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Conserved domains on  [gi|158508463|ref|NP_058732|]
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prolactin-4A1 precursor [Rattus norvegicus]

Protein Classification

prolactin_like domain-containing protein( domain architecture ID 10443541)

prolactin_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Hormone_1 pfam00103
Somatotropin hormone family;
25-227 1.27e-87

Somatotropin hormone family;


:

Pssm-ID: 306585  Cd Length: 214  Bit Score: 257.69  E-value: 1.27e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463   25 WENTASAMRAKLLNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRG-FERRTTRCHTSSLSSPENKEQAQQ 103
Cdd:pfam00103   9 WENVASCPSCAPDNVGCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGyFIRRTTSCHTNSIHTPENREKAQQ 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  104 FQLEVLLGLSHSLLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNF-EINEKANYTAWSEL 182
Cdd:pfam00103  89 TSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIDpERTENEAYPAWSGL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 158508463  183 GFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLLKCRLIRS-KC 227
Cdd:pfam00103 169 SSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKdSC 214
 
Name Accession Description Interval E-value
Hormone_1 pfam00103
Somatotropin hormone family;
25-227 1.27e-87

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 257.69  E-value: 1.27e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463   25 WENTASAMRAKLLNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRG-FERRTTRCHTSSLSSPENKEQAQQ 103
Cdd:pfam00103   9 WENVASCPSCAPDNVGCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGyFIRRTTSCHTNSIHTPENREKAQQ 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  104 FQLEVLLGLSHSLLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNF-EINEKANYTAWSEL 182
Cdd:pfam00103  89 TSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIDpERTENEAYPAWSGL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 158508463  183 GFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLLKCRLIRS-KC 227
Cdd:pfam00103 169 SSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKdSC 214
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
37-227 3.31e-77

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 231.00  E-value: 3.31e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  37 LNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRGF-ERRTTRCHTSSLSSPENKEQAQQFQLEVLLGLSHS 115
Cdd:cd10288    7 GNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFvDRALTSCHTSSLTTPENKEQAQQIKNEDLLKLIIS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463 116 LLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNFEINEKANYTAWSELGFLQSPNRDTRYF 195
Cdd:cd10288   87 LLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEENEDYPVWSGLPSLQSSDEDSRLF 166
                        170       180       190
                 ....*....|....*....|....*....|...
gi 158508463 196 AFYNLFHCLKKDSNNVEMYLKLLKCRLI-RSKC 227
Cdd:cd10288  167 AFYNLFHCLRRDSHKIDTYLKLLKCRIIhGNDC 199
 
Name Accession Description Interval E-value
Hormone_1 pfam00103
Somatotropin hormone family;
25-227 1.27e-87

Somatotropin hormone family;


Pssm-ID: 306585  Cd Length: 214  Bit Score: 257.69  E-value: 1.27e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463   25 WENTASAMRAKLLNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRG-FERRTTRCHTSSLSSPENKEQAQQ 103
Cdd:pfam00103   9 WENVASCPSCAPDNVGCRMSLEDLFDNATLLSHNMYNLASDMFTEFDENYAQGKGyFIRRTTSCHTNSIHTPENREKAQQ 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  104 FQLEVLLGLSHSLLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNF-EINEKANYTAWSEL 182
Cdd:pfam00103  89 TSNEELLKWSLMLLYSWLEPLYHLVTELSSMKEVSDTILSKAKDIEEKNKDLLEGIERIFSKVIDpERTENEAYPAWSGL 168
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 158508463  183 GFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLLKCRLIRS-KC 227
Cdd:pfam00103 169 SSLTSSDEDRRHFAFYNLFYCLRRDSRKVDTYLKILKCRLIYKdSC 214
prolactin_like cd10288
Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; ...
37-227 3.31e-77

Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones; Prolactin is primarily responsible for stimulating milk production and breast development in mammals. Aside from roles in reproduction, various functions have been attributed to prolactin, more than for other pituitary gland hormones combined. These are roles in growth and development, metamorphosis, metabolism of lipids, carbohydrates, and steroids, brain biochemistry and even immunoregulation, among others. Most of these roles are poorly understood, but it has become clear that many prolactin-like hormones are actually produced in the placenta and not the pituitary.


Pssm-ID: 198438  Cd Length: 199  Bit Score: 231.00  E-value: 3.31e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  37 LNVHNYTSYGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRGF-ERRTTRCHTSSLSSPENKEQAQQFQLEVLLGLSHS 115
Cdd:cd10288    7 GNGGCQLSLEDLFDRAVSLSHNIHNLSSEMFNEFDENYAQGRGFvDRALTSCHTSSLTTPENKEQAQQIKNEDLLKLIIS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463 116 LLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNFEINEKANYTAWSELGFLQSPNRDTRYF 195
Cdd:cd10288   87 LLRSWNEPLKHLVTELSSMKGAPDTILSKAKEIEEKNKELLEGLKRILSRVQPGIEENEDYPVWSGLPSLQSSDEDSRLF 166
                        170       180       190
                 ....*....|....*....|....*....|...
gi 158508463 196 AFYNLFHCLKKDSNNVEMYLKLLKCRLI-RSKC 227
Cdd:cd10288  167 AFYNLFHCLRRDSHKIDTYLKLLKCRIIhGNDC 199
growth_hormone_like cd10284
Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes ...
50-227 1.93e-28

Somatotropin/prolactin hormone family; The somatotropin/prolactin hormone family includes growth hormones 1 and 2, prolactin, prolactin 2, and other members that play vital roles in a variety of processes, including growth control. They are long-chain class-I helical cytokines, most of which are secreted by the pituitary gland, and are active as monomers, binding to cellular receptors with EpoR-like ligand binding domains.


Pssm-ID: 198434  Cd Length: 178  Bit Score: 105.66  E-value: 1.93e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  50 NQAIKISQDMNQYISDLSTHVKIFYAQGRG-FERRTTRCHTSSLSSPENKEQAQQFQLEVLLGLSHSLLQAWLNPLHHLW 128
Cdd:cd10284    3 DRAIPHAERVYHLSSEAYAEFEEKYIPGENpPNNVVMSCHTASIPTPSSKEEAQQKSDKELLRISLELLQSWSEPLLHLH 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463 129 AEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKK-GNFEINEKANYTAWSElgflQSPNRDTRYFAFYNLFHCLKKD 207
Cdd:cd10284   83 TVLANSKGTSLALLPKAKQVSEMLKLLEDGVETLSERiKDLPLEFNSVGALWSV----DETHNSLRRMHDYDLLSCFKKD 158
                        170       180
                 ....*....|....*....|
gi 158508463 208 SNNVEMYLKLLKCRLIRSKC 227
Cdd:cd10284  159 AHKVETYLKILKCRRFEHSC 178
prolactin_2 cd10287
Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the ...
47-223 2.15e-19

Vertebrate, non-mammalian prolactin 2 (PRL2); A functionally uncharacterized subfamily of the growth-hormone-like helical cytokines, which is found in vertebrata (except for mammals). The protein has been shown to be expressed in the zebrafish eye and brain, but not the pituitary gland, and might play a role in retina development.


Pssm-ID: 198437  Cd Length: 184  Bit Score: 82.23  E-value: 2.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  47 DTWNQAIKISQDMNQYISDLSTHVKIFYAQGRGfERRTTRCHTSSLSSPENKEQAQQFQLEVLLGLSHSLLQAWLNPLHH 126
Cdd:cd10287    3 DLFDRVIQHSSRMHSLSSELHWELEQYFLPSRN-IRRKRKCHTAGILTPNGKENAQKLEREELTEVILRLLGAWREPLSH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463 127 LWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIKNIAKKGNF--EINEKANYTAWSELGFLQSPNrDTRYFAFYNLFHCL 204
Cdd:cd10287   82 FHQSMGHDKDFNSYSPGKAKQMSDMVHELRDGVEKVTEKMQLlgVISNSLGGLSPEDAGPSAISG-HLDAMSDYDLLHCF 160
                        170
                 ....*....|....*....
gi 158508463 205 KKDSNNVEMYLKLLKCRLI 223
Cdd:cd10287  161 RRDSNKVQNYLKILKCRIF 179
somatolactin cd10286
Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to ...
85-221 1.22e-11

Somatolactin (SL) and somatolactin-like proteins; This family of hormones specific to Actinopterygii is expressed in the pars intermedia bordering the neurohypophysis (posterior pituitary). Somatolactin appears to be involved in acid-base regulation, but much of its physiological role remains to be understood.


Pssm-ID: 198436  Cd Length: 207  Bit Score: 61.80  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  85 TRCHTSSLSSPENKEQAQQFQLEVLLglsHSLL---QAWLNPLHHLWAEMcDRLGSTPPTLYK-------ALMLKESNIK 154
Cdd:cd10286   63 NACSTKTVSIPTSKTEIQQISDKWLL---HSVLilvQFWIDPLVDLQTSL-DRYDNAPSALLNktkwmstKLMNLEQGVL 138
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 158508463 155 LLdaIKNIAKKGNFEINE--KANYTAWSELGFLQSPNRDtryfafYNLFHCLKKDSNNVEMYLKLLKCR 221
Cdd:cd10286  139 VL--IRKMLGEGMLLNNEspADTLDHFVMSDMLESVLRD------YTLLSCFKKDAHKVETFLKLLKCR 199
somatotropin_like cd10285
Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; ...
87-227 1.22e-09

Somatotropin or growth hormone (GH), placental lactogen, and related pituitary gland hormones; Growth hormone (GH) or somatotropin is a peptide hormone synthesized by the pituitary gland, which mediates anabolic effects in development. GH is known to activate, via binding to specific cellular receptors, the MAPK/ERK and JAK-STAT signaling pathways. Via the latter, it triggers the secretion of insulin-like growth factor 1 (mostly in the liver). Besides increasing body height, GH has been shown to have a host of other effects.


Pssm-ID: 198435  Cd Length: 180  Bit Score: 55.53  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158508463  87 CHTSSLSSPENKEQAQQFQLEVLLGLSHSLLQAWLNPLHHL-WAEMCDRLGSTPPTLYKALMLKESNIKLLdaIKNIaKK 165
Cdd:cd10285   44 CYSESIPAPTGKDETQQKSDLELLRISLLLIQSWLKPVQFLsSVFTNQLHFGSSDRIYEKLKDLEEGIQTL--IREL-ED 120
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 158508463 166 GNFEINEKANYTAWSelgFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLLKCRL-IRSKC 227
Cdd:cd10285  121 GSPRGGQLLKQTYSK---FDVNLRSDEALLKNYGLLSCFKKDMHKVETYLRVMKCRRfPESNC 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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