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Conserved domains on  [gi|8392983|ref|NP_058783|]
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biglycan precursor [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-314 4.56e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 4.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   93 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 170
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  171 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 247
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8392983  248 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLSRVPAgLPDLKLLQVVYLHSNNIT 314
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
LRRNT smart00013
Leucine rich repeat N-terminal domain;
63-95 9.50e-12

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 58.87  E-value: 9.50e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 8392983      63 MCPFGCHCHLRVVQCSDLGLKTVPKEISPDTTL 95
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-314 4.56e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 4.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   93 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 170
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  171 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 247
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8392983  248 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLSRVPAgLPDLKLLQVVYLHSNNIT 314
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-298 2.00e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.73  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    65 PFGCHCHLRVVQCSDLGLKTVPKEIsPDTT-LLDLQNNDISELRKDDFKGLQhlyALVLVNNKISKIHEKAfsPlRKLQK 143
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATL-PDTIqEMELSINRITELPERLPSALQ---SLDLFHNKISCLPENL--P-EELRY 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   144 LYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMnciEMGGNPLEN--SGFEPgafdglKLNYLRISEAKL 221
Cdd:PRK15370 288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTL---EAGENALTSlpASLPP------ELQVLDVSKNQI 358

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983   222 TGIPKDLPETLNELHLDHNKIqaieledllrysklyrlglghnqIRMIENgslsfLP-TLRELHLDNNKLSRVPAGLP 298
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNAL-----------------------TNLPEN-----LPaALQIMQASRNNLVRLPESLP 408
LRRNT smart00013
Leucine rich repeat N-terminal domain;
63-95 9.50e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 58.87  E-value: 9.50e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 8392983      63 MCPFGCHCHLRVVQCSDLGLKTVPKEISPDTTL 95
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-294 2.74e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 2.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   71 HLRvvqCSDLGLKTVPKEIS-PDTTLLDLQNNDISELRK-DDFKGLQHLYalvLVNNKISKIheKAFSPLRKLQKLYISK 148
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKI--ENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  149 NHL--VEippNL--PSSLVELRIHDNRIRKvpkgvfsglrnmnciemgGNPLEnsgFEPGAFDGLKlnylriseakltgi 224
Cdd:cd21340  78 NRIsvVE---GLenLTNLEELHIENQRLPP------------------GEKLT---FDPRSLAALS-------------- 119

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8392983  225 pkdlpETLNELHLDHNKIQaiELEDLLRYSKLYRLGLGHNQIRMIEN--GSLSFLPTLRELHLDNNKLSRVP 294
Cdd:cd21340 120 -----NSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
94-151 7.11e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 7.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983     94 TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHL 151
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 63-90 8.43e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.40  E-value: 8.43e-10
                          10        20
                  ....*....|....*....|....*...
gi 8392983     63 MCPFGCHCHLRVVQCSDLGLKTVPKEIS 90
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-314 4.56e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.62  E-value: 4.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   93 TTLLDLQNNDISELRKDDFKGLQHLYALVLVNNKiskihekAFSPLRKLQKLYISKNHLVEIPPNLPS--SLVELRIHDN 170
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNN 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  171 RIRKVPKgVFSGLRNMNCIEMGGNPLENsgfEPGAFDGLK-LNYLRISEAKLTGIPKDL--PETLNELHLDHNKIQAIEl 247
Cdd:COG4886 147 QLTDLPE-PLGNLTNLKSLDLSNNQLTD---LPEELGNLTnLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLP- 221

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 8392983  248 EDLLRYSKLYRLGLGHNQIRMIEngSLSFLPTLRELHLDNNKLSRVPAgLPDLKLLQVVYLHSNNIT 314
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
71-312 1.21e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   71 HLRVVQCSDLGLKTVPKEISPDTTL--LDLQNNDISELRkDDFKGLQHLYALVLVNNKISKIhEKAFSPLRKLQKLYISK 148
Cdd:COG4886 114 NLESLDLSGNQLTDLPEELANLTNLkeLDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSN 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  149 NHLVEIPPNL--PSSLVELRIHDNRIRKVPKGvFSGLRNMNCIEMGGNPLEnsgfEPGAFDGL-KLNYLRISEAKLTGIP 225
Cdd:COG4886 192 NQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT----DLPELGNLtNLEELDLSNNQLTDLP 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  226 KDLP-ETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIE-NGSLSFLPTLRELHLDNNKLSRVPAGLPDLKLL 303
Cdd:COG4886 267 PLANlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLElLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSL 346


                ....*....
gi 8392983  304 QVVYLHSNN 312
Cdd:COG4886 347 LALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-298 2.00e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.73  E-value: 2.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    65 PFGCHCHLRVVQCSDLGLKTVPKEIsPDTT-LLDLQNNDISELRKDDFKGLQhlyALVLVNNKISKIHEKAfsPlRKLQK 143
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATL-PDTIqEMELSINRITELPERLPSALQ---SLDLFHNKISCLPENL--P-EELRY 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   144 LYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMnciEMGGNPLEN--SGFEPgafdglKLNYLRISEAKL 221
Cdd:PRK15370 288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTL---EAGENALTSlpASLPP------ELQVLDVSKNQI 358

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983   222 TGIPKDLPETLNELHLDHNKIqaieledllrysklyrlglghnqIRMIENgslsfLP-TLRELHLDNNKLSRVPAGLP 298
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNAL-----------------------TNLPEN-----LPaALQIMQASRNNLVRLPESLP 408
LRRNT smart00013
Leucine rich repeat N-terminal domain;
63-95 9.50e-12

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 58.87  E-value: 9.50e-12
                           10        20        30
                   ....*....|....*....|....*....|...
gi 8392983      63 MCPFGCHCHLRVVQCSDLGLKTVPKEISPDTTL 95
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-294 2.74e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 2.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   71 HLRvvqCSDLGLKTVPKEIS-PDTTLLDLQNNDISELRK-DDFKGLQHLYalvLVNNKISKIheKAFSPLRKLQKLYISK 148
Cdd:cd21340   6 HLY---LNDKNITKIDNLSLcKNLKVLYLYDNKITKIENlEFLTNLTHLY---LQNNQIEKI--ENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  149 NHL--VEippNL--PSSLVELRIHDNRIRKvpkgvfsglrnmnciemgGNPLEnsgFEPGAFDGLKlnylriseakltgi 224
Cdd:cd21340  78 NRIsvVE---GLenLTNLEELHIENQRLPP------------------GEKLT---FDPRSLAALS-------------- 119

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8392983  225 pkdlpETLNELHLDHNKIQaiELEDLLRYSKLYRLGLGHNQIRMIEN--GSLSFLPTLRELHLDNNKLSRVP 294
Cdd:cd21340 120 -----NSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
94-151 7.11e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 7.11e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983     94 TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHL 151
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 63-90 8.43e-10

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 53.40  E-value: 8.43e-10
                          10        20
                  ....*....|....*....|....*...
gi 8392983     63 MCPFGCHCHLRVVQCSDLGLKTVPKEIS 90
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-314 6.07e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 6.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    95 LLDLQNNDISELRKDDFKG--------LQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-EIPPNLPSS--LV 163
Cdd:PLN00113 304 VIQLQNLEILHLFSNNFTGkipvaltsLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLF 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   164 ELRIHDNRIR-KVPKGVfSGLRNMNCIEMGGNPLenSGFEPGAFDGLKL-NYLRISEAKLTG----IPKDLPeTLNELHL 237
Cdd:PLN00113 384 KLILFSNSLEgEIPKSL-GACRSLRRVRLQDNSF--SGELPSEFTKLPLvYFLDISNNNLQGrinsRKWDMP-SLQMLSL 459

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983   238 DHNKIQAiELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLS-RVPAGLPDLKLLQVVYLHSNNIT 314
Cdd:PLN00113 460 ARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 235-316 7.26e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 7.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  235 LHLDHNKIQAIEleDLLRYSKLYRLGLGHNQIRMIENgsLSFLPTLRELHLDNNKLSRVPaGLPDLKLLQVVYLHSNNIT 314
Cdd:cd21340   7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIS 81


                ..
gi 8392983  315 KV 316
Cdd:cd21340  82 VV 83
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 94-311 6.32e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 6.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    94 TLLDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLveiPPNLPSSLVELR------I 167
Cdd:PLN00113 359 TVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSF---SGELPSEFTKLPlvyfldI 435

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   168 HDNRIrkvpKGVFSGLR-NMNCIEMGGNPLEN-SGFEPGAFDGLKLNYLRISEAKLTG-IPK---DLPEtLNELHLDHNK 241
Cdd:PLN00113 436 SNNNL----QGRINSRKwDMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQFSGaVPRklgSLSE-LMQLKLSENK 510

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8392983   242 IQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLS-RVPAGLPDLKLLQVVYLHSN 311
Cdd:PLN00113 511 LSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
254-313 8.36e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 8.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8392983    254 SKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLSRV-PAGLPDLKLLQVVYLHSNNI 313
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
115-172 3.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 3.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 8392983    115 QHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPN----LPsSLVELRIHDNRI 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLP-SLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-314 6.41e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 6.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    85 VPKEISPDTTL--LDLQNNDISELRKDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLV-EIPpnlpss 161
Cdd:PLN00113 228 IPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIP------ 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   162 lvELRIHdnrirkvpkgvfsgLRNMNCIEMGGNPLenSGFEPGAFDGL-KLNYLRISEAKLTG-IPKDLPE--TLNELHL 237
Cdd:PLN00113 302 --ELVIQ--------------LQNLEILHLFSNNF--TGKIPVALTSLpRLQVLQLWSNKFSGeIPKNLGKhnNLTVLDL 363

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 8392983   238 DHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNKLS-RVPAGLPDLKLLQVVYLHSNNIT 314
Cdd:PLN00113 364 STNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQ 441
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
207-344 7.34e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 7.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   207 DGLKLN--YLRISEAKLTGIPKDLPETLNELHLDHNKIQAIElEDLlrYSKLYRLGLGHNQIRMIEngslSFLP-TLREL 283
Cdd:PRK15370 174 DCLKNNktELRLKILGLTTIPACIPEQITTLILDNNELKSLP-ENL--QGNIKTLYANSNQLTSIP----ATLPdTIQEM 246

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8392983   284 HLDNNKLSRVPAGLPdlKLLQVVYLHSNNITkvGINDFCPMGFGVKRAYYNGISLFNNPVP 344
Cdd:PRK15370 247 ELSINRITELPERLP--SALQSLDLFHNKIS--CLPENLPEELRYLSVYDNSIRTLPAHLP 303
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
72-252 1.77e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    72 LRVVQCSDLGLKTVPKEISPDTTLLDLQNNDISELRKDDFKGLQhlyALVLVNNKISKIHEkAFSPlrKLQKLYISKNHL 151
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSLPA-SLPP--ELQVLDVSKNQI 358

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   152 VEIPPNLPSSLVELRIHDNRIRKVPKGVfsglrnmnciemggnplensgfePGAfdglkLNYLRISEAKLTGIPKDLPET 231
Cdd:PRK15370 359 TVLPETLPPTITTLDVSRNALTNLPENL-----------------------PAA-----LQIMQASRNNLVRLPESLPHF 410

                        170       180
                 ....*....|....*....|....*..
gi 8392983   232 LNE------LHLDHNKIQAIELEDLLR 252
Cdd:PRK15370 411 RGEgpqptrIIVEYNPFSERTIQNMQR 437
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 96-323 1.88e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 1.88e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   96 LDLQNNDISELRKDD-FKGLQHLYALVLVNNKISKIHEKAFS----PLRKLQKLYISKNHLVEIPPNLPS---------S 161
Cdd:cd00116   3 LSLKGELLKTERATElLPKLLCLQVLRLEGNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRGLQSllqgltkgcG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  162 LVELRIHDNRIRKVPKGVF-SGLRNMNCIEMggnPLENSGFEPGAfdglklnylrisEAKLTGIPKDLPETLNELHLDHN 240
Cdd:cd00116  83 LQELDLSDNALGPDGCGVLeSLLRSSSLQEL---KLNNNGLGDRG------------LRLLAKGLKDLPPALEKLVLGRN 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  241 KIQAIELEDLLR----YSKLYRLGLGHNQIRmiENG------SLSFLPTLRELHLDNNKLSR-----VPAGLPDLKLLQV 305
Cdd:cd00116 148 RLEGASCEALAKalraNRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEV 225

                       250
                ....*....|....*...
gi 8392983  306 VYLHSNNITKVGINDFCP 323
Cdd:cd00116 226 LNLGDNNLTDAGAAALAS 243
LRR_8 pfam13855
Leucine rich repeat;
160-217 1.08e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 8392983    160 SSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLenSGFEPGAFDGL-KLNYLRIS 217
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLpSLRYLDLS 57
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-252 2.52e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 2.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   72 LRVVQCSDLGLKTVPKEISPDTTL--LDLQNNDISELrkDDFKGLQHLYALVLVNNKISKIHEkaFSPLRKLQKLYISKN 149
Cdd:COG4886 207 LEELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983  150 HLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLTGIPKDLP 229
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                       170       180
                ....*....|....*....|...
gi 8392983  230 ETLNELHLDHNKIQAIELEDLLR 252
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALL 385
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
28-164 3.79e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983    28 TLDDGLLMM----NDEEASGSDTTSGVPDLDSLTPTFSAMcPFGCHCHLRVVQCSDLGLKTVPKEISPDTTLLDLQNNDI 103
Cdd:PRK15370 280 NLPEELRYLsvydNSIRTLPAHLPSGITHLNVQSNSLTAL-PETLPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQI 358

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 8392983   104 SELRKDDFKGLQHLYalvLVNNKISKIHEKAFSPLRKLQKlyiSKNHLVEIPPNLPSSLVE 164
Cdd:PRK15370 359 TVLPETLPPTITTLD---VSRNALTNLPENLPAALQIMQA---SRNNLVRLPESLPHFRGE 413
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
141-283 8.07e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.30  E-value: 8.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   141 LQKLYISKNHLVEIPpNLPSSLVELRIHDNRIRKVPkGVFSGLRNMnciEMGGNPLENSGFEPGafdglKLNYLRISEAK 220
Cdd:PRK15387 344 LQELSVSDNQLASLP-TLPSELYKLWAYNNRLTSLP-ALPSGLKEL---IVSGNRLTSLPVLPS-----ELKELMVSGNR 413

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 8392983   221 LTGIPKdLPETLNELHLDHNKIQAIElEDLLRYSKLYRLGLGHNQIrmiengSLSFLPTLREL 283
Cdd:PRK15387 414 LTSLPM-LPSGLLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPL------SERTLQALREI 468
LRR_9 pfam14580
Leucine-rich repeat;
96-176 1.39e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983     96 LDLQNNDISELrkDDFKGLQHLYALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLP----SSLVELRIHDNR 171
Cdd:pfam14580  47 IDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPlaslKKLTFLSLLRNP 124


                  ....*
gi 8392983    172 IRKVP 176
Cdd:pfam14580 125 VTNKP 129
LRR_8 pfam13855
Leucine rich repeat;
278-324 3.28e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 3.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 8392983    278 PTLRELHLDNNKLSRVPAG-LPDLKLLQVVYLHSNNITKVGINDFCPM 324
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGL 48
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 211-314 7.88e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8392983   211 LNYLRISEAKLTG-IPKDLPETLNELHLDHNKIQAIELEDLLRYSKLYRLGLGHNQIRMIENGSLSFLPTLRELHLDNNK 289
Cdd:PLN00113 120 LRYLNLSNNNFTGsIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199

                         90       100
                 ....*....|....*....|....*.
gi 8392983   290 LS-RVPAGLPDLKLLQVVYLHSNNIT 314
Cdd:PLN00113 200 LVgQIPRELGQMKSLKWIYLGYNNLS 225
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 278-312 9.62e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 9.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 8392983    278 PTLRELHLDNNKLSRVPaGLPDLKLLQVVYLHSNN 312
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNN 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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