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Conserved domains on  [gi|11128037|ref|NP_061745|]
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protocadherin gamma-B1 isoform 1 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 13228202)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-339 2.48e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.48e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 243 VYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPIStSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGV 322
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11128037 323 --HTAHCNVQIEIVDENDN 339
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-109 1.07e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.10  E-value: 1.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    30 QIRYTIPEELANGSRVGKLAKDLGLSVRELPTRKLRVSAED---YFNVSLESGDLLVNGRIDREKICGRKLECALEFETV 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGnkqYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128037   107 AEN 109
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 452-554 4.83e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 4.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 452 SYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEprellSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR 531
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128037 532 DQGSPALSANVSLRVLVGDLNDN 554
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 683-765 3.01e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 117.24  E-value: 3.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   683 ELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTgLCSKSGPGVPPNHSEGTLP--YSYNLCIASHSAKTE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 11128037   761 FNSLN 765
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail super family cl24520
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 806-900 1.08e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


The actual alignment was detected with superfamily member pfam15974:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   806 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 881
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128037   882 HVPD-YRQNVYIPGSNATLT 900
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-444 1.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQEEVP---FKLESTSknyYKLVIAGALNREQTADYNVTIIATDKGKPA 427
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 11128037 428 LSSRTSITLHISDINDN 444
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-235 2.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 137 LEICESALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLStkespdgSKYPVLLLEKPLDREHQSSHRLILTAMD 213
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11128037 214 GGDPPLSGTTHIWIRVTDANDN 235
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-658 2.46e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 652
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128037 653 TATLHL 658
Cdd:cd11304  85 TATVTI 90
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-339 2.48e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.48e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 243 VYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPIStSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGV 322
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11128037 323 --HTAHCNVQIEIVDENDN 339
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-109 1.07e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.10  E-value: 1.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    30 QIRYTIPEELANGSRVGKLAKDLGLSVRELPTRKLRVSAED---YFNVSLESGDLLVNGRIDREKICGRKLECALEFETV 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGnkqYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128037   107 AEN 109
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 452-554 4.83e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 4.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 452 SYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEprellSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR 531
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128037 532 DQGSPALSANVSLRVLVGDLNDN 554
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 683-765 3.01e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 117.24  E-value: 3.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   683 ELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTgLCSKSGPGVPPNHSEGTLP--YSYNLCIASHSAKTE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 11128037   761 FNSLN 765
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 806-900 1.08e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   806 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 881
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128037   882 HVPD-YRQNVYIPGSNATLT 900
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 263-341 1.27e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 1.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    263 ATDQDEGINAEITYaFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNA 340
Cdd:smart00112   2 ATDADSGENGKVTY-SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                   .
gi 11128037    341 P 341
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-444 1.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQEEVP---FKLESTSknyYKLVIAGALNREQTADYNVTIIATDKGKPA 427
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 11128037 428 LSSRTSITLHISDINDN 444
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-235 2.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 137 LEICESALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLStkespdgSKYPVLLLEKPLDREHQSSHRLILTAMD 213
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11128037 214 GGDPPLSGTTHIWIRVTDANDN 235
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-658 2.46e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 652
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128037 653 TATLHL 658
Cdd:cd11304  85 TATVTI 90
Cadherin pfam00028
Cadherin domain;
244-332 5.45e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 5.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   244 YRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPIStSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 11128037   324 ----TAHCNVQIE 332
Cdd:pfam00028  80 plssTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 471-556 8.05e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    471 SASDPDLGPNGRVSYSILASDLEprellSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 550
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11128037    551 LNDNAP 556
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
453-548 1.53e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   453 YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRellsyVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 11128037   533 QGSPALSANVSLRVLV 548
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 153-237 2.99e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.99e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    153 SAQDADVEGNSLKLYTI---NPNQYFSLSTKespDGskypVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRV 229
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDPE---TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 11128037    230 TDANDNAP 237
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 366-446 8.54e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 8.54e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    366 KVRDKDSGQNGMVTC---YTQEEVPFKLESTSKnyyKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISDIN 442
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 11128037    443 DNAP 446
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-659 1.16e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.16e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11128037    588 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATLHLI 659
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
348-438 5.90e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   348 FSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTcY--TQEEVP--FKLESTSKNyykLVIAGALNREQTADYNVTIIATDK 423
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YsiLGGGPGgnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 11128037   424 GKPALSSRTSITLHI 438
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
138-230 9.99e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 9.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   138 EICESALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKespDGskypVLLLEKPLDREHQSSHRLILTAMDG 214
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPD---TG----DISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 11128037   215 GDPPLSGTTHIWIRVT 230
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-657 1.14e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 652
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83


                  ....*
gi 11128037   653 TATLH 657
Cdd:pfam00028  84 TATVT 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-126 7.27e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 7.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037  30 QIRYTIPEELANGSRVGKL-AKDLGLSVRELPT-RKLRVSAEDYFNVSLESGDLLVNGRIDREKICGRKLecalefeTV- 106
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVsATDPDSGENGEVTySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTL-------TVt 73

                        90       100
                ....*....|....*....|....*
gi 11128037 107 ----AENPMNVF-HVVVVIQDINDN 126
Cdd:cd11304  74 atdgGGPPLSSTaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-128 1.06e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 1.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 11128037     67 SAEDYFNVSLESGDLLVNGRIDREKICgrklecALEFETVAEN-----PMNVFHVVVVIQDINDNAP 128
Cdd:smart00112  21 NDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEATDgggppLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 243-339 2.48e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 2.48e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 243 VYRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPIStSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGV 322
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
gi 11128037 323 --HTAHCNVQIEIVDENDN 339
Cdd:cd11304  80 ppLSSTATVTITVLDVNDN 98
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-109 1.07e-32

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 121.10  E-value: 1.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    30 QIRYTIPEELANGSRVGKLAKDLGLSVRELPTRKLRVSAED---YFNVSLESGDLLVNGRIDREKICGRKLECALEFETV 106
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGnkqYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 11128037   107 AEN 109
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 452-554 4.83e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.11  E-value: 4.83e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 452 SYVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEprellSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQAR 531
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 11128037 532 DQGSPALSANVSLRVLVGDLNDN 554
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 683-765 3.01e-31

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 117.24  E-value: 3.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   683 ELQFYLVVALALISVLFLLAVILAIALRLRRSSSLDTEGCFQTgLCSKSGPGVPPNHSEGTLP--YSYNLCIASHSAKTE 760
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPqsYSYEVCLTSDSGKSE 79


                  ....*
gi 11128037   761 FNSLN 765
Cdd:pfam16492  80 FKFLK 84
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 806-900 1.08e-29

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 114.73  E-value: 1.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   806 PPNTDWRFSQAQRPGTSGS-QNGDDTGTWPNNQFDTEMLQAMIlASASEAADGSSTL---GGGAGTMGLSARYGPQFTLQ 881
Cdd:pfam15974   2 PPNPDWRYSASLRAGPMQSsVHMEEAGVLRGGPGGLEQQWPTV-SSATPEPEAGEVSppvGAGVNSNSWTFRYGPGNPKQ 80

                          90       100
                  ....*....|....*....|
gi 11128037   882 HVPD-YRQNVYIPGSNATLT 900
Cdd:pfam15974  81 PVPGeYPENFIIPGSPAIIS 100
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 263-341 1.27e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.49  E-value: 1.27e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    263 ATDQDEGINAEITYaFLNSPISTSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGV--HTAHCNVQIEIVDENDNA 340
Cdd:smart00112   2 ATDADSGENGKVTY-SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDNA 80


                   .
gi 11128037    341 P 341
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 351-444 1.55e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 1.55e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 351 QIPEDSDLGTVIALIKVRDKDSGQNGMVTCYTQEEVP---FKLESTSknyYKLVIAGALNREQTADYNVTIIATDKGKPA 427
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdglFSIDPST---GEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                        90
                ....*....|....*..
gi 11128037 428 LSSRTSITLHISDINDN 444
Cdd:cd11304  82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 137-235 2.86e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 137 LEICESALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLStkespdgSKYPVLLLEKPLDREHQSSHRLILTAMD 213
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 11128037 214 GGDPPLSGTTHIWIRVTDANDN 235
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-658 2.46e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037 574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 652
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPL-DREEQSSyTLTVTATDGGGPPLSS 84


                ....*.
gi 11128037 653 TATLHL 658
Cdd:cd11304  85 TATVTI 90
Cadherin pfam00028
Cadherin domain;
244-332 5.45e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 5.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   244 YRVSLQENVPWGTSVLRVMATDQDEGINAEITYAFLNSPIStSLFNLNPNTGDITTNGTLDFEETSRYVLSVEAKDGGVH 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 11128037   324 ----TAHCNVQIE 332
Cdd:pfam00028  80 plssTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 471-556 8.05e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    471 SASDPDLGPNGRVSYSILASDLEprellSYVSVSPQSGVVFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGD 550
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 11128037    551 LNDNAP 556
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
453-548 1.53e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   453 YVVHVSENNPPGASIAQVSASDPDLGPNGRVSYSILASDLEPRellsyVSVSPQSGVVFAQRAFDHEQLRAFELTLQARD 532
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*.
gi 11128037   533 QGSPALSANVSLRVLV 548
Cdd:pfam00028  76 SGGPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 153-237 2.99e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.99e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    153 SAQDADVEGNSLKLYTI---NPNQYFSLSTKespDGskypVLLLEKPLDREHQSSHRLILTAMDGGDPPLSGTTHIWIRV 229
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDPE---TG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITV 73


                   ....*...
gi 11128037    230 TDANDNAP 237
Cdd:smart00112  74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 366-446 8.54e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.85  E-value: 8.54e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037    366 KVRDKDSGQNGMVTC---YTQEEVPFKLESTSKnyyKLVIAGALNREQTADYNVTIIATDKGKPALSSRTSITLHISDIN 442
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 11128037    443 DNAP 446
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-659 1.16e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.16e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11128037    588 VAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDA-ARQRLLVAVRDGGQPPLSATATLHLI 659
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPL-DREEqPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin pfam00028
Cadherin domain;
348-438 5.90e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.10  E-value: 5.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   348 FSNQIPEDSDLGTVIALIKVRDKDSGQNGMVTcY--TQEEVP--FKLESTSKNyykLVIAGALNREQTADYNVTIIATDK 423
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF-YsiLGGGPGgnFRIDPDTGD---ISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*
gi 11128037   424 GKPALSSRTSITLHI 438
Cdd:pfam00028  77 GGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
138-230 9.99e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 9.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   138 EICESALPGVKFSLDSAQDADVEGNSLKLYTI---NPNQYFSLSTKespDGskypVLLLEKPLDREHQSSHRLILTAMDG 214
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlggGPGGNFRIDPD---TG----DISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 11128037   215 GDPPLSGTTHIWIRVT 230
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-657 1.14e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 61.55  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037   574 VPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALgDRDAARQ-RLLVAVRDGGQPPLSA 652
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL-DRESIGEyELTVEATDSGGPPLSS 83


                  ....*
gi 11128037   653 TATLH 657
Cdd:pfam00028  84 TATVT 88
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-126 7.27e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 7.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037  30 QIRYTIPEELANGSRVGKL-AKDLGLSVRELPT-RKLRVSAEDYFNVSLESGDLLVNGRIDREKICGRKLecalefeTV- 106
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVsATDPDSGENGEVTySIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTL-------TVt 73

                        90       100
                ....*....|....*....|....*
gi 11128037 107 ----AENPMNVF-HVVVVIQDINDN 126
Cdd:cd11304  74 atdgGGPPLSSTaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-126 7.84e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.63  E-value: 7.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11128037  31 IRYTIPEELANGSRVGKLAKDLGlsvrELPTRKLRVSAE------DYFNVSLESGDLLVNGRIDREKICGRKLECALEfE 104
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAgkealpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAA-S 76

                        90       100
                ....*....|....*....|..
gi 11128037 105 TVAENPMNVFHVVVVIQDINDN 126
Cdd:cd00031  77 LGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 67-128 1.06e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 1.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 11128037     67 SAEDYFNVSLESGDLLVNGRIDREKICgrklecALEFETVAEN-----PMNVFHVVVVIQDINDNAP 128
Cdd:smart00112  21 NDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEATDgggppLSSTATVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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