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Conserved domains on  [gi|31542713|ref|NP_060368|]
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mitochondrial amidoxime reducing component 2 isoform a precursor [Homo sapiens]

Protein Classification

MOSC domain-containing protein( domain architecture ID 11461388)

MOSC (molybdenum cofactor sulfurase C-terminal) domain-containing protein similar to vertebrate mitochondrial amidoxime reducing component, which is part of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime

EC:  1.7.-.-
PubMed:  11886751

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YcbX COG3217
N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and ...
54-331 1.87e-71

N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


:

Pssm-ID: 442450 [Multi-domain]  Cd Length: 240  Bit Score: 221.60  E-value: 1.87e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  54 VGTVAKLWIYPVKSCKGVPVSEAECTAMGLRsgnlRDRFWLVIKEDGHMVTARQEPRLVLISIIY-ENNCLIFRAPDMDQ 132
Cdd:COG3217   1 MGRVSRLYRYPVKSLAGEALESATLTAGGLP----GDRRWALVDADGRFLTQRRHPRLALLRARLdEDGGLTLTAPGGES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 133 LVlpskqpssnklhncriFGLDikgRDCGNEAAKWFTNFLKTEAyRLVQFEtnmkgrtsrkllPTLDQNFQVAYPDYCPL 212
Cdd:COG3217  77 LT----------------VDLD---DDAGDAAAAWLSEYLGRPV-RLVRLP------------PESRRGPPVGFADGYPV 124
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 213 LIMTDASLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTW--DELLIGSVEVKKVMACPRCILTTVDPDTGVIDrKQPL 290
Cdd:COG3217 125 LLISTASLADLNARLGAPVDMRRFRPNLVVDGLEPFAEDDWvgRRLRIGEVRLRVVKPCSRCVVTTVDPETGERD-PEPL 203
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31542713 291 DTLKSYRlcdpseRELYKlsPLFGIYYSVEKIGSLRVGDPV 331
Cdd:COG3217 204 RTLARYR------GADGH--VDFGVNAIVLEGGTIRVGDEV 236
 
Name Accession Description Interval E-value
YcbX COG3217
N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and ...
54-331 1.87e-71

N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 442450 [Multi-domain]  Cd Length: 240  Bit Score: 221.60  E-value: 1.87e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  54 VGTVAKLWIYPVKSCKGVPVSEAECTAMGLRsgnlRDRFWLVIKEDGHMVTARQEPRLVLISIIY-ENNCLIFRAPDMDQ 132
Cdd:COG3217   1 MGRVSRLYRYPVKSLAGEALESATLTAGGLP----GDRRWALVDADGRFLTQRRHPRLALLRARLdEDGGLTLTAPGGES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 133 LVlpskqpssnklhncriFGLDikgRDCGNEAAKWFTNFLKTEAyRLVQFEtnmkgrtsrkllPTLDQNFQVAYPDYCPL 212
Cdd:COG3217  77 LT----------------VDLD---DDAGDAAAAWLSEYLGRPV-RLVRLP------------PESRRGPPVGFADGYPV 124
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 213 LIMTDASLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTW--DELLIGSVEVKKVMACPRCILTTVDPDTGVIDrKQPL 290
Cdd:COG3217 125 LLISTASLADLNARLGAPVDMRRFRPNLVVDGLEPFAEDDWvgRRLRIGEVRLRVVKPCSRCVVTTVDPETGERD-PEPL 203
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31542713 291 DTLKSYRlcdpseRELYKlsPLFGIYYSVEKIGSLRVGDPV 331
Cdd:COG3217 204 RTLARYR------GADGH--VDFGVNAIVLEGGTIRVGDEV 236
MOSC_N pfam03476
MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The ...
54-175 4.66e-44

MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.


Pssm-ID: 281474  Cd Length: 118  Bit Score: 147.12  E-value: 4.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713    54 VGTVAKLWIYPVKSCKGVPVSEAECTAMGLRsgnlRDRFWLVIKEDGHMVTARQEPRLVLISIIYENNC-LIFRAPDMDQ 132
Cdd:pfam03476   1 MARVSSLYVYPIKSCRGESLSRAELTAAGLA----WDRRFMVVDSDGKFVTARREPRLVLIRTTLDEDGgLTLTAPGMPD 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 31542713   133 LVLPSKQPsSNKLHNCRIFGLDIKGRDCGNEAAKWFTNFLKTE 175
Cdd:pfam03476  77 LSVPLADN-KFDLRGVLVWGLSFSGRDCGDAAADWFSDFLGKP 118
PLN02724 PLN02724
Molybdenum cofactor sulfurase
62-331 5.19e-30

Molybdenum cofactor sulfurase


Pssm-ID: 215384 [Multi-domain]  Cd Length: 805  Bit Score: 120.74  E-value: 5.19e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713   62 IYPVKSCKGVPVSEAECTAMGLrsgnLRDRFWLVIKEDGHMVTARQEPRLVLIS--IIYENNCLIFRAPDMD-QLVLPSK 138
Cdd:PLN02724 525 VYPIKSCAGFSVERWPLSETGL----LYDREWMIQSLTGEILTQKKVPEMCLITtfIDLESGKLVVRAPRCDhKLEIPLE 600
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  139 QPSSNKLHNCRIF-GLDIKGRDCGNEAAKWFTNFLKTEAyRLVQFE---TNMKGRTSRKLLPTLDQNFQVAYPDYCPLLI 214
Cdd:PLN02724 601 SDSQHEESGEVILcGNRAESMSYGTEINEWFTNALGRRC-TLVRKSssnTRVCRNRNPSHSPCGDDESRLSFANEGQFLL 679
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  215 MTDASLVDLNTRMEKKMKME-------NFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTTVDPDTGVIDRK 287
Cdd:PLN02724 680 ISEASVEDLNRRLATGQEDAkirldptRFRPNLVVSGGEAYAEDEWQSLSIGDAEFTVLGGCNRCQMINIDQETGLVNPS 759
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 31542713  288 -QPLDTLKSYRlcdpsereLYKLSPLFGI---YYSVEKIGS-LRVGDPV 331
Cdd:PLN02724 760 nEPLATLASYR--------RVKGKILFGIllrYEISDKRDQwIAVGSRV 800
 
Name Accession Description Interval E-value
YcbX COG3217
N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and ...
54-331 1.87e-71

N-hydroxylaminopurine reductase subunit YcbX, contains MOSC domain [Nucleotide transport and metabolism, Defense mechanisms];


Pssm-ID: 442450 [Multi-domain]  Cd Length: 240  Bit Score: 221.60  E-value: 1.87e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  54 VGTVAKLWIYPVKSCKGVPVSEAECTAMGLRsgnlRDRFWLVIKEDGHMVTARQEPRLVLISIIY-ENNCLIFRAPDMDQ 132
Cdd:COG3217   1 MGRVSRLYRYPVKSLAGEALESATLTAGGLP----GDRRWALVDADGRFLTQRRHPRLALLRARLdEDGGLTLTAPGGES 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 133 LVlpskqpssnklhncriFGLDikgRDCGNEAAKWFTNFLKTEAyRLVQFEtnmkgrtsrkllPTLDQNFQVAYPDYCPL 212
Cdd:COG3217  77 LT----------------VDLD---DDAGDAAAAWLSEYLGRPV-RLVRLP------------PESRRGPPVGFADGYPV 124
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713 213 LIMTDASLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTW--DELLIGSVEVKKVMACPRCILTTVDPDTGVIDrKQPL 290
Cdd:COG3217 125 LLISTASLADLNARLGAPVDMRRFRPNLVVDGLEPFAEDDWvgRRLRIGEVRLRVVKPCSRCVVTTVDPETGERD-PEPL 203
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31542713 291 DTLKSYRlcdpseRELYKlsPLFGIYYSVEKIGSLRVGDPV 331
Cdd:COG3217 204 RTLARYR------GADGH--VDFGVNAIVLEGGTIRVGDEV 236
MOSC_N pfam03476
MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The ...
54-175 4.66e-44

MOSC N-terminal beta barrel domain; This domain is found to the N-terminus of pfam03473. The function of this domain is unknown, however it is predicted to adopt a beta barrel fold.


Pssm-ID: 281474  Cd Length: 118  Bit Score: 147.12  E-value: 4.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713    54 VGTVAKLWIYPVKSCKGVPVSEAECTAMGLRsgnlRDRFWLVIKEDGHMVTARQEPRLVLISIIYENNC-LIFRAPDMDQ 132
Cdd:pfam03476   1 MARVSSLYVYPIKSCRGESLSRAELTAAGLA----WDRRFMVVDSDGKFVTARREPRLVLIRTTLDEDGgLTLTAPGMPD 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 31542713   133 LVLPSKQPsSNKLHNCRIFGLDIKGRDCGNEAAKWFTNFLKTE 175
Cdd:pfam03476  77 LSVPLADN-KFDLRGVLVWGLSFSGRDCGDAAADWFSDFLGKP 118
PLN02724 PLN02724
Molybdenum cofactor sulfurase
62-331 5.19e-30

Molybdenum cofactor sulfurase


Pssm-ID: 215384 [Multi-domain]  Cd Length: 805  Bit Score: 120.74  E-value: 5.19e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713   62 IYPVKSCKGVPVSEAECTAMGLrsgnLRDRFWLVIKEDGHMVTARQEPRLVLIS--IIYENNCLIFRAPDMD-QLVLPSK 138
Cdd:PLN02724 525 VYPIKSCAGFSVERWPLSETGL----LYDREWMIQSLTGEILTQKKVPEMCLITtfIDLESGKLVVRAPRCDhKLEIPLE 600
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  139 QPSSNKLHNCRIF-GLDIKGRDCGNEAAKWFTNFLKTEAyRLVQFE---TNMKGRTSRKLLPTLDQNFQVAYPDYCPLLI 214
Cdd:PLN02724 601 SDSQHEESGEVILcGNRAESMSYGTEINEWFTNALGRRC-TLVRKSssnTRVCRNRNPSHSPCGDDESRLSFANEGQFLL 679
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713  215 MTDASLVDLNTRMEKKMKME-------NFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTTVDPDTGVIDRK 287
Cdd:PLN02724 680 ISEASVEDLNRRLATGQEDAkirldptRFRPNLVVSGGEAYAEDEWQSLSIGDAEFTVLGGCNRCQMINIDQETGLVNPS 759
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 31542713  288 -QPLDTLKSYRlcdpsereLYKLSPLFGI---YYSVEKIGS-LRVGDPV 331
Cdd:PLN02724 760 nEPLATLASYR--------RVKGKILFGIllrYEISDKRDQwIAVGSRV 800
MOSC pfam03473
MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich ...
201-332 2.62e-19

MOSC domain; The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as Swiss:P32157, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.


Pssm-ID: 460936  Cd Length: 116  Bit Score: 81.86  E-value: 2.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31542713   201 NFQVAYPDYCPLLIMTDASLVDLNTRM-EKKMKMENFRPNIVVTGcdafeeDTWDELLIGSVeVKKVMACPRcilttvdp 279
Cdd:pfam03473   1 DRKHHGGDDKAVLLYSRESYDAWNAELgRGPLDPGRFRENLVVSG------GTWKEVCIGDR-FRIGGACLR-------- 65
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 31542713   280 dTGVIDRKQPLDTLKSyRLCDPSERELYKLSPLFGIYYSVEKIGSLRVGDPVY 332
Cdd:pfam03473  66 -LEVTQPREPCKTLAK-RFGERRVDKRFKGSGRFGWYLRVLEEGTVRVGDEVE 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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