RNA demethylase ALKBH5 [Homo sapiens]
2OG-Fe(II) oxygenase family protein( domain architecture ID 229412)
2OG-Fe(II) oxygenase family protein belongs to the large and diverse Fe(II)- and 2-oxoglutarate (2-OG)-dependent dioxygenase superfamily and may share a common reaction mechanism, using Fe(II) and the cosubstrate 2-OG in the active site to activate oxygen, resulting in the two-electron oxidation of a target substrate
List of domain hits
Name | Accession | Description | Interval | E-value | |||
2OG-FeII_Oxy super family | cl21496 | 2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and ... |
136-270 | 6.57e-10 | |||
2OG-Fe(II) oxygenase superfamily; This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB. The actual alignment was detected with superfamily member pfam13532: Pssm-ID: 473886 Cd Length: 191 Bit Score: 58.09 E-value: 6.57e-10
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Name | Accession | Description | Interval | E-value | |||
2OG-FeII_Oxy_2 | pfam13532 | 2OG-Fe(II) oxygenase superfamily; |
136-270 | 6.57e-10 | |||
2OG-Fe(II) oxygenase superfamily; Pssm-ID: 433285 Cd Length: 191 Bit Score: 58.09 E-value: 6.57e-10
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AlkB | COG3145 | Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair]; |
188-258 | 3.97e-03 | |||
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair]; Pssm-ID: 442379 Cd Length: 200 Bit Score: 38.22 E-value: 3.97e-03
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Name | Accession | Description | Interval | E-value | |||
2OG-FeII_Oxy_2 | pfam13532 | 2OG-Fe(II) oxygenase superfamily; |
136-270 | 6.57e-10 | |||
2OG-Fe(II) oxygenase superfamily; Pssm-ID: 433285 Cd Length: 191 Bit Score: 58.09 E-value: 6.57e-10
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AlkB | COG3145 | Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair]; |
188-258 | 3.97e-03 | |||
Alkylated DNA repair dioxygenase AlkB [Replication, recombination and repair]; Pssm-ID: 442379 Cd Length: 200 Bit Score: 38.22 E-value: 3.97e-03
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Blast search parameters | ||||
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