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Conserved domains on  [gi|20336260|ref|NP_056950|]
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PR domain zinc finger protein 2 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 23-145 2.58e-82

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


:

Pssm-ID: 380965  Cd Length: 123  Bit Score: 265.46  E-value: 2.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   23 LRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 102
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 20336260  103 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 145
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 360-382 8.47e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 8.47e-04
                           10        20
                   ....*....|....*....|...
gi 20336260    360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 483-506 6.64e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


:

Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 20336260    483 HPCKYCKKVFGTHTNMRRHQRRVH 506
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTHH 24
 
Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 23-145 2.58e-82

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 265.46  E-value: 2.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   23 LRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 102
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 20336260  103 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 145
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 28-147 5.99e-22

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 92.78  E-value: 5.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260      28 EEVRLFPSavDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVK-----------NNVYMWEVYYpnlgWMCIDATdpEKG 96
Cdd:smart00317    1 NKLEVFKS--PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEerpkaydtdgaKAFYLFDIDS----DLCIDAR--RKG 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 20336260      97 NWLRYVNWACSGEEQNLFPLEINRA-IYYKTLKPIAPGEELLVWYNGEDNPE 147
Cdd:smart00317   73 NLARFINHSCEPNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYANE 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 43-141 1.37e-16

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 77.18  E-value: 1.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260     43 GVWATKPILKGKKFGPFVG----------DKKKRSQVKNNVYMWEVYY---PNLGWMCIDATDPEKGNWLRYVNWACsge 109
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYVEvllitkeeadKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSC--- 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 20336260    110 EQN----LFPLEINRAIYYKTLKPIAPGEELLVWYN 141
Cdd:pfam00856   80 DPNcevrVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 360-382 8.47e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 8.47e-04
                           10        20
                   ....*....|....*....|...
gi 20336260    360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
ZnF_C2H2 smart00355
zinc finger;
360-382 5.06e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 5.06e-03
                            10        20
                    ....*....|....*....|...
gi 20336260     360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 483-506 6.64e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 20336260    483 HPCKYCKKVFGTHTNMRRHQRRVH 506
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTHH 24
 
Name Accession Description Interval E-value
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 23-145 2.58e-82

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 265.46  E-value: 2.58e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   23 LRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYV 102
Cdd:cd19188    1 LMGLPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 20336260  103 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 145
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGEDN 123
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 26-144 5.00e-36

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 133.13  E-value: 5.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWA 105
Cdd:cd19193    4 LPPGLSIKRSSIPGAGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSGYSWQIYKGGKLSHYIDAKDESKSNWMRYVNCA 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 20336260  106 CSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYnGED 144
Cdd:cd19193   84 RNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWY-GDE 121
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 25-140 5.70e-30

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 115.89  E-value: 5.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   25 GLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNV---YMWEVYYPNLGWMCIDATDPEKGNWLRY 101
Cdd:cd19187    2 SLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGAnrkYFWRIYSNGEFYHYIDGFDPSKSNWMRY 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 20336260  102 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 140
Cdd:cd19187   82 VNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 26-147 6.44e-29

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 113.23  E-value: 6.44e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVKNNVYMWEV---YYPNLGWmcIDATDPEKGNWLRYV 102
Cdd:cd19200   10 IPPDFELRESAAVGAGLGVWTKVRIEVGEKFGPFVG--VQRSSVKDPTYAWEIvdeFGKVKFW--IDASEPGTGNWMKYI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 20336260  103 NWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPE 147
Cdd:cd19200   86 RSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLLYMKAAVYPH 130
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 26-141 1.28e-28

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 110.36  E-value: 1.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKkkrsqvknnvymwevyypnlgwmcidatdpekgNWLRYVNWA 105
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV---------------------------------NWMRFVRPA 47

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 20336260  106 CSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 141
Cdd:cd10534   48 RNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWYS 83
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 26-145 8.02e-28

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 109.75  E-value: 8.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQV---KNNVYMWEVYYPNlGWMC--IDATDPEKGNWLR 100
Cdd:cd19196    1 LPSQVIIAQSSIPGAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVdpcKNNNLMWEVFNED-GTVShfIDASQENHRSWMT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 20336260  101 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 145
Cdd:cd19196   80 FVNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWYGNSYN 124
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 26-146 8.35e-24

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 99.63  E-value: 8.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKkkRSQVKNNVYMWEVY--YPNLGWmCIDATDPEKGNWLRYVN 103
Cdd:cd19214   30 IPSEFELRESNIPGTGLGIWTKRKIEVGEKFGPYVGEQ--RSNLKDPSYGWEVLdeFGNVKF-CIDASQPDVGSWLKYIR 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 20336260  104 WACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNP 146
Cdd:cd19214  107 FAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLFMKSEDYS 149
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 26-140 1.14e-23

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 98.24  E-value: 1.14e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKT-RIGVWATKPILKGKKFGPFVGDKKKRSQVK---NNVYMWEVYYP-NLGWMcIDATdPEKGNWLR 100
Cdd:cd19198    3 LPEGLRVLQTSFGGTpHYGVFCKKTIPKGTRFGPFRGRVVNTSEIKtydDNSFMWEIFEDgKLSHF-IDGR-GSTGNWMS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 20336260  101 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 140
Cdd:cd19198   81 YVNCARYAEEQNLIAIQCQGQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 26-141 5.12e-22

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 93.31  E-value: 5.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQ----VKNNVYMWEVYYPNlGWMC--IDATDPEKGNWL 99
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKqigaVRNTQHLWEIYDQE-GTLQhfIDGGDPSKSSWM 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 20336260  100 RYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 141
Cdd:cd19191   80 RYIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYD 121
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 28-147 5.99e-22

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 92.78  E-value: 5.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260      28 EEVRLFPSavDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVK-----------NNVYMWEVYYpnlgWMCIDATdpEKG 96
Cdd:smart00317    1 NKLEVFKS--PGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEerpkaydtdgaKAFYLFDIDS----DLCIDAR--RKG 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|..
gi 20336260      97 NWLRYVNWACSGEEQNLFPLEINRA-IYYKTLKPIAPGEELLVWYNGEDNPE 147
Cdd:smart00317   73 NLARFINHSCEPNCELLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYANE 124
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 26-139 8.20e-21

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 91.09  E-value: 8.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVKNNVYMWEVYYPNLGW------------------MC 87
Cdd:cd19213   20 IPSDFELRESSIPGAGLGVWAKRKIEAGERFGPYTG--VQRSTLKDTNFGWEQILNDVEVssqegcitkivddlgnekFC 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 20336260   88 IDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVW 139
Cdd:cd19213   98 VDAGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 26-141 1.91e-19

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 85.86  E-value: 1.91e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLF-PSAVDKTRIGVWATKPILKGKKFGPFVGdkKKRSQVKNNVYMWEVYYPNL---GWMCIDATDPekGNWLRY 101
Cdd:cd19201    3 LPGELELRkPSQDAGRSGGVWAKQPLPEGTRFGPYPG--KLVKEPLDPSYEWKVEAQGSkggEGLLLLTEDS--GTWLKL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 20336260  102 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYN 141
Cdd:cd19201   79 VRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLR 118
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 26-140 4.00e-18

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 82.13  E-value: 4.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVDKTrIGVWATKPILKGKKFGPFVGDKKKRSQV-----KNNVYMWEVYYPNLGWMCIDATDPEKGNWLR 100
Cdd:cd19189    6 LPRQLYLRQSETGAE-VGVWTKETIPVRTCFGPLIGQQSHSAEVadwtdKAAPHIWKIYHNDVLEFCIITTDENECNWMM 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 20336260  101 YVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWY 140
Cdd:cd19189   85 FVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYY 124
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 43-141 1.37e-16

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 77.18  E-value: 1.37e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260     43 GVWATKPILKGKKFGPFVG----------DKKKRSQVKNNVYMWEVYY---PNLGWMCIDATDPEKGNWLRYVNWACsge 109
Cdd:pfam00856    3 GLFATEDIPKGEFIGEYVEvllitkeeadKRELLYYDKLELRLWGPYLftlDEDSEYCIDARALYYGNWARFINHSC--- 79

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 20336260    110 EQN----LFPLEINRAIYYKTLKPIAPGEELLVWYN 141
Cdd:pfam00856   80 DPNcevrVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 37-140 8.10e-16

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 75.47  E-value: 8.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   37 VDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGW-MCIDATDPEKGNWLRYVNWACSGEEQNLFP 115
Cdd:cd19194   15 FGETLGGVFAKRRIPKRTQFGPLEGPLVKKSELKDNKIHPLELEEDDGEdLYFDLSDENKCNWMMFVRPAQNHLEQNLVA 94

                         90       100
                 ....*....|....*....|....*
gi 20336260  116 LEINRAIYYKTLKPIAPGEELLVWY 140
Cdd:cd19194   95 YQYGQEIYFTTIKNIEPKQELKVWY 119
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 43-140 1.35e-14

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 72.06  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   43 GVWATKPILKGKKFGPFVGDKKKRSQvKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAI 122
Cdd:cd19199   22 GVFALVPLVKRTQFGPFEAKRVARLD-GFAVFPLKVFEKDGSVVYLDTSNEDDCNWMMFVRPATDVEHQNLTAYQQGEDI 100

                         90
                 ....*....|....*...
gi 20336260  123 YYKTLKPIAPGEELLVWY 140
Cdd:cd19199  101 YFTTSRDIQPGAELRVWY 118
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 26-144 1.37e-14

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 71.94  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   26 LPEEVRLFPSAVdKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNV---YMWEVYYPNLGWMCI-DATDPEKGNWLRY 101
Cdd:cd19190    5 VPDRFSLKSSKV-QDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMdprLMWEVRGSKGEVLYIlDASNPRHSNWLRF 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 20336260  102 VNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGED 144
Cdd:cd19190   84 VHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSD 126
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 23-139 1.06e-13

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 69.37  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   23 LRGLPEEVRLFPSAVDKTRIGVWAT-KPILKGKKFGPFVGD---KKKRSQVKNNVymwevyyPNLGwMCIDATDPEK-GN 97
Cdd:cd10520    2 LRSLPPGLALGPSLAQEERLGVWCVgDALQKGTFLGPLEEElesHDLTEGGSPRQ-------EESG-QSGDVLACEQsSK 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 20336260   98 WLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVW 139
Cdd:cd10520   74 WMRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 50-143 1.12e-11

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 63.72  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   50 ILKGKKFGPFVGDKKKRSQvKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKP 129
Cdd:cd19195   28 IPKGHIFGPYEGQICTQDK-SSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYFRACRD 106

                         90
                 ....*....|....
gi 20336260  130 IAPGEELLVWYNGE 143
Cdd:cd19195  107 IRPGEKLRVWYSED 120
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 34-143 1.64e-10

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 60.52  E-value: 1.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   34 PSAVDKTRIGVWATKPILKGKKFGPFVG---------DKKKRSQVKNNVYMweVYYPNLGWMcidATDPEKGNWLRYVNW 104
Cdd:cd19192   12 KSVLTDIFTSVVTTTDIPAGTIFGPCVLsftlgydiaDIALKTTDKRVVPY--IFRVDTGAC---NGSSEPSDWLRLVQP 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 20336260  105 ACSGEEQNL-FPLEINRAIYYKTLKPIAPGEELLVWYNGE 143
Cdd:cd19192   87 ARDRHEQNLeAFRKNEGQVYFRTLRRIRKGEELLVWYSDE 126
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 43-141 1.32e-07

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 51.96  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   43 GVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWE----VYYPNLGWMCIDATdpEKGNWLRYVNwacSGEEQNLFPLEI 118
Cdd:cd10522   16 GLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYdplyPFDLNGDILVIDAG--KKGNLTRFIN---HSDQPNLELIVR 90

                         90       100
                 ....*....|....*....|....*..
gi 20336260  119 NRA----IYYKTLKPIAPGEELLVWYN 141
Cdd:cd10522   91 TLKgeqhIGFVAIRDIKPGEELFISYG 117
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 40-140 1.32e-06

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 48.28  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20336260   40 TRIGvwatkPILKGKKFGPFVGDKKkRSQVKNNVYMWEVyypnlgwmciDATDPEKGN----WLRYVNWACSGEEQNLfp 115
Cdd:cd19197    5 LRLG-----PVPGIFKLGKYLSDRK-EPGNKKKVRRVRG----------DYLVDESGSpateWIGLVRAARNNQEQNL-- 66

                         90       100       110
                 ....*....|....*....|....*....|
gi 20336260  116 lEI-----NRAIYYKTLKPIAPGEELLVWY 140
Cdd:cd19197   67 -EAiadlpGGQIFYRALRDIQPGEELTVWY 95
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 360-382 8.47e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 8.47e-04
                           10        20
                   ....*....|....*....|...
gi 20336260    360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 119-143 2.40e-03

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.54  E-value: 2.40e-03
                         10        20
                 ....*....|....*....|....*
gi 20336260  119 NRAIYYKTLKPIAPGEELLVWYNGE 143
Cdd:cd10540   85 NQTIVFYALRDIEAGEELTINYGDD 109
ZnF_C2H2 smart00355
zinc finger;
360-382 5.06e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.90  E-value: 5.06e-03
                            10        20
                    ....*....|....*....|...
gi 20336260     360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 360-382 5.14e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.08  E-value: 5.14e-03
                           10        20
                   ....*....|....*....|...
gi 20336260    360 FPCQHCERKFTTKQGLERHMHIH 382
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 483-506 6.64e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.70  E-value: 6.64e-03
                           10        20
                   ....*....|....*....|....
gi 20336260    483 HPCKYCKKVFGTHTNMRRHQRRVH 506
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTHH 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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