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Conserved domains on  [gi|13124773|ref|NP_057542|]
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protein HGH1 homolog [Homo sapiens]

Protein Classification

HGH1 family protein( domain architecture ID 10513361)

HGH1 family protein simmilar to protein HGH1, which is an armadillo repeat protein that binds to the dynamic central domain III of eukaryotic elongation factor 2 (eEF2) via a bipartite interface; contains both DUF383 and DUF384 domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
155-287 6.54e-68

Domain of unknown function (DUF383);


:

Pssm-ID: 461153  Cd Length: 188  Bit Score: 212.79  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124773   155 LERLVRALC---TPGYNARAPLHYLAPLLSNLSQRPAARAFLLDP----DRCVVQRLLPLTQYpDSSVRRGGVVGTLRNC 227
Cdd:pfam04063  49 IDQLVDLFVkgaDGGYNKHANYDYLAYVFANLSQLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNC 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13124773   228 CFEHRHHEWLLGPE-VDILPFLLLPLAGPEDFSEEEMERLPVDLQYLPPDKQREPDADIRK 287
Cdd:pfam04063 128 CFDTEAHEWLLSEEeIDILPYLLLPLAGPEEYDEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
292-346 2.50e-19

Domain of unknown function (DUF384);


:

Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.57  E-value: 2.50e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 13124773   292 AIMLLTATAPGRQQVRDQGAYLILRELHSWEPEPDVRTACEKLIQVLIGDEPERG 346
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
155-287 6.54e-68

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 212.79  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124773   155 LERLVRALC---TPGYNARAPLHYLAPLLSNLSQRPAARAFLLDP----DRCVVQRLLPLTQYpDSSVRRGGVVGTLRNC 227
Cdd:pfam04063  49 IDQLVDLFVkgaDGGYNKHANYDYLAYVFANLSQLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNC 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13124773   228 CFEHRHHEWLLGPE-VDILPFLLLPLAGPEDFSEEEMERLPVDLQYLPPDKQREPDADIRK 287
Cdd:pfam04063 128 CFDTEAHEWLLSEEeIDILPYLLLPLAGPEEYDEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
292-346 2.50e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.57  E-value: 2.50e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 13124773   292 AIMLLTATAPGRQQVRDQGAYLILRELHSWEPEPDVRTACEKLIQVLIGDEPERG 346
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Name Accession Description Interval E-value
DUF383 pfam04063
Domain of unknown function (DUF383);
155-287 6.54e-68

Domain of unknown function (DUF383);


Pssm-ID: 461153  Cd Length: 188  Bit Score: 212.79  E-value: 6.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13124773   155 LERLVRALC---TPGYNARAPLHYLAPLLSNLSQRPAARAFLLDP----DRCVVQRLLPLTQYpDSSVRRGGVVGTLRNC 227
Cdd:pfam04063  49 IDQLVDLFVkgaDGGYNKHANYDYLAYVFANLSQLPEGRKYFLTPqeydGVVPLSKLLVFTEH-DSVIRRGGVASTIKNC 127

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 13124773   228 CFEHRHHEWLLGPE-VDILPFLLLPLAGPEDFSEEEMERLPVDLQYLPPDKQREPDADIRK 287
Cdd:pfam04063 128 CFDTEAHEWLLSEEeIDILPYLLLPLAGPEEYDEEDMEKLPPELQLLPPDKKREPDPDIRL 188
DUF384 pfam04064
Domain of unknown function (DUF384);
292-346 2.50e-19

Domain of unknown function (DUF384);


Pssm-ID: 461154  Cd Length: 55  Bit Score: 80.57  E-value: 2.50e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 13124773   292 AIMLLTATAPGRQQVRDQGAYLILRELHSWEPEPDVRTACEKLIQVLIGDEPERG 346
Cdd:pfam04064   1 SLLLLCTTREGREYLRSKGVYPILRELHKWEEDEKVREACERLVQLLIRDEEEEG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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