NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|74136552|ref|NP_055969|]
View 

LRP chaperone MESD precursor [Homo sapiens]

Protein Classification

Mesd domain-containing protein( domain architecture ID 10562823)

Mesd domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Mesd pfam10185
Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly ...
 52-201 2.88e-97

Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs). The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation).


:

Pssm-ID: 462985  Cd Length: 155  Bit Score: 280.50  E-value: 2.88e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136552    52 KKDIRDYNDADMARLLEQWEKDDD-IEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETE 130
Cdd:pfam10185   1 KKDIRDYNDADLERLLDQWEEDDEpLEPDELPEHLRPPPPIDFSKIDPSNPENLLKMSKKGKTLMMFVTVSGDPTEKETE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74136552   131 EITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKN 201
Cdd:pfam10185  81 EITKLWQTSLWNNHIQAERYIIDDNRAIFMFRDGSQAWEAKDFLVEQERCKEVTIEGQTYPGKGAKKDNKS 151
 
Name Accession Description Interval E-value
Mesd pfam10185
Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly ...
 52-201 2.88e-97

Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs). The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation).


Pssm-ID: 462985  Cd Length: 155  Bit Score: 280.50  E-value: 2.88e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136552    52 KKDIRDYNDADMARLLEQWEKDDD-IEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETE 130
Cdd:pfam10185   1 KKDIRDYNDADLERLLDQWEEDDEpLEPDELPEHLRPPPPIDFSKIDPSNPENLLKMSKKGKTLMMFVTVSGDPTEKETE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74136552   131 EITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKN 201
Cdd:pfam10185  81 EITKLWQTSLWNNHIQAERYIIDDNRAIFMFRDGSQAWEAKDFLVEQERCKEVTIEGQTYPGKGAKKDNKS 151
 
Name Accession Description Interval E-value
Mesd pfam10185
Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly ...
 52-201 2.88e-97

Chaperone for wingless signalling and trafficking of LDL receptor; Mesd is a family of highly conserved proteins found from nematodes to humans. The final C-terminal residues, KEDL, are the endoplasmic reticulum retention sequence as it is an ER protein specifically required for the intracellular trafficking of members of the low-density lipoprotein family of receptors (LDLRs). The N- and C-terminal sequences are predicted to adopt a random coil conformation, with the exception of an isolated predicted helix within the N-terminal region, The central folded domain flanked by natively unstructured regions is the necessary structure for facilitating maturation of LRP6 (Low-Density Lipoprotein Receptor-Related Protein 6 Maturation).


Pssm-ID: 462985  Cd Length: 155  Bit Score: 280.50  E-value: 2.88e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74136552    52 KKDIRDYNDADMARLLEQWEKDDD-IEEGDLPEHKRPSAPVDFSKIDPSKPESILKMTKKGKTLMMFVTVSGSPTEKETE 130
Cdd:pfam10185   1 KKDIRDYNDADLERLLDQWEEDDEpLEPDELPEHLRPPPPIDFSKIDPSNPENLLKMSKKGKTLMMFVTVSGDPTEKETE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 74136552   131 EITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWEIKDFLVGQDRCADVTLEGQVYPGKGGGSKEKN 201
Cdd:pfam10185  81 EITKLWQTSLWNNHIQAERYIIDDNRAIFMFRDGSQAWEAKDFLVEQERCKEVTIEGQTYPGKGAKKDNKS 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH