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Conserved domains on  [gi|157278034|ref|NP_064324|]
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zinc finger protein 111 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-57 6.15e-20

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.15e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 157278034     8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 57
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
346-641 2.20e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 346 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 422
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 423 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 480
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 481 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 560
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 561 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 627
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 157278034 628 YKC--DRCGKAFSQKS 641
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-394 1.81e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 117 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 196
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 197 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 276
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 277 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 346
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 157278034 347 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 394
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
643-665 5.73e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.73e-04
                          10        20
                  ....*....|....*....|...
gi 157278034  643 LQVHKRIHTGEKPFKCEECGKEF 665
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-57 6.15e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.15e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 157278034     8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 57
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.56e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.56e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157278034    8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 7.22e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.22e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 157278034   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
346-641 2.20e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 346 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 422
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 423 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 480
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 481 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 560
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 561 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 627
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 157278034 628 YKC--DRCGKAFSQKS 641
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-394 1.81e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 117 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 196
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 197 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 276
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 277 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 346
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 157278034 347 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 394
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 157278034  614 HLQSHQRVHTGEKPYKCDRCGKAFSQ 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 598-646 5.52e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 157278034 598 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 646
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
643-665 5.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.73e-04
                          10        20
                  ....*....|....*....|...
gi 157278034  643 LQVHKRIHTGEKPFKCEECGKEF 665
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-304 7.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.92e-04
                          10        20
                  ....*....|....*....|....*
gi 157278034  280 LQAHKRIHTGEKPYKCGDCGKRFSC 304
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 624-676 9.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157278034 624 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 676
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-57 6.15e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 83.80  E-value: 6.15e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 157278034     8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVGGQSPNKMEI 57
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLI 50
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 2.56e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.36  E-value: 2.56e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157278034    8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNLLAVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-44 7.22e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 68.73  E-value: 7.22e-15
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 157278034   8 VTFRDVAVVFSEEELGLLDAAQRKLYHDVMLENFRNL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
346-641 2.20e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 346 KPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSV--CGKGFSRTSYLQTHQRVHSGDKPY-QCDSCGKGFTQLSHLQAH 422
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 423 ERIHTDQKPYKCGDCGK------------RFSCSSNLHTHQRVHTGEKPYKCE----------ECGKGFSLVSGLQAHQR 480
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 481 VETGKKPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSLNSGLI 560
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 561 AHRRVHTGE-------KPYECKDCGKGFSLASSLRTHQR--VHTGE--KPFQCNE--CQKRFSQVSHLQSHQRVHTGEKP 627
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330
                 ....*....|....*.
gi 157278034 628 YKC--DRCGKAFSQKS 641
Cdd:COG5048  352 AKEklLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-618 4.88e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 4.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 209 YRCQECGKAFRQSSALQTHQRVHTGEKPY--RGNSRGKNFSRSSDLNIHRQVHTREKPYTCKvckkrfmQCSLLQAHKRI 286
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNS-------KSLPLSNSKAS 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 287 HTGEKPYKCGDCGKRFSCISNFHIHQRVHTKSKP-SKCDYGKPFNLRCN------------------------------F 335
Cdd:COG5048  107 SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLlSISNLRNNPLPGNNsssvntpqsnslhpplpanslskdpssnlsL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 336 HSHQRVHTGEKPYKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQ 415
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 416 LSHLQAHERIHTD-------QKPYKCGDCGKRFSCSSNLHTHQR--VHTGE--KPYKCEE--CGKGFSLVSGLQAHQRVE 482
Cdd:COG5048  267 TASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 483 TGKKPFKCNACQkrfsqawnlhaHQRVHTGEKPYKcdtcgkafgqRSGLQIHQRIHTGEKPFKCE--ECGKEFSLNSGLI 560
Cdd:COG5048  347 TSISPAKEKLLN-----------SSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 561 AHRRVHTGEKPYECKD--CGKGFSLASSLRTHQRVHTGEKPFQCNeCQKRFSQVSHLQSH 618
Cdd:COG5048  406 LHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCS-ILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
401-684 2.75e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 401 DKPYQCDSCGKGFTQLSHLQAHERIHTDQKPYKCGD--CGKRFSCSSNLHTHQRVHTGEKPYKCE--------------- 463
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssl 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 464 -ECGKGFSLVSGLQAHQRVETGKKPFKCNACQKRFSQ-----------------AWNLHAHQRVHTGEKPYKCDTCG--- 522
Cdd:COG5048  111 sSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRnnplpgnnsssvntpqsNSLHPPLPANSLSKDPSSNLSLLiss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 523 -KAFGQRSGLQIHQRIHTGEKPFKCEECGKEFSlNSGLIAHRRVHTGEKPYECkdcgkgfSLASSLRTHQRVHTGEKPFQ 601
Cdd:COG5048  191 nVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLS-------QSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 602 CNECQKRFSQVSHLQSHQRVHTG-EKPYKCDRCGKAFSQKSGLQVHKR--IHTGE--KPFKCEE--CGKEFIWSSGLSAH 674
Cdd:COG5048  263 SSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                        330
                 ....*....|
gi 157278034 675 RKVHTGEKPY 684
Cdd:COG5048  343 ILLHTSISPA 352
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
117-394 1.81e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 117 PRDSEDSSSPDLTNDHSSITENQEFLSGRAQGSwgkrrlRKRQNHQKNCLQTlmkNKPQLLAQHSPVHSTQEDTRHSFSV 196
Cdd:COG5048  207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS------LLSQSPSSLSSSD---SSSSASESPRSSLPTASSQSSSPNE 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 197 PVQESIYPGRKRYRCQECGKAFRQSSALQTHQRvhtgekpyrgnsrgknfSRSSDLNIHRQVHTREKPytckvCKKRFMQ 276
Cdd:COG5048  278 SDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLR-----------------SVNHSGESLKPFSCPYSL-----CGKLFSR 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 277 CSLLQAHKRIHTGEKPYKC--GDCGKRFSCISNFHIHQRVHTKSKPSK-----CDYG---KPFNLRCNFHSHQRVHTGEK 346
Cdd:COG5048  336 NDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSNsciRNFKRDSNLSLHIITHLSFR 415

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 157278034 347 P--YKCEECGKGFTSASSFQRHQRVHTGEKPFVCSVCGKgFSRTSYLQTH 394
Cdd:COG5048  416 PynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 2.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 157278034  614 HLQSHQRVHTGEKPYKCDRCGKAFSQ 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 598-646 5.52e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 157278034 598 KPFqCNECQKRFSQVSHLQSHQRvhtgEKPYKCDRCGKAFSQKSGLQVH 646
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
643-665 5.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.73e-04
                          10        20
                  ....*....|....*....|...
gi 157278034  643 LQVHKRIHTGEKPFKCEECGKEF 665
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 570-622 6.65e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 6.65e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157278034 570 KPYeCKDCGKGFSLASSLRTHQRvhtgEKPFQCNECQKRFSQVSHLQSH-QRVH 622
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
586-611 7.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.92e-04
                          10        20
                  ....*....|....*....|....*.
gi 157278034  586 SLRTHQRVHTGEKPFQCNECQKRFSQ 611
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
280-304 7.92e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.92e-04
                          10        20
                  ....*....|....*....|....*
gi 157278034  280 LQAHKRIHTGEKPYKCGDCGKRFSC 304
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 624-676 9.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 9.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157278034 624 GEKPYKCD--RCGKAFSQKSGLQVHKR-------------------IHTGEKPFKCEECGKEFIWSSGLSAHRK 676
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-554 9.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.27e-04
                          10        20
                  ....*....|....*....|....
gi 157278034  531 LQIHQRIHTGEKPFKCEECGKEFS 554
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 512-563 9.78e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.78e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157278034 512 GEKPYKCDT--CGKAFGQRSGLQIH-------------------QRIHTGEKPFKCEECGKEFSLNSGLIAHR 563
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmlhghqnqklhenpspekmNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 456-534 1.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 456 GEKPYKCE--ECGKGFSLVSGLQAHQrvetgkkpfKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQI 533
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 157278034 534 H 534
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 344-428 1.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 344 GEKPYKCE--ECGKGFTSASSFQRHqRVHtgekpfvcSVCGKGFSRTSYLQTHQRVHSGDKPYQCDSCGKGFTQLSHLQA 421
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*..
gi 157278034 422 HERIHTD 428
Cdd:COG5189  417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
362-387 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 157278034  362 SFQRHQRVHTGEKPFVCSVCGKGFSR 387
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 514-566 2.16e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157278034 514 KPYkCDTCGKAFGQRSGLQIHQRIHTgekpFKCEECGKEFSLNSGLIAH-RRVH 566
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-415 2.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.70e-03
                          10        20
                  ....*....|....*....|....*.
gi 157278034  390 YLQTHQRVHSGDKPYQCDSCGKGFTQ 415
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 561-647 3.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 561 AHRRVHTGEKPYECK--DCGKGFSLASSLRTHqRVHtgekpfqcNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFS 638
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                 ....*....
gi 157278034 639 QKSGLQVHK 647
Cdd:COG5189  410 NLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 400-478 3.18e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 400 GDKPYQCD--SCGKGFTQLSHLQAHeRIHtdqkpykcGDCGKRFSCSSNLHTHQRVHTGEKPYKCEECGKGFSLVSGLQA 477
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 157278034 478 H 478
Cdd:COG5189  417 H 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-359 3.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.81e-03
                          10        20
                  ....*....|....*....|...
gi 157278034  337 SHQRVHTGEKPYKCEECGKGFTS 359
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
418-443 3.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 157278034  418 HLQAHERIHTDQKPYKCGDCGKRFSC 443
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
428-679 5.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 5.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 428 DQKPYKCGDCGKRFSCSSNLHTHQRVHTGEKPYKC--EECGKGFSLVSGLQAHQRVETGKKPFKCNAC-----QKRFSQA 500
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSlplsnSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 501 WNLHAHQRVhtgeKPYKCDTCGKAFGQRSGLQIHQRIHTGEKPFKCEECGKEF-----SLNSGLIAHRRVHTGEKPYEck 575
Cdd:COG5048  110 LSSSSSNSN----DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqSNSLHPPLPANSLSKDPSSN-- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157278034 576 dcgkgfslaSSLRTHQRVHTGEKPFQCNECQKRFSQVSHLQSHQRVHTGEKPYKCDRCGKAFSQKSGLQVHKRIHTGEKP 655
Cdd:COG5048  184 ---------LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        250       260
                 ....*....|....*....|....
gi 157278034 656 FKCEECGKEFIWSSGLSAHRKVHT 679
Cdd:COG5048  255 SSASESPRSSLPTASSQSSSPNES 278
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 348-370 6.90e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.90e-03
                          10        20
                  ....*....|....*....|...
gi 157278034  348 YKCEECGKGFTSASSFQRHQRVH 370
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-525 6.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.94e-03
                          10        20
                  ....*....|....*....|
gi 157278034  506 HQRVHTGEKPYKCDTCGKAF 525
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 209-231 7.47e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.47e-03
                          10        20
                  ....*....|....*....|...
gi 157278034  209 YRCQECGKAFRQSSALQTHQRVH 231
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-470 8.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.21e-03
                          10        20
                  ....*....|....*....|....*
gi 157278034  446 NLHTHQRVHTGEKPYKCEECGKGFS 470
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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