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Conserved domains on  [gi|7657465|ref|NP_056535|]
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podocalyxin-like protein 2 precursor [Homo sapiens]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 10533843)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 393-605 3.07e-87

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 3.07e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    393 ILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLGDIRRS 472
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    473 LEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSH-GEELRFVENGCHDN 551
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7657465    552 PTLDVASDSQSEMQEKhPSLNGGGALNGPGSWGALMgGKRDPEDSDVFEEDTHL 605
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAQENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 393-605 3.07e-87

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 3.07e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    393 ILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLGDIRRS 472
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    473 LEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSH-GEELRFVENGCHDN 551
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7657465    552 PTLDVASDSQSEMQEKhPSLNGGGALNGPGSWGALMgGKRDPEDSDVFEEDTHL 605
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAQENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 393-605 3.07e-87

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 3.07e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    393 ILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVvPTQDVLSMLGDIRRS 472
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGL-PPKAVLELLKDKRRD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657465    473 LEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSH-GEELRFVENGCHDN 551
Cdd:pfam06365  80 LEELGIQNFTYGTECQEEDVQSHQDYSKLTLIALVTSGILLAILLVAGYYGCLHRRRSKSKAGERlGEELQTVENGYHDN 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 7657465    552 PTLDVASDSQSEMQEKhPSLNGGGALNGPGSWGALMgGKRDPEDSDVFEEDTHL 605
Cdd:pfam06365 160 PTLSVAPDTQSEMQEK-PSVNGGAQENGTGSWIVPL-SRNGHSDRQHVEEDTHL 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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