NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18373305|ref|NP_056498|]
View 

arrestin domain-containing protein 2 isoform 1 [Homo sapiens]

Protein Classification

arrestin family protein( domain architecture ID 10448464)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens beta-arrestin-1 and arrestin domain-containing protein

CATH:  2.60.40.840
Gene Ontology:  GO:0005515
PubMed:  7720881|7833798|35563378
SCOP:  4007521

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 9.05e-54

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


:

Pssm-ID: 425619  Cd Length: 148  Bit Score: 175.56  E-value: 9.05e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305     9 FSVQLDGAtagvEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSA--GSSTAYTQSYSERVEVVSHRA 86
Cdd:pfam00339   1 FTIEFDKP----DGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTET 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    87 TLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDIN 158
Cdd:pfam00339  77 SLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 181-307 7.73e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 117.83  E-value: 7.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305    181 RGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVL-PRAAVVQTQTFM-ARGARKQKRA------------VVASLAGE 246
Cdd:smart01017   2 SGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKkIKVSLVQTVTYVsSDGPVKRSLAekskekkadrktLVKELDGG 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    247 PVGPGQRALWQGRaLRIPPVGPSILHCRVLHVDYALKVCVDIPG-TSKLLLELPLVIGTIPL 307
Cdd:smart01017  82 PVLPGNKDKFEGQ-LKVPPLPPTSRTCRLIKVEYKLKVKLRLSGkHSELRLELPITIGTVPL 142
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 9.05e-54

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 175.56  E-value: 9.05e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305     9 FSVQLDGAtagvEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSA--GSSTAYTQSYSERVEVVSHRA 86
Cdd:pfam00339   1 FTIEFDKP----DGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTET 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    87 TLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDIN 158
Cdd:pfam00339  77 SLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 181-307 7.73e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 117.83  E-value: 7.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305    181 RGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVL-PRAAVVQTQTFM-ARGARKQKRA------------VVASLAGE 246
Cdd:smart01017   2 SGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKkIKVSLVQTVTYVsSDGPVKRSLAekskekkadrktLVKELDGG 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    247 PVGPGQRALWQGRaLRIPPVGPSILHCRVLHVDYALKVCVDIPG-TSKLLLELPLVIGTIPL 307
Cdd:smart01017  82 PVLPGNKDKFEGQ-LKVPPLPPTSRTCRLIKVEYKLKVKLRLSGkHSELRLELPITIGTVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 180-307 2.49e-30

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 113.58  E-value: 2.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305   180 NRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLP-RAAVVQTQTFMARGAR---KQKRAVVASLAGEPVGPGQRAL 255
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKiKISLVQQLTYKAKTPLgesKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 18373305   256 WQ-GRALRIP-PVGPSILHCRVLHVDYALKVCVDIPG-TSKLLLELPLVIGTIPL 307
Cdd:pfam02752  81 WEkELQLQIPtDLPPSSTKCKIIKVEYKLKVTVDLSGsASELRLELPITIGTSPL 135
ART10-like cd22952
Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking ...
 22-171 4.56e-06

Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The specific target protein for ART10 is not yet known.


Pssm-ID: 438568 [Multi-domain]  Cd Length: 409  Bit Score: 48.52  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305  22 PVFSGGQAVAGRVLLELSSAARVGALRLRARGrahvhwtESRSA---GSSTAYTQSYSERVEVVSHR-----ATLLAPD- 92
Cdd:cd22952  11 EFYTNLDVISGRVILKLTKSESISAIVVKLEG-------ESRTRlkvPKGNYNGQNDRGRTATEVHKllykvQQVFPPPn 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305  93 -----TGETTTLPPGRHEFLFSFQLP-------------------------------------PTLVTSFeGKHGSVRYC 130
Cdd:cd22952  84 vrsvsSSKSFTLTPGEYEYPFEFKIPfnnscsdphskstsgglggslmdglppsfnrhvkktlPPSLTGF-PGEAEIRYY 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 18373305 131 IKATLHRPWV--PARRARKVFTVIePVDINTPALLAPQAGARE 171
Cdd:cd22952 163 VKVTVQRPSFfkENIRAQVPFKFL-PIEPPRPPSTGEEAFARR 204
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 9-158 9.05e-54

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 175.56  E-value: 9.05e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305     9 FSVQLDGAtagvEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHWTESRSA--GSSTAYTQSYSERVEVVSHRA 86
Cdd:pfam00339   1 FTIEFDKP----DGVYFPGETVTGRVLLENEEPKKARAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTET 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    87 TLLAPDTGETTTLPPGRHEFLFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRARKVFTVIEPVDIN 158
Cdd:pfam00339  77 SLWGSKTGGQNKLPAGTHTFPFSFTLPPNCPSSFEGKHGGIRYEVKVTLDRPWKFNKSFRRVFTVIPKLDLN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 181-307 7.73e-32

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 117.83  E-value: 7.73e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305    181 RGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVL-PRAAVVQTQTFM-ARGARKQKRA------------VVASLAGE 246
Cdd:smart01017   2 SGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKkIKVSLVQTVTYVsSDGPVKRSLAekskekkadrktLVKELDGG 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18373305    247 PVGPGQRALWQGRaLRIPPVGPSILHCRVLHVDYALKVCVDIPG-TSKLLLELPLVIGTIPL 307
Cdd:smart01017  82 PVLPGNKDKFEGQ-LKVPPLPPTSRTCRLIKVEYKLKVKLRLSGkHSELRLELPITIGTVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 180-307 2.49e-30

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 113.58  E-value: 2.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305   180 NRGLVSLSAKIDRKGYTPGEVIPVFAEIDNGSTRPVLP-RAAVVQTQTFMARGAR---KQKRAVVASLAGEPVGPGQRAL 255
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKiKISLVQQLTYKAKTPLgesKREERVVAKEKNPGVAPGSKDK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 18373305   256 WQ-GRALRIP-PVGPSILHCRVLHVDYALKVCVDIPG-TSKLLLELPLVIGTIPL 307
Cdd:pfam02752  81 WEkELQLQIPtDLPPSSTKCKIIKVEYKLKVTVDLSGsASELRLELPITIGTSPL 135
ART10-like cd22952
Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking ...
 22-171 4.56e-06

Arrestin-related trafficking adapter 10 and similar proteins; Arrestin-related trafficking adaptors (ARTs) function by targeting specific plasma membrane proteins to the endocytic system. They contain multiple PY motifs that are required for recruitment of Rsp5/Nedd4-like ubiquitin ligase which modifies the cargoes. It has been proposed that ARTs remodel the cell surface in response to environmental cues and may serve as part of a quality-control system at the plasma membrane, targeting damaged and misfolded membrane proteins for ubiquitination and subsequent degradation in the lysosome/vacuole. The specific target protein for ART10 is not yet known.


Pssm-ID: 438568 [Multi-domain]  Cd Length: 409  Bit Score: 48.52  E-value: 4.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305  22 PVFSGGQAVAGRVLLELSSAARVGALRLRARGrahvhwtESRSA---GSSTAYTQSYSERVEVVSHR-----ATLLAPD- 92
Cdd:cd22952  11 EFYTNLDVISGRVILKLTKSESISAIVVKLEG-------ESRTRlkvPKGNYNGQNDRGRTATEVHKllykvQQVFPPPn 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18373305  93 -----TGETTTLPPGRHEFLFSFQLP-------------------------------------PTLVTSFeGKHGSVRYC 130
Cdd:cd22952  84 vrsvsSSKSFTLTPGEYEYPFEFKIPfnnscsdphskstsgglggslmdglppsfnrhvkktlPPSLTGF-PGEAEIRYY 162

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 18373305 131 IKATLHRPWV--PARRARKVFTVIePVDINTPALLAPQAGARE 171
Cdd:cd22952 163 VKVTVQRPSFfkENIRAQVPFKFL-PIEPPRPPSTGEEAFARR 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH