  E-value: 3.76e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  812 DVDECAGASPCGPHGTCTNLPGSFRCICHGGYTGPFC 848
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
160-197 7.20e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 53.02  E-value: 7.20e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   160 DIDECRAGASCRHGGTCINTPGSFHCLCPLGYT-GLLCE 197
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1423-1460 9.22e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 52.71  E-value: 9.22e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1423 VDDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1460
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1427-1460 1.62e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.62e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1937891262 1427 WRQCEALQCWRLFNNSRCDPACSSPACLYDNFDC 1460
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDC 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
1943-1994 1.86e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 52.28  E-value: 1.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1943 SALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1994
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1476-1502 1.90e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.76  E-value: 1.90e-08
                           10        20
                   ....*....|....*....|....*..
gi 1937891262 1476 YCADHFADGRCDQGCNTEECGWDGLDC 1502
Cdd:pfam00066    8 YCWDKFGNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1382-1419 2.27e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.27e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262  1382 EVPEEPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDC 1419
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1386-1420 2.98e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 51.37  E-value: 2.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1937891262 1386 EPRCPRAACQAKRGDQNCDRECNSPGCGWDGGDCS 1420
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1748-1981 3.19e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 3.19e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1748 DCRQWTQHHLVAAdirvaPAMALTPPQgdADADGMDVNVRGPDGFTPLMLASFCGGALEPmpaeedeaddtsasiISDLI 1827
Cdd:PHA02876   271 DCKNTPLHHASQA-----PSLSRLVPK--LLERGADVNAKNIKGETPLYLMAKNGYDTEN---------------IRTLI 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1828 CQGAQLGArTDRTGETALHLAARYARADAAK-RLLDAGADTNAQDHSGRTPLHTAVTADAqgvfqILIRNRSTDLDARMA 1906
Cdd:PHA02876   329 MLGADVNA-ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNN-----VVIINTLLDYGADIE 402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1907 DGSTALILAARLAVEGM-----VEELIASHADVNAVDELGKSALHWAAAVN-NVEATLALLKNGANKDMQDSKEETPLFL 1980
Cdd:PHA02876   403 ALSQKIGTALHFALCGTnpymsVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLI 482


                   .
gi 1937891262 1981 A 1981
Cdd:PHA02876   483 A 483
EGF_CA smart00179
Calcium-binding EGF-like domain;
812-849 7.40e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.32  E-value: 7.40e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   812 DVDECAGASPCGPHGTCTNLPGSFRCICHGGYT-GPFCD 849
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-507 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  471 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFSGSTCQ 507
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2029-2316 8.08e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.41  E-value: 8.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGLGPLLC---PPGaflpglkavQSGTKKSRRPPGKTGL----GPQGTRGRGKKLTLAcPGPLADSSVTL 2101
Cdd:PHA03247  2680 PQRPRRRAARPTVGSLTSladPPP---------PPPTPEPAPHALVSATplppGPAAARQASPALPAA-PAPPAVPAGPA 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2102 SPVDSLDSPRP--FGGPPAS-PGGFPLEGPyATTATTVSLAQLGASR-AGPLGRQPPggcvlslgllnPVAVPLDWARLP 2177
Cdd:PHA03247  2750 TPGGPARPARPptTAGPPAPaPPAAPAAGP-PRRLTRPAVASLSESReSLPSPWDPA-----------DPPAAVLAPAAA 2817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2178 PPAPPGPSFLLPLAPGSQllnPATPVSPHERPPPYLA-----APG-----HGEEYPAAGTHSSPTKARFLRVPSehPYLT 2247
Cdd:PHA03247  2818 LPPAASPAGPLPPPTSAQ---PTAPPPPPGPPPPSLPlggsvAPGgdvrrRPPSRSPAAKPAAPARPPVRRLAR--PAVS 2892

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1937891262 2248 PSPESpehWASPSPPSLSDWSDSTPSPATATSATAAGALPaQPHPisvPSLPQSQTQLGPQPEVTPKRQ 2316
Cdd:PHA03247  2893 RSTES---FALPPDQPERPPQPQAPPPPQPQPQPPPPPQP-QPPP---PPPPRPQPPLAPTTDPAGAGE 2954
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 393-431 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1937891262  393 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYTGPRCE 431
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1860-1999 1.80e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 1.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRN----------------------RSTDLDARMADGSTALILAAR 1917
Cdd:PHA02874    54 FIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNgvdtsilpipciekdmiktildCGIDVNIKDAELKTFLHYAIK 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1918 LAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHF 1997
Cdd:PHA02874   134 KGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213


                   ..
gi 1937891262 1998 AN 1999
Cdd:PHA02874   214 NH 215
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1474-1502 3.77e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.77e-07
                            10        20
                    ....*....|....*....|....*....
gi 1937891262  1474 KKYCADHFADGRCDQGCNTEECGWDGLDC 1502
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1837-1975 4.10e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.64  E-value: 4.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1837 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrstdldARMADGSTA---LI 1913
Cdd:PLN03192   554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHF------ASISDPHAAgdlLC 627

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1914 LAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEE 1975
Cdd:PLN03192   628 TAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 509-545 6.11e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  509 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFEGTLCE 545
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 851-886 6.29e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  851 DIDDCD-PNPCLNGGSCQDGVGSFSCSCLSGFAGPRC 886
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2029-2313 8.26e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 8.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGLGPLLCPPgafLPGLKAVQSgtkKSRRPpgktGLGPQGTRGR------GKKLTLACPGPLADSSVTLS 2102
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAP---RPSEPAVTS---RARRP----DAPPQSARPRapvddrGDPRGPAPPSPLPPDTHAPD 2625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2103 PVDSLDSPRPF--GGPPASPGGFPLEGPYATTATTVSLAQLGASRA------GPLGRQPPGGCVLSLGLLNPVAVPLDWA 2174
Cdd:PHA03247  2626 PPPPSPSPAANepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGraaqasSPPQRPRRRAARPTVGSLTSLADPPPPP 2705

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2175 RLPPPAPPGPSFLLPLAPGSQLLN---PATPVSPHERPPPYLAA-PGHGEEYPAAGTHSSPTKARFLRVPSEHP--YLTP 2248
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARqasPALPAAPAPPAVPAGPAtPGGPARPARPPTTAGPPAPAPPAAPAAGPprRLTR 2785

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937891262 2249 ---SPESPEHWASPSPPSLSDWSDSTPSPATATSATAAGALPAQPHPISVPSLPQSQTqlGPQPEVTP 2313
Cdd:PHA03247  2786 pavASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP--GPPPPSLP 2851
EGF_CA smart00179
Calcium-binding EGF-like domain;
393-431 8.83e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.83e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1937891262   393 DVDECSIGaNPCEHLGRCVNTQGSFLCQCGRGYT-GPRCE 431
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 433-469 1.03e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  433 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFTGTFCE 469
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1860-1915 1.25e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.34  E-value: 1.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1937891262 1860 LLDAG-ADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRStDLDARMADGSTALILA 1915
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
471-507 1.31e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.31e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   471 DIDECQS-SPCVNGGVCKDRVNGFSCTCPSGFS-GSTCQ 507
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1173-1205 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.52e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1937891262 1173 DSGLRCLHNGTCVDLVGGFRCNCPPGYTGLHCE 1205
Cdd:cd00054      6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1860-2004 1.92e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALilaaRLAVEG------MVEELIASHA 1932
Cdd:PHA03100    92 LLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeYLLDNGANVNIKNSDGENLL----HLYLESnkidlkILKLLIDKGV 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1933 DVNA----------------VDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1996
Cdd:PHA03100   168 DINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247


                   ....*...
gi 1937891262 1997 FANREITD 2004
Cdd:PHA03100   248 GPSIKTII 255
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 931-962 2.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.04e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  931 SPSSCFNGGTCVDGVNSFSCLCRPGYTGTHCQ 962
Cdd:cd00054      7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1860-1999 2.91e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.36  E-value: 2.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTN--AQDHSGRTPLHTAVTADAQGVFQI--LIRNRSTDLDARMADGSTALILAARLAVEG--MVEELIASHAD 1933
Cdd:PHA03100    54 LLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIvkLLLEYGANVNAPDNNGITPLLYAISKKSNSysIVEYLLDNGAN 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1934 VNAVDELGKSALHWAAAVNNVEATLA------------------LLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLD 1995
Cdd:PHA03100   134 VNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD 213


                   ....
gi 1937891262 1996 HFAN 1999
Cdd:PHA03100   214 LGAN 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 276-313 3.02e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.02e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  276 DVDECQlQPNACHNGGTCFNLLGGHSCVCVNGWTGESC 313
Cdd:cd00054      1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1124-1160 3.05e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.05e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262 1124 DVDECASQ-PCQNGGSCIDLVAHYLCSCPPGTLGVLCE 1160
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
433-469 4.59e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.59e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   433 DVNECLSG-PCRNQATCLDRIGQFTCICMAGFT-GTFCE 469
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
509-545 5.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.47e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   509 DVDECAST-PCRNGAKCVDQPDGYECRCAEGFE-GTLCE 545
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1860-1994 6.38e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 51.79  E-value: 6.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNrSTDLDARMADGSTAL---ILAARLAVEGMVEELiASHADVNA 1936
Cdd:PLN03192   544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNTALwnaISAKHHKIFRILYHF-ASISDPHA 621

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1937891262 1937 VDELgksaLHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLL 1994
Cdd:PLN03192   622 AGDL----LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1781-1962 9.63e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 9.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1781 GMDVNVRGPDGFTPL--MLASfcggalepmpaeedeaDDTSASIISDLICQGAQLGARTDRtGETALH--LAARYARADA 1856
Cdd:PHA03095   142 GADVNALDLYGMTPLavLLKS----------------RNANVELLRLLIDAGADVYAVDDR-FRSLLHhhLQSFKPRARI 204

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1857 AKRLLDAGADTNAQDHSGRTPLHTAVTADAQG---VFQILIRNrsTDLDARMADGSTALILAARLAVEGMVEELIASHAD 1933
Cdd:PHA03095   205 VRELIRAGCDPAATDMLGNTPLHSMATGSSCKrslVLPLLIAG--ISINARNRYGQTPLHYAAVFNNPRACRRLIALGAD 282

                          170       180
                   ....*....|....*....|....*....
gi 1937891262 1934 VNAVDELGKSALHWAAAVNNVEATLALLK 1962
Cdd:PHA03095   283 INAVSSDGNTPLSLMVRNNNGRAVRAALA 311
EGF_CA smart00179
Calcium-binding EGF-like domain;
1124-1160 1.11e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262  1124 DVDECAS-QPCQNGGSCIDLVAHYLCSCPPG-TLGVLCE 1160
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 889-924 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  889 DVDECLS-SPCGP-GTCTDHVASFTCTCPPGYGGFHCE 924
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1087-1122 1.14e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262 1087 VDPC-TAQPCQHGGTCRGYMGGYVCECPAGYSGDSCE 1122
Cdd:cd00054      2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2014-2313 1.32e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2014 AQERLHQDIVRLLDQPSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQS-GTKKSRRPPGKT--GLGPQGTRGRGKKLT--- 2087
Cdd:pfam03154  162 AQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPqGSPATSQPPNQTqsTAAPHTLIQQTPTLHpqr 241

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2088 LACPGPlADSSVTLSPVDSLDSPRPFGGP----PASPGGFPLEG-----PYATTATTVSLAQLGASRAGPLGRQPpggcv 2158
Cdd:pfam03154  242 LPSPHP-PLQPMTQPPPPSQVSPQPLPQPslhgQMPPMPHSLQTgpshmQHPVPPQPFPLTPQSSQSQVPPGPSP----- 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2159 lslgllnpvAVPLDWARLPPPAPPGPSFLLPLAPGSQLLNPATPVSPHERPPPYLAAPghgeEYPAAGTHSSPTKarfLR 2238
Cdd:pfam03154  316 ---------AAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIP----QLPNPQSHKHPPH---LS 379

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1937891262 2239 VPSehPYLTPSpespehwASPSPPSLSDWSDSTPSPatatsataagalPAQPHPISVPSLPQSQtQLGPQPEVTP 2313
Cdd:pfam03154  380 GPS--PFQMNS-------NLPPPPALKPLSSLSTHH------------PPSAHPPPLQLMPQSQ-QLPPPPAQPP 432
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1892-2026 1.39e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 50.64  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1892 ILIRNRSTDLDARMAdgsTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQD 1971
Cdd:PLN03192   512 LLGDNGGEHDDPNMA---SNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRD 588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1972 SKEETPLF-------------------------------LAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQ 2020
Cdd:PLN03192   589 ANGNTALWnaisakhhkifrilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHV 668


                   ....*.
gi 1937891262 2021 DIVRLL 2026
Cdd:PLN03192   669 DMVRLL 674
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 238-274 1.44e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 1.44e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  238 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCT 274
Cdd:cd00054      1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1931-1981 1.54e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.26  E-value: 1.54e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1937891262 1931 HADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLA 1981
Cdd:pfam13857    6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
851-886 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.63e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262   851 DIDDC-DPNPCLNGGSCQDGVGSFSCSCLSGF-AGPRC 886
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1838-2023 1.78e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1838 DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTdLDARMADGSTALILAAR 1917
Cdd:PHA02874   121 DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAE 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1918 LAVEGMVEELIASHADVNAVDELGKSALHWAAAVNnvEATLALLKNGANKDMQDSKEETPLFLAAR-EGSYEAAKLLLDH 1996
Cdd:PHA02874   200 YGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYH 277

                          170       180
                   ....*....|....*....|....*..
gi 1937891262 1997 FANREITDHLDRLPRDVAQERLHQDIV 2023
Cdd:PHA02874   278 KADISIKDNKGENPIDTAFKYINKDPV 304
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1876-1996 4.69e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.74  E-value: 4.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1876 TPLHTAVTADAqgVFQILIRNRSTDLDARMADGSTaliLAARLavegmveeLIASHADVNAVDELGKSALHWAAAVNNVE 1955
Cdd:PTZ00322    63 TPDHNLTTEEV--IDPVVAHMLTVELCQLAASGDA---VGARI--------LLTGGADPNCRDYDGRTPLHIACANGHVQ 129

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1937891262 1956 ATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDH 1996
Cdd:PTZ00322   130 VVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1874-2010 4.75e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1874 GRTPLHTAVTADAQGVFQILIRNRSTDLDARMA----DGSTALILAARLAVEGMVEELIASHADVNA-----------VD 1938
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPELVNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSpratgtffrpgPK 130

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937891262 1939 EL---GKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDH---LDRLP 2010
Cdd:cd22192    131 NLiyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
Ank_4 pfam13637
Ankyrin repeats (many copies);
1908-1961 4.95e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 4.95e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1937891262 1908 GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALL 1961
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA smart00179
Calcium-binding EGF-like domain;
1178-1205 5.23e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 5.23e-05
                            10        20
                    ....*....|....*....|....*....
gi 1937891262  1178 CLHNGTCVDLVGGFRCNCPPGYT-GLHCE 1205
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1860-2026 5.62e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 48.34  E-value: 5.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1860 LLDAGADTNAQDHSGRTPLHTAVTA-DAQGVFQILIRNRSTDLDARMADGSTA----------LILAARL---------- 1918
Cdd:PHA02878    56 LLTRGHNVNQPDHRDLTPLHIICKEpNKLGMKEMIRSINKCSVFYTLVAIKDAfnnrnveifkIILTNRYkniqtidlvy 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1919 --------AVEGMVEELIASH-ADVNAVDE-LGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYE 1988
Cdd:PHA02878   136 idkkskddIIEAEITKLLLSYgADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKP 215

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1937891262 1989 AAKLLLDHFANREITDHLDRLPRDVAQERLHQ-DIVRLL 2026
Cdd:PHA02878   216 IVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLL 254
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 585-620 6.27e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 6.27e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  585 VDECRSQ-PCRYGGKCLDLVDKYLCRCPPGTTGVNCE 620
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
931-962 7.16e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 7.16e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1937891262   931 SPSSCFNGGTCVDGVNSFSCLCRPGYT-GTHCQ 962
Cdd:smart00179    7 SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 547-582 7.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 7.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1937891262  547 NVDDC-SPDPC-HHGRCVDGIASFSCACAPGYTGIRCE 582
Cdd:cd00054      1 DIDECaSGNPCqNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-313 7.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 7.24e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   276 DVDECQlQPNACHNGGTCFNLLGGHSCVCVNGWT-GESC 313
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 660-688 9.76e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 9.76e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1937891262  660 INECAS-SPCGEGGSCVDGENGFHCLCPPG 688
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPG 31
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1946-2026 1.15e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.59  E-value: 1.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1946 HWAAAVNNVEATLaLLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRL 2025
Cdd:PTZ00322    88 QLAASGDAVGARI-LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                   .
gi 1937891262 2026 L 2026
Cdd:PTZ00322   167 L 167
EGF_CA smart00179
Calcium-binding EGF-like domain;
659-688 1.22e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.22e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1937891262   659 EINECAS-SPCGEGGSCVDGENGFHCLCPPG 688
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
889-924 1.38e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.38e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   889 DVDECLS-SPCGPG-TCTDHVASFTCTCPPGY-GGFHCE 924
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYtDGRNCE 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1804-2027 1.67e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1804 ALEPMPAEEDEADDTSASIISDLICQGAQLGARtDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVT 1883
Cdd:PHA02876   142 SIEYMKLIKERIQQDELLIAEMLLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVD 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1884 ADAQGVFQILIRNRS----TDLDARMADGSTALILAARLAVEGMveeliashaDVNAVDELGKSALHWAAAVNNVEATL- 1958
Cdd:PHA02876   221 SKNIDTIKAIIDNRSninkNDLSLLKAIRNEDLETSLLLYDAGF---------SVNSIDDCKNTPLHHASQAPSLSRLVp 291

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1959 ALLKNGANKDMQDSKEETPLFLAAREG-SYEAAKLLLDHFANREITDHLDRLPRDVAQ--ERLHQDIVRLLD 2027
Cdd:PHA02876   292 KLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 163-193 1.81e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.54  E-value: 1.81e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1937891262  163 ECRAGASCRHGGTCINTPGSFHCLCPLGYTG 193
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 815-847 2.16e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.54  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1937891262  815 ECAGASPCGPHGTCTNLPGSFRCICHGGYTGPF 847
Cdd:cd00053      1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2028-2299 2.99e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 2.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2028 QPSGPRSPSGPHGLGPLLCPPGAFLPGLKA--------------VQSGTKKSRRPPGKTGLGPQGTRGRGKKLTLACPGP 2093
Cdd:PHA03247  2594 QSARPRAPVDDRGDPRGPAPPSPLPPDTHApdppppspspaanePDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA 2673

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2094 LADSSV-----------TLSPVDSLDSPRPFGGPPASPGGFPLEGPYATTATTVSLAQLGASRAGPLGRQPPGGCVLSLG 2162
Cdd:PHA03247  2674 AQASSPpqrprrraarpTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2163 LLNPVAVPLdwarlpppappgpsfllPLAPGSqllnPATPVSPHERPPPYLAAPGHGEEYPAAGTHSSPtkarflRVPSE 2242
Cdd:PHA03247  2754 PARPARPPT-----------------TAGPPA----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSP------WDPAD 2806

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937891262 2243 HPYLTPSPESPEHW----ASPSPPSLSdwsdstpspatatsATAAGalPAQPHPISVPSLP 2299
Cdd:PHA03247  2807 PPAAVLAPAAALPPaaspAGPLPPPTS--------------AQPTA--PPPPPGPPPPSLP 2851
EGF_CA smart00179
Calcium-binding EGF-like domain;
1086-1122 3.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.25e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262  1086 EVDPC-TAQPCQHGGTCRGYMGGYVCECPAGYS-GDSCE 1122
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 965-1000 4.39e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 4.39e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  965 VDPCFSR-PCLHGGICNPTHSGFECTCREGFTGNQCQ 1000
Cdd:cd00054      2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 2099-2317 4.44e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 4.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2099 VTLSPVDSLdsprpFGGPPASPG----------GFPLEGPYATTATTVSLAQLGASRAGPLGRQPPggcvlSLGLLNPVA 2168
Cdd:PRK10263   285 VAADPDDVL-----FSGNRATQPeydeydpllnGAPITEPVAVAAAATTATQSWAAPVEPVTQTPP-----VASVDVPPA 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2169 VP-LDWARlpppappgpsfllplAPGSQLLNPATPVSPHERPP-PYLAAPG--HGEEYPAAGTHSSPTKARFLRVPSEHP 2244
Cdd:PRK10263   355 QPtVAWQP---------------VPGPQTGEPVIAPAPEGYPQqSQYAQPAvqYNEPLQQPVQPQQPYYAPAAEQPAQQP 419

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1937891262 2245 YLTPSPESPEHWASPSPPSLSDWSDSTPSPATATSATAAGAL--PAQPHPISVPSLPQSQTQ--LGPQPEVTPKRQV 2317
Cdd:PRK10263   420 YYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTyqTEQTYQQPAAQEPLYQQPqpVEQQPVVEPEPVV 496
EGF_CA pfam07645
Calcium-binding EGF domain;
393-424 5.36e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.14  E-value: 5.36e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  393 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRG 424
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1918-2046 5.71e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1918 LAVEGMVEELIASHADVNAvdelgKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHF 1997
Cdd:PLN03192   507 LNVGDLLGDNGGEHDDPNM-----ASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1937891262 1998 ANREITDHLDRLPRDVAQERLHQDIVRLLDQPSgprSPSGPHGLGPLLC 2046
Cdd:PLN03192   582 CNVHIRDANGNTALWNAISAKHHKIFRILYHFA---SISDPHAAGDLLC 627
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2029-2269 6.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 6.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGlgPLLCPPGAFLPGLKAVQSGTKKSRRPPGKTGLGPQGTRGRGKKL-TLACPGPLADSSVTLSPVDSL 2107
Cdd:PHA03247  2763 TAGPPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALpPAASPAGPLPPPTSAQPTAPP 2840

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2108 DSPRPFGGPPASPGGFPLEGPYATTATTVSLAQLGASRAGPLGRQppggcvLSLGLLNPVAVPLDWARLPPPAPPGPSFL 2187
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR------LARPAVSRSTESFALPPDQPERPPQPQAP 2914

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2188 LPLAPGSQLLNPATPvSPHERPPPYLAAPGHGEEYPAAGTHSS---PTKARFLRVPSEHP---YLTPSPESPEHWASPSP 2261
Cdd:PHA03247  2915 PPPQPQPQPPPPPQP-QPPPPPPPRPQPPLAPTTDPAGAGEPSgavPQPWLGALVPGRVAvprFRVPQPAPSREAPASST 2993


                   ....*...
gi 1937891262 2262 PSLSDWSD 2269
Cdd:PHA03247  2994 PPLTGHSL 3001
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 855-885 6.78e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 6.78e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1937891262  855 CDPNPCLNGGSCQDGVGSFSCSCLSGFAGPR 885
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
238-274 6.87e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 6.87e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   238 NVDDC-PGHRCLNGGTCVDGVNTYNCQCPPEWT-GQFCT 274
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
585-620 8.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 8.70e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1937891262   585 VDECRS-QPCRYGGKCLDLVDKYLCRCPPG-TTGVNCE 620
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
160-190 9.76e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 9.76e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  160 DIDECRAG-ASCRHGGTCINTPGSFHCLCPLG 190
Cdd:pfam07645    1 DVDECATGtHNCPANTVCVNTIGSFECRCPDG 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1810-1903 9.89e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 9.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1810 AEEDEADDTSASIISDLICQ----GAQLGART-----------DRTGETALHLAARYARADAAKRLLDAGADTNAQDHSG 1874
Cdd:PTZ00322    69 TTEEVIDPVVAHMLTVELCQlaasGDAVGARIlltggadpncrDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDG 148

                           90       100
                   ....*....|....*....|....*....
gi 1937891262 1875 RTPLHTAVTADAQGVFQILIRNRSTDLDA 1903
Cdd:PTZ00322   149 KTPLELAEENGFREVVQLLSRHSQCHFEL 177
EGF_CA pfam07645
Calcium-binding EGF domain;
276-307 1.02e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 1.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1937891262  276 DVDECQLQPNACHNGGTCFNLLGGHSCVCVNG 307
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1090-1119 1.10e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 1.10e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1937891262 1090 CTAQPCQHGGTCRGYMGGYVCECPAGYSGD 1119
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1891-2026 1.17e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.80  E-value: 1.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1891 QILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGA----- 1965
Cdd:PHA02874    18 EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsil 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1937891262 1966 -----NKDM-------------QDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLL 2026
Cdd:PHA02874    98 pipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLL 176
EGF_CA smart00179
Calcium-binding EGF-like domain;
547-582 1.47e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.47e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1937891262   547 NVDDC-SPDPCHHG-RCVDGIASFSCACAPGYT-GIRCE 582
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 242-270 1.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.98e-03
                           10        20
                   ....*....|....*....|....*....
gi 1937891262  242 CPGHRCLNGGTCVDGVNTYNCQCPPEWTG 270
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1839-1969 2.11e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 2.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1839 RTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTdLDARMADGSTALILAARL 1918
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAK 178

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1937891262 1919 AVEGMVEELIASHADVNAVDELGKSALHWAAAVNN-VEATLALLKNGANKDM 1969
Cdd:PHA02875   179 GDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNkIDIVRLFIKRGADCNI 230
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 513-541 2.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.79e-03
                           10        20
                   ....*....|....*....|....*....
gi 1937891262  513 CASTPCRNGAKCVDQPDGYECRCAEGFEG 541
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1177-1203 3.14e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.14e-03
                           10        20
                   ....*....|....*....|....*..
gi 1937891262 1177 RCLHNGTCVDLVGGFRCNCPPGYTGLH 1203
Cdd:pfam00008    5 PCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 738-772 3.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1937891262  738 DACESQ-PCQAGGTCTSDGIGFHCTCAPGFQGHQCE 772
Cdd:cd00054      3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1178-1205 3.26e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 3.26e-03
                           10        20
                   ....*....|....*....|....*....
gi 1937891262 1178 CLHNGTCVDLVGGFRCNCPPGYTG-LHCE 1205
Cdd:cd00053      8 CSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 385-426 3.36e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.22  E-value: 3.36e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1937891262  385 FTGGACdQDVDECSIGANPCEHLgrCVNTQGSFLCQCGRGYT 426
Cdd:cd01475    179 FQGKIC-VVPDLCATLSHVCQQV--CISTPGSYLCACTEGYA 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2029-2299 3.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 3.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2029 PSGPRSPSGPHGLGPLLCPPGAFLPGLKAVQSGTKKSRRPPgktglgPQGTRGRGKKLTLACPGPLADSSVTLSPVDSLD 2108
Cdd:PHA03247  2745 PAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR------PAVASLSESRESLPSPWDPADPPAAVLAPAAAL 2818

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2109 SP--RPFGGPPASPGGFPLEGPYATTATTVSLAQLGA-SRAGPLGRQPPGGcvlslgllNPVAVPLDWARLPPPAPPGPS 2185
Cdd:PHA03247  2819 PPaaSPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvAPGGDVRRRPPSR--------SPAAKPAAPARPPVRRLARPA 2890

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2186 flLPLAPGSQLLNPATPVSPHERPPPYLAAPGHGEEYPAAGTHSSPTKARflrvpsEHPYLTPSPEsPEHWASPSPPSLS 2265
Cdd:PHA03247  2891 --VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR------PQPPLAPTTD-PAGAGEPSGAVPQ 2961

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1937891262 2266 DWSDSTPSPATATSATAAGAlPAQPHPISVPSLP 2299
Cdd:PHA03247  2962 PWLGALVPGRVAVPRFRVPQ-PAPSREAPASSTP 2994
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 622-656 3.60e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  622 NIDDCAS-NPCTF-GVCRDGINRYDCVCQPGFTGPLC 656
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 316-351 3.79e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.79e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1937891262  316 NIDDCATA-VCFHGATCHDRVASFYCACPMGKTGLLC 351
Cdd:cd00054      1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1909-1994 4.66e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.31  E-value: 4.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1909 STALILAARlavEGMVEE----LIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNG---ANKDMQDS--KEETPLF 1979
Cdd:cd22192     18 ESPLLLAAK---ENDVQAikklLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQGETALH 94

                           90
                   ....*....|....*
gi 1937891262 1980 LAAREGSYEAAKLLL 1994
Cdd:cd22192     95 IAVVNQNLNLVRELI 109
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 170-193 4.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.84e-03
                           10        20
                   ....*....|....*....|....
gi 1937891262  170 CRHGGTCINTPGSFHCLCPLGYTG 193
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTG 29
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1841-2008 5.37e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 42.05  E-value: 5.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1841 GETALHLAARYARADAAKRLLDAGADTNAQdhsgrtplhtavtadAQGVFqilirNRSTDLDARMADGSTALILAARLAV 1920
Cdd:cd22194    141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF-----FNPKYKHEGFYFGETPLALAACTNQ 200

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1921 EGMVEELIA-SHADVNAVDELGKSALHWAAAV-NNVEATLA--------LLKNGANKD---MQDSKEETPLFLAAREGSY 1987
Cdd:cd22194    201 PEIVQLLMEkESTDITSQDSRGNTVLHALVTVaEDSKTQNDfvkrmydmILLKSENKNletIRNNEGLTPLQLAAKMGKA 280

                          170       180
                   ....*....|....*....|....*
gi 1937891262 1988 EaaklLLDHFANREITD----HLDR 2008
Cdd:cd22194    281 E----ILKYILSREIKEkpnrSLSR 301
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2028-2312 5.53e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 5.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2028 QPSGPRSPSGPHGLGPLLCPP--GAFLPGLKAVQSGTKKSRRP--PGKTGLGPQGTRGRGKKL-TLACPGPLADSSVTLS 2102
Cdd:pfam03154  250 QPMTQPPPPSQVSPQPLPQPSlhGQMPPMPHSLQTGPSHMQHPvpPQPFPLTPQSSQSQVPPGpSPAAPGQSQQRIHTPP 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2103 PVDSLDSPRPFGGPPASPGgfPLEGPYATTATTVSLAQLGASRA--------GPLGRQ-----PPGGCVLSLGLLN---- 2165
Cdd:pfam03154  330 SQSQLQSQQPPREQPLPPA--PLSMPHIKPPPTTPIPQLPNPQShkhpphlsGPSPFQmnsnlPPPPALKPLSSLSthhp 407

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2166 PVAVPLDwarlpppappgpsflLPLAPGSQLLnPATPVSP------HERPPPYLAAPghgeeyPAAGTHSSPTKARFLR- 2238
Cdd:pfam03154  408 PSAHPPP---------------LQLMPQSQQL-PPPPAQPpvltqsQSLPPPAASHP------PTSGLHQVPSQSPFPQh 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 2239 --VPSEHPYLTPsPESPEHWASPS-----PPSLSDWSDSTPSPATATSATAAGALPAQP-----HPISVPSLPQSqtqlg 2306
Cdd:pfam03154  466 pfVPGGPPPITP-PSGPPTSTSSAmpgiqPPSSASVSSSGPVPAAVSCPLPPVQIKEEAldeaeEPESPPPPPRS----- 539


                   ....*.
gi 1937891262 2307 PQPEVT 2312
Cdd:pfam03154  540 PSPEPT 545
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 698-731 6.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1937891262  698 NHPCAHkpcsHGVCHDAPGGFQCVCEPGWSGPRC 731
Cdd:cd00054      8 GNPCQN----GGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 818-845 6.39e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.42  E-value: 6.39e-03
                           10        20
                   ....*....|....*....|....*...
gi 1937891262  818 GASPCGPHGTCTNLPGSFRCICHGGYTG 845
Cdd:pfam12947    4 NNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 402-429 6.77e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.77e-03
                           10        20
                   ....*....|....*....|....*...
gi 1937891262  402 NPCEHLGRCVNTQGSFLCQCGRGYTGPR 429
Cdd:pfam00008    4 NPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 247-268 6.92e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 6.92e-03
                           10        20
                   ....*....|....*....|..
gi 1937891262  247 CLNGGTCVDGVNTYNCQCPPEW 268
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1178-1199 8.10e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 35.77  E-value: 8.10e-03
                           10        20
                   ....*....|....*....|..
gi 1937891262 1178 CLHNGTCVDLVGGFRCNCPPGY 1199
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 931-962 8.46e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 8.46e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1937891262  931 SPSSCFNGGTCVDGVNSFSCLCRPGYTG-THCQ 962
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
PHA02946 PHA02946
ankyin-like protein; Provisional
 1837-1980 8.58e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.19  E-value: 8.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1837 TDRTGETALHLAARYARADAAKRLLDAGADTNAQDHSGRTPLHTAVTADAQGVFQI-LIRNRSTDLDARMADGSTALILA 1915
Cdd:PHA02946    68 TDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERInLLVQYGAKINNSVDEEGCGPLLA 147

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1937891262 1916 ARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLA--LLKNGANKDMQDSKEETPLFL 1980
Cdd:PHA02946   148 CTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGNTPLHI 214
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1841-1989 8.67e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 41.15  E-value: 8.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1841 GETALHLAARYARADAAKRLLDAGAD-----TNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMAD-------- 1907
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpgpk 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937891262 1908 -----GSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNveATLA------LLKNGANKD------MQ 1970
Cdd:cd22192    131 nliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPN--KTFAcqmydlILSYDKEDDlqpldlVP 208

                          170
                   ....*....|....*....
gi 1937891262 1971 DSKEETPLFLAAREGSYEA 1989
Cdd:cd22192    209 NNQGLTPFKLAAKEGNIVM 227
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-580 8.91e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.91e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1937891262  551 CSPDPCHH-GRCVDGIASFSCACAPGYTGIR 580
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-345 9.52e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 9.52e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1937891262   316 NIDDCATA-VCFHGATCHDRVASFYCACPMG 345
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPG 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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