first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283   1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                        90
                ....*....|..
gi 8922569  220 LVQLSEEFGTPN 231
Cdd:cd18283  81 LIQLSEEFGTPN 92

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283   1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                        90
                ....*....|..
gi 8922569  220 LVQLSEEFGTPN 231
Cdd:cd18283  81 LIQLSEEFGTPN 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569     143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrfQNVDIL 220
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESdkSEIYLD----DVSPEDFRALLNFLYTGKLDLPE---ENVEEL 73

                           90
                   ....*....|
gi 8922569     221 VQLSEEFGTP 230
Cdd:smart00225  74 LELADYLQIP 83

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 8922569    269 CLDEELKAHKAVISARSPFFRNLLQRRIRTGEEITdrtlrtptrIILDESiipkKYATV--ILHCMYTD 335
Cdd:pfam00651  17 VGDKEFRAHKAVLAACSPYFKALFSGQESESSVSE---------ITLDDV----SPEDFeaLLEFMYTG 72

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  140 YCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNVDI 219
Cdd:cd18283   1 YCTDVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDV 80

                        90
                ....*....|..
gi 8922569  220 LVQLSEEFGTPN 231
Cdd:cd18283  81 LIQLSEEFGTPN 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569    137 EYKYCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPE--YGAEIIMDintaGIDMPMFSALLHYLYTGEFGMEDsrf 214
Cdd:pfam00651   7 QGELC-DVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESesSVSEITLD----DVSPEDFEALLEFMYTGKLISEE--- 78

                          90       100
                  ....*....|....*....|.
gi 8922569    215 qNVDILVQLSEEFGTPNSLDV 235
Cdd:pfam00651  79 -NVDDLLAAADKLQIPSLVDK 98

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  130 KDMADLYEYKYCTDVDLIFQE-TCFPVHRAILAARCPFFKTLLSsspeYGAEIIMDintAGIDMPMFSALLHYLYTGEFG 208
Cdd:cd18299   1 EDLRNLLHSPSCADVVFILQGgVRIFAHRIVLAAASSVFADLFL----MMTVVTLD---SDITPEAFRRVLEFLYTGVLD 73

                        90
                ....*....|....*..
gi 8922569  209 MEDSRFQNVDILVQLSE 225
Cdd:cd18299  74 ENEDDLKELKDAAELLE 90

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  127 TLQKDMADLYEYK---YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAGIDMPMFSALLHYLY 203
Cdd:cd18309   4 TLEQDMEAFLESVggdFC-DITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSRQAFDSLLRYIY 82

                        90
                ....*....|.
gi 8922569  204 TGEFGM--EDS 212
Cdd:cd18309  83 YGDVTMppEDS 93

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLS-SSPEYGAEII-MDINTAGidmpMFSALLHYLYTG 205
Cdd:cd18286   4 LGKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSgSWAESNSSEItLTGVSHA----AVSFVLLFIYGG 79

                        90       100       110
                ....*....|....*....|....*....|
gi 8922569  206 EfgMEDSRFQNVDILVQLSEEFGTPNSLDV 235
Cdd:cd18286  80 V--LDLPDDVNLGELLSLADMYGLDGLKDV 107

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8922569  143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIimDINTAGIDMPMFSALLHYLYTG 205
Cdd:cd18295  21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREI--NLKHPLVNPDAFRALLQYLYTG 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18269  14 LQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLE----DVDPDVMGMILKYLYTS 89

                        90       100
                ....*....|....*....|....*
gi 8922569  206 EFGMEDsrfQNVDILVQLSEEFGTP 230
Cdd:cd18269  90 EIDLND---QNVQDIFALASRFQIP 111

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8922569  141 CTDVDLIFQE-TCFPVHRAILAARCPFFKTLLSSSPEYGA---------EIIMDintAGIDMPMFSALLHYLYTGEFG 208
Cdd:cd18310  18 YSDAEIIVEGgRPVPVHRCILAARSPFFRDIFASAKAEGAntkpklelrELIPG---GIVGYDAFMLVLSYLYSGRLR 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  120 LARPEARtLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALL 199
Cdd:cd18343   1 LKVPECR-LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND--VDPEVFKEMM 77

                ....*.
gi 8922569  200 HYLYTG 205
Cdd:cd18343  78 RFIYTG 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  128 LQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSS--SPEYGAEIIMDintaGIDMPMFSALLHYLYTG 205
Cdd:cd18341  14 LQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSeeSEEKKKEVVLD----NVDPNIMDMILKYLYSA 89

                        90       100       110
                ....*....|....*....|....*....|
gi 8922569  206 EFGMEDSrfqNVDILVQLSEEFGTPNSLDV 235
Cdd:cd18341  90 EIDLNDG---NVQDIFALASRFQIPSVFTV 116

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  128 LQKDMADLYEYKYCTDV--DLIFQ---ETcFPVHRAILAARCPFFKTLLSSSPEYGAEIIMD--INTAGIDMPMFSALLH 200
Cdd:cd18301   1 FQEDFKKLLDEADEGDNihDVVFQvggKT-FPAHKFILASRSDYFRKLFLSSLLTSEDAVGCdvVHIEKVPPEIFEQLLQ 79

                ....*
gi 8922569  201 YLYTG 205
Cdd:cd18301  80 FIYTD 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLssSPEYGAEIIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV-- 217
Cdd:cd18256  20 FC-DVQLQVGMELFSVHRLVLAASSPYFAALF--AGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELlv 96

                        90
                ....*....|
gi 8922569  218 --DILvQLSE 225
Cdd:cd18256  97 aaDML-QLTE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGA---EIIMDINTAGIDmpMFSALLHY 201
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESkqsEIELVEDPECAA--VFEKFLRY 78

                ....*
gi 8922569  202 LYTGE 206
Cdd:cd18292  79 LYTGQ 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  125 ARTLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEiiMDINTAGIDMPMFSALLHYLYT 204
Cdd:cd18270  10 AVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQ--THVHLRNVDAATLQIIITYAYT 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 8922569  205 GEFGMEDSR---------FQNVDILVQLSEEF 227
Cdd:cd18270  88 GNLAINDSTveqlyetacFLQVEDVLQRCREY 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  127 TLQKDMADLYEYKYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYLYTGE 206
Cdd:cd18344   9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD--LDPQVFKEMMGFIYTGK 86

                        90
                ....*....|....
gi 8922569  207 FGMEDSRFQNVDIL 220
Cdd:cd18344  87 APHLHSHSMACDVL 100

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8922569     268 NCLDEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsiIPKKYATVILHCMYTDVVDLS 340
Cdd:smart00225   5 VVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDK---------SEIYLDD--VSPEDFRALLNFLYTGKLDLP 66

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSS--PEYGAEIIMdintAGIDMPMFSALLHYLYTGEFGmEDSRFQNVDIL 220
Cdd:cd18300  11 DVTFIVEDGTIPAHKALLVARCDVMAAMFGGNfrESSAKEVEL----PGVSKETFLALLEYLYTDQAP-ILEDGDCVGLI 85

                        90
                ....*....|.
gi 8922569  221 VqLSEEFGTPN 231
Cdd:cd18300  86 V-LANRLCLPR 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  124 EARTLQKDMADLyeykyctDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG-AEIIMDINTAGidmpMFSALLHYL 202
Cdd:cd18231   6 EQRLFQPDLCDV-------DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQLQrVELSLEALTSQ----GLQQILNFI 74

                        90
                ....*....|....*
gi 8922569  203 YTGEFGMEDSRFQNV 217
Cdd:cd18231  75 YTSKLLVNSCNVQDV 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIimdinTAGIDMPMFSALLHYLYTGEFGM 209
Cdd:cd18290  27 YC-DVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVEL-----PAAVQPQSFQQILSFCYTGRLSM 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  144 VDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYG--AEIIMDintaGIDMPMFSALLHYLYTGEFGMEDSrfqNVDILV 221
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESgqAEINLR----DISPEDFRALLEFLYGGKRDLDAS---NLLELL 73

                ..
gi 8922569  222 QL 223
Cdd:cd01165  74 EA 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8922569  140 YCtDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTAgidmpMFSALLHYLYTGEFGMEDS 212
Cdd:cd18289  29 YC-DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPA-----CFQQILSFCYTGKLTMAAS 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8922569  143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAeiIMDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18194  25 DCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRD--LVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDV 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 8922569  142 TDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINtaGIDMPMFSALLHYLYTGE 206
Cdd:cd18253  19 TDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEIN--GILAEAMDCFLQYVYTGK 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8922569  271 DEELKAHKAVISARSPFFRNLLQRRIRTGEEitdrtlrtpTRIILDEsIIPKKYaTVILHCMYTDV 336
Cdd:cd18280  23 GEKFRAHKLVLAARSPVFRSMLFGPMREENE---------GEIVIED-VEPPVF-KALLHFIYKDE 77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  139 KYCTDVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEYGAEIImDINTagIDMPMFSALLHYLYTGefGMEDSRFQNVD 218
Cdd:cd18351  22 KEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCI-EISY--VKYHIFQLVMQYLYCG--GTESLLIKNNE 96

                ....*.
gi 8922569  219 ILVQLS 224
Cdd:cd18351  97 IMELLS 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 8922569  153 FPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINTagIDMPMFSALLHYLYTG 205
Cdd:cd18297  24 FYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPD--IRYDIFQLMMQYLYTG 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  125 ARTLQKDMADLYEYKYCTDVDL--------IFQETCFPVHRAILAARCPFFKTL----LSSSPEYGAEIimdintAGIDM 192
Cdd:cd18273  10 ARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMftggLYESKQETVTI------HDVDS 83

                        90       100
                ....*....|....*....|....*
gi 8922569  193 PMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18273  84 ESMALIIDYCYTGRVTLSEANVQRL 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 8922569  143 DVDLIFQETCFPVHRAILAARCPFFKTLLS-SSPEYGAEiimDINTAGIDMPMFSALLHYLYTGEFGMEDSRFQNV 217
Cdd:cd18261  30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSlCMVESEAD---EVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 8922569  153 FPVHRAILAARCPFFKTLLSSSPEYGAEIIMDINtaGIDMPMFSALLHYLYTG 205
Cdd:cd18306  30 IPAHRAVLACASPYLFELFSSDSDGESILTVKLD--GLDPDAVEVLVNYAYTS 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8922569  143 DVDLIFQETCFPVHRAILAARCPFFKTLLSSSPEygaEIIMD-INTAGIDMPMFSALLHYLYTGEFGMEDsrfQNVDILV 221
Cdd:cd18250  23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELR---ESRADrVVLHGVSAEILGLLLDFSYTGRVTVTQ---DNVEALL 96

                ....*....
gi 8922569  222 QLSEEFGTP 230
Cdd:cd18250  97 RAADLFQFP 105