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Conserved domains on  [gi|9256596|ref|NP_061734|]
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protocadherin alpha-8 isoform 1 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175747)

protocadherin is a transmembrane protein belonging to the cadherin superfamily and may be a calcium-dependent cell-adhesion protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.22e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


:

Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.22e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256596    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.72e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 124.56  E-value: 8.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     30 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256596    110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 2.18e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 2.18e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  246 EYEVRIFENADNGTTVIKLNASDPDEGANGAISYSfnsLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256596  326 GHPPMAGHCTVLVRILDKNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 2.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERrvgerSLSSYISVHTESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256596  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 1.39e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256596  434 SLWATASLSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 4.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 4.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  140 LFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHD---YFMLDVNSkndenklVELVLRKSLDREDAPAHHLFLTATD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST-------GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 9256596  217 GGKPELTGTVQLLVTVLDVNDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.72e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 9256596  661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.22e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.22e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256596    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.72e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 124.56  E-value: 8.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     30 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256596    110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 2.18e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 2.18e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  246 EYEVRIFENADNGTTVIKLNASDPDEGANGAISYSfnsLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256596  326 GHPPMAGHCTVLVRILDKNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 2.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERrvgerSLSSYISVHTESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256596  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 1.39e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256596  434 SLWATASLSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 2.38e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 2.38e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     265 NASDPDEGANGAISYSFNSLVETmviDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKN 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 9256596     345 DNVP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 4.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 4.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  140 LFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHD---YFMLDVNSkndenklVELVLRKSLDREDAPAHHLFLTATD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST-------GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 9256596  217 GGKPELTGTVQLLVTVLDVNDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-341 1.16e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    247 YEVRIFENADNGTTVIKLNASDPDEGANGAISYSfnsLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 9256596    327 HPPMAGHCTVLVRIL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.72e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 9256596  661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 8.58e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.58e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     478 SARDADAQENALVSYSLVERRVGerslsSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 9256596     558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.80e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     157 ASDADVGANSVLTYRLSSHDYF-MLDVNSKNDEnklveLVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDV 235
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 9256596     236 NDNAP 240
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 6.53e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 6.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     373 SVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 9256596     453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 9.06e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 9.06e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9256596     595 RAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
460-556 9.06e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 9.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERslssyISVHTESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256596    540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
581-669 1.32e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                  ....*....
gi 9256596    661 ATATVLVSL 669
Cdd:pfam00028  83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
359-445 3.73e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    359 VREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 9256596    439 ASLSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 4.89e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 4.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    142 VSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF-MLDVNSKNDEnklveLVLRKSLDREDAPAHHLFLTATDGGKP 220
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGD-----ISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 9256596    221 ELTGTVQLLVTVL 233
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 3.10e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596   32 HYSVPEEAKHGTFVGRI-AQDLGLELAELVprLFRVASKRHRDLLEVSLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 9256596  111 -DRPLQVF----HVDVEVKDVNDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 8.45e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 8.45e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9256596      64 FRVASKRHRDLLEVSLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVDVEVKDVNDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_tail pfam15974
Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic ...
 800-916 2.22e-70

Cadherin C-terminal cytoplasmic tail, catenin-binding region; Cadherin_tail is the cytoplasmic domain at the C-terminus of cadherin proteins. This domain binds p120 catenin, an action critical for the surface stability of cadherin-catenin cell-cell adhesion complexes.


Pssm-ID: 435046  Cd Length: 134  Bit Score: 229.14  E-value: 2.22e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    800 RQPNPDWRYSASLRAG-MHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQ 878
Cdd:pfam15974   1 KPPNPDWRYSASLRAGpMQSSVHMEEAGVLRGGPGGLEQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFRYGPGNPKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 9256596    879 SGPGELPDKFIIPGSPAIISIRQEPTNSQiDKSDFITF 916
Cdd:pfam15974  81 PVPGEYPENFIIPGSPAIISIRQPQAQTQ-DQSDFITF 117
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-111 8.72e-34

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 124.56  E-value: 8.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     30 QLHYSVPEEAKHGTFVGRIAQDLGLELAELVPRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVI 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ..
gi 9256596    110 VD 111
Cdd:pfam08266  81 LE 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 2.18e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.96  E-value: 2.18e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  246 EYEVRIFENADNGTTVIKLNASDPDEGANGAISYSfnsLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDK 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
gi 9256596  326 GHPPMAGHCTVLVRILDKNDN 346
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 459-561 2.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.33  E-value: 2.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  459 EYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERrvgerSLSSYISVHTESGKVYALQPLDHEELELLQFQVSAR 538
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-----NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 9256596  539 DAGVPPLGSNVTLQVFVLDENDN 561
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-451 1.39e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 1.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  354 SLSLPVREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSP 433
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                        90
                ....*....|....*...
gi 9256596  434 SLWATASLSVEVADVNDN 451
Cdd:cd11304  81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 2.38e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 2.38e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     265 NASDPDEGANGAISYSFNSLVETmviDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKN 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD---GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 9256596     345 DNVP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 140-238 4.16e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 4.16e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  140 LFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHD---YFMLDVNSkndenklVELVLRKSLDREDAPAHHLFLTATD 216
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSIDPST-------GEITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 9256596  217 GGKPELTGTVQLLVTVLDVNDN 238
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-341 1.16e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    247 YEVRIFENADNGTTVIKLNASDPDEGANGAISYSfnsLVETMVIDHFSIDRNTGEIVIRGNLDFEQENLYKILIDATDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 9256596    327 HPPMAGHCTVLVRIL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 581-670 3.72e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.91  E-value: 3.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596  581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|
gi 9256596  661 ATATVLVSLV 670
Cdd:cd11304  84 STATVTITVL 93
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 478-563 8.58e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.41  E-value: 8.58e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     478 SARDADAQENALVSYSLVERRVGerslsSYISVHTESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLD 557
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 9256596     558 ENDNAP 563
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.80e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.25  E-value: 1.80e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     157 ASDADVGANSVLTYRLSSHDYF-MLDVNSKNDEnklveLVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDV 235
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
gi 9256596     236 NDNAP 240
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-453 6.53e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.01  E-value: 6.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596     373 SVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWATASLSVEVADVNDNA 452
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 9256596     453 P 453
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-670 9.06e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 9.06e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9256596     595 RAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALTATATVLVSLV 670
Cdd:smart00112   1 SATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
Cadherin pfam00028
Cadherin domain;
460-556 9.06e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 9.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    460 YTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRVGERslssyISVHTESGKVYALQPLDHEELELLQFQVSARD 539
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 9256596    540 AGVPPLGSNVTLQVFVL 556
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
581-669 1.32e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    581 VPRSVGAGHVVAKVRAVDADSGYNAWLSYELQPaaSSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT 660
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                  ....*....
gi 9256596    661 ATATVLVSL 669
Cdd:pfam00028  83 STATVTITV 91
Cadherin pfam00028
Cadherin domain;
359-445 3.73e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    359 VREDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSAYELVVTARDGGSPSLWAT 438
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 9256596    439 ASLSVEV 445
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
142-233 4.89e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.01  E-value: 4.89e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596    142 VSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYF-MLDVNSKNDEnklveLVLRKSLDREDAPAHHLFLTATDGGKP 220
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGD-----ISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 9256596    221 ELTGTVQLLVTVL 233
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-129 3.10e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596   32 HYSVPEEAKHGTFVGRI-AQDLGLELAELVprLFRVASKRHRDLLEVSLQNGILFVNSRIDREELcgrsaeCSIHLEVIV 110
Cdd:cd11304   3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                        90       100
                ....*....|....*....|....
gi 9256596  111 -DRPLQVF----HVDVEVKDVNDN 129
Cdd:cd11304  75 tDGGGPPLsstaTVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 33-129 2.43e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.87  E-value: 2.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9256596   33 YSVPEEAKHGTFVGRIAQDLGlelaELVPRLFRVASK---RHRDLLEVSLQNGILFVNSRIDREELcgrsaeCSIHLEVI 109
Cdd:cd00031   4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAgkeALPSWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                        90       100
                ....*....|....*....|....*
gi 9256596  110 VDRPLQVFHVD-----VEVKDVNDN 129
Cdd:cd00031  74 AASLGANVPQTssvfsIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 64-131 8.45e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 41.95  E-value: 8.45e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9256596      64 FRVASKRHRDLLEVSLQNGILFVNSRIDREELCgrsaecSIHLEVIV----DRPLQVF-HVDVEVKDVNDNPP 131
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQP------EYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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