CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283046678 778 CGGEL-GDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 855
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 283046678 856 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 889
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 283046678  670 GEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDC 717
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678   47 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 82
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678  405 CSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDC 440
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678  215 CNHGNGGCQHSCEDTAEGPECSCHPRYRLHADGRSC 250
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 283046678   93 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 124
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283046678 778 CGGEL-GDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 855
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 283046678 856 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 889
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283046678   787 GYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCQTYERPIAFTSRS 865
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 283046678   866 KKLWIQFKSNEGNSARGFQVPY 887
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 283046678  670 GEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDC 717
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678   47 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 82
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678  405 CSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDC 440
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 283046678 310 FTLQVDGKTCKDIDECQTRNGGCNHFCKNTVGSFDCSCKKGFKLLTDEKS 359
Cdd:cd01475  175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 283046678 357 EKSCQDVDECS-LERTCDHSCINHPGTFICACNPGYTL 393
Cdd:cd01475  181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 283046678    43 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYQgEGRQCE 83
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 283046678 124 CLDMDECLENNGGCQHICTNVIGSYECRCKEGFFLSDNQHT 164
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 283046678   321 DIDECQTRNG-GCNHFCKNTVGSFDCSCKKGFkllTDEKSCQ 361
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 283046678   362 DVDECSLERTCDH--SCINHPGTFICACNPGYT 392
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 283046678  175 CMNKDHGCGHICKEAPrGSVACECRPGFELAKNQKDC 211
Cdd:pfam14670   1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283046678 778 CGGEL-GDFTGYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCqTY 855
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 283046678 856 ERPIAFTSRSKKLWIQFKSNEGNSARGFQVPYVT 889
Cdd:cd00041   80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 283046678   787 GYIESPNYPGNYPANSECTWTINPPPKRRILIVVPEIFLPIEDDCG-DYLVMRKTSSSNSVTTYETCQTYERPIAFTSRS 865
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 283046678   866 KKLWIQFKSNEGNSARGFQVPY 887
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 283046678  670 GEYSANGFAPCQLCALGTFQPDVGRTSCLSCGGGLPTKHLGATSFQDC 717
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678   47 CAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQC 82
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 283046678  405 CSVNNGGCQQVCINTVGSYECQCHPGFKLHWNKKDC 440
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 283046678 310 FTLQVDGKTCKDIDECQTRNGGCNHFCKNTVGSFDCSCKKGFKLLTDEKS 359
Cdd:cd01475  175 LTKKFQGKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 283046678 357 EKSCQDVDECS-LERTCDHSCINHPGTFICACNPGYTL 393
Cdd:cd01475  181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 283046678  43 DVDECAQGlDDCHADALCQNTPTSYKCSCKPGYqgEGRQCE 83
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGY--TGRNCE 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 283046678   93 NGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNC 124
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|..
gi 283046678  303 HCSCPTGFTLQVDGKTCKDIDE 324
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 283046678   321 DIDECQTRNG-GCNHFCKNTVGSFDCSCKKGFkllTDEKSCQ 361
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 283046678   362 DVDECSLERTCDH--SCINHPGTFICACNPGYT 392
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYT 33

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|
gi 283046678  405 CSVNNGGC--QQVCINTVGSYECQCHPGFK 432
Cdd:pfam12947   1 CSDNNGGChpNATCTNTGGSFTCTCNDGYT 30

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 283046678 321 DIDECQTRNG-GCNHFCKNTVGSFDCSCKKGFKLLT 355
Cdd:cd00054    1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 283046678   126 DMDECLENNGgCQH--ICTNVIGSYECRCKEGF 156
Cdd:smart00179   1 DIDECASGNP-CQNggTCVNTVGSYRCECPPGY 32

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 283046678  46 ECAQGlDDCHADALCQNTPTSYKCSCKPGYQGEGR 80
Cdd:cd00053    1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 283046678    84 DMDECDNTLNGGCVHDCLNIPGNYRCTCFDGFmlaHDGHNC 124
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNC 38