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Conserved domains on  [gi|41281447|ref|NP_055529|]
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intraflagellar transport protein 140 homolog [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 18610525)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956   67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956  147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956  202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                        250       260
                 ....*....|....*....|..
gi 41281447 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956  254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 41281447   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956    7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956   74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                        250       260
                 ....*....|....*....|....*.
gi 41281447 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956  184 LAELYLEQGDYEEA---IAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956   67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956  147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956  202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                        250       260
                 ....*....|....*....|..
gi 41281447 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956  254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 41281447   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 3.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200   51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281447  174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200  194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956    7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956   74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                        250       260
                 ....*....|....*....|....*.
gi 41281447 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956  184 LAELYLEQGDYEEA---IAALERALE 206
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 951-1233 4.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447    951 KMKDK-TLWRWWAQYLESQGEMDAALHYYELAR----DHF----SLVRIHCFQGNVQKAAQ-----IANETGNLAASYHL 1016
Cdd:TIGR02917  460 KQPDNaSLHNLLGAIYLGKGDLAKAREAFEKALsiepDFFpaaaNLARIDIQEGNPDDAIQrfekvLTIDPKNLRAILAL 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1017 ARQYESQEEVGQAVHFYTRAQAfknairlckengLDDQLMNLALLsspedmieAARYYEEKGvQMDRAVMLyhkaghFSK 1096
Cdd:TIGR02917  540 AGLYLRTGNEEEAVAWLEKAAE------------LNPQEIEPALA--------LAQYYLGKG-QLKKALAI------LNE 592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1097 ALELAFATQQFVAL----QLIAEDLDE--TSDPALLARCSDFFIEHSQ----YERAVELLLAARKYQEALQL----CLGQ 1162
Cdd:TIGR02917  593 AADAAPDSPEAWLMlgraQLAAGDLNKavSSFKKLLALQPDSALALLLladaYAVMKNYAKAITSLKRALELkpdnTEAQ 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1163 NMSITEEMAEKMTV-AKDSSDLPEESRRE---LLEQIADCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDT 1231
Cdd:TIGR02917  673 IGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalGFELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNT 752


                   ..
gi 41281447   1232 EK 1233
Cdd:TIGR02917  753 AE 754
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 6.29e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 6.29e-03
                            10        20
                    ....*....|....*....|....*....
gi 41281447     102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 7.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 7.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 41281447     63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894   40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956   67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956  147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956  202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                        250       260
                 ....*....|....*....|..
gi 41281447 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956  254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319  286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 41281447   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 850-1149 2.30e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 2.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  850 AVLATQLGMLEDAEQLYRKckrhdllNKFYQAAGRWQEALQVAEHHDRVHLR-STYHRYAGHLEasadcsRALSYYEKsd 928
Cdd:COG2956    3 LPVAAALGWYFKGLNYLLN-------GQPDKAIDLLEEALELDPETVEAHLAlGNLYRRRGEYD------RAIRIHQK-- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  929 thrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYELARD--------HFSLVRIHCFQGNVQKA 1000
Cdd:COG2956   68 --------LLERDPDRAEALLEL----------AQDYLKAGLLDRAEELLEKLLEldpddaeaLRLLAEIYEQEGDWEKA 129

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1001 AQIANE-----TGNLAASYHLARQYESQEEVGQAVHFYTRA-QAFKNAIRLckenglddqLMNLA-LLSSPEDMIEAARY 1073
Cdd:COG2956  130 IEVLERllklgPENAHAYCELAELYLEQGDYDEAIEALEKAlKLDPDCARA---------LLLLAeLYLEQGDYEEAIAA 200

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281447 1074 YEEKGVQMDRAVMLYHKAGHFSKALElafatQQFVALQLIAEDLDETSDPALLARCSDFFIEHSQYERAVELLLAA 1149
Cdd:COG2956  201 LERALEQDPDYLPALPRLAELYEKLG-----DPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
WD40 COG2319
WD40 repeat [General function prediction only];
16-139 2.97e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   16 GSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKE 94
Cdd:COG2319  247 GSVRSVAFSPDGRLLA----SGSADGTVRLWdLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 41281447   95 QHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 3.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200   51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281447  174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200  194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
21-140 3.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 3.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   21 ISWHPVHPFLAVAyistTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMP 99
Cdd:COG2319  210 VAFSPDGKLLASG----SADGTVRLWdLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 41281447  100 LTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQG 140
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 COG2319
WD40 repeat [General function prediction only];
63-133 8.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 8.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281447   63 RVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 9.44e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 9.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   14 AAGSPSFISWHPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEV 85
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFspdgktlASGSADGTVRLWdLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 41281447   86 TVFNKQD-KEQHTMPlTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  187 RLWDLATgKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 829-1091 9.97e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 46.06  E-value: 9.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  829 HARGARALRE------AEQEPELEARVAVLATQL----GMLEDA----EQLYRKCKRH----DLLNKFYQAAGRWQEALQ 890
Cdd:COG3071   61 QALGDYERRDeylaqaLELAPEAELAVLLTRAELlldqGQAEQAlatlEALRAGAPRHpqvlRLLLQAYRQLGDWEELLE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  891 VAE------HHDRVHLRSTYHR-YAGHLEASADCSRALsyyeksdthrfevpRMLSEDLPSLElyvnkMKDKTLWRWWAQ 963
Cdd:COG3071  141 LLPalrkhkALSAEEAQALERRaYLGLLRQAARDAEAL--------------KALWKALPRAE-----RRDPELAAAYAR 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  964 YLESQGEMDAALHYYELARDHF---SLVRI--HCFQGNVQKAAQIAN-----ETGNLAASYHLARQYESQEEVGQAVHFY 1033
Cdd:COG3071  202 ALIALGDHDEAERLLREALKRQwdpRLVRLygRLQGGDPAKQLKRAEkwlkkHPNDPDLLLALGRLCLRNQLWGKAREYL 281

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 41281447 1034 TRAqafknairlckenglddqlmnLALLSSPEDMIEAARYYEEKGvQMDRAVMLYHKA 1091
Cdd:COG3071  282 EAA---------------------LALRPSAEAYAELARLLEQLG-DPEEAAEHYRKA 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-121 1.60e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   19 SFISWHPVHPFLavayISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHT 97
Cdd:cd00200  181 NSVAFSPDGEKL----LSSSSDGTIKLWdLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         90       100
                 ....*....|....*....|....*
gi 41281447   98 MpLT-HTADITVLRWSPSGNCLLSG 121
Cdd:cd00200  256 T-LSgHTNSVTSLAWSPDGKRLASG 279
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 785-894 2.42e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 2.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  785 IGDMDEAFKSI-KLIKSE----AVWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAVLATQLGML 859
Cdd:COG4783   17 AGDYDEAEALLeKALELDpdnpEAFALLGEILLQLGDLDEAIVLL--------HEALELDPDEPEARLNLGLALLKAGDY 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 41281447  860 EDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAEH 894
Cdd:COG4783   89 DEALALLEKALKLDpehpeaylRLARAYRALGRPDEAIAALEK 131
WD40 COG2319
WD40 repeat [General function prediction only];
35-139 3.36e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 3.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   35 ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSP 113
Cdd:COG2319   94 ASASADGTVRLWdLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                         90       100
                 ....*....|....*....|....*.
gi 41281447  114 SGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKLLR 198
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 4.40e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 4.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   14 AAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 41281447   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956    7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956   74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                        250       260
                 ....*....|....*....|....*.
gi 41281447 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956  184 LAELYLEQGDYEEA---IAALERALE 206
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 951-1233 4.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447    951 KMKDK-TLWRWWAQYLESQGEMDAALHYYELAR----DHF----SLVRIHCFQGNVQKAAQ-----IANETGNLAASYHL 1016
Cdd:TIGR02917  460 KQPDNaSLHNLLGAIYLGKGDLAKAREAFEKALsiepDFFpaaaNLARIDIQEGNPDDAIQrfekvLTIDPKNLRAILAL 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1017 ARQYESQEEVGQAVHFYTRAQAfknairlckengLDDQLMNLALLsspedmieAARYYEEKGvQMDRAVMLyhkaghFSK 1096
Cdd:TIGR02917  540 AGLYLRTGNEEEAVAWLEKAAE------------LNPQEIEPALA--------LAQYYLGKG-QLKKALAI------LNE 592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1097 ALELAFATQQFVAL----QLIAEDLDE--TSDPALLARCSDFFIEHSQ----YERAVELLLAARKYQEALQL----CLGQ 1162
Cdd:TIGR02917  593 AADAAPDSPEAWLMlgraQLAAGDLNKavSSFKKLLALQPDSALALLLladaYAVMKNYAKAITSLKRALELkpdnTEAQ 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447   1163 NMSITEEMAEKMTV-AKDSSDLPEESRRE---LLEQIADCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDT 1231
Cdd:TIGR02917  673 IGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalGFELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNT 752


                   ..
gi 41281447   1232 EK 1233
Cdd:TIGR02917  753 AE 754
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 829-1066 5.45e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 5.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  829 HARGARALREAEQEPELEARVAVLATQLG--MLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRV--HLRSTY 904
Cdd:COG3914   36 ALAAALGLALLLLAALAEAAAAALLALAAgeAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALnpDNAEAL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  905 HRYAGHLEASADCSRALSYYEKSdthrfevprmLSEDLPSLELYVNkmkdktlwrwWAQYLESQGEMDAALHYYE--LAR 982
Cdd:COG3914  116 FNLGNLLLALGRLEEALAALRRA----------LALNPDFAEAYLN----------LGEALRRLGRLEEAIAALRraLEL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  983 D------HFSLVRIHCFQGNVQKAAQIANET-----GNLAASYHLARQYESQEEvgqavhfYTRAQAFKNAIRLCKENGl 1051
Cdd:COG3914  176 DpdnaeaLNNLGNALQDLGRLEEAIAAYRRAleldpDNADAHSNLLFALRQACD-------WEVYDRFEELLAALARGP- 247

                        250
                 ....*....|....*
gi 41281447 1052 dDQLMNLALLSSPED 1066
Cdd:COG3914  248 -SELSPFALLYLPDD 261
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 6.29e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 6.29e-03
                            10        20
                    ....*....|....*....|....*....
gi 41281447     102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
803-1043 7.69e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 7.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  803 VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD------LLN 876
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDY--------EKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpddaeaLNN 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  877 K--FYQAAGRWQEALqvaEHHDRV-----HLRSTYHRYAGHLEASADCSRALSYYEKsdthrfevprmlsedlpSLELyv 949
Cdd:COG0457   82 LglALQALGRYEEAL---EDYDKAleldpDDAEALYNLGLALLELGRYDEAIEAYER-----------------ALEL-- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281447  950 nKMKDKTLWRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQYESQEEVGQA 1029
Cdd:COG0457  140 -DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218

                        250
                 ....*....|....
gi 41281447 1030 VHFYTRAQAFKNAI 1043
Cdd:COG0457  219 LAELLLLALALLLA 232
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 7.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 7.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 41281447     63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894   40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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