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Conserved domains on  [gi|145864493|ref|NP_061217|]
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A-kinase anchor protein 7 isoform 1 [Mus musculus]

Protein Classification

AKAP7 2'5' RNA ligase-like domain-containing protein; AKAP7-like phosphoesterase domain-containing protein( domain architecture ID 12106243)

AKAP7 (A-kinase anchoring protein 7) 2'5' RNA ligase-like domain-containing protein| AKAP7-like phosphoesterase domain-containing protein with similarities to the domain found in the cyclic AMP-dependent protein kinase A (PKA) anchor protein, AKAP7 (also known as AKAP18), which belongs to the 2H RNA-phosphoesterase family and contains two conserved His-x-Thr motifs which may bind AMP and CMP. May act as a phosphoesterase or as an AMP sensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 51-249 1.15e-64

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 202.50  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493   51 PNYFLSIPITNKKITTGIKVLQNSILQQDKRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 129
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  130 LALPFQGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRT-FKPHLTFMKLSKAPMLRKKGVR 203
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 145864493  204 KIEP-GLYEQFIDHRFGEELLYQIDLCSMLKKKQSNGYYHCESSIVI 249
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 256-311 2.23e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


:

Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 2.23e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145864493  256 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDN 311
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 51-249 1.15e-64

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 202.50  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493   51 PNYFLSIPITNKKITTGIKVLQNSILQQDKRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 129
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  130 LALPFQGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRT-FKPHLTFMKLSKAPMLRKKGVR 203
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 145864493  204 KIEP-GLYEQFIDHRFGEELLYQIDLCSMLKKKQSNGYYHCESSIVI 249
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 256-311 2.23e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 2.23e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145864493  256 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDN 311
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 53-220 7.86e-05

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 42.71  E-value: 7.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  53 YFLSIPItNKKITTGIKVLQNSILQQDK-RLTKAmvgdGSFHITLLVMQLLNEDEV----NIGTDALLELKPFveeileg 127
Cdd:COG1514    3 LFIALPP-PEELREALAALRARLKAAPGgRWVRP----ENLHLTLAFLGEVDEERLealaEALARAAAGAPPF------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 128 khlALPFQGIGTFQGQVG---FVKLADGDhvsALLEIAETAKRTFREKGiLAGESRTFKPHLTfmklskapMLRKKGVRK 204
Cdd:COG1514   71 ---ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT--------LARGKRPAP 135

                        170
                 ....*....|....*.
gi 145864493 205 IEPGLYEQFIDHRFGE 220
Cdd:COG1514  136 PLAPALAELRDFEFPE 151
PLN00108 PLN00108
unknown protein; Provisional
 53-247 4.02e-04

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 41.21  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  53 YFLSIPIT-NKKITTGIKVLQNSILQQDKR-------------LTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLEL 117
Cdd:PLN00108  38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstlaemgIEKSIfVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 118 KPFVEEILEGKHLALPFQGIGTFQG-----QVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRT-FKPHLTFMKL 191
Cdd:PLN00108 118 CSNVRQALKDRPVFIRLRGLDCMNGsldktRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 192 SkapmLRKKGVRKIEP----GLYEQFIDHRFGEELLYQIDLcSMLKKKQSNGYYHCESSI 247
Cdd:PLN00108 198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
 
Name Accession Description Interval E-value
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 51-249 1.15e-64

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 202.50  E-value: 1.15e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493   51 PNYFLSIPITNKKITTGIKVLQNSILQQDKRLTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKH 129
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECREEIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  130 LALPFQGIGTF-----QGQVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRT-FKPHLTFMKLSKAPMLRKKGVR 203
Cdd:pfam10469  81 LSLRFKGLETFnddpsAVRVLYAKVEEDDHSPKLQELADRIIRRFQEAGLLVKENNSrVKLHMTLMNTRYRKKKYAKSKE 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 145864493  204 KIEP-GLYEQFIDHRFGEELLYQIDLCSMLKKKQSNGYYHCESSIVI 249
Cdd:pfam10469 161 SFDArEILDEFKDFDFGTQKVSELHLCSMGSSDESDGFYHVEASVKL 207
AKAP7_RIRII_bdg pfam10470
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ...
 256-311 2.23e-29

PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal.


Pssm-ID: 463101  Cd Length: 56  Bit Score: 106.58  E-value: 2.23e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145864493  256 EPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDN 311
Cdd:pfam10470   1 EPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNRPGDGSSVKAEEADRGGNGSDN 56
ThpR COG1514
RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and ...
 53-220 7.86e-05

RNA 2',3'-cyclic phosphodiesterase (2'-5' RNA ligase) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441123 [Multi-domain]  Cd Length: 181  Bit Score: 42.71  E-value: 7.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  53 YFLSIPItNKKITTGIKVLQNSILQQDK-RLTKAmvgdGSFHITLLVMQLLNEDEV----NIGTDALLELKPFveeileg 127
Cdd:COG1514    3 LFIALPP-PEELREALAALRARLKAAPGgRWVRP----ENLHLTLAFLGEVDEERLealaEALARAAAGAPPF------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 128 khlALPFQGIGTFQGQVG---FVKLADGDhvsALLEIAETAKRTFREKGiLAGESRTFKPHLTfmklskapMLRKKGVRK 204
Cdd:COG1514   71 ---ELRLDGLGAFPRPRPrvlWLGVEPSP---ELLALHRRLRAALARAG-LPPERRPFVPHVT--------LARGKRPAP 135

                        170
                 ....*....|....*.
gi 145864493 205 IEPGLYEQFIDHRFGE 220
Cdd:COG1514  136 PLAPALAELRDFEFPE 151
PLN00108 PLN00108
unknown protein; Provisional
 53-247 4.02e-04

unknown protein; Provisional


Pssm-ID: 177724  Cd Length: 257  Bit Score: 41.21  E-value: 4.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493  53 YFLSIPIT-NKKITTGIKVLQNSILQQDKR-------------LTKAM-VGDGSFHITLLVMQLLNEDEVNIGTDALLEL 117
Cdd:PLN00108  38 HFVSLPLAiYPDLKKNIEAFQNSVLGNNDKdplkfqstlaemgIEKSIfVSPKTFHLTVVMLKLENNESVVKAQNILKSI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 118 KPFVEEILEGKHLALPFQGIGTFQG-----QVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRT-FKPHLTFMKL 191
Cdd:PLN00108 118 CSNVRQALKDRPVFIRLRGLDCMNGsldktRVLYAPVEEVGHEGRLLNACHVIIDAFENAGFAGKDAKSrLKLHATLMNA 197

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145864493 192 SkapmLRKKGVRKIEP----GLYEQFIDHRFGEELLYQIDLcSMLKKKQSNGYYHCESSI 247
Cdd:PLN00108 198 S----YRKDKSKKMDTfdarEIHKEFENKDWGTYLIREAHI-SQRYKYDPNGYFHCCASL 252
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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