NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|117938314|ref|NP_057543|]
View 

marginal zone B- and B1-cell-specific protein precursor [Homo sapiens]

Protein Classification

canopy family protein( domain architecture ID 37159)

canopy family protein is a DUF3456 domain-containing protein; similar to Homo sapiens protein canopy homolog 1 and marginal zone B- and B1-cell-specific protein

PubMed:  16488878

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3456 super family cl13389
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 49-178 3.97e-06

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


The actual alignment was detected with superfamily member pfam11938:

Pssm-ID: 463404  Cd Length: 151  Bit Score: 44.63  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938314   49 RCDACRAVAYQMWQNLAKAETKLHTS------NSGGRREL-------SELVYTDVLDRSCSRNWqDYGVREVDQVKRLT- 114
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDvggfrlDPDGKRKKkkipyarSELRLTELLEGVCERML-DYNLHKERSTSTRTf 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117938314  115 --------GPGLSEGPePSISVMVTGGPWPTRLSRTCLHYLGEFgEDQIYEA--HQQGRGALEALLCGGPQGAC 178
Cdd:pfam11938  80 vtlhglnkGVKVDLGI-PYELWDEPSAEVNKSLKFQCETIVEEY-EDEIEEWyfNHQDEKDLEKYLCSEDSDLC 151
 
Name Accession Description Interval E-value
DUF3456 pfam11938
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 49-178 3.97e-06

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


Pssm-ID: 463404  Cd Length: 151  Bit Score: 44.63  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938314   49 RCDACRAVAYQMWQNLAKAETKLHTS------NSGGRREL-------SELVYTDVLDRSCSRNWqDYGVREVDQVKRLT- 114
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDvggfrlDPDGKRKKkkipyarSELRLTELLEGVCERML-DYNLHKERSTSTRTf 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117938314  115 --------GPGLSEGPePSISVMVTGGPWPTRLSRTCLHYLGEFgEDQIYEA--HQQGRGALEALLCGGPQGAC 178
Cdd:pfam11938  80 vtlhglnkGVKVDLGI-PYELWDEPSAEVNKSLKFQCETIVEEY-EDEIEEWyfNHQDEKDLEKYLCSEDSDLC 151
 
Name Accession Description Interval E-value
DUF3456 pfam11938
TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, ...
 49-178 3.97e-06

TLR4 regulator and MIR-interacting MSAP; This family of proteins, found from plants to humans, is PRAT4 (A and B), a Protein Associated with Toll-like receptor 4. The Toll family of receptors - TLRs - plays an essential role in innate recognition of microbial products, the first line of defence against bacterial infection. PRAT4A influences the subcellular distribution and the strength of TLR responses and alters the relative activity of each TLR. PRAT4B regulates TLR4 trafficking to the cell surface and the extent of its expression there. TLR4 recognizes lipopolysaccharide (LPS), one of the most immuno-stimulatory glycolipids constituting the outer membrane of the Gram-negative bacteria. This family has also been described as a SAP-like MIR-interacting protein family.


Pssm-ID: 463404  Cd Length: 151  Bit Score: 44.63  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117938314   49 RCDACRAVAYQMWQNLAKAETKLHTS------NSGGRREL-------SELVYTDVLDRSCSRNWqDYGVREVDQVKRLT- 114
Cdd:pfam11938   1 KCEVCKALADELEYALSKTDPSKEVDvggfrlDPDGKRKKkkipyarSELRLTELLEGVCERML-DYNLHKERSTSTRTf 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117938314  115 --------GPGLSEGPePSISVMVTGGPWPTRLSRTCLHYLGEFgEDQIYEA--HQQGRGALEALLCGGPQGAC 178
Cdd:pfam11938  80 vtlhglnkGVKVDLGI-PYELWDEPSAEVNKSLKFQCETIVEEY-EDEIEEWyfNHQDEKDLEKYLCSEDSDLC 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH