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Conserved domains on  [gi|42542403|ref|NP_057019|]
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eEF1A lysine and N-terminal methyltransferase isoform 1 [Homo sapiens]

Protein Classification

eEF1A lysine and N-terminal methyltransferase( domain architecture ID 20705015)

eEF1A lysine and N-terminal methyltransferase is a dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0016279|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
499-639 2.01e-28

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


:

Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 112.61  E-value: 2.01e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403 499 VVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQS----DRMKVHIADGLDYIAslagggEARPCYDVIMf 574
Cdd:COG0421  43 IIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFPLLAPafddPRLRVVIGDGRAFLR------EAEESYDVII- 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542403 575 dVDSKDPTlgmsCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLK--DSVLAGLKAVFPLLYV 639
Cdd:COG0421 116 -VDLTDPV----GPAEGLFTREFYEDCRRALKPGGVLVVNLGSPFYGLDllRRVLATLREVFPHVVL 177
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-154 1.36e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


:

Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.90  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403    52 VLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltde 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|...
gi 42542403   132 eekTLQQVDRMLAEVGRVLQVGG 154
Cdd:pfam13649  77 ---PDPDLEAALREIARVLKPGG 96
 
Name Accession Description Interval E-value
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
499-639 2.01e-28

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 112.61  E-value: 2.01e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403 499 VVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQS----DRMKVHIADGLDYIAslagggEARPCYDVIMf 574
Cdd:COG0421  43 IIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFPLLAPafddPRLRVVIGDGRAFLR------EAEESYDVII- 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542403 575 dVDSKDPTlgmsCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLK--DSVLAGLKAVFPLLYV 639
Cdd:COG0421 116 -VDLTDPV----GPAEGLFTREFYEDCRRALKPGGVLVVNLGSPFYGLDllRRVLATLREVFPHVVL 177
PRK04457 PRK04457
polyamine aminopropyltransferase;
499-673 2.15e-20

polyamine aminopropyltransferase;


Pssm-ID: 179854 [Multi-domain]  Cd Length: 262  Bit Score: 91.25  E-value: 2.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  499 VVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVA-TQWFGFSQSDRMKVHIADGLDYIAslagggEARPCYDVIMFD-V 576
Cdd:PRK04457  72 QIGLGGGSLAKFIYTYLPDTRQTAVEINPQVIAVArNHFELPENGERFEVIEADGAEYIA------VHRHSTDVILVDgF 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  577 DSKDptlgmscPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDlGLKDSVLAGLKAVFP-LLYVRRIEGEVNEILFCQLH 655
Cdd:PRK04457 146 DGEG-------IIDALCTQPFFDDCRNALSSDGIFVVNLWSRD-KRYDRYLERLESSFEgRVLELPAESHGNVAVFAFKS 217

                        170
                 ....*....|....*...
gi 42542403  656 PEQKLATPELLETAQALE 673
Cdd:PRK04457 218 APKELRWDKLRKRAKKLE 235
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-154 1.36e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.90  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403    52 VLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltde 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|...
gi 42542403   132 eekTLQQVDRMLAEVGRVLQVGG 154
Cdd:pfam13649  77 ---PDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-159 1.63e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.10  E-value: 1.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  30 EWYGTYLELCGVLHkyIKPREKVLVIGCGNSELSEQLYDVGYRdIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQME 109
Cdd:COG2226   6 ARYDGREALLAALG--LRPGARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLP 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 42542403 110 FPDASFQVVLDKGTLDAVltdeeektlQQVDRMLAEVGRVLQVGGRYLCI 159
Cdd:COG2226  83 FPDGSFDLVISSFVLHHL---------PDPERALAEIARVLKPGGRLVVV 123
MFS_SpdSyn NF037959
fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major ...
 474-635 1.30e-09

fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major Facilitator Superfamily) transporter domain and a C-terminal spermidine synthase (SpdSyn)-like domain. The encoding genes usually near the genes encoding S-adenosylmethionine decarboxylase (AdoMetDC) on many bacterial genomes. It has been shown in Shewanella oneidensis that the fused protein aminopropylates a substrate other than putrescine, and has a role outside of polyamine biosynthesis.


Pssm-ID: 468290 [Multi-domain]  Cd Length: 480  Bit Score: 61.01  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  474 HKAMIAGLALLRNPELLLEIPLallvvgLGGG--SLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFsQSDRMKVHIAD 551
Cdd:NF037959 260 YAAMLDELARLRMGRADFSAFF------IGGGayTLPRAWAARRPAGRITVAEIDPAVTRVAAEDFWF-DPASATVLHED 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  552 gldyiASLAGGGEARPCYDVIMFDVdSKDPTLgmscpPPAFVEQSFLQKVKSILTPEGVFILNLV--CRDLGLKDSVLAG 629
Cdd:NF037959 333 -----ARRALRRRPEERFDVIVGDA-FTDIAV-----PAHLVTREFFELVRARLTPDGVYLMNVIdhADRLRALAALVAT 401


                 ....*.
gi 42542403  630 LKAVFP 635
Cdd:NF037959 402 LREVFP 407
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 51-159 4.87e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.36  E-value: 4.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  51 KVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQ-MSFLKMDMTQ-MEFPDASFQVVLDKGTLDAVL 128
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEElPPEADESFDVIISDPPLHHLV 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 42542403 129 TDeeektlqqVDRMLAEVGRVLQVGGRYLCI 159
Cdd:cd02440  81 ED--------LARFLEEARRLLKPGGVLVLT 103
Spermine_synth pfam01564
Spermine/spermidine synthase domain; Spermine and spermidine are polyamines. This family ...
 477-635 5.39e-09

Spermine/spermidine synthase domain; Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyzes the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.


Pssm-ID: 396237 [Multi-domain]  Cd Length: 183  Bit Score: 56.17  E-value: 5.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   477 MIAGLALLRNPELLLeiplallVVGLGGGSL----PLFVHDhfPKSCIDAVEIDPSMLEVATQWF----GFSQSDRMKVH 548
Cdd:pfam01564   7 MIAHVPLCSHPNPKK-------VLIIGGGDGgvlrEVVKHP--SVEKITLVDIDEKVIDFSKKFLpslaIGFQDPRVKVV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   549 IADGLDYIASLAGGgearpcYDVIMfdVDSKDPTlgmsCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKD--SV 626
Cdd:pfam01564  78 IGDGFKFLKDYLNT------FDVII--VDSTDPV----GPAENLFSKPFFDLLKKALKEDGVFITQAESPWLHLELiiNI 145


                  ....*....
gi 42542403   627 LAGLKAVFP 635
Cdd:pfam01564 146 LKNGKQVFP 154
PRK08317 PRK08317
hypothetical protein; Provisional
 46-158 1.03e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 56.48  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   46 IKPREKVLVIGCGNS----ELSEQLYDVGyrDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFqvvldk 121
Cdd:PRK08317  17 VQPGDRVLDVGCGPGndarELARRVGPEG--RVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLPFPDGSF------ 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 42542403  122 gtlDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLC 158
Cdd:PRK08317  89 ---DAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
 
Name Accession Description Interval E-value
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
499-639 2.01e-28

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 112.61  E-value: 2.01e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403 499 VVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQS----DRMKVHIADGLDYIAslagggEARPCYDVIMf 574
Cdd:COG0421  43 IIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFPLLAPafddPRLRVVIGDGRAFLR------EAEESYDVII- 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542403 575 dVDSKDPTlgmsCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLK--DSVLAGLKAVFPLLYV 639
Cdd:COG0421 116 -VDLTDPV----GPAEGLFTREFYEDCRRALKPGGVLVVNLGSPFYGLDllRRVLATLREVFPHVVL 177
PRK04457 PRK04457
polyamine aminopropyltransferase;
499-673 2.15e-20

polyamine aminopropyltransferase;


Pssm-ID: 179854 [Multi-domain]  Cd Length: 262  Bit Score: 91.25  E-value: 2.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  499 VVGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVA-TQWFGFSQSDRMKVHIADGLDYIAslagggEARPCYDVIMFD-V 576
Cdd:PRK04457  72 QIGLGGGSLAKFIYTYLPDTRQTAVEINPQVIAVArNHFELPENGERFEVIEADGAEYIA------VHRHSTDVILVDgF 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  577 DSKDptlgmscPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDlGLKDSVLAGLKAVFP-LLYVRRIEGEVNEILFCQLH 655
Cdd:PRK04457 146 DGEG-------IIDALCTQPFFDDCRNALSSDGIFVVNLWSRD-KRYDRYLERLESSFEgRVLELPAESHGNVAVFAFKS 217

                        170
                 ....*....|....*...
gi 42542403  656 PEQKLATPELLETAQALE 673
Cdd:PRK04457 218 APKELRWDKLRKRAKKLE 235
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-154 1.36e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 69.90  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403    52 VLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDAVltde 131
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHL---- 76

                          90       100
                  ....*....|....*....|...
gi 42542403   132 eekTLQQVDRMLAEVGRVLQVGG 154
Cdd:pfam13649  77 ---PDPDLEAALREIARVLKPGG 96
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 30-159 1.63e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.10  E-value: 1.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  30 EWYGTYLELCGVLHkyIKPREKVLVIGCGNSELSEQLYDVGYRdIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQME 109
Cdd:COG2226   6 ARYDGREALLAALG--LRPGARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLP 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 42542403 110 FPDASFQVVLDKGTLDAVltdeeektlQQVDRMLAEVGRVLQVGGRYLCI 159
Cdd:COG2226  83 FPDGSFDLVISSFVLHHL---------PDPERALAEIARVLKPGGRLVVV 123
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 53-158 5.13e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.60  E-value: 5.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403    53 LVIGCGNSELSEQLYDVGYRdIVNIDISEVVIKQMKECNatRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLDavltdee 132
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGAR-VTGVDISPEMLELAREKA--PREGLTFVVGDAEDLPFPDNSFDLVLSSEVLH------- 70

                          90       100
                  ....*....|....*....|....*.
gi 42542403   133 ekTLQQVDRMLAEVGRVLQVGGRYLC 158
Cdd:pfam08241  71 --HVEDPERALREIARVLKPGGILII 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 37-150 8.75e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.95  E-value: 8.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  37 ELCGVLHKYIKPREKVLVIGCGNSELSEQLYDVGYrDIVNIDISEVVIKQMKEcnATRRPQMSFLKMDMTQMEFPDASFQ 116
Cdd:COG2227  13 RLAALLARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARE--RAAELNVDFVQGDLEDLPLEDGSFD 89

                        90       100       110
                ....*....|....*....|....*....|....
gi 42542403 117 VVLDKGTLDAVltDEEEKTLQQVDRMLAEVGRVL 150
Cdd:COG2227  90 LVICSEVLEHL--PDPAALLRELARLLKPGGLLL 121
MFS_SpdSyn NF037959
fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major ...
 474-635 1.30e-09

fused MFS/spermidine synthase; Proteins of this family are fusion of a N-terminal MFS (Major Facilitator Superfamily) transporter domain and a C-terminal spermidine synthase (SpdSyn)-like domain. The encoding genes usually near the genes encoding S-adenosylmethionine decarboxylase (AdoMetDC) on many bacterial genomes. It has been shown in Shewanella oneidensis that the fused protein aminopropylates a substrate other than putrescine, and has a role outside of polyamine biosynthesis.


Pssm-ID: 468290 [Multi-domain]  Cd Length: 480  Bit Score: 61.01  E-value: 1.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  474 HKAMIAGLALLRNPELLLEIPLallvvgLGGG--SLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFsQSDRMKVHIAD 551
Cdd:NF037959 260 YAAMLDELARLRMGRADFSAFF------IGGGayTLPRAWAARRPAGRITVAEIDPAVTRVAAEDFWF-DPASATVLHED 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  552 gldyiASLAGGGEARPCYDVIMFDVdSKDPTLgmscpPPAFVEQSFLQKVKSILTPEGVFILNLV--CRDLGLKDSVLAG 629
Cdd:NF037959 333 -----ARRALRRRPEERFDVIVGDA-FTDIAV-----PAHLVTREFFELVRARLTPDGVYLMNVIdhADRLRALAALVAT 401


                 ....*.
gi 42542403  630 LKAVFP 635
Cdd:NF037959 402 LREVFP 407
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 46-197 1.32e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 57.04  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403    46 IKPREKVLVIGCGNSELSEQLYDVGYRD--IVNIDISEVVIKQMKEcNATRRP--QMSFLKMDMTQME--FPDASFQVVL 119
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARE-NAQKLGfdNVEFEQGDIEELPelLEDDKFDVVI 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42542403   120 DKGTLDAVltDEEEKTLQqvdrmlaEVGRVLQVGGRYLCISLAQAHILKKAVGHFSREGWMVRVHQVANSQDQVLEAE 197
Cdd:pfam13847  80 SNCVLNHI--PDPDKVLQ-------EILRVLKPGGRLIISDPDSLAELPAHVKEDSTYYAGCVGGAILKKKLYELLEE 148
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 51-159 4.87e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 54.36  E-value: 4.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  51 KVLVIGCGNSELSEQLYDVGYRDIVNIDISEVVIKQMKECNATRRPQ-MSFLKMDMTQ-MEFPDASFQVVLDKGTLDAVL 128
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADnVEVLKGDAEElPPEADESFDVIISDPPLHHLV 80

                        90       100       110
                ....*....|....*....|....*....|.
gi 42542403 129 TDeeektlqqVDRMLAEVGRVLQVGGRYLCI 159
Cdd:cd02440  81 ED--------LARFLEEARRLLKPGGVLVLT 103
Spermine_synth pfam01564
Spermine/spermidine synthase domain; Spermine and spermidine are polyamines. This family ...
 477-635 5.39e-09

Spermine/spermidine synthase domain; Spermine and spermidine are polyamines. This family includes spermidine synthase that catalyzes the fifth (last) step in the biosynthesis of spermidine from arginine, and spermine synthase.


Pssm-ID: 396237 [Multi-domain]  Cd Length: 183  Bit Score: 56.17  E-value: 5.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   477 MIAGLALLRNPELLLeiplallVVGLGGGSL----PLFVHDhfPKSCIDAVEIDPSMLEVATQWF----GFSQSDRMKVH 548
Cdd:pfam01564   7 MIAHVPLCSHPNPKK-------VLIIGGGDGgvlrEVVKHP--SVEKITLVDIDEKVIDFSKKFLpslaIGFQDPRVKVV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   549 IADGLDYIASLAGGgearpcYDVIMfdVDSKDPTlgmsCPPPAFVEQSFLQKVKSILTPEGVFILNLVCRDLGLKD--SV 626
Cdd:pfam01564  78 IGDGFKFLKDYLNT------FDVII--VDSTDPV----GPAENLFSKPFFDLLKKALKEDGVFITQAESPWLHLELiiNI 145


                  ....*....
gi 42542403   627 LAGLKAVFP 635
Cdd:pfam01564 146 LKNGKQVFP 154
PRK08317 PRK08317
hypothetical protein; Provisional
 46-158 1.03e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 56.48  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   46 IKPREKVLVIGCGNS----ELSEQLYDVGyrDIVNIDISEVVIKQMKECNATRRPQMSFLKMDMTQMEFPDASFqvvldk 121
Cdd:PRK08317  17 VQPGDRVLDVGCGPGndarELARRVGPEG--RVVGIDRSEAMLALAKERAAGLGPNVEFVRGDADGLPFPDGSF------ 88

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 42542403  122 gtlDAVLTDEEEKTLQQVDRMLAEVGRVLQVGGRYLC 158
Cdd:PRK08317  89 ---DAVRSDRVLQHLEDPARALAEIARVLRPGGRVVV 122
PRK00811 PRK00811
polyamine aminopropyltransferase;
520-612 3.15e-08

polyamine aminopropyltransferase;


Pssm-ID: 234843 [Multi-domain]  Cd Length: 283  Bit Score: 55.55  E-value: 3.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  520 IDAVEIDPSMLEVATQWF-----GFSQSDRMKVHIADGLDYIAslagggEARPCYDVIMfdVDSKDPTlGmscppPA--- 591
Cdd:PRK00811 103 ITLVEIDERVVEVCRKYLpeiagGAYDDPRVELVIGDGIKFVA------ETENSFDVII--VDSTDPV-G-----PAegl 168

                         90       100
                 ....*....|....*....|.
gi 42542403  592 FvEQSFLQKVKSILTPEGVFI 612
Cdd:PRK00811 169 F-TKEFYENCKRALKEDGIFV 188
PLN02366 PLN02366
spermidine synthase
 520-610 6.72e-07

spermidine synthase


Pssm-ID: 215208 [Multi-domain]  Cd Length: 308  Bit Score: 51.57  E-value: 6.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  520 IDAVEIDPSMLEVATQWF-----GFSQSdRMKVHIADGLDYIASLAGGGearpcYDVIMfdVDSKDPtLGmscPPPAFVE 594
Cdd:PLN02366 118 IDICEIDKMVIDVSKKFFpdlavGFDDP-RVNLHIGDGVEFLKNAPEGT-----YDAII--VDSSDP-VG---PAQELFE 185

                         90
                 ....*....|....*.
gi 42542403  595 QSFLQKVKSILTPEGV 610
Cdd:PLN02366 186 KPFFESVARALRPGGV 201
COG4262 COG4262
Predicted spermidine synthase with an N-terminal membrane domain [General function prediction ...
 520-615 2.13e-06

Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only];


Pssm-ID: 443404 [Multi-domain]  Cd Length: 426  Bit Score: 50.63  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403 520 IDAVEIDPSMLEVATQWFGFSQ-------SDRMKVHIADGLDYIAslagggEARPCYDVIMFD-VDSKDPTLGmscpppA 591
Cdd:COG4262 313 VTLVDLDPEVTDLAKTNPFLRElnggalnDPRVTVVNADAFQFLR------ETDEKYDVIIVDlPDPSNFSLG------K 380

                        90       100
                ....*....|....*....|....
gi 42542403 592 FVEQSFLQKVKSILTPEGVFILNL 615
Cdd:COG4262 381 LYSVEFYRLVRRHLAPGGVLVVQA 404
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
46-181 1.44e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.14  E-value: 1.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  46 IKPREKVLVIGCGNSELSEQLYDVGYRdIVNIDISEVVIKQMKEcnatRRPQMSFLKMDMTQMEFPDASFQVVLDKGTLD 125
Cdd:COG4976  44 PGPFGRVLDLGCGTGLLGEALRPRGYR-LTGVDLSEEMLAKARE----KGVYDRLLVADLADLAEPDGRFDLIVAADVLT 118

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42542403 126 AVltDEEEKTLQQVDRMLAEVGRV------LQVGGRYlciSLAQAHILKKAVGH-FSREGWMV 181
Cdd:COG4976 119 YL--GDLAAVFAGVARALKPGGLFifsvedADGSGRY---AHSLDYVRDLLAAAgFEVPGLLV 176
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 500-613 7.22e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 44.75  E-value: 7.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403 500 VGLGGGSLPLFVHDHFPKSCIDAVEIDPSMLEVATQWFGFSQ-SDRMKVHIADGLDYIASLAGGgearpCYDVIM----- 573
Cdd:COG4123  44 LGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGlEDRITVIHGDLKEFAAELPPG-----SFDLVVsnppy 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 42542403 574 FDVDSkdptlGMSCPPP----AFVE-----QSFLQKVKSILTPEGVFIL 613
Cdd:COG4123 119 FKAGS-----GRKSPDEaraiARHEdaltlEDLIRAAARLLKPGGRFAL 162
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 46-150 1.27e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.99  E-value: 1.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403  46 IKPREKVLVIGCGNSELSEQL---YDVgyrDIVNIDISEVVIKQMKECNATR--RPQMSFLKMDMTQMEfPDASFQVVLD 120
Cdd:COG2230  49 LKPGMRVLDIGCGWGGLALYLarrYGV---RVTGVTLSPEQLEYARERAAEAglADRVEVRLADYRDLP-ADGQFDAIVS 124

                        90       100       110
                ....*....|....*....|....*....|
gi 42542403 121 KGTLDAVLTDEEEKTLQQVDRMLAEVGRVL 150
Cdd:COG2230 125 IGMFEHVGPENYPAYFAKVARLLKPGGRLL 154
PRK14968 PRK14968
putative methyltransferase; Provisional
 46-157 1.42e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 40.27  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42542403   46 IKPREKVLVIGCGNSELSEQLYDVGyRDIVNIDISEVVIKQMKE---CNATRRPQMSFLKMDMtqmefpdasFQVVlDKG 122
Cdd:PRK14968  21 DKKGDRVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYAVECAKCnakLNNIRNNGVEVIRSDL---------FEPF-RGD 89

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 42542403  123 TLDAVL-------TDEEEKT--------------LQQVDRMLAEVGRVLQVGGRYL 157
Cdd:PRK14968  90 KFDVILfnppylpTEEEEEWddwlnyalsggkdgREVIDRFLDEVGRYLKPGGRIL 145
PLN03075 PLN03075
nicotianamine synthase; Provisional
 502-572 4.54e-03

nicotianamine synthase; Provisional


Pssm-ID: 178624  Cd Length: 296  Bit Score: 39.65  E-value: 4.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42542403  502 LGGGSLPL----FVHDHFPKSCIDAVEIDPSMLEVATQWFGF--SQSDRMKVHIADGLDYIASLAGggearpcYDVI 572
Cdd:PLN03075 130 VGSGPLPLtsivLAKHHLPTTSFHNFDIDPSANDVARRLVSSdpDLSKRMFFHTADVMDVTESLKE-------YDVV 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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