NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7656932|ref|NP_056583|]
View 

prokineticin-2 isoform 1 precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Prokineticin super family cl05897
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-125 1.54e-37

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


The actual alignment was detected with superfamily member pfam06607:

Pssm-ID: 148298  Cd Length: 97  Bit Score: 122.57  E-value: 1.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656932     23 AGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGQVGDSCHPLTRKshvangrqerrrakrrkrkkeVPFWGRRM 102
Cdd:pfam06607  16 ASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHK---------------------VPFFGKRQ 74

                          90       100
                  ....*....|....*....|...
gi 7656932    103 HHTCPCLPGLACLRTSFNRFICL 125
Cdd:pfam06607  75 HHTCPCLPNLTCSRFSDSKYRCL 97
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-125 1.54e-37

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 122.57  E-value: 1.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656932     23 AGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGQVGDSCHPLTRKshvangrqerrrakrrkrkkeVPFWGRRM 102
Cdd:pfam06607  16 ASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHK---------------------VPFFGKRQ 74

                          90       100
                  ....*....|....*....|...
gi 7656932    103 HHTCPCLPGLACLRTSFNRFICL 125
Cdd:pfam06607  75 HHTCPCLPNLTCSRFSDSKYRCL 97
Dkk_Cys2 cd23012
second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises ...
 31-116 5.69e-03

second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.


Pssm-ID: 437997  Cd Length: 77  Bit Score: 33.48  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656932   31 GACDKDSQCGGGMCCAVSIWVksiRICTPMGQVGDSCH-PLTRKSHvangrqerrrakrrkrkkeVPFWGRrmhhtCPCL 109
Cdd:cd23012   6 ESCLRSRDCAEGLCCARHLWS---KRCKPILLEGDVCTkPRRKKSR-------------------GLIFQR-----CDCG 58


                ....*..
gi 7656932  110 PGLACLR 116
Cdd:cd23012  59 SGLSCRP 65
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 23-125 1.54e-37

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 122.57  E-value: 1.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656932     23 AGDAAVITGACDKDSQCGGGMCCAVSIWVKSIRICTPMGQVGDSCHPLTRKshvangrqerrrakrrkrkkeVPFWGRRM 102
Cdd:pfam06607  16 ASDGAVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHK---------------------VPFFGKRQ 74

                          90       100
                  ....*....|....*....|...
gi 7656932    103 HHTCPCLPGLACLRTSFNRFICL 125
Cdd:pfam06607  75 HHTCPCLPNLTCSRFSDSKYRCL 97
Dkk_Cys2 cd23012
second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises ...
 31-116 5.69e-03

second cysteine-rich (Cys-2) domain of Dickkopf proteins; The Dickkopf (Dkk) family comprises a discrete class of secreted Wnt inhibitors. The Wnt gene family is a large class of secreted proteins that are expressed in a variety of tissues and organs, and are required for many developmental processes, including segmentation, endoderm development, limb polarity, neural crest differentiation, kidney morphogenesis, sex determination and brain development. Dkks 1-4 each possesses an N-terminal signal peptide and contains two conserved cysteine-rich domains (Cys-1 and Cys-2) separated by a linker region. Each domain possesses 10 conserved cysteine residues. The Cys-2 domain is closely similar to those in the colipase family; it has been suggested that the Cys-2 domain of Dkks may enable interaction with lipids in order to regulate Wnt function. This model corresponds to the Cys-2 domain of Dickkopf proteins 1- 4.


Pssm-ID: 437997  Cd Length: 77  Bit Score: 33.48  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656932   31 GACDKDSQCGGGMCCAVSIWVksiRICTPMGQVGDSCH-PLTRKSHvangrqerrrakrrkrkkeVPFWGRrmhhtCPCL 109
Cdd:cd23012   6 ESCLRSRDCAEGLCCARHLWS---KRCKPILLEGDVCTkPRRKKSR-------------------GLIFQR-----CDCG 58


                ....*..
gi 7656932  110 PGLACLR 116
Cdd:cd23012  59 SGLSCRP 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH