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Conserved domains on  [gi|7657548|ref|NP_055378|]
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trafficking protein particle complex subunit 2 isoform 1 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 2( domain architecture ID 13000541)

trafficking protein particle complex subunit 2, also called sedlin, is a component of the multisubunit TRAPP (transport protein particle) complex that prevents transcriptional repression and induction of cell death by ENO1, and may play a role in vesicular transport from endoplasmic reticulum to Golgi

CATH:  3.30.450.70
Gene Ontology:  GO:0006888|GO:0030008
PubMed:  27066478|9564032|18801063|22669257|20966969

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 4-138 1.89e-86

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


:

Pssm-ID: 341429  Cd Length: 135  Bit Score: 248.21  E-value: 1.89e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    4 SFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRF 83
Cdd:cd14825   1 SYYFVIVGPNDNPLYEAEFGSSKKSEFRDDHRHLNQFIAHAALDLVDELQWTTNNMYLKSVDRFNEWSVSAFVTAGNIRF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7657548   84 IMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHL 138
Cdd:cd14825  81 LLLHDNKNDDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPAFDRRVRALAKKYL 135
 
Name Accession Description Interval E-value
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 4-138 1.89e-86

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 248.21  E-value: 1.89e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    4 SFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRF 83
Cdd:cd14825   1 SYYFVIVGPNDNPLYEAEFGSSKKSEFRDDHRHLNQFIAHAALDLVDELQWTTNNMYLKSVDRFNEWSVSAFVTAGNIRF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7657548   84 IMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHL 138
Cdd:cd14825  81 LLLHDNKNDDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPAFDRRVRALAKKYL 135
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 9-136 6.88e-65

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 193.63  E-value: 6.88e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548      9 IVGHHDNPVFEMEFLPAGKAESKDdHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHD 88
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEDKE-HKHLNQFIAHASLDIVDELQWKTNNMYLGTIDKFYKLSVSAYVTNSHIKFILVHE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 7657548     89 I--RQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKK 136
Cdd:pfam04628  80 SstKSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
6-138 3.82e-43

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 138.89  E-value: 3.82e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    6 YFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIM 85
Cdd:COG5603   4 YLAIIGEKDNPVYEREYDPINKTSDGEYCRLLNQFIIHASLDIVVWLQWSVNTSYFDCLDSFGDLRISAYIMPSGMKFLF 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 7657548   86 LHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHL 138
Cdd:COG5603  84 IHQNQSRKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREAARVCL 136
 
Name Accession Description Interval E-value
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 4-138 1.89e-86

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 248.21  E-value: 1.89e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    4 SFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRF 83
Cdd:cd14825   1 SYYFVIVGPNDNPLYEAEFGSSKKSEFRDDHRHLNQFIAHAALDLVDELQWTTNNMYLKSVDRFNEWSVSAFVTAGNIRF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7657548   84 IMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHL 138
Cdd:cd14825  81 LLLHDNKNDDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPAFDRRVRALAKKYL 135
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 9-136 6.88e-65

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 193.63  E-value: 6.88e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548      9 IVGHHDNPVFEMEFLPAGKAESKDdHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHD 88
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEDKE-HKHLNQFIAHASLDIVDELQWKTNNMYLGTIDKFYKLSVSAYVTNSHIKFILVHE 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 7657548     89 I--RQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKK 136
Cdd:pfam04628  80 SstKSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 5-133 8.00e-49

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 153.02  E-value: 8.00e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    5 FYFVIVGHHDNPVFEMEFLPAGKAEskDDHRHLNQFIAHAALDLVDENMWLSNN--MYLKTVDKFNEWFVSAFVTAGHMR 82
Cdd:cd14853   1 FYFVVVGHHGNPLYEREFTPPGQAE--DDNEEEYKLLAGMLHSVRSINSKLSPNveKYLKLSDKTNEYKVHAYVTATGLK 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 7657548   83 FIMLHD---IRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFL 133
Cdd:cd14853  79 FVMLTDvlmDRIEDVLKNFFSDLYVLYVKKNPNPFYEPNSPIRSRLFDSKVQSL 132
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
6-138 3.82e-43

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 138.89  E-value: 3.82e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    6 YFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIM 85
Cdd:COG5603   4 YLAIIGEKDNPVYEREYDPINKTSDGEYCRLLNQFIIHASLDIVVWLQWSVNTSYFDCLDSFGDLRISAYIMPSGMKFLF 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 7657548   86 LHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHL 138
Cdd:COG5603  84 IHQNQSRKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREAARVCL 136
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 9-134 4.93e-21

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 82.25  E-value: 4.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657548    9 IVGHHDNPVFEMEFlpagKAESKDDHRHlnQFIAHAALDLVDE------NMWLSNNMYLKTVDKFNEWFVSAFVTAGHMR 82
Cdd:cd14854   5 VIGKQNNPLYLRTF----PSGEDNDLKL--HYIAHSSLDVVEEklsaskKGGDTSDMYLGLLYPTEDYKVYGYVTNTKVK 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7657548   83 FIML-----HDIRQEDgIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLG 134
Cdd:cd14854  79 FILVledtnTPLRDND-VRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 81-131 7.33e-10

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 53.29  E-value: 7.33e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 7657548   81 MRFIMLHDIRQEdGIKNFFTDVYDLYIKFSM-NPFYEPNSPIRSSAFDRKVQ 131
Cdd:cd14856  75 IKFVLVADPKQP-GLDALLRRVYELYADYVLkNPFYELEMPIRCELFDENLQ 125
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 81-131 1.38e-07

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 47.31  E-value: 1.38e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 7657548     81 MRFIMLHDIRQEDGIKNFFTDVYDLYIKFSM-NPFYEPNSPIRSSAFDRKVQ 131
Cdd:pfam04099  77 IKFVLVTDPGTGINRDSLLRKYYELYSDYVLkNPFYSLGMPIRCELFDEKLD 128
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 75-130 4.50e-03

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 34.83  E-value: 4.50e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7657548   75 FVTAGHMRFIMLHDIRQEDgIKNFFTDVY-DLYIKF-SMNPFYEPNSPIRSSAFDRKV 130
Cdd:cd14855  73 YETPTGLKFVLLTDPNVGD-LRDVLQQIYsNIYVEYvVKNPLYPPGEPITSELFRSKL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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