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Conserved domains on  [gi|7524356|ref|NP_039230|]
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paired box protein Pax-3 isoform PAX3b [Homo sapiens]

Protein Classification

MarR family transcriptional regulator; GntR family transcriptional regulator( domain architecture ID 11091156)

MarR family transcriptional regulator such as the multiple antibiotic resistance transcriptional regulator MarR, the repressor of the marRAB operon involved in the activation of both antibiotic resistance and oxidative stress genes| GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.85e-83

'Paired box' domain;


:

Pssm-ID: 366005  Cd Length: 125  Bit Score: 242.85  E-value: 2.85e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7524356    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.85e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 242.85  E-value: 2.85e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7524356    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX smart00351
Paired Box domain;
34-159 6.15e-83

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 241.84  E-value: 6.15e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356      34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 7524356     114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 34-161 1.54e-82

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.78  E-value: 1.54e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356   34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7524356  114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
transpos_IS630 NF033545
IS630 family transposase;
56-177 4.50e-05

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 43.01  E-value: 4.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356    56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS--- 130
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhwt 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 7524356   131 -WEIRDKLlkDAVCDRNTvpSVSSISRILRsKFG------KGEEEEADLERKEA 177
Cdd:NF033545  81 lRELAALL--EEEFGVEY--SRSTVRRLLK-RLGlspkkpRPRAPKQDPEFVEK 129
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 58-159 5.53e-05

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 42.92  E-value: 5.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356   58 KIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqvTTPDVEKKIEEY-KRENPGMFS-W-- 131
Cdd:COG3415  30 RAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSK--LSDEQRERLLELlREKSPDQGSrWtl 107

                        90       100
                ....*....|....*....|....*....
gi 7524356  132 -EIRDKLLKdavcDRNTVPSVSSISRILR 159
Cdd:COG3415 108 aELAELLEE----EFGVEVSPSTVRRLLK 132
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.85e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 242.85  E-value: 2.85e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 7524356    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX smart00351
Paired Box domain;
34-159 6.15e-83

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 241.84  E-value: 6.15e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356      34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 7524356     114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 34-161 1.54e-82

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.78  E-value: 1.54e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356   34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7524356  114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
transpos_IS630 NF033545
IS630 family transposase;
56-177 4.50e-05

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 43.01  E-value: 4.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356    56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS--- 130
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhwt 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 7524356   131 -WEIRDKLlkDAVCDRNTvpSVSSISRILRsKFG------KGEEEEADLERKEA 177
Cdd:NF033545  81 lRELAALL--EEEFGVEY--SRSTVRRLLK-RLGlspkkpRPRAPKQDPEFVEK 129
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 58-159 5.53e-05

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 42.92  E-value: 5.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7524356   58 KIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqvTTPDVEKKIEEY-KRENPGMFS-W-- 131
Cdd:COG3415  30 RAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSK--LSDEQRERLLELlREKSPDQGSrWtl 107

                        90       100
                ....*....|....*....|....*....
gi 7524356  132 -EIRDKLLKdavcDRNTVPSVSSISRILR 159
Cdd:COG3415 108 aELAELLEE----EFGVEVSPSTVRRLLK 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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