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Conserved domains on  [gi|24158478|ref|NP_057735|]
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dapper homolog 1 isoform 1 [Homo sapiens]

Protein Classification

Dapper domain-containing protein( domain architecture ID 12172817)

Dapper domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dapper pfam15268
Dapper; This is a family of signalling proteins. They act in a diverse range of signaling ...
46-836 0e+00

Dapper; This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.


:

Pssm-ID: 464605  Cd Length: 766  Bit Score: 852.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478    46 ERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGellGEAAQRSRLEEKFLEENILLLRKQLNCLRRRDAGL 125
Cdd:pfam15268   1 ERLEAALAGLQELQLLRARQELLVRGALALQRPPPPAAPAAG---PGGEAASSLEEQRLEANLLALKEQLSRLRRQDAGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   126 LNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSStcFCSPLEAT----L 201
Cdd:pfam15268  78 KTHLQQLDQQISELKLDVEKTSTEHLESDSRPSSGFYELSDGGSCSLSNSCNSVFSECLSSSLSS--LLPPLQAPkarpL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   202 SLSDGCPKSADLIGLLEykeghcedQASGAVCRSLSTPQFNSLDVI--ADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQ 279
Cdd:pfam15268 156 SMGDGRPRSADLDRMLP--------PGSGLVKASLDAKSSPSLDDIptHDVDPKYQCDLVSKNGNDVYRYPSPLHAVALQ 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   280 SPMFLLCLtgnplreedrlgnhasDICGGSELDAVKTDSSLPSPSSLWSASHPSSS-------KKMDGYILSLVQKKTHP 352
Cdd:pfam15268 228 SPLFSLSG----------------ETCIGPELDGQKPPTSSPLGPASLSTSQPSSStppsleaKKADGYIDKLLQRRAQP 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   353 VRTNKPRTSVNADPTKGLLRNGSVCVRAPGG-VSQGNSVNLKNSKQACLPSGGIPSL-NNGTFSPPKQWSKESKAEQAES 430
Cdd:pfam15268 292 VRTNKPRTSVNTDPTKGILRQGSLCVRQPSGqVSQGQTADLKGSKQKCLPSPGRESLgGAGTSSPLKQWSKESKGEQQEG 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   431 KRVPLPEGCPS--GAASDLQSKHLPK--TAKPASQEHARCSAigTGESPKESAQLSGASPKESPSRgpappqenkvvqpl 506
Cdd:pfam15268 372 PRVLLGATFTEhpSSLPEEQSKPLNKcvLGKTDSQGLARSPV--PGDSPKEGGPSPSSSPQESPGR-------------- 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   507 kkmsqknslqgvppatppllstafpveERPALDFKSEGS-SQSLEEA------HLVKAQFIPGQQPSVRLHRGHRNMGVV 579
Cdd:pfam15268 436 ---------------------------ERPALDFSSEGSsSQSLDEGsspasgEFVHAQFVPAQSQRVKLRQGGRKTKAV 488
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   580 K---NSSLKHRGpalqGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKA-----SSKGRKSGGGP-EAGVPGRPAGGG 650
Cdd:pfam15268 489 KlkrRSSEKPRA----KREQQPPLLREKPRGAHKKCRFPDELDPNKKPKGKgtlagESRGRSCSESSlYPPPFLVPLHVA 564
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   651 HRAGSRAHGHG------REAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENVGLYPA-------PVPLPYASPY 717
Cdd:pfam15268 565 RPESHGASAQAlfskeaAHGRLAKPKAKRKDYRRWQSSVEISYEEALASPRPPARRAGGMRRAsargrrePARQDYCSPY 644
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   718 AYVA-SDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGEFVGESTTTSDSEES--GGLIWSQFVQTLPIQ 794
Cdd:pfam15268 645 AYRSeSDSEYSAECASLFHSTIAETSEDEASDYTTNRFGDSESSQSDSEFSSDSSLSLDSEESeeGGLVWPQAVQGPPAA 724
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 24158478   795 TVTAPDLHNHPAKTFVKIKASHNLKKKILRFRSGSLKLMTTV 836
Cdd:pfam15268 725 GRPLLPPVSRPEPKFCRIKASHALKKKIRRFQPASLKVMTMV 766
 
Name Accession Description Interval E-value
Dapper pfam15268
Dapper; This is a family of signalling proteins. They act in a diverse range of signaling ...
46-836 0e+00

Dapper; This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.


Pssm-ID: 464605  Cd Length: 766  Bit Score: 852.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478    46 ERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGellGEAAQRSRLEEKFLEENILLLRKQLNCLRRRDAGL 125
Cdd:pfam15268   1 ERLEAALAGLQELQLLRARQELLVRGALALQRPPPPAAPAAG---PGGEAASSLEEQRLEANLLALKEQLSRLRRQDAGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   126 LNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSStcFCSPLEAT----L 201
Cdd:pfam15268  78 KTHLQQLDQQISELKLDVEKTSTEHLESDSRPSSGFYELSDGGSCSLSNSCNSVFSECLSSSLSS--LLPPLQAPkarpL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   202 SLSDGCPKSADLIGLLEykeghcedQASGAVCRSLSTPQFNSLDVI--ADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQ 279
Cdd:pfam15268 156 SMGDGRPRSADLDRMLP--------PGSGLVKASLDAKSSPSLDDIptHDVDPKYQCDLVSKNGNDVYRYPSPLHAVALQ 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   280 SPMFLLCLtgnplreedrlgnhasDICGGSELDAVKTDSSLPSPSSLWSASHPSSS-------KKMDGYILSLVQKKTHP 352
Cdd:pfam15268 228 SPLFSLSG----------------ETCIGPELDGQKPPTSSPLGPASLSTSQPSSStppsleaKKADGYIDKLLQRRAQP 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   353 VRTNKPRTSVNADPTKGLLRNGSVCVRAPGG-VSQGNSVNLKNSKQACLPSGGIPSL-NNGTFSPPKQWSKESKAEQAES 430
Cdd:pfam15268 292 VRTNKPRTSVNTDPTKGILRQGSLCVRQPSGqVSQGQTADLKGSKQKCLPSPGRESLgGAGTSSPLKQWSKESKGEQQEG 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   431 KRVPLPEGCPS--GAASDLQSKHLPK--TAKPASQEHARCSAigTGESPKESAQLSGASPKESPSRgpappqenkvvqpl 506
Cdd:pfam15268 372 PRVLLGATFTEhpSSLPEEQSKPLNKcvLGKTDSQGLARSPV--PGDSPKEGGPSPSSSPQESPGR-------------- 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   507 kkmsqknslqgvppatppllstafpveERPALDFKSEGS-SQSLEEA------HLVKAQFIPGQQPSVRLHRGHRNMGVV 579
Cdd:pfam15268 436 ---------------------------ERPALDFSSEGSsSQSLDEGsspasgEFVHAQFVPAQSQRVKLRQGGRKTKAV 488
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   580 K---NSSLKHRGpalqGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKA-----SSKGRKSGGGP-EAGVPGRPAGGG 650
Cdd:pfam15268 489 KlkrRSSEKPRA----KREQQPPLLREKPRGAHKKCRFPDELDPNKKPKGKgtlagESRGRSCSESSlYPPPFLVPLHVA 564
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   651 HRAGSRAHGHG------REAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENVGLYPA-------PVPLPYASPY 717
Cdd:pfam15268 565 RPESHGASAQAlfskeaAHGRLAKPKAKRKDYRRWQSSVEISYEEALASPRPPARRAGGMRRAsargrrePARQDYCSPY 644
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   718 AYVA-SDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGEFVGESTTTSDSEES--GGLIWSQFVQTLPIQ 794
Cdd:pfam15268 645 AYRSeSDSEYSAECASLFHSTIAETSEDEASDYTTNRFGDSESSQSDSEFSSDSSLSLDSEESeeGGLVWPQAVQGPPAA 724
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 24158478   795 TVTAPDLHNHPAKTFVKIKASHNLKKKILRFRSGSLKLMTTV 836
Cdd:pfam15268 725 GRPLLPPVSRPEPKFCRIKASHALKKKIRRFQPASLKVMTMV 766
PHA03378 PHA03378
EBNA-3B; Provisional
406-566 5.29e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478  406 PSLNNGTFSPPKQWSKESKAEQAESKRVPLPEGCPsGAASDLQSKHLPKTAKPASQEHARCSAIGTGESPKESAQLSGAS 485
Cdd:PHA03378 697 PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP-GRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT 775
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478  486 PKESPSRGPAPPQENKVVQPLKKMSQ--KNSLQGVPPATP----------PLLSTAFPVEERPALDFKSEG--------- 544
Cdd:PHA03378 776 PQPPPQAPPAPQQRPRGAPTPQPPPQagPTSMQLMPRAAPgqqgptkqilRQLLTGGVKRGRPSLKKPAALerqaaagpt 855
                        170       180
                 ....*....|....*....|....*
gi 24158478  545 -SSQSLEEAHLVKAQ--FIPGQQPS 566
Cdd:PHA03378 856 pSPGSGTSDKIVQAPvfYPPVLQPI 880
 
Name Accession Description Interval E-value
Dapper pfam15268
Dapper; This is a family of signalling proteins. They act in a diverse range of signaling ...
46-836 0e+00

Dapper; This is a family of signalling proteins. They act in a diverse range of signaling pathways and have a range of binding partners. They act as homo- and heterodimers.


Pssm-ID: 464605  Cd Length: 766  Bit Score: 852.09  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478    46 ERQEATLAGLAELEYLRQRQELLVRGALRGAGGAGAAAPRAGellGEAAQRSRLEEKFLEENILLLRKQLNCLRRRDAGL 125
Cdd:pfam15268   1 ERLEAALAGLQELQLLRARQELLVRGALALQRPPPPAAPAAG---PGGEAASSLEEQRLEANLLALKEQLSRLRRQDAGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   126 LNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSStcFCSPLEAT----L 201
Cdd:pfam15268  78 KTHLQQLDQQISELKLDVEKTSTEHLESDSRPSSGFYELSDGGSCSLSNSCNSVFSECLSSSLSS--LLPPLQAPkarpL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   202 SLSDGCPKSADLIGLLEykeghcedQASGAVCRSLSTPQFNSLDVI--ADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQ 279
Cdd:pfam15268 156 SMGDGRPRSADLDRMLP--------PGSGLVKASLDAKSSPSLDDIptHDVDPKYQCDLVSKNGNDVYRYPSPLHAVALQ 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   280 SPMFLLCLtgnplreedrlgnhasDICGGSELDAVKTDSSLPSPSSLWSASHPSSS-------KKMDGYILSLVQKKTHP 352
Cdd:pfam15268 228 SPLFSLSG----------------ETCIGPELDGQKPPTSSPLGPASLSTSQPSSStppsleaKKADGYIDKLLQRRAQP 291
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   353 VRTNKPRTSVNADPTKGLLRNGSVCVRAPGG-VSQGNSVNLKNSKQACLPSGGIPSL-NNGTFSPPKQWSKESKAEQAES 430
Cdd:pfam15268 292 VRTNKPRTSVNTDPTKGILRQGSLCVRQPSGqVSQGQTADLKGSKQKCLPSPGRESLgGAGTSSPLKQWSKESKGEQQEG 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   431 KRVPLPEGCPS--GAASDLQSKHLPK--TAKPASQEHARCSAigTGESPKESAQLSGASPKESPSRgpappqenkvvqpl 506
Cdd:pfam15268 372 PRVLLGATFTEhpSSLPEEQSKPLNKcvLGKTDSQGLARSPV--PGDSPKEGGPSPSSSPQESPGR-------------- 435
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   507 kkmsqknslqgvppatppllstafpveERPALDFKSEGS-SQSLEEA------HLVKAQFIPGQQPSVRLHRGHRNMGVV 579
Cdd:pfam15268 436 ---------------------------ERPALDFSSEGSsSQSLDEGsspasgEFVHAQFVPAQSQRVKLRQGGRKTKAV 488
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   580 K---NSSLKHRGpalqGLENGLPTVREKTRAGSKKCRFPDDLDTNKKLKKA-----SSKGRKSGGGP-EAGVPGRPAGGG 650
Cdd:pfam15268 489 KlkrRSSEKPRA----KREQQPPLLREKPRGAHKKCRFPDELDPNKKPKGKgtlagESRGRSCSESSlYPPPFLVPLHVA 564
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   651 HRAGSRAHGHG------REAVVAKPKHKRTDYRRWKSSAEISYEEALRRARRGRRENVGLYPA-------PVPLPYASPY 717
Cdd:pfam15268 565 RPESHGASAQAlfskeaAHGRLAKPKAKRKDYRRWQSSVEISYEEALASPRPPARRAGGMRRAsargrrePARQDYCSPY 644
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478   718 AYVA-SDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGEFVGESTTTSDSEES--GGLIWSQFVQTLPIQ 794
Cdd:pfam15268 645 AYRSeSDSEYSAECASLFHSTIAETSEDEASDYTTNRFGDSESSQSDSEFSSDSSLSLDSEESeeGGLVWPQAVQGPPAA 724
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|..
gi 24158478   795 TVTAPDLHNHPAKTFVKIKASHNLKKKILRFRSGSLKLMTTV 836
Cdd:pfam15268 725 GRPLLPPVSRPEPKFCRIKASHALKKKIRRFQPASLKVMTMV 766
PHA03378 PHA03378
EBNA-3B; Provisional
406-566 5.29e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478  406 PSLNNGTFSPPKQWSKESKAEQAESKRVPLPEGCPsGAASDLQSKHLPKTAKPASQEHARCSAIGTGESPKESAQLSGAS 485
Cdd:PHA03378 697 PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAP-GRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT 775
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24158478  486 PKESPSRGPAPPQENKVVQPLKKMSQ--KNSLQGVPPATP----------PLLSTAFPVEERPALDFKSEG--------- 544
Cdd:PHA03378 776 PQPPPQAPPAPQQRPRGAPTPQPPPQagPTSMQLMPRAAPgqqgptkqilRQLLTGGVKRGRPSLKKPAALerqaaagpt 855
                        170       180
                 ....*....|....*....|....*
gi 24158478  545 -SSQSLEEAHLVKAQ--FIPGQQPS 566
Cdd:PHA03378 856 pSPGSGTSDKIVQAPvfYPPVLQPI 880
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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