NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9789931|ref|NP_062644|]
View 

protein diaphanous homolog 3 [Mus musculus]

Protein Classification

Drf_FH3 and FH2 domain-containing protein( domain architecture ID 10533905)

protein containing domains Drf_GBD, Drf_FH3, and FH2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
615-987 8.70e-137

Formin Homology 2 Domain;


:

Pssm-ID: 396655  Cd Length: 372  Bit Score: 419.75  E-value: 8.70e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     615 PKKEFKPEISMRRLNWLKIGPNEMSEnCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNtNDFDEKKVIKKRMKELKFL 694
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG-TVWDKLDDESFELDGDLSELEELFSAKAKTKKN-KKSEDKSSSKKKPKEVSLL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     695 DPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKR 774
Cdd:pfam02181   79 DPKRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     775 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKS 854
Cdd:pfam02181  159 LEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     855 ADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSS 934
Cdd:pfam02181  239 TDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALDEHPDDKFREVLKE 318
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 9789931     935 FVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSF 987
Cdd:pfam02181  319 FLKSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEF 371
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
284-471 3.63e-66

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


:

Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 221.38  E-value: 3.63e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     284 EEVLEALTSAGEE-RKIDRFFSIVEGLRHN---SVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGI 359
Cdd:pfam06367    4 EKVLEATLNFKEVcRERGRFQSLVGALDSSendNVEYKVATMQFINALVNSPEDLQFRLHLRSEFTALGLDRILDKLREL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     360 KNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKL 439
Cdd:pfam06367   84 ENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLIRDDEEELPSYWKL 163
                          170       180       190
                   ....*....|....*....|....*....|..
gi 9789931     440 IDECVSQIVLHRDGTDPDFTYRKRLDLDLSQF 471
Cdd:pfam06367  164 LEELVSQIVLHRTKPDPKFDERKNLEIDINRL 195
Drf_GBD super family cl05720
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
96-276 2.31e-54

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


The actual alignment was detected with superfamily member pfam06371:

Pssm-ID: 461886  Cd Length: 188  Bit Score: 187.52  E-value: 2.31e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      96 LPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTG------SLRSSRQISPQEFLHELKMGYTDE 169
Cdd:pfam06371    4 PDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKSTNFQKEgggsksDSESNETGSPEYYVKKLKDDSISS 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     170 rlfTYLESLRVSLTSHPVSWVQSF-GHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMSDKRS 248
Cdd:pfam06371   84 ---KQLESLRVALRTQPLSWVRRFiEAQGLGALLNVLSKINRKKSQEEEDLDREYEILKCLKALMNNKFGLDHVLGHPSS 160
                          170       180
                   ....*....|....*....|....*...
gi 9789931     249 LSLLAKAMDPRQPAMMADVVKLLSAVCI 276
Cdd:pfam06371  161 IDLLVQSLDSERLKTRKLVLELLTALCL 188
Casc1_N super family cl25546
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
999-1061 9.87e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


The actual alignment was detected with superfamily member pfam15927:

Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 38.88  E-value: 9.87e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9789931     999 EAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEGDETgvmdsLLEALQSGAAFRDRRKRT 1061
Cdd:pfam15927    1 ARLREEEEERLRAEEEEAERLEEERREEEEEERLAAEQDR-----RAEELEELKHLLEERKEA 58
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
615-987 8.70e-137

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 419.75  E-value: 8.70e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     615 PKKEFKPEISMRRLNWLKIGPNEMSEnCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNtNDFDEKKVIKKRMKELKFL 694
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG-TVWDKLDDESFELDGDLSELEELFSAKAKTKKN-KKSEDKSSSKKKPKEVSLL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     695 DPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKR 774
Cdd:pfam02181   79 DPKRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     775 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKS 854
Cdd:pfam02181  159 LEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     855 ADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSS 934
Cdd:pfam02181  239 TDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALDEHPDDKFREVLKE 318
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 9789931     935 FVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSF 987
Cdd:pfam02181  319 FLKSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEF 371
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
616-1049 1.26e-127

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 396.34  E-value: 1.26e-127
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      616 KKEFKPEISMRRLNWLKIGPNEMSEnCFWIKVNENkyeNRDLLCKLENTFCCQEKEKRNTNDFDEKKVIKKRM--KELKF 693
Cdd:smart00498    1 KKEPKPKKKLKPLHWDKLNPSDLSG-TVWDKIDEE---SEGDLDELEELFSAKEKTKSASKDVSEKKSILKKKasQEFKI 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      694 LDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRS-DYNSLCEPEQFAVVMSNV 772
Cdd:smart00498   77 LDPKRSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNI 156
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      773 KRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDT 852
Cdd:smart00498  157 PYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDV 236
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      853 KSADQKTTLLHFLVDVCEEKHadilhfvddlahldkasrvsvemleknvkqmgrqlqqleknLETFPPPEDLHDKFVIKM 932
Cdd:smart00498  237 KSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDDKFIEVM 275
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      933 SSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREaAEKEKRARIAKE 1012
Cdd:smart00498  276 KPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEE-EEEERRKKLVKE 354
                           410       420       430
                    ....*....|....*....|....*....|....*...
gi 9789931     1013 RAEKERL-ERQQEKKRLLEMKTEGDETGVMDSLLEALQ 1049
Cdd:smart00498  355 TTEYEQSsSRQKERNPSMDFEVERDFLGVLDSLLEELG 392
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
284-471 3.63e-66

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 221.38  E-value: 3.63e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     284 EEVLEALTSAGEE-RKIDRFFSIVEGLRHN---SVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGI 359
Cdd:pfam06367    4 EKVLEATLNFKEVcRERGRFQSLVGALDSSendNVEYKVATMQFINALVNSPEDLQFRLHLRSEFTALGLDRILDKLREL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     360 KNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKL 439
Cdd:pfam06367   84 ENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLIRDDEEELPSYWKL 163
                          170       180       190
                   ....*....|....*....|....*....|..
gi 9789931     440 IDECVSQIVLHRDGTDPDFTYRKRLDLDLSQF 471
Cdd:pfam06367  164 LEELVSQIVLHRTKPDPKFDERKNLEIDINRL 195
Drf_GBD pfam06371
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
96-276 2.31e-54

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


Pssm-ID: 461886  Cd Length: 188  Bit Score: 187.52  E-value: 2.31e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      96 LPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTG------SLRSSRQISPQEFLHELKMGYTDE 169
Cdd:pfam06371    4 PDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKSTNFQKEgggsksDSESNETGSPEYYVKKLKDDSISS 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     170 rlfTYLESLRVSLTSHPVSWVQSF-GHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMSDKRS 248
Cdd:pfam06371   84 ---KQLESLRVALRTQPLSWVRRFiEAQGLGALLNVLSKINRKKSQEEEDLDREYEILKCLKALMNNKFGLDHVLGHPSS 160
                          170       180
                   ....*....|....*....|....*...
gi 9789931     249 LSLLAKAMDPRQPAMMADVVKLLSAVCI 276
Cdd:pfam06371  161 IDLLVQSLDSERLKTRKLVLELLTALCL 188
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
999-1061 9.87e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 38.88  E-value: 9.87e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9789931     999 EAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEGDETgvmdsLLEALQSGAAFRDRRKRT 1061
Cdd:pfam15927    1 ARLREEEEERLRAEEEEAERLEEERREEEEEERLAAEQDR-----RAEELEELKHLLEERKEA 58
 
Name Accession Description Interval E-value
FH2 pfam02181
Formin Homology 2 Domain;
615-987 8.70e-137

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 419.75  E-value: 8.70e-137
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     615 PKKEFKPEISMRRLNWLKIGPNEMSEnCFWIKVNENKYENRDLLCKLENTFCCQEKEKRNtNDFDEKKVIKKRMKELKFL 694
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG-TVWDKLDDESFELDGDLSELEELFSAKAKTKKN-KKSEDKSSSKKKPKEVSLL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     695 DPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRSDYNSLCEPEQFAVVMSNVKR 774
Cdd:pfam02181   79 DPKRAQNIAILLRKLKLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKLKEYKGDPSELGRAEQFLLELSKIPR 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     775 LRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDTKS 854
Cdd:pfam02181  159 LEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDGTRRGQAKGFKLSSLLKLSDTKS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     855 ADQKTTLLHFLVDVCEEKHADILHFVDDLAHLDKASRVSVEMLEKNVKQMGRQLQQLEKNLETFPPPEDLHDKFVIKMSS 934
Cdd:pfam02181  239 TDNKTTLLHYLVKIIREKFPEVLDFSSELSHVKKAAKVNLEQLEKDVKQLERGLKKLERELELSALDEHPDDKFREVLKE 318
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 9789931     935 FVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSF 987
Cdd:pfam02181  319 FLKSAEEKLDKLESLLREALELFKELVEYFGEDPKETSPEEFFKILRDFLKEF 371
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
616-1049 1.26e-127

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 396.34  E-value: 1.26e-127
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      616 KKEFKPEISMRRLNWLKIGPNEMSEnCFWIKVNENkyeNRDLLCKLENTFCCQEKEKRNTNDFDEKKVIKKRM--KELKF 693
Cdd:smart00498    1 KKEPKPKKKLKPLHWDKLNPSDLSG-TVWDKIDEE---SEGDLDELEELFSAKEKTKSASKDVSEKKSILKKKasQEFKI 76
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      694 LDPKIAQNLSIFLSSFRVPYEKIRTMILEVDETQLSESMIQNLIKHLPDEEQLKSLSQFRS-DYNSLCEPEQFAVVMSNV 772
Cdd:smart00498   77 LDPKRSQNLAILLRKLHMSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEeDPEELARAEQFLLLISNI 156
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      773 KRLRPRLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKGFSKLLELVLLMGNYMNAGSRNAQTFGFDLSSLCKLKDT 852
Cdd:smart00498  157 PYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGGSRRGQAYGFKLSSLLKLSDV 236
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      853 KSADQKTTLLHFLVDVCEEKHadilhfvddlahldkasrvsvemleknvkqmgrqlqqleknLETFPPPEDLHDKFVIKM 932
Cdd:smart00498  237 KSADNKTTLLHFLVKIIRKKY-----------------------------------------LGGLSDPENLDDKFIEVM 275
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      933 SSFVISANEQYEKLSTLLGSMTQLYQSIMGYYAVDMKKVSVEEFFNDLNNFRTSFMLALKENIKKREaAEKEKRARIAKE 1012
Cdd:smart00498  276 KPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYGEDPKDTSPEEFFKDFNEFLKEFSKAAEENIKKEE-EEEERRKKLVKE 354
                           410       420       430
                    ....*....|....*....|....*....|....*...
gi 9789931     1013 RAEKERL-ERQQEKKRLLEMKTEGDETGVMDSLLEALQ 1049
Cdd:smart00498  355 TTEYEQSsSRQKERNPSMDFEVERDFLGVLDSLLEELG 392
Drf_FH3 pfam06367
Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.
284-471 3.63e-66

Diaphanous FH3 Domain; This region is found in the Formin-like and and diaphanous proteins.


Pssm-ID: 461885 [Multi-domain]  Cd Length: 195  Bit Score: 221.38  E-value: 3.63e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     284 EEVLEALTSAGEE-RKIDRFFSIVEGLRHN---SVNLQVACMQLINALVTSPDDLDFRLHLRNEFMRCGLKEILPNLKGI 359
Cdd:pfam06367    4 EKVLEATLNFKEVcRERGRFQSLVGALDSSendNVEYKVATMQFINALVNSPEDLQFRLHLRSEFTALGLDRILDKLREL 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     360 KNDGLDIQLKVFDEHKEEDLSEFFHRLEDIRAELDEASDVYSMLWDTVKETRAEGHFLSILQHLLLIRNDRFIREQYFKL 439
Cdd:pfam06367   84 ENDELDDQLQAFEENREEDVEELLERFDDVNVDLDDPSELFELLWNKLKDTEAEPHLLSILQHLLLIRDDEEELPSYWKL 163
                          170       180       190
                   ....*....|....*....|....*....|..
gi 9789931     440 IDECVSQIVLHRDGTDPDFTYRKRLDLDLSQF 471
Cdd:pfam06367  164 LEELVSQIVLHRTKPDPKFDERKNLEIDINRL 195
Drf_GBD pfam06371
Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, ...
96-276 2.31e-54

Diaphanous GTPase-binding Domain; This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.


Pssm-ID: 461886  Cd Length: 188  Bit Score: 187.52  E-value: 2.31e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931      96 LPESEVLKLFEKMMEDMNLNEDKKAPLREKDFGIKKEMVMQYINTASKTG------SLRSSRQISPQEFLHELKMGYTDE 169
Cdd:pfam06371    4 PDENEIDELFDELMEEMNLPEEKRRPMLAKPIEKKWQLIVQYKSTNFQKEgggsksDSESNETGSPEYYVKKLKDDSISS 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9789931     170 rlfTYLESLRVSLTSHPVSWVQSF-GHEGLGLLLDILEKLINGQIQEKVVKKTQHKVIQCLRALMNTQYGLERIMSDKRS 248
Cdd:pfam06371   84 ---KQLESLRVALRTQPLSWVRRFiEAQGLGALLNVLSKINRKKSQEEEDLDREYEILKCLKALMNNKFGLDHVLGHPSS 160
                          170       180
                   ....*....|....*....|....*...
gi 9789931     249 LSLLAKAMDPRQPAMMADVVKLLSAVCI 276
Cdd:pfam06371  161 IDLLVQSLDSERLKTRKLVLELLTALCL 188
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
999-1061 9.87e-03

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 38.88  E-value: 9.87e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9789931     999 EAAEKEKRARIAKERAEKERLERQQEKKRLLEMKTEGDETgvmdsLLEALQSGAAFRDRRKRT 1061
Cdd:pfam15927    1 ARLREEEEERLRAEEEEAERLEEERREEEEEERLAAEQDR-----RAEELEELKHLLEERKEA 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH