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Conserved domains on  [gi|30089935|ref|NP_060340|]
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transmembrane protein 132A isoform a precursor [Homo sapiens]

Protein Classification

transmembrane protein 132( domain architecture ID 12174329)

transmembrane protein 132 (TMEM132) such as Rattus norvegicus TMEM132D, also called mature oligodendrocytes transmembrane protein (MOLT), that may serve as a cell-surface marker for oligodendrocyte differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 2.64e-147

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


:

Pssm-ID: 465003  Cd Length: 344  Bit Score: 442.11  E-value: 2.64e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    408 ELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    488 RLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAeGPAEPAAEASDEAE--RRARGCHLQYQRAGVRFLAPFAAHPLDGGRr 565
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGS-NKRRPARDSEDEEEddRKGRGCRLQYQHATVRVLARFVAEDADTGQ- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    566 LTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPV 645
Cdd:pfam16070  159 VSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLV 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    646 MGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQGAQL 725
Cdd:pfam16070  239 SGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRW 318

                          330       340
                   ....*....|....*....|....*.
gi 30089935    726 GVVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  319 PVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 4.78e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 155.46  E-value: 4.78e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935     48 AALELLDAPEHFRVQQVGHYPPANSSLSSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 30089935    121 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGS--LPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSerLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 837-902 2.41e-25

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


:

Pssm-ID: 464814  Cd Length: 84  Bit Score: 100.45  E-value: 2.41e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30089935    837 MVPAPQHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTsPQPHNWVWLGTD 902
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 2.64e-147

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 442.11  E-value: 2.64e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    408 ELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    488 RLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAeGPAEPAAEASDEAE--RRARGCHLQYQRAGVRFLAPFAAHPLDGGRr 565
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGS-NKRRPARDSEDEEEddRKGRGCRLQYQHATVRVLARFVAEDADTGQ- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    566 LTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPV 645
Cdd:pfam16070  159 VSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLV 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    646 MGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQGAQL 725
Cdd:pfam16070  239 SGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRW 318

                          330       340
                   ....*....|....*....|....*.
gi 30089935    726 GVVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  319 PVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 4.78e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 155.46  E-value: 4.78e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935     48 AALELLDAPEHFRVQQVGHYPPANSSLSSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 30089935    121 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGS--LPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSerLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 837-902 2.41e-25

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 100.45  E-value: 2.41e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30089935    837 MVPAPQHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTsPQPHNWVWLGTD 902
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Name Accession Description Interval E-value
TMEM132 pfam16070
Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 ...
 408-751 2.64e-147

Transmembrane protein family 132; This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.


Pssm-ID: 465003  Cd Length: 344  Bit Score: 442.11  E-value: 2.64e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    408 ELVNTAPLTGVPQHVPVRLVTVDGGGALVEVTEHVGCESANTQVLQVSEACDAVFVAGKESRGARGVRVDFWWRRLRASL 487
Cdd:pfam16070    1 EILNTAILTGRTVAVPVKVVAVEADGTVTDVTESVSCSSTDEDVLKVSSSCDSVYVNGKESRGSSNASVNFTYGTLSAQL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    488 RLTVWAPLLPLRIELTDTTLEQVRGWRVPGPAeGPAEPAAEASDEAE--RRARGCHLQYQRAGVRFLAPFAAHPLDGGRr 565
Cdd:pfam16070   81 EFTVWVPRLPLEIEVSDTELSQIKGWRVPIGS-NKRRPARDSEDEEEddRKGRGCRLQYQHATVRVLARFVAEDADTGQ- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    566 LTHLLGPDWLLDVSHLVAPHARVLDSRVASLEGGRVVVGREPGVTSIEVRSPLSDSILGEQALAVTDDKVSVLELRVQPV 645
Cdd:pfam16070  159 VSYLLGSDWQVDVTDLVADFLRVEDPRVARLQDGRVLQGREPGTTTVQVLSPLSDSVLGEKTITVLDDKVTITDLGVQLV 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935    646 MGISLTLSRGTAHPGEVTATCWAQSALPAPKQEVALSLWLSFSDHTVAPAELYDRRDLGLSVSAEEPGAILPAEEQGAQL 725
Cdd:pfam16070  239 SGLSLSLQPSPGSNRAIVATTTAQETLTAPKQEALLSAWLQFSDGSVTPLDLYDPSDYNLSVTSLDEAVVAVSQDPASRW 318

                          330       340
                   ....*....|....*....|....*.
gi 30089935    726 GVVVSGAGAEGLPLHVALHPPEPCRR 751
Cdd:pfam16070  319 PVVVAEGEGQGPLVRVELTISEACQK 344
TMEM132D_N pfam15705
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal ...
 48-168 4.78e-44

Mature oligodendrocyte transmembrane protein, TMEM132D, N-term; TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464813 [Multi-domain]  Cd Length: 129  Bit Score: 155.46  E-value: 4.78e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30089935     48 AALELLDAPEHFRVQQVGHYPPANSSLSSRSETFLLLQPwpRAQPLLRASYPPFATQQVVPPRV-------TEPHQRPVP 120
Cdd:pfam15705    1 VSYQLSNADSAFFLKEANQDLMRNSSLQSRSESFFIYQA--RQPPVLNASYGPFSVEQVVPLELllpssplGSPNKFTFN 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 30089935    121 WDVRAVSVEAAVTPAEPYARVLFHLKGQDWPPGSGS--LPCARLHATHPA 168
Cdd:pfam15705   79 WKLRAHILDSRVYSSRPKVQVLFYIAGRDWDDYDPSerLPCVRLFAFRET 128
TMEM132D_C pfam15706
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal ...
 837-902 2.41e-25

Mature oligodendrocyte transmembrane protein, TMEM132D, C-term; TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.


Pssm-ID: 464814  Cd Length: 84  Bit Score: 100.45  E-value: 2.41e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30089935    837 MVPAPQHVTELELGMYALLGVFCVAIFIFLVNGVVFVLRYQRKEPPDSATDPTsPQPHNWVWLGTD 902
Cdd:pfam15706   20 LVQAFRGLTDLEIGMYALLGVFCLAILVFLINCVVYALKFRHKQVPVEGQGPV-PHSHDWVWLGRE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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