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Conserved domains on  [gi|1519314423|ref|NP_057532|]
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denticleless protein homolog isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-391 3.80e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 3.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  67 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 146
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 147 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 225
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 226 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 300
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 301 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 380
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 1519314423 381 DDNTLKIWRLN 391
Cdd:COG2319   392 ADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-391 3.80e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 3.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  67 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 146
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 147 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 225
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 226 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 300
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 301 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 380
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 1519314423 381 DDNTLKIWRLN 391
Cdd:COG2319   392 ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-389 5.97e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 5.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  55 CTFSSAPNMehvLAVANEEGFVRLYNTESQSFrKKCFKEwmaHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIG 134
Cdd:cd00200    15 VAFSPDGKL---LATGSGDGTIKVWDLETGEL-LRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 135 TCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWDTRCNKkdgfyrQVNQISGaHNtsdkqtpskpkkkqnskglapsvd 214
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT------------------------ 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 215 fqQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGSstrKLGYSSLILDSTGSTLFANCTDDN 294
Cdd:cd00200   136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTGH---TGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 295 IYMFNMTGLKTspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSVCWCPsDFT 374
Cdd:cd00200   201 IKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP-DGK 274

                         330
                  ....*....|....*
gi 1519314423 375 KIATCSDDNTLKIWR 389
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 349-388 1.14e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1519314423  349 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 388
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
350-388 2.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1519314423 350 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 388
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 231-398 2.50e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 231 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgsstrklgysSLILDSTGSTLFANCTDDNiymfnmtglKTSPVAI 310
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 311 FNGHQNSTFYVKSSLS----PDD--QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 384
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                         170
                  ....*....|....*..
gi 1519314423 385 LKIWRLN---RGLEEKP 398
Cdd:PLN00181  684 LKLWDLSmsiSGINETP 700
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
67-391 3.80e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.68  E-value: 3.80e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  67 LAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSV 146
Cdd:COG2319   135 LASGSADGTVRLWDLATG----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 147 AFSKFEKAVFcTGGRDGNIMVWDTrcnkkdgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-Q 225
Cdd:COG2319   211 AFSPDGKLLA-SGSADGTVRLWDL---------------------------------ATGKLLRTLTGHSGSVRSVAFsP 256

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 226 DENTLVSAGAvDGIIKVWDLRknytayrqepiasksflyPGSSTRKLGY-----SSLILDSTGSTLFANCTDDNIYMFNM 300
Cdd:COG2319   257 DGRLLASGSA-DGTVRLWDLA------------------TGELLRTLTGhsggvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 301 TGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPWQPPTvLLGHSQEVTSVCWCPsDFTKIATCS 380
Cdd:COG2319   318 ATGK--LLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVRLWDLATGELLRT-LTGHTGAVTSVAFSP-DGRTLASGS 391

                         330
                  ....*....|.
gi 1519314423 381 DDNTLKIWRLN 391
Cdd:COG2319   392 ADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 55-389 5.97e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 5.97e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  55 CTFSSAPNMehvLAVANEEGFVRLYNTESQSFrKKCFKEwmaHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIG 134
Cdd:cd00200    15 VAFSPDGKL---LATGSGDGTIKVWDLETGEL-LRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 135 TCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWDTRCNKkdgfyrQVNQISGaHNtsdkqtpskpkkkqnskglapsvd 214
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGK------CLTTLRG-HT------------------------ 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 215 fqQSVTVVLFQDENTLVSAGAVDGIIKVWDLRKNYTAYRqepiasksflYPGSstrKLGYSSLILDSTGSTLFANCTDDN 294
Cdd:cd00200   136 --DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----------LTGH---TGEVNSVAFSPDGEKLLSSSSDGT 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 295 IYMFNMTGLKTspVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSVCWCPsDFT 374
Cdd:cd00200   201 IKLWDLSTGKC--LGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAWSP-DGK 274

                         330
                  ....*....|....*
gi 1519314423 375 KIATCSDDNTLKIWR 389
Cdd:cd00200   275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-395 5.15e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.43  E-value: 5.15e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  46 TGVPVPPFGCTFSSAPnmeHVLAVANEEGFVRLYNTESqsfrKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFW 125
Cdd:COG2319    75 LGHTAAVLSVAFSPDG---RLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 126 DVKAGELIGTCKGHQCSLKSVAFSKFEKAVFcTGGRDGNIMVWDTRcnkkDGfyRQVNQISGaHntsdkqtpskpkkkqn 205
Cdd:COG2319   148 DLATGKLLRTLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVRLWDLA----TG--KLLRTLTG-H---------------- 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 206 skglapsvdfQQSVTVVLF-QDENTLVSAGAvDGIIKVWDLRknytayRQEPIASksflYPGSSTrklGYSSLILDSTGS 284
Cdd:COG2319   204 ----------TGAVRSVAFsPDGKLLASGSA-DGTVRLWDLA------TGKLLRT----LTGHSG---SVRSVAFSPDGR 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 285 TLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWKVSTPwQPPTVLLGHSQEVT 364
Cdd:COG2319   260 LLASGSADGTVRLWDLATGE--LLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVR 334

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1519314423 365 SVCWCPsDFTKIATCSDDNTLKIWRLNRGLE 395
Cdd:COG2319   335 SVAFSP-DGKTLASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
96-393 3.71e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 3.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  96 AHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFcTGGRDGNIMVWDTrcnkk 175
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA-SASADGTVRLWDL----- 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 176 dgfyrqvnqisgahntsdkqtpskpkkkQNSKGLAPSVDFQQSVTVVLF-QDENTLVSAGAvDGIIKVWDLRknytayRQ 254
Cdd:COG2319   108 ----------------------------ATGLLLRTLTGHTGAVRSVAFsPDGKTLASGSA-DGTVRLWDLA------TG 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 255 EPIASksflYPGSSTRklgYSSLILDSTGSTLFANCTDDNIYMFNMTGLKtsPVAIFNGHQNStfyVKS-SLSPDDQFLV 333
Cdd:COG2319   153 KLLRT----LTGHSGA---VTSVAFSPDGKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGA---VRSvAFSPDGKLLA 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 334 SGSSDEAAYIWKVSTPwQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRG 393
Cdd:COG2319   221 SGSADGTVRLWDLATG-KLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-393 2.04e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 2.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 132 LIGTCKGHQCSLKSVAFSKfEKAVFCTGGRDGNIMVWDTrcNKKDGFYRQVNQISGAhntsdkqtpskpkkkqnskglap 211
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPV----------------------- 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 212 svdfqqsVTVVLFQDENTLVSAGAvDGIIKVWDLRKNYTAYRQEpiasksflypgsstrklGYSSLILD---STGSTLFA 288
Cdd:cd00200    55 -------RDVAASADGTYLASGSS-DKTIRLWDLETGECVRTLT-----------------GHTSYVSSvafSPDGRILS 109

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 289 NCTDDN-IYMFNMTglKTSPVAIFNGHQNStfyVKS-SLSPDDQFLVSGSSDEAAYIWKVSTpWQPPTVLLGHSQEVTSV 366
Cdd:cd00200   110 SSSRDKtIKVWDVE--TGKCLTTLRGHTDW---VNSvAFSPDGTFVASSSQDGTIKLWDLRT-GKCVATLTGHTGEVNSV 183

                         250       260
                  ....*....|....*....|....*..
gi 1519314423 367 CWCPsDFTKIATCSDDNTLKIWRLNRG 393
Cdd:cd00200   184 AFSP-DGEKLLSSSSDGTIKLWDLSTG 209
WD40 COG2319
WD40 repeat [General function prediction only];
66-171 1.07e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  66 VLAVANEEGFVRLYNTESqsfrKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWDVKAGELIGTCKGHQCSLKS 145
Cdd:COG2319   302 LLASGSDDGTVRLWDLAT----GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTS 377

                          90       100
                  ....*....|....*....|....*.
gi 1519314423 146 VAFSKFEKAVFcTGGRDGNIMVWDTR 171
Cdd:COG2319   378 VAFSPDGRTLA-SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-169 4.10e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 4.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423  40 HTSYGETGvPVppFGCTFSsaPNMEHvLAVANEEGFVRLYNTESQsfrkKCFKEWMAHWNAVFDLAWVPGELKLVTAAGD 119
Cdd:cd00200   171 ATLTGHTG-EV--NSVAFS--PDGEK-LLSSSSDGTIKLWDLSTG----KCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1519314423 120 QTAKFWDVKAGELIGTCKGHQCSLKSVAFSKfEKAVFCTGGRDGNIMVWD 169
Cdd:cd00200   241 GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 349-388 1.14e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1519314423  349 PWQPPTVLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIW 388
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
350-388 2.37e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1519314423 350 WQPPTVLLGHSQEVTSVCWCPSDfTKIATCSDDNTLKIW 388
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 231-398 2.50e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 231 VSAGAVDGIIKVWDLRKNYTAYRQEPIASKSFlypgsstrklgysSLILDSTGSTLFANCTDDNiymfnmtglKTSPVAI 310
Cdd:PLN00181  548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVW-------------SIDYSSADPTLLASGSDDG---------SVKLWSI 605

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 311 FNGHQNSTFYVKSSLS----PDD--QFLVSGSSDEAAYIWKVSTPWQPPTVLLGHSQEVTSVCWCpsDFTKIATCSDDNT 384
Cdd:PLN00181  606 NQGVSIGTIKTKANICcvqfPSEsgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFV--DSSTLVSSSTDNT 683

                         170
                  ....*....|....*..
gi 1519314423 385 LKIWRLN---RGLEEKP 398
Cdd:PLN00181  684 LKLWDLSmsiSGINETP 700
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 119-383 3.40e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 119 DQTAKFWDVKAGELIGTCKGHQCSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKKDGfyrqvnQISGAHNTSDKQTPS 198
Cdd:PLN00181  554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIG------TIKTKANICCVQFPS 627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 199 KPKKK---------------QNSK-GLAPSVDFQQSVTVVLFQDENTLVSAgAVDGIIKVWDLRknytayrqepiasksf 262
Cdd:PLN00181  628 ESGRSlafgsadhkvyyydlRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDLS---------------- 690

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1519314423 263 lypgsstrklgysslildstgstlfanctddniymFNMTGLKTSPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAY 342
Cdd:PLN00181  691 -----------------------------------MSISGINETPLHSFMGHTNVKNFV--GLSVSDGYIATGSETNEVF 733

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1519314423 343 IWKVSTPWQPPTVLLGH------------SQEVTSVCWCPSDFTKIATCSDDN 383
Cdd:PLN00181  734 VYHKAFPMPVLSYKFKTidpvsglevddaSQFISSVCWRGQSSTLVAANSTGN 786
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-397 1.10e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.10e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1519314423 355 VLLGHSQEVTSVCWCPsDFTKIATCSDDNTLKIWRLNRGLEEK 397
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLR 45
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 130-169 2.04e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.04e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1519314423  130 GELIGTCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWD 169
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
130-169 1.17e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1519314423 130 GELIGTCKGHQCSLKSVAFSKFEKaVFCTGGRDGNIMVWD 169
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 88-126 1.52e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1519314423   88 KKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
88-126 2.67e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1519314423  88 KKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQTAKFWD 126
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 306-345 5.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 5.90e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1519314423  306 SPVAIFNGHQNSTFYVksSLSPDDQFLVSGSSDEAAYIWK 345
Cdd:smart00320   3 ELLKTLKGHTGPVTSV--AFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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