2'-5'-oligoadenylate synthase 1 isoform 1 [Homo sapiens]
Protein Classification
nucleotidyltransferase domain-containing protein; CCA tRNA nucleotidyltransferase( domain architecture ID 10143812)
nucleotidyltransferase domain-containing protein, similar to African swine fever virus repair DNA polymerase X| [cytidine(C)-cytidine(C)-adenosine (A)] tRNA nucleotidyltransferase adds the CCA sequence one nucleotide at a time onto the 3' end of tRNA
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| OAS1_C | pfam10421 | 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, ... |
163-343 | 2.34e-142 | ||||
2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909. : Pssm-ID: 463087 Cd Length: 188 Bit Score: 402.63 E-value: 2.34e-142
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| NT_2-5OAS_ClassI-CCAase | cd05400 | Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ... |
29-211 | 1.31e-22 | ||||
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family. : Pssm-ID: 143390 [Multi-domain] Cd Length: 143 Bit Score: 92.85 E-value: 1.31e-22
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| Name | Accession | Description | Interval | E-value | ||||
| OAS1_C | pfam10421 | 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, ... |
163-343 | 2.34e-142 | ||||
2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909. Pssm-ID: 463087 Cd Length: 188 Bit Score: 402.63 E-value: 2.34e-142
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| NT_2-5OAS_ClassI-CCAase | cd05400 | Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ... |
29-211 | 1.31e-22 | ||||
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family. Pssm-ID: 143390 [Multi-domain] Cd Length: 143 Bit Score: 92.85 E-value: 1.31e-22
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| NTP_transf_2 | pfam01909 | Nucleotidyltransferase domain; Members of this family belong to a large family of ... |
37-125 | 5.74e-06 | ||||
Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug. Pssm-ID: 396474 Cd Length: 91 Bit Score: 44.33 E-value: 5.74e-06
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| Name | Accession | Description | Interval | E-value | ||||
| OAS1_C | pfam10421 | 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, ... |
163-343 | 2.34e-142 | ||||
2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus; This is the largely alpha-helical, C-terminal half of 2'-5'-oligoadenylate synthetase 1, being described as domain 2 of the enzyme and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between 320 and 344 at the extreme C-terminal end. Oligoadenylate synthetases are antiviral enzymes that counteract vial attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesize 2'.5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication. This domain is often associated with NTP_transf_2 pfam01909. Pssm-ID: 463087 Cd Length: 188 Bit Score: 402.63 E-value: 2.34e-142
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| NT_2-5OAS_ClassI-CCAase | cd05400 | Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class ... |
29-211 | 1.31e-22 | ||||
Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; In vertebrates, 2-5OASs are induced by interferon during the innate immune response to protect against RNA virus infections. In the presence of an RNA activator, 2-5OASs catalyze the oligomerization of ATP into 2-5A. 2-5A activates endoribonuclease L, which leads to degradation of the viral RNA. 2-5OASs are also implicated in cell growth control, differentiation, and apoptosis. This family includes human OAS1, -2, -3, and OASL. CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This class I group includes the archaeal Sulfolobus shibatae and Archeoglobus fulgidus CCA-adding enzymes. It belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are conserved in this family. Pssm-ID: 143390 [Multi-domain] Cd Length: 143 Bit Score: 92.85 E-value: 1.31e-22
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| NTP_transf_2 | pfam01909 | Nucleotidyltransferase domain; Members of this family belong to a large family of ... |
37-125 | 5.74e-06 | ||||
Nucleotidyltransferase domain; Members of this family belong to a large family of nucleotidyltransferases. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug. Pssm-ID: 396474 Cd Length: 91 Bit Score: 44.33 E-value: 5.74e-06
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| Blast search parameters | ||||
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