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Conserved domains on  [gi|7524986|ref|NP_050084|]
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NADH dehydrogenase subunit 9 (mitochondrion) [Dictyostelium discoideum]

Protein Classification

complex I 30 kDa subunit family protein( domain architecture ID 10012648)

complex I 30 kDa subunit family protein, such as bacterial NADH-quinone oxidoreductase subunit C (NuoC) and eukaryotic NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, which are part of the core domain of complex I of the respiratory chain that couples the transfer of electrons from NADH to quinone/ubiquinone with the translocation of protons across the membrane

CATH:  3.30.460.80
EC:  7.1.1.-
Gene Ontology:  GO:0016655|GO:0045271
PubMed:  26807915|33957129|32058886|31935361

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK06074 PRK06074
NADH dehydrogenase subunit C; Provisional
 13-182 9.63e-53

NADH dehydrogenase subunit C; Provisional


:

Pssm-ID: 235691 [Multi-domain]  Cd Length: 189  Bit Score: 167.78  E-value: 9.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    13 NLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNIEEikigRFKLIYVLNSIY 92
Cdd:PRK06074   6 ELVAKLLEKLPDAIGKVTVAFGELTLKVPAEKILEVLTFLRDDPELRFEQLIDLTGVDYPERGK----RFEVVYHLLSYK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    93 NNTRVHLSTYVENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVND 172
Cdd:PRK06074  82 HNVRLRVKVRAPEDPVVPSVVDIWPSANWYEREAYDLYGIVFEGHPDLRRILTDYGFEGHPLRKDFPLTGYVEVRYDDEQ 161

                        170
                 ....*....|
gi 7524986   173 KKIIYKPIEL 182
Cdd:PRK06074 162 KRVVYEPVTL 171
 
Name Accession Description Interval E-value
PRK06074 PRK06074
NADH dehydrogenase subunit C; Provisional
 13-182 9.63e-53

NADH dehydrogenase subunit C; Provisional


Pssm-ID: 235691 [Multi-domain]  Cd Length: 189  Bit Score: 167.78  E-value: 9.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    13 NLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNIEEikigRFKLIYVLNSIY 92
Cdd:PRK06074   6 ELVAKLLEKLPDAIGKVTVAFGELTLKVPAEKILEVLTFLRDDPELRFEQLIDLTGVDYPERGK----RFEVVYHLLSYK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    93 NNTRVHLSTYVENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVND 172
Cdd:PRK06074  82 HNVRLRVKVRAPEDPVVPSVVDIWPSANWYEREAYDLYGIVFEGHPDLRRILTDYGFEGHPLRKDFPLTGYVEVRYDDEQ 161

                        170
                 ....*....|
gi 7524986   173 KKIIYKPIEL 182
Cdd:PRK06074 162 KRVVYEPVTL 171
NuoC COG0852
NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) [Energy production and conversion]; ...
 14-175 3.40e-47

NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) [Energy production and conversion]; NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440613 [Multi-domain]  Cd Length: 164  Bit Score: 152.68  E-value: 3.40e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986   14 LGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEasKYQCNMLLDIVCVDCLNIEEikigRFKLIYVLNSIYN 93
Cdd:COG0852   7 LLEALEEKFGDAVLEVEEARGELTLTVPPEDLVDVARFLRD--DLGFDHLSDLTGVDYPERGD----RFEVVYHLLSLTH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986   94 NTRVHLSTYV-ENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVND 172
Cdd:COG0852  81 NRRLRLKVFVpRDDPVVPSVTDVWPGANWHEREAYDMFGIVFEGHPDLRRILLPEDWEGHPLRKDFPLEGYVEVRYDEEL 160


                ...
gi 7524986  173 KKI 175
Cdd:COG0852 161 KRL 163
Complex1_30kDa pfam00329
Respiratory-chain NADH dehydrogenase, 30 Kd subunit;
38-163 2.33e-46

Respiratory-chain NADH dehydrogenase, 30 Kd subunit;


Pssm-ID: 459763 [Multi-domain]  Cd Length: 121  Bit Score: 149.17  E-value: 2.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986     38 IQVEKEKMLTVLKYLKEaSKYQCNMLLDIVCVDclnieEIKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGLFE 117
Cdd:pfam00329   1 VTVDPEDLLEVARFLRD-DELGFDHLSDLTGVD-----YPEEGRFEVVYHLLSITHNVRVRVKVPLEDDPVVPSVTDIWP 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7524986    118 SSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGY 163
Cdd:pfam00329  75 GANWYEREVYDMFGIVFEGHPDLRRILLPEDWEGHPLRKDFPLTGY 120
NuoC_fam TIGR01961
NADH (or F420H2) dehydrogenase, subunit C; This model describes the C subunit of the NADH ...
 36-162 2.04e-38

NADH (or F420H2) dehydrogenase, subunit C; This model describes the C subunit of the NADH dehydrogenase complex I in bacteria, as well as many instances of the corresponding mitochondrial subunit (NADH dehydrogenase subunit 9) and of the F420H2 dehydrogenase in Methanosarcina. Complex I contains subunits designated A-N. This C subunit often occurs as a fusion protein with the D subunit. This model excludes the NAD(P)H and plastoquinone-dependent form of chloroplasts and [Energy metabolism, Electron transport]


Pssm-ID: 273897 [Multi-domain]  Cd Length: 121  Bit Score: 128.89  E-value: 2.04e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986     36 LEIQVEKEKMLTVLKYLKEASKyQCNMLLDIVCVDCLnieeiKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGL 115
Cdd:TIGR01961   1 LVVWIKKEQLLEVLTFLKDPAL-GFELLTDVSGVDYP-----KEKRFEVVYHLLSIKKNRRIRLKVRLSEDDPVPSLTSV 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 7524986    116 FESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITG 162
Cdd:TIGR01961  75 FPTANWYERETYDMYGIVFDGHPDLRRILMPDDFEGHPLRKDYPLTG 121
 
Name Accession Description Interval E-value
PRK06074 PRK06074
NADH dehydrogenase subunit C; Provisional
 13-182 9.63e-53

NADH dehydrogenase subunit C; Provisional


Pssm-ID: 235691 [Multi-domain]  Cd Length: 189  Bit Score: 167.78  E-value: 9.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    13 NLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNIEEikigRFKLIYVLNSIY 92
Cdd:PRK06074   6 ELVAKLLEKLPDAIGKVTVAFGELTLKVPAEKILEVLTFLRDDPELRFEQLIDLTGVDYPERGK----RFEVVYHLLSYK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    93 NNTRVHLSTYVENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVND 172
Cdd:PRK06074  82 HNVRLRVKVRAPEDPVVPSVVDIWPSANWYEREAYDLYGIVFEGHPDLRRILTDYGFEGHPLRKDFPLTGYVEVRYDDEQ 161

                        170
                 ....*....|
gi 7524986   173 KKIIYKPIEL 182
Cdd:PRK06074 162 KRVVYEPVTL 171
NuoC COG0852
NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) [Energy production and conversion]; ...
 14-175 3.40e-47

NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) [Energy production and conversion]; NADH:ubiquinone oxidoreductase 27 kD subunit (chain C) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440613 [Multi-domain]  Cd Length: 164  Bit Score: 152.68  E-value: 3.40e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986   14 LGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEasKYQCNMLLDIVCVDCLNIEEikigRFKLIYVLNSIYN 93
Cdd:COG0852   7 LLEALEEKFGDAVLEVEEARGELTLTVPPEDLVDVARFLRD--DLGFDHLSDLTGVDYPERGD----RFEVVYHLLSLTH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986   94 NTRVHLSTYV-ENNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGYLEVYYDVND 172
Cdd:COG0852  81 NRRLRLKVFVpRDDPVVPSVTDVWPGANWHEREAYDMFGIVFEGHPDLRRILLPEDWEGHPLRKDFPLEGYVEVRYDEEL 160


                ...
gi 7524986  173 KKI 175
Cdd:COG0852 161 KRL 163
Complex1_30kDa pfam00329
Respiratory-chain NADH dehydrogenase, 30 Kd subunit;
38-163 2.33e-46

Respiratory-chain NADH dehydrogenase, 30 Kd subunit;


Pssm-ID: 459763 [Multi-domain]  Cd Length: 121  Bit Score: 149.17  E-value: 2.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986     38 IQVEKEKMLTVLKYLKEaSKYQCNMLLDIVCVDclnieEIKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGLFE 117
Cdd:pfam00329   1 VTVDPEDLLEVARFLRD-DELGFDHLSDLTGVD-----YPEEGRFEVVYHLLSITHNVRVRVKVPLEDDPVVPSVTDIWP 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7524986    118 SSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITGY 163
Cdd:pfam00329  75 GANWYEREVYDMFGIVFEGHPDLRRILLPEDWEGHPLRKDFPLTGY 120
NuoC_fam TIGR01961
NADH (or F420H2) dehydrogenase, subunit C; This model describes the C subunit of the NADH ...
 36-162 2.04e-38

NADH (or F420H2) dehydrogenase, subunit C; This model describes the C subunit of the NADH dehydrogenase complex I in bacteria, as well as many instances of the corresponding mitochondrial subunit (NADH dehydrogenase subunit 9) and of the F420H2 dehydrogenase in Methanosarcina. Complex I contains subunits designated A-N. This C subunit often occurs as a fusion protein with the D subunit. This model excludes the NAD(P)H and plastoquinone-dependent form of chloroplasts and [Energy metabolism, Electron transport]


Pssm-ID: 273897 [Multi-domain]  Cd Length: 121  Bit Score: 128.89  E-value: 2.04e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986     36 LEIQVEKEKMLTVLKYLKEASKyQCNMLLDIVCVDCLnieeiKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGL 115
Cdd:TIGR01961   1 LVVWIKKEQLLEVLTFLKDPAL-GFELLTDVSGVDYP-----KEKRFEVVYHLLSIKKNRRIRLKVRLSEDDPVPSLTSV 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 7524986    116 FESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITG 162
Cdd:TIGR01961  75 FPTANWYERETYDMYGIVFDGHPDLRRILMPDDFEGHPLRKDYPLTG 121
PRK11742 PRK11742
bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional
 40-159 2.34e-23

bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional


Pssm-ID: 236965 [Multi-domain]  Cd Length: 575  Bit Score: 96.91  E-value: 2.34e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    40 VEKEKMLTVLKYLKEASK-YqcNMLLDIVCVDclniEEIKIGR-------FKLIYVLNSIYNNTRVHLS-TYVENNGIIE 110
Cdd:PRK11742  28 VKREQLLEVLRFLRKLPKpY--VMLFDLHGID----ERLRTHReglpaadFTVFYHLISIERNRDIMLKvALSENDLHVP 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 7524986   111 TTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFP 159
Cdd:PRK11742 102 TITKIFPNANWYERETWDMFGITFDGHPHLRRILMPPTWEGHPLRKDYP 150
PRK13292 PRK13292
NADH-quinone oxidoreductase subunit B/C/D;
13-159 1.34e-19

NADH-quinone oxidoreductase subunit B/C/D;


Pssm-ID: 183955 [Multi-domain]  Cd Length: 788  Bit Score: 86.37  E-value: 1.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    13 NLGEHLRLSIPGLVKKIMYKTHYLEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVD--CLNiEEIKIGRFKLIYVLNS 90
Cdd:PRK13292 223 GLAGELEGAFGDDVRLDEGATDMLTYRCPPELVPEVLRHLKKRASSPFRRLEDLAAVDesCRR-DREKFPDFTVNYHLLS 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    91 IYNNTRVHLSTYVEN-NGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFP 159
Cdd:PRK13292 302 FDTPGHVRIKTELRGrTPELPSATGVFPAANWYEREAFDMFGIRFAGHPNLRRILMPPDWEGHPLRKEHP 371
PRK08491 PRK08491
NADH-quinone oxidoreductase subunit C;
38-162 2.57e-19

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 181449  Cd Length: 263  Bit Score: 83.18  E-value: 2.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    38 IQVEKEKMLTVLKYLKEASkYQCnmLLDIVCVDCLNieeiKIGRFKLIYVLNSIYNNTRVHLSTYVENNGIIETTSGLFE 117
Cdd:PRK08491  61 IWIKKDDNFKVLKILKHLG-YEC--LSEMSAIDFLA----KKGGFEVFYQLLSMSKRKRVRVKCFLKEKEALQSVSFLFK 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 7524986   118 SSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITG 162
Cdd:PRK08491 134 SANWSEREMYDMFGIVINNHPYLKRILMPDDWVGHPLLKSYPLKG 178
HycE1 COG3262
Ni,Fe-hydrogenase III component G [Energy production and conversion];
13-159 2.57e-17

Ni,Fe-hydrogenase III component G [Energy production and conversion];


Pssm-ID: 442493 [Multi-domain]  Cd Length: 523  Bit Score: 79.61  E-value: 2.57e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986   13 NLGEHLRLSIPGLVKKIMYKTHY-LEIQVEKEKMLTVLKYLKEASKYQcnmLLDIVCVDclniEEIKIGRFKLIYVLNSI 91
Cdd:COG3262   2 TRPEELRARFGGSILERRWVRPNeVWVEVDREDLPELAEFLAEGGGGR---LAALWGND----ERELGGGFAVYYVFALE 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7524986   92 YNNTRVHLSTYVE-NNGIIETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGF-VG-YPLKKDFP 159
Cdd:COG3262  75 GEGALVTLKVSVPkDDPVFPSITDLFPAASWYEREIRDLFGIVPEGHPDPRRLVLHDDWpEGiYPLRKDFK 145
PRK12494 PRK12494
NAD(P)H-quinone oxidoreductase subunit J;
114-158 1.42e-12

NAD(P)H-quinone oxidoreductase subunit J;


Pssm-ID: 183557 [Multi-domain]  Cd Length: 172  Bit Score: 63.05  E-value: 1.42e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 7524986   114 GLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDF 158
Cdd:PRK12494 116 WIWKGADWQERETYDMYGINFEGHPNLKRILMPEDWVGWPLRKDY 160
PRK07785 PRK07785
NADH dehydrogenase subunit C; Provisional
 36-162 3.51e-12

NADH dehydrogenase subunit C; Provisional


Pssm-ID: 181115 [Multi-domain]  Cd Length: 235  Bit Score: 63.09  E-value: 3.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524986    36 LEIQVEKEKMLTVLKYLKEASKYQCNMLLDIVCVDCLNieeiKIGR-FKLIYVLNSIYNNTRVHLSTYV-ENNGIIETTS 113
Cdd:PRK07785  91 LTLHVRREHLVEVAQTLRDDPALRFELCLGVSGVHYPH----DTGReLHAVYHLTSITHNRRIRLEVAVpDADPHIPSLV 166

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 7524986   114 GLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDFPITG 162
Cdd:PRK07785 167 SVYPTNDWHERETYDFFGIVFDGHPALTRIEMPDDWVGHPQRKDYPLGG 215
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
109-158 8.00e-11

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 60.38  E-value: 8.00e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 7524986   109 IETTSGLFESSVWLEREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDF 158
Cdd:PRK07735 374 VESVTPLWKGANWPEREAYDLLGIVFKGHPNLSRILLPDDWVGHPLRKDY 423
ndhJ CHL00012
NADH dehydrogenase subunit J
 123-158 2.62e-09

NADH dehydrogenase subunit J


Pssm-ID: 176955 [Multi-domain]  Cd Length: 158  Bit Score: 53.93  E-value: 2.62e-09
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 7524986   123 EREIWDMFGIYFEKHPDLRRILTDYGFVGYPLKKDF 158
Cdd:CHL00012 111 ERESYDMLGISYDNHPRLKRILMPESWIGWPLRKDY 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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